Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000548)
DM Name	Capsaicin metabolite M2
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A1 (CYP1A1)	DME0006	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 1A2 (CYP1A2)	DME0003	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 2E1 (CYP2E1)	DME0013	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Capsaicin	Oxidation - Omega-Hydroxylation	Capsaicin	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Capsaicin		DR0268	Approved		Herpes zoster

References
1	Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.

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