Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0038)
DME Name Vitamin D(3) 24-hydroxylase (CYP24A1), Homo sapiens DME Info
UniProt ID
CP24A_HUMAN
EC Number    EC: 1.14.15.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.16
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dicrotophos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos up-regulates the expression of DME CYP24A1 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium inhibits the expression of DME CYP24A1 [2]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME CYP24A1 [3]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01512   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc up-regulates the expression of DME CYP24A1 [4]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Nano-sized iron particle Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00831   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Nano-sized iron particle inhibits the expression of DME CYP24A1 [5]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate induces the drug-metabolizing activity of DME CYP24A1 [6], [7]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Amphibole asbestos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00995   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Amphibole asbestos inhibits the expression of DME CYP24A1 [8]
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter up-regulates the expression of DME CYP24A1 [9]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Hyperforin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01335   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Hyperforin up-regulates the expression of DME CYP24A1 [10]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Apple polyphenol extract Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00757   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Apple polyphenol extract up-regulates the expression of DME CYP24A1 [11]
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Plant extracts up-regulates the expression of DME CYP24A1 [12]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang up-regulates the expression of DME CYP24A1 [13]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      18 Xenobiotics
                              Ampicillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00096   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ampicillin inhibits the expression of DME CYP24A1 [14]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME CYP24A1 [15]
                              Calcifediol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00230   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcifediol up-regulates the expression of DME CYP24A1 [16]
                              Calcipotriene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00261   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcipotriene up-regulates the expression of DME CYP24A1 [17]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol induces the drug-metabolizing activity of DME CYP24A1 [18], [19]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the expression of DME CYP24A1 [13]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME CYP24A1 [20]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME CYP24A1 [21]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME CYP24A1 [22], [14]
                              Gemcitabine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00361   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gemcitabine inhibits the expression of DME CYP24A1 [23]
                              Itraconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00250   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Itraconazole inhibits the drug-metabolizing activity of DME CYP24A1 [24]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP24A1 (IC50 = 0.126 microM) [25]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME CYP24A1 [26], [27]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin up-regulates the expression of DME CYP24A1 and leads to increasing the drug-metabolizing activity of this enzyme [28], [29]
                              Teriflunomide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00749   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Teriflunomide inhibits the expression of DME CYP24A1 [27]
                              Vitamin D Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00747   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vitamin D up-regulates the expression of DME CYP24A1 [30], [31]
                              Alfacalcidol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00490   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Alfacalcidol up-regulates the expression of DME CYP24A1 [32]
                              Maxacalcitol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00474   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Maxacalcitol up-regulates the expression of DME CYP24A1 [33]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin induces the drug-metabolizing activity of DME CYP24A1 [34]
                              Seocalcitol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00652   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Seocalcitol up-regulates the expression of DME CYP24A1 [35]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the drug-metabolizing activity of DME CYP24A1 [19]
                              MS-275 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 up-regulates the expression of DME CYP24A1 [36]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the drug-metabolizing activity of DME CYP24A1 [37]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME CYP24A1 [38]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME CYP24A1 [39]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Lithocholic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00787   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Lithocholic acid up-regulates the expression of DME CYP24A1 [40]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Gold up-regulates the expression of DME CYP24A1 [41]
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