Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0019)
DME Name Cytochrome P450 2C9 (CYP2C9), Homo sapiens DME Info
UniProt ID
CP2C9_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium adolescentis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium adolescentis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Benzbromarone Click to Show/Hide the Detail
                                 Drug ID DR0193   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium breve co-metabolize the drug Benzbromarone, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium breve co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium breve co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium breve co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium longum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium longum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Bupropion Click to Show/Hide the Detail
                                 Drug ID DR0247   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Bupropion, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bifidobacterium ruminatum co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pitavastatin calcium Click to Show/Hide the Detail
                                 Drug ID DR1306   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Collinsella aerofaciens co-metabolize the drug Pitavastatin calcium, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Collinsella aerofaciens co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Collinsella intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Collinsella intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Dopamine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0532   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eggerthella lenta co-metabolize the drug Dopamine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [13]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eggerthella lenta co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Mycobacterium tuberculosis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dextromethorphan hydrobromide Click to Show/Hide the Detail
                                 Drug ID DR0476   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Mycobacterium tuberculosis co-metabolize the drug Dextromethorphan hydrobromide, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [15]
                  Nocardia farcinica (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Nocardia farcinica co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [16]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Coumarin Click to Show/Hide the Detail
                                 Drug ID DR0386   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Streptomyces avermitilis co-metabolize the drug Coumarin, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [18], [19]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [18], [21]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Streptomyces avermitilis co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [23], [18]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Alistipes indistinctus co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Alistipes indistinctus co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Alistipes indistinctus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Alistipes indistinctus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides caccae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides cellulosilyticus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides cellulosilyticus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides cellulosilyticus co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Glipizide Click to Show/Hide the Detail
                                 Drug ID DR0778   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Glipizide, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides coprophilus co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:      20 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [20], [30]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Doxazosin Click to Show/Hide the Detail
                                 Drug ID DR0542   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Doxazosin, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Gliclazide Click to Show/Hide the Detail
                                 Drug ID DR0776   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Gliclazide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Glipizide Click to Show/Hide the Detail
                                 Drug ID DR0778   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Glipizide, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Venlafaxine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1679   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Venlafaxine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides dorei co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides eggerthii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides eggerthii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides eggerthii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides eggerthii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides eggerthii co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides finegoldii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides finegoldii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:      23 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Gliclazide Click to Show/Hide the Detail
                                 Drug ID DR0776   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Gliclazide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Glipizide Click to Show/Hide the Detail
                                 Drug ID DR0778   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Glipizide, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [39], [40]
                              Naftopidil Click to Show/Hide the Detail
                                 Drug ID DR1124   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Naftopidil, which can collectively affect efficacy, safety or bioavailability of this drug. [41], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Rosuvastatin Click to Show/Hide the Detail
                                 Drug ID DR1445   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Rosuvastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [43], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Tranilast Click to Show/Hide the Detail
                                 Drug ID DR1628   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Tranilast, which can collectively affect efficacy, safety or bioavailability of this drug. [44], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides fragilis co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides intestinalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides intestinalis co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides oleiciplenus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides oleiciplenus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [45]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      10 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides ovatus co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:      19 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Venlafaxine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1679   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Venlafaxine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides sartorii co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        8 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Venlafaxine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1679   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides stercoris co-metabolize the drug Venlafaxine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:      17 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Gliclazide Click to Show/Hide the Detail
                                 Drug ID DR0776   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Gliclazide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Tranilast Click to Show/Hide the Detail
                                 Drug ID DR1628   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Tranilast, which can collectively affect efficacy, safety or bioavailability of this drug. [44], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides thetaiotaomicron co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides uniformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides uniformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      19 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Gliclazide Click to Show/Hide the Detail
                                 Drug ID DR0776   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Gliclazide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [46], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Indomethacin, and Bacteroides vulgatus further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [47]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Venlafaxine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1679   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Venlafaxine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [35], [2]
                              Verapamil hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1681   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Verapamil hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides vulgatus co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:      17 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides xylanisolvens co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:      17 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Gliclazide Click to Show/Hide the Detail
                                 Drug ID DR0776   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Gliclazide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Glipizide Click to Show/Hide the Detail
                                 Drug ID DR0778   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Glipizide, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Odoribacter splanchnicus co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:      12 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Gliclazide Click to Show/Hide the Detail
                                 Drug ID DR0776   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Gliclazide, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [33], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
                              Voriconazole Click to Show/Hide the Detail
                                 Drug ID DR1709   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides distasonis co-metabolize the drug Voriconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [36], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Estrone sulfate Click to Show/Hide the Detail
                                 Drug ID DR0650   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Estrone sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [48]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides johnsonii co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Parabacteroides merdae co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Prevotella buccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Estrone sulfate Click to Show/Hide the Detail
                                 Drug ID DR0650   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella buccae co-metabolize the drug Estrone sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [49], [50]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella copri co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [51], [52]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella copri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella copri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella copri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella copri co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Valsartan Click to Show/Hide the Detail
                                 Drug ID DR1668   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Prevotella copri co-metabolize the drug Valsartan, which can collectively affect efficacy, safety or bioavailability of this drug. [34], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerobutyricum hallii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerobutyricum hallii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerobutyricum hallii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerococcus hydrogenalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerococcus hydrogenalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerococcus hydrogenalis co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Imatinib mesylate Click to Show/Hide the Detail
                                 Drug ID DR0858   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerostipes hadrus co-metabolize the drug Imatinib mesylate, which can collectively affect efficacy, safety or bioavailability of this drug. [46], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerostipes hadrus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Anaerotruncus colihominis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerotruncus colihominis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Anaerotruncus colihominis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [53]
                              Dextromethorphan hydrobromide Click to Show/Hide the Detail
                                 Drug ID DR0476   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacillus megaterium co-metabolize the drug Dextromethorphan hydrobromide, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [53]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [54]
                              Mefenamic acid Click to Show/Hide the Detail
                                 Drug ID DR1014   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacillus megaterium co-metabolize the drug Mefenamic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [55], [54]
                              Progesterone Click to Show/Hide the Detail
                                 Drug ID DR1346   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. [56], [57]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacillus megaterium co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [57], [58]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides pectinophilus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides pectinophilus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides pectinophilus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Bacteroides pectinophilus co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:      18 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Doxazosin Click to Show/Hide the Detail
                                 Drug ID DR0542   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Doxazosin, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [38], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Nevirapine Click to Show/Hide the Detail
                                 Drug ID DR1142   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Nevirapine, which can collectively affect efficacy, safety or bioavailability of this drug. [59], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Rosuvastatin Click to Show/Hide the Detail
                                 Drug ID DR1445   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Rosuvastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [43], [2]
                              Sildenafil citrate Click to Show/Hide the Detail
                                 Drug ID DR1481   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Sildenafil citrate, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia hansenii co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Blautia luti (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Blautia luti co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [60]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridioides difficile co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridioides difficile co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Sildenafil citrate Click to Show/Hide the Detail
                                 Drug ID DR1481   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridioides difficile co-metabolize the drug Sildenafil citrate, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:      13 Drugs Metabolized
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Doxazosin Click to Show/Hide the Detail
                                 Drug ID DR0542   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Doxazosin, which can collectively affect efficacy, safety or bioavailability of this drug. [31], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Fluconazole Click to Show/Hide the Detail
                                 Drug ID DR0704   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Fluconazole, which can collectively affect efficacy, safety or bioavailability of this drug. [32], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Nateglinide Click to Show/Hide the Detail
                                 Drug ID DR1132   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug. [37], [2]
                              Nevirapine Click to Show/Hide the Detail
                                 Drug ID DR1142   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Nevirapine, which can collectively affect efficacy, safety or bioavailability of this drug. [59], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Oxaprozin Click to Show/Hide the Detail
                                 Drug ID DR1212   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Oxaprozin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Sildenafil citrate Click to Show/Hide the Detail
                                 Drug ID DR1481   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Sildenafil citrate, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium botulinum co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium perfringens co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [61]
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium perfringens co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [61]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium scindens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium scindens co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium spiroforme co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium spiroforme co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium sporogenes co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Celecoxib Click to Show/Hide the Detail
                                 Drug ID DR0286   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium sporogenes co-metabolize the drug Celecoxib, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Clopidogrel bisulfate Click to Show/Hide the Detail
                                 Drug ID DR0355   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium sporogenes co-metabolize the drug Clopidogrel bisulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [27], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium sporogenes co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium sporogenes co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium symbiosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Clostridium symbiosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Coprococcus comes co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Coprococcus comes co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Dorea formicigenerans co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Dorea formicigenerans co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Dorea formicigenerans co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterocloster asparagiformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterocloster asparagiformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterocloster bolteae co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterocloster bolteae co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterocloster bolteae co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterococcus casseliflavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterococcus casseliflavus co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [62]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [60]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterococcus faecalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterococcus faecalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterococcus gallinarum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterococcus gallinarum co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [62]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Erysipelatoclostridium ramosum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Indomethacin, and Erysipelatoclostridium ramosum further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [47]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Erysipelatoclostridium ramosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eubacterium rectale co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eubacterium rectale co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eubacterium ventriosum co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eubacterium ventriosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Eubacterium ventriosum co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [20], [30]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Celecoxib Click to Show/Hide the Detail
                                 Drug ID DR0286   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Celecoxib, which can collectively affect efficacy, safety or bioavailability of this drug. [42], [2]
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [24], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Glipizide Click to Show/Hide the Detail
                                 Drug ID DR0778   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Glipizide, which can collectively affect efficacy, safety or bioavailability of this drug. [29], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Tolazamide Click to Show/Hide the Detail
                                 Drug ID DR1611   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Holdemanella biformis co-metabolize the drug Tolazamide, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Hungatella hathewayi co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Hungatella hathewayi co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Jeotgalicoccus psychrophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Jeotgalicoccus psychrophilus co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [51], [52]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Lactobacillus reuteri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Lactobacillus reuteri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [20], [30]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Marvinbryantia formatexigens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Roseburia hominis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Indomethacin, and Roseburia hominis further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [47]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Roseburia intestinalis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Roseburia intestinalis co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Indomethacin, and Roseburia intestinalis further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [47]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Roseburia intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Roseburia intestinalis co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Ruminococcus albus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus albus co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [51], [52]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [20], [30]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus gnavus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus gnavus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus gnavus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus lactaris co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus lactaris co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus lactaris co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ruminococcus torques co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Subdoligranulum variabile co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Subdoligranulum variabile co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diltiazem hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0509   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Victivallis vadensis co-metabolize the drug Diltiazem hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [25], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Victivallis vadensis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Proteobacteria
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [60]
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Edwardsiella tarda co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Edwardsiella tarda co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterobacter cancerogenus co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterobacter cancerogenus co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterobacter cancerogenus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterobacter cancerogenus co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Enterobacter cloacae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Enterobacter cloacae co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [63]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        8 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [60]
                              Bupropion Click to Show/Hide the Detail
                                 Drug ID DR0247   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Escherichia coli co-metabolize the drug Bupropion, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Duloxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0554   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Escherichia coli co-metabolize the drug Duloxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [28], [2]
                              Flunitrazepam Click to Show/Hide the Detail
                                 Drug ID DR0712   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Escherichia coli co-metabolize the drug Flunitrazepam, which can collectively affect efficacy, safety or bioavailability of this drug. [64], [65]
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Escherichia coli co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Indomethacin, and Escherichia coli further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [66]
                              Ketoprofen Click to Show/Hide the Detail
                                 Drug ID DR0907   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Ketoprofen, and Escherichia coli further metabolizes its metabolite (Ketoprofen glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [67], [68]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Escherichia coli co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Helicobacter apodemus (epsilon-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Helicobacter apodemus co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [51], [52]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Proteus penneri co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Proteus penneri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Proteus penneri co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Providencia alcalifaciens (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Providencia alcalifaciens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia rettgeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Providencia rettgeri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Providencia stuartii co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Providencia stuartii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Terbinafine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1557   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Providencia stuartii co-metabolize the drug Terbinafine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Pseudomonas putida (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nicotine Click to Show/Hide the Detail
                                 Drug ID DR1148   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Pseudomonas putida co-metabolize the drug Nicotine, which can collectively affect efficacy, safety or bioavailability of this drug. [69], [70]
                  Ralstonia solanacearum (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ANW-43703 Click to Show/Hide the Detail
                                 Drug ID DR1458   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Ralstonia solanacearum co-metabolize the drug ANW-43703, which can collectively affect efficacy, safety or bioavailability of this drug. [71], [72], [73]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fluoxetine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0720   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Salmonella enterica co-metabolize the drug Fluoxetine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Salmonella enterica co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Salmonella typhimurium (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Niclosamide Click to Show/Hide the Detail
                                 Drug ID DR1146   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Salmonella typhimurium co-metabolize the drug Niclosamide, which can collectively affect efficacy, safety or bioavailability of this drug. [74], [75]
                  Shewanella oneidensis (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Shewanella oneidensis co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [76], [77], [78]
                  Sphingomonas colocasiae (alpha-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ibuprofen Click to Show/Hide the Detail
                                 Drug ID DR0844   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Sphingomonas colocasiae co-metabolize the drug Ibuprofen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [79]
      Bacteria: Synergistetes
                  Synergistetes bacterium (synergistetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Synergistetes bacterium co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [76], [80], [81]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Naftopidil Click to Show/Hide the Detail
                                 Drug ID DR1124   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Akkermansia muciniphila co-metabolize the drug Naftopidil, which can collectively affect efficacy, safety or bioavailability of this drug. [41], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Akkermansia muciniphila co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Fungi: Ascomycota
                  Saccharomyces cerevisiae (ascomycota) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug. [11], [60]
      Archaea: Euryarchaeota
                  Methanobrevibacter oralis (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Methanobrevibacter oralis co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [82]
                  Methanobrevibacter smithii (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Methanobrevibacter smithii co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [82]
                  Methanomassiliicoccus luminyensis (thermoplasmata) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Methanomassiliicoccus luminyensis co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [82]
                  Methanosphaera stadtmanae (methanobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rifampicin Click to Show/Hide the Detail
                                 Drug ID DR1420   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Methanosphaera stadtmanae co-metabolize the drug Rifampicin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [82]
      Amoebozoa: Evosea
                  Entamoeba histolytica (eukaryotes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Entamoeba histolytica co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [83]
      Metamonada: Fornicata
                  Giardia intestinalis (diplomonads) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Giardia intestinalis co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [83]
      Metamonada: Parabasalia
                  Trichomonas vaginalis (trichomonads) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Metronidazole Click to Show/Hide the Detail
                                 Drug ID DR1073   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C9 (CYP2C9) and Trichomonas vaginalis co-metabolize the drug Metronidazole, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [83]
References
1 Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism. Med Chem. 2009 May;5(3):263-70.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.
4 Quantitative binding models for CYP2C9 based on benzbromarone analogues. Biochemistry. 2004 Jun 8;43(22):6948-58.
5 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
6 Product Monograph of Wellbutrin SR(Bupropion Hydrochloride).
7 Rapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray. World J Gastroenterol. 2003 Jun;9(6):1342-6.
8 Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics. J Clin Pharmacol. 1997 Apr;37(4):267-78.
9 Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83.
10 Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs. 2017 Apr;17(2):157-168.
11 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
12 Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
13 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
14 Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J Pharm Pharmacol. 1998 Sep;50(9):997-1004.
15 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.
16 Mechanism of rifampicin inactivation in Nocardia farcinica. PLoS One. 2016 Oct 5;11(10):e0162578.
17 Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2017 Dec 28;8(1).
18 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
19 Cloning, expression and characterization of CYP102D1, a self-sufficient P450 monooxygenase from Streptomyces avermitilis. FEBS J. 2012 May;279(9):1650-62.
20 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
21 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
22 Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
23 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
24 CYP2C9 polymorphisms in human tumors. Anticancer Res. 2006 Jan-Feb;26(1A):299-305.
25 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
26 The role of CYP2C9 genetic polymorphism in carvedilol O-desmethylation in vitro. Eur J Drug Metab Pharmacokinet. 2016 Feb;41(1):79-86.
27 Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther. 2007 May;81(5):735-41.
28 Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94.
29 Clinical consequences of cytochrome P450 2C9 polymorphisms. Clin Pharmacol Ther. 2005 Jan;77(1):1-16.
30 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
31 Product monograph: CARDURA (Doxazosin mesylate).
32 Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Eur J Clin Pharmacol. 2000 Jun;56(3):225-9.
33 Antiepileptic drug interactions - principles and clinical implications. Curr Neuropharmacol. 2010 Sep;8(3):254-67.
34 In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists. Eur J Clin Pharmacol. 2000 May;56(2):135-40.
35 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
36 Effect of voriconazole on the pharmacokinetics of diclofenac. Fundam Clin Pharmacol. 2007 Dec;21(6):651-6.
37 Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet. 2007;46(2):93-108.
38 Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man. Xenobiotica. 2004 May;34(5):449-61.
39 Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington State. J Clin Microbiol. 2004 Sep;42(9):4127-9. Case Reports
40 Biotransformation of 1-nitropyrene in intestinal anaerobic bacteria. Microbiol Immunol. 1982;26(11):993-1005.
41 Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. J Pharm Pharmacol. 2014 Nov;66(11):1534-51.
42 Drug interactions in dentistry: the importance of knowing your CYPs. J Am Dent Assoc. 2004 Mar;135(3):298-311.
43 Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12.
44 Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite. Drug Metab Dispos. 2007 Apr;35(4):583-9.
45 Metabolism of omeprazole by gut flora in rats. J Pharm Sci. 1995 Apr;84(4):516-7. Letter
46 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
47 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
48 Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642.
49 Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946-2956.
50 Regulating gut flora dysbiosis in obese mice by electroacupuncture. Am J Chin Med. 2018 Oct 4:1-17.
51 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
52 Gut microbiota-mediated drug-drug interaction between amoxicillin and aspirin. Sci Rep. 2019 Nov 7;9(1):16194.
53 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
54 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
55 Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases. Chem Res Toxicol. 2014 Dec 15;27(12):2071-81.
56 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
57 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
58 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
59 Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. J Clin Pharmacol. 2001 Jan;41(1):85-91.
60 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
61 Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.
62 Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200.
63 Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60.
64 CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40.
65 Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9.
66 Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973.
67 Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):167-73.
68 Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica. 2014 Jan;44(1):28-35.
69 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
70 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
71 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56.
72 Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.
73 Involvement of a PadR regulator PrhP on virulence of Ralstonia solanacearum by controlling detoxification of phenolic acids and type III secretion system. Mol Plant Pathol. 2019 Nov;20(11):1477-1490.
74 Generation and evaluation of a CYP2C9 heteroactivation pharmacophore. J Pharmacol Exp Ther. 2003 Dec;307(3):878-87.
75 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
76 Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Life Sci. 2005 May 27;77(2):205-19.
77 Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation. 2018 Apr;29(2):129-140.
78 The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation. Res Microbiol. 2010 Mar;161(2):144-52.
79 Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2. Microbiology. 2013 Mar;159(Pt 3):621-632.
80 Bacterial community changes and antibiotic resistance gene quantification in microbial electrolysis cells during long-term sulfamethoxazole treatment. Bioresour Technol. 2019 Dec;294:122170.
81 Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches. Microb Pathog. 2016 May;94:90-103.
82 The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea. J Antimicrob Chemother. 2011 Sep;66(9):2038-44.
83 Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64.

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