Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01230)
Xenobiotics Name
Butyric acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
264
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [1]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [1]
Eosinophil peroxidase (EPX) DME Info Homo sapiens [2]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [1]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1], [3]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [1]
References
1 Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology. 2019 Jan 15;412:1-11.
2 The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells. J Interferon Cytokine Res. 2003 Dec;23(12):737-44.
3 Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid. Biosci Biotechnol Biochem. 2007 Oct;71(10):2428-34.

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