Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0045)
DME Name Monoamine oxidase type B (MAO-B), Homo sapiens DME Info
UniProt ID
AOFB_HUMAN
EC Number    EC: 1.4.3.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH2 donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.4.3.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME MAOB [1]
                              Uranium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00964   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Uranium inhibits the expression of DME MAOB [2]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME MAOB [3]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              5-nitroindazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01164   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 5-nitroindazole inhibits the drug-metabolizing activity of DME MAOB (IC50 = 2.5 microM) [4]
                              Butyraldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00999   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Butyraldehyde inhibits the expression of DME MAOB [5]
                              Caffeic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01232   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Caffeic acid inhibits the drug-metabolizing activity of DME MAOB [6]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the expression of DME MAOB [7]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of DME MAOB [8]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter induces the drug-metabolizing activity of DME MAOB [9]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Heliotrine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01551   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Heliotrine inhibits the expression of DME MAOB [10]
                              Pyrrolizidine alkaloid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01582   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Pyrrolizidine alkaloid inhibits the expression of DME MAOB [5]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      15 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME MAOB [11], [12]
                              Benzyl benzoate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00008   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Benzyl benzoate inhibits the drug-metabolizing activity of DME MAOB [6]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME MAOB [13]
                              Carbamazepine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine up-regulates the expression of DME MAOB [14]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME MAOB [15]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME MAOB [16]
                              Menadione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione inhibits the drug-metabolizing activity of DME MAOB (Ki = 0.4 microM) [17]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate induces the drug-metabolizing activity of DME MAOB [18]
                              Methylene blue Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00417   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methylene blue inhibits the drug-metabolizing activity of DME MAOB [19]
                              Pargyline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00420   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pargyline inhibits the drug-metabolizing activity of DME MAOB (IC50 = 0.13 microM) [20], [21]
                              Rasagiline mesylate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00320   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rasagiline mesylate inhibits the drug-metabolizing activity of DME MAOB (IC50 = 0.004 microM) [22]
                              Selegiline hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00323   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Selegiline hydrochloride inhibits the drug-metabolizing activity of DME MAOB (IC50 = 0.000017 microM) [23]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the expression of DME MAOB [2]
                              Valproic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid up-regulates the expression of DME MAOB [24]
                              Tanshinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00486   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Tanshinone induces the drug-metabolizing activity of DME MAOB [25], [26]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Triclosan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan inhibits the expression of DME MAOB [27]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Chlorogenic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01246   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Chlorogenic acid inhibits the drug-metabolizing activity of DME MAOB [6]
                              Lazabemide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00620   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Lazabemide inhibits the drug-metabolizing activity of DME MAOB (IC50 = 0.091 microM) [28]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Beta-carboline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00701   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Beta-carboline inhibits the drug-metabolizing activity of DME MAOB (Ki = 1.2 microM) [17]
References
1 Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium. BMC Med Genomics. 2013;6 Suppl 1:S2.
2 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
3 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
4 Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency. J Med Chem. 2014 Aug 14;57(15):6679-703.
5 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
6 Combining initro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.
7 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARgama/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
8 Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20970-5.
9 Oxidative stress induced by palytoxin in human keratinocytes is mediated by a H+-dependent mitochondrial pathway. Toxicol Appl Pharmacol. 2013 Jan 1;266(1):1-8.
10 Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicol In Vitro. 2015 Oct;29(7):1669-82.
11 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
12 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
13 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
14 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
15 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
16 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
17 Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. Bioorg Med Chem. 2011 Dec 15;19(24):7416-24.
18 Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf). 2004 Jan;60(1):75-80.
19 Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
20 Structure-based design and optimization of multitarget-directed 2H-chromen-2-one derivatives as potent inhibitors of monoamine oxidase B and cholinesterases. J Med Chem. 2015 Jul 23;58(14):5561-78.
21 Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity. J Med Chem. 2013 Sep 26;56(18):7334-42.
22 Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors. J Med Chem. 2011 Oct 27;54(20):7127-37.
23 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Bioorg Med Chem. 2010 Nov 1;18(21):7675-99.
24 Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2004 Jan;255(1-2):247-56.
25 Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenaseMediation through different signaling pathways. J Biol Chem. 2000 Sep 8;275(36):28173-9.
26 Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 1999 Sep 1;59(17):4356-62.
27 Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway. Ecotoxicol Environ Saf. 2018 Jul 30;156:148-153.
28 The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase. Eur J Med Chem. 2017 Jul 28;135:196-203.

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