Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0036)
DME Name Aldosterone synthase (CYP11B2), Homo sapiens DME Info
UniProt ID
C11B2_HUMAN
EC Number    EC: 1.14.15.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Enniatins Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01289   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Enniatins up-regulates the expression of DME CYP11B2 [1]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME CYP11B2 [2]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              3-Methylsulfonyl-dde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01100   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 3-Methylsulfonyl-dde up-regulates the expression of DME CYP11B2 [3]
                              Acenaphthenes Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00991   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Acenaphthenes inhibits the drug-metabolizing activity of DME CYP11B2 [4]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid up-regulates the expression of DME CYP11B2 [5]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol up-regulates the expression of DME CYP11B2 [6]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Amoxicillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00246   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amoxicillin induces the drug-metabolizing activity of DME CYP11B2 [7]
                              Carbamazepine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine up-regulates the expression of DME CYP11B2 [8]
                              Dutasteride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00192   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dutasteride up-regulates the expression of DME CYP11B2 [9]
                              Erythromycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00111   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Erythromycin induces the drug-metabolizing activity of DME CYP11B2 [7]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP11B2 (IC50 = 0.067 microM) [10]
                              Potassium chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00395   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Potassium chloride induces the drug-metabolizing activity of DME CYP11B2 [11]
                              Fadrozole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00468   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Fadrozole inhibits the drug-metabolizing activity of DME CYP11B2 (IC50 = 0.0008 microM) [12]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Anacetrapib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00561   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Anacetrapib up-regulates the expression of DME CYP11B2 [13]
                              Dalcetrapib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00564   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Dalcetrapib induces the drug-metabolizing activity of DME CYP11B2 [13]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME CYP11B2 [14]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin up-regulates the expression of DME CYP11B2 [15]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bay K 8644 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01143   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Bay K 8644 up-regulates the expression of DME CYP11B2 [16]
                              Mequindox Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01373   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Mequindox inhibits the drug-metabolizing activity of DME CYP11B2 [17], [18]
                              Tributyltin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01491   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Tributyltin up-regulates the expression of DME CYP11B2 [19]
      Other Chemical Compound(s) or Element(s)
                  Cosmetic Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-acetyltributylcitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01612   XEOTIC Info Gene Form mRNA
                                 Classification Cosmetic Additive
                                 DME Modulation 2-acetyltributylcitrate up-regulates the expression of DME CYP11B2 [15]
References
1 An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicol Lett. 2015 Mar 4;233(2):84-94.
2 Transcriptional signatures of environmentally relevant exposures in normal human mammary epithelial cells: benzo[a]pyrene. Cancer Lett. 2005 Apr 28;221(2):201-11.
3 Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):281-9.
4 Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2). Bioorg Med Chem Lett. 2006 Jan 1;16(1):25-30.
5 Effects of brominated flame retardants and brominated dioxins on steroidogenesis in H295R human adrenocortical carcinoma cell line. Environ Toxicol Chem. 2007 Apr;26(4):764-72.
6 An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicol Lett. 2012 Nov 15;214(3):268-78.
7 Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicol Appl Pharmacol. 2007 Dec 1;225(2):142-53.
8 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
9 Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7.
10 First selective CYP11B1 inhibitors for the treatment of cortisol-dependent diseases. ACS Med Chem Lett. 2010 Oct 22;2(1):2-6.
11 Consumption of argan oil may have an antiatherogenic effect by improving paraoxonase activities and antioxidant status: Intervention study in healthy men. Nutr Metab Cardiovasc Dis. 2005 Oct;15(5):352-60.
12 Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem. 2014 Jun 26;57(12):5179-89.
13 Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.
14 Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells. Chemosphere. 2016 Mar;147:9-19.
15 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
16 Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. Mol Endocrinol. 1997 May;11(5):638-49.
17 delta-Aminolevulinate dehydratase activity and oxidative stress during melphalan and cyclophosphamide-BCNU-etoposide (CBV) conditioning regimens in autologous bone marrow transplantation patients. Pharmacol Res. 2009 Apr;59(4):279-84.
18 Synthesis of monomeric derivatives to probe memoquin's bivalent interactions. J Med Chem. 2011 Dec 22;54(24):8299-304.
19 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.

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