Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0027)
DME Name Steroid 11-beta-hydroxylase (CYP11B1), Homo sapiens DME Info
UniProt ID
C11B1_HUMAN
EC Number    EC: 1.14.15.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Prochloraz Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00955   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Prochloraz inhibits the drug-metabolizing activity of DME CYP11B1 [1], [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Enniatins Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01289   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Enniatins up-regulates the expression of DME CYP11B1 [3]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              3-Methylsulfonyl-dde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01100   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 3-Methylsulfonyl-dde up-regulates the expression of DME CYP11B1 [4]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the expression of DME CYP11B1 [5]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol up-regulates the expression of DME CYP11B1 [6]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Alpha-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01192   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Alpha-naphthoflavone up-regulates the expression of DME CYP11B1 [7]
                              Apigenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01203   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Apigenin inhibits the expression of DME CYP11B1 [7]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP11B1 (IC50 = 0.116 microM) [8]
                              Fadrozole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00468   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Fadrozole inhibits the drug-metabolizing activity of DME CYP11B1 (IC50 = 0.0063 microM) [9]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Anacetrapib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00561   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Anacetrapib up-regulates the expression of DME CYP11B1 [10]
                              Dalcetrapib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00564   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Dalcetrapib up-regulates the expression of DME CYP11B1 [10]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME CYP11B1 [11]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin induces the drug-metabolizing activity of DME CYP11B1 [12]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the expression of DME CYP11B1 [13]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cyclic AMP Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01267   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Cyclic AMP up-regulates the expression of DME CYP11B1 [7]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tetramethylpyrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00697   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Tetramethylpyrazine up-regulates the expression of DME CYP11B1 [14], [15]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME CYP11B1 [7]
                              Cyadox Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01264   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Cyadox inhibits the expression of DME CYP11B1 [16]
                              Mequindox Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01373   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Mequindox inhibits the drug-metabolizing activity of DME CYP11B1 [17]
                              Tributyltin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01491   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Tributyltin inhibits the expression of DME CYP11B1 [18]
References
1 Cr(VI) induces lipid peroxidation, protein oxidation and alters the activities of antioxidant enzymes in human erythrocytes. Biol Trace Elem Res. 2011 Dec;144(1-3):426-35.
2 3,4-Dihydroxybenzaldehyde quenches ROS and RNS and protects human blood cells from Cr(VI)-induced cytotoxicity and genotoxicity. Toxicol In Vitro. 2018 Aug;50:293-304.
3 An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicol Lett. 2015 Mar 4;233(2):84-94.
4 Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):281-9.
5 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARgama/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
6 An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicol Lett. 2012 Nov 15;214(3):268-78.
7 Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. Toxicol Appl Pharmacol. 2012 Feb 1;258(3):343-50.
8 Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5825-5829.
9 Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem. 2014 Jun 26;57(12):5179-89.
10 Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.
11 Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells. Chemosphere. 2016 Mar;147:9-19.
12 Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression. J Endocrinol. 2003 Jan;176(1):69-82.
13 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
14 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation. Toxicol Sci. 2013 Mar;132(1):235-49.
15 Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands. J Pharmacol Exp Ther. 2006 Dec;319(3):1162-71.
16 High risk of adrenal toxicity of N1-desoxy quinoxaline 1,4-dioxide derivatives and the protection of oligomeric proanthocyanidins (OPC) in the inhibition of the expression of aldosterone synthetase in H295R cells. Toxicology. 2016 Feb 3;341-343:1-16.
17 delta-Aminolevulinate dehydratase activity and oxidative stress during melphalan and cyclophosphamide-BCNU-etoposide (CBV) conditioning regimens in autologous bone marrow transplantation patients. Pharmacol Res. 2009 Apr;59(4):279-84.
18 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.

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