Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0201)
DME Name Arachidonate 5-lipoxygenase (ALOX5), Homo sapiens DME Info
UniProt ID
LOX5_HUMAN
EC Number    EC: 1.13.11.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.34
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Endosulfan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01074   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Endosulfan up-regulates the expression of DME ALOX5 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01119   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the expression of DME ALOX5 [2]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Melitten Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00817   XEOTIC Info Gene Form mRNA
                                 Classification Biotoxin
                                 DME Modulation Melitten up-regulates the expression of DME ALOX5 [3]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Sodium bichromate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01024   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Sodium bichromate inhibits the expression of DME ALOX5 [4]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME ALOX5 [5]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01512   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc up-regulates the expression of DME ALOX5 [6]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Butyraldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00999   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Butyraldehyde up-regulates the expression of DME ALOX5 [7]
                              Pirinixic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01433   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Pirinixic acid inhibits the expression of DME ALOX5 [8]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Arzanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01207   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Arzanol inhibits the drug-metabolizing activity of DME ALOX5 [9]
                              Thapsigargin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00809   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Thapsigargin up-regulates the expression of DME ALOX5 [10], [11]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      10 Xenobiotics
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol induces the drug-metabolizing activity of DME ALOX5 [12]
                              Cetirizine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00348   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cetirizine inhibits the drug-metabolizing activity of DME ALOX5 [13]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME ALOX5 [14], [15]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride up-regulates the expression of DME ALOX5 [16]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide induces the drug-metabolizing activity of DME ALOX5 [17]
                              Meclofenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00415   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Meclof DMEenamic acid inhibits the drug-metabolizing activity of DME ALOX5 [18]
                              Niclosamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00405   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Niclosamide induces the drug-metabolizing activity of DME ALOX5 [19], [20]
                              Nicotine polacrilex Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex up-regulates the expression of DME ALOX5 [21], [22]
                              Tretinoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin up-regulates the expression of DME ALOX5 [23]
                              Zoledronic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00140   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Zoledronic acid up-regulates the expression of DME ALOX5 [24]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Seocalcitol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00652   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Seocalcitol up-regulates the expression of DME ALOX5 [6]
                              Vitamin E Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00547   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Vitamin E inhibits the expression of DME ALOX5 [25], [24]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Calcimycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00604   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Calcimycin induces the drug-metabolizing activity of DME ALOX5 [26]
                              Ebselen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00544   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ebselen inhibits the drug-metabolizing activity of DME ALOX5 [27]
                              Efletirizine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00617   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Efletirizine inhibits the drug-metabolizing activity of DME ALOX5 [13]
                              MS-275 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 up-regulates the expression of DME ALOX5 [28]
                              Tenidap Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00608   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Tenidap inhibits the drug-metabolizing activity of DME ALOX5 [29]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite up-regulates the expression of DME ALOX5 [4], [30]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME ALOX5 [31]
                              AA-861 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00689   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation AA-861 inhibits the drug-metabolizing activity of DME ALOX5 [32]
                              BW-755C Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00699   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation BW-755C inhibits the drug-metabolizing activity of DME ALOX5 [33]
                              CJ-13610 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00726   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation CJ-13610 inhibits the drug-metabolizing activity of DME ALOX5 [34]
                              REV-5901 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00695   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation REV-5901 inhibits the drug-metabolizing activity of DME ALOX5 [35]
                              ICI-211965 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01338   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICI-211965 inhibits the drug-metabolizing activity of DME ALOX5 [36]
                              JHW-015 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00731   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation JHW-015 inhibits the drug-metabolizing activity of DME ALOX5 [37]
                              L-708714 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01360   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation L-708714 inhibits the drug-metabolizing activity of DME ALOX5 [38]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benoxaprofen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00515   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Benoxaprof DMEen inhibits the drug-metabolizing activity of DME ALOX5 [39], [33]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME ALOX5 [40]
                              Cotylenin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01260   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Cotylenin A up-regulates the expression of DME ALOX5 [41]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Pentanal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01034   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Pentanal up-regulates the expression of DME ALOX5 [24]
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