Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0069)
DME Name Butyrylcholine esterase (BCHE), Homo sapiens DME Info
UniProt ID
CHLE_HUMAN
EC Number    EC: 3.1.1.8     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              Carbofuran Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01597   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Carbof DMEuran inhibits the drug-metabolizing activity of DME BCHE [1]
                              Demeton-S-methyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00887   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Demeton-S-methyl inhibits the drug-metabolizing activity of DME BCHE [2]
                              Dichlorvos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01049   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dichlorvos inhibits the drug-metabolizing activity of DME BCHE [3]
                              Dimethoate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01073   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dimethoate inhibits the drug-metabolizing activity of DME BCHE [4], [5]
                              Ethyl paraoxon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00882   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Ethyl paraoxon inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.007 microM) [6]
                              Fenthion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00867   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenthion inhibits the drug-metabolizing activity of DME BCHE [4]
                              Isomalathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01058   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Isomalathion inhibits the drug-metabolizing activity of DME BCHE [7]
                              Methamidophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01059   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Methamidophos inhibits the drug-metabolizing activity of DME BCHE [8]
                              Mipafox Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01061   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Mipafox inhibits the drug-metabolizing activity of DME BCHE [9]
                              Parathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01064   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Parathion inhibits the expression of DME BCHE [10]
                              Trichlorfon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01072   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Trichlorfon inhibits the drug-metabolizing activity of DME BCHE [11]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME BCHE [12]
                              Chlorpyrifos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos inhibits the drug-metabolizing activity of DME BCHE [13]
                              Dimethoxon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01615   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Dimethoxon inhibits the drug-metabolizing activity of DME BCHE [3]
                              Ethephon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01610   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Ethephon inhibits the drug-metabolizing activity of DME BCHE [14]
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME BCHE [15]
                              Paraquat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat inhibits the expression of DME BCHE [16]
                              Phenylmethylsulfonyl fluoride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01427   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Phenylmethylsulfonyl fluoride inhibits the expression of DME BCHE [17]
                              Sarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00779   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Sarin inhibits the expression of DME BCHE [18]
                              Tetraisopropylpyrophosphamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01482   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Tetraisopropylpyrophosphamide inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.733 microM) [19]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Ethyl methanesulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate inhibits the expression of DME BCHE [15]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME BCHE [20], [21]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diazinon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01274   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Diazinon inhibits the drug-metabolizing activity of DME BCHE [3]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Alpha-linolenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00873   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Alpha-linolenic acid up-regulates the expression of DME BCHE [22]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the expression of DME BCHE [23]
                  Neurotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tabun Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01596   XEOTIC Info Gene Form mRNA
                                 Classification Neurotoxin
                                 DME Modulation Tabun inhibits the expression of DME BCHE [24]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cryptotanshinone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01534   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cryptotanshinone inhibits the drug-metabolizing activity of DME BCHE [25]
                              Solanidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01589   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Solanidine inhibits the expression of DME BCHE [26]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      31 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME BCHE [27]
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide up-regulates the expression of DME BCHE [28]
                              Bicalutamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00009   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bicalutamide inhibits the expression of DME BCHE [29]
                              Calcitriol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol inhibits the expression of DME BCHE [30]
                              Chlorpheniramine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00239   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpheniramine inhibits the drug-metabolizing activity of DME BCHE [31]
                              Choline C-11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00281   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Choline C-11 inhibits the drug-metabolizing activity of DME BCHE [32]
                              Cyclophosphamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00018   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclophosphamide inhibits the drug-metabolizing activity of DME BCHE [33]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME BCHE [34], [35]
                              Decamethonium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00020   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decamethonium inhibits the drug-metabolizing activity of DME BCHE [32]
                              Dimenhydrinate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00107   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dimenhydrinate inhibits the drug-metabolizing activity of DME BCHE [31]
                              Diphenhydramine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00353   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diphenhydramine inhibits the drug-metabolizing activity of DME BCHE [31]
                              Echothiophate iodide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00106   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Echothiophate iodide inhibits the drug-metabolizing activity of DME BCHE [36]
                              Edrophonium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00355   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Edrophonium inhibits the drug-metabolizing activity of DME BCHE [32]
                              Galantamine hydrobromide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00298   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Galantamine hydrobromide inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.17 microM) [37]
                              Isoflurophate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00093   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isof DMElurophate inhibits the drug-metabolizing activity of DME BCHE [38]
                              Isosorbide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00112   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isosorbide inhibits the drug-metabolizing activity of DME BCHE [39]
                              Malathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00056   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Malathion inhibits the drug-metabolizing activity of DME BCHE [40]
                              Promethazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00074   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Promethazine inhibits the expression of DME BCHE [41], [42]
                              Ranitidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00379   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ranitidine inhibits the expression of DME BCHE [43]
                              Rivastigmine tartrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00321   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rivastigmine tartrate inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.03 microM) [44]
                              Rosiglitazone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone inhibits the expression of DME BCHE [45]
                              Tacrine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00328   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tacrine hydrochloride inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.0000267 microM) [46]
                              Testosterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone inhibits the expression of DME BCHE [47]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME BCHE [48]
                              Vorinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00079   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vorinostat up-regulates the expression of DME BCHE [49], [50]
                              Zoledronic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00140   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Zoledronic acid inhibits the expression of DME BCHE [51]
                              Bambuterol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00462   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Bambuterol inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.003 microM) [52]
                              Linoleic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01367   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linoleic acid up-regulates the expression of DME BCHE [22]
                              Obidoxime chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01406   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Obidoxime chloride up-regulates the expression of DME BCHE [53]
                              Profenamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00477   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Prof DMEenamine inhibits the drug-metabolizing activity of DME BCHE (IC50 = 0.3 microM) [44]
                              Trimedoxime Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01493   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Trimedoxime inhibits the expression of DME BCHE [54]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diethyltoluamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00582   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Diethyltoluamide inhibits the drug-metabolizing activity of DME BCHE [55]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME BCHE [56]
                              MS-275 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 inhibits the expression of DME BCHE [50]
                              SNX-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00594   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation SNX-001 inhibits the drug-metabolizing activity of DME BCHE [57]
                              Tetraethylammonium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01481   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Tetraethylammonium inhibits the expression of DME BCHE [58]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Trichostatin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01492   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Trichostatin A up-regulates the expression of DME BCHE [59]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              HI-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01208   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation HI-6 inhibits the drug-metabolizing activity of DME BCHE [60]
                              Phenylsaligenin cyclic phosphate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01428   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Phenylsaligenin cyclic phosphate inhibits the drug-metabolizing activity of DME BCHE [61]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Amiridine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01196   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Amiridine inhibits the drug-metabolizing activity of DME BCHE [62]
                              Malachite green Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01013   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Malachite green inhibits the drug-metabolizing activity of DME BCHE [63]
References
1 Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro. Ecotoxicology. 2007 May;16(4):363-9.
2 The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate. Toxicol In Vitro. 2011 Apr;25(3):754-9.
3 Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry. J Appl Toxicol. 2010 Jul;30(5):469-75.
4 Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2013 Dec;136(2):274-83.
5 Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients. Toxicol Lett. 2009 Dec 15;191(2-3):297-304.
6 Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate. Bioorg Med Chem. 2017 Jun 15;25(12):3053-3058.
7 Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol Sci. 2007 Nov;100(1):136-45.
8 Mercury reduces the enzymatic activity of neprilysin in differentiated SH-SY5Y cells. Toxicol Sci. 2015 May;145(1):128-37.
9 Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. J Biol Chem. 2003 Feb 21;278(8):5736-43.
10 Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
11 Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environ Health Perspect. 2009 Sep;117(9):1402-8.
12 Microarray analysis of gene expression patterns in human proximal tubule cells over a short and long time course of cadmium exposure. J Toxicol Environ Health A. 2011;74(1):24-42.
13 New tools in diagnosis and biomonitoring of intoxications with organophosphorothioates: case studies with chlorpyrifos and diazinon. Chem Biol Interact. 2013 Mar 25;203(1):96-102.
14 Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor. Chem Res Toxicol. 2013 Mar 18;26(3):422-31.
15 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
16 Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer. 2009 Nov;45(16):2882-92.
17 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
18 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
19 Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9.
20 Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
21 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
22 Butyrylcholinesterase expression is regulated by fatty acids in HepG2 cells. Chem Biol Interact. 2016 Nov 25;259(Pt B):276-281.
23 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARgama/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
24 Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis. 2003 Dec;24(12):1903-11.
25 Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chem Biol Interact. 2010 Sep 6;187(1-3):335-9.
26 Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. Environ Health Perspect. 2002 Dec;110 Suppl 6:931-41.
27 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
28 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
29 Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
30 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
31 Cholinesterase inhibition by phenothiazine and nonphenothiazine antihistaminics: analysis of its postulated role in synergizing organophosphate toxicity. Toxicol Appl Pharmacol. 1975 Feb;31(2):179-90.
32 The mechanism and benefit of human butyrylcholinesterase activation by what would otherwise be inhibitors. Chem Biol Interact. 2019 Aug 1;308:350-356.
33 Qualitative defects of pseudocholinesterase activity. Anaesthesia. 1967 Jan;22(1):55-68.
34 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
35 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
36 His-tag truncated butyrylcholinesterase as a useful construct for in vitro characterization of wild-type and variant butyrylcholinesterases. Protein Expr Purif. 2011 Nov;80(1):22-7.
37 Lichens of parmelioid clade as promising multitarget neuroprotective agents. Chem Res Toxicol. 2019 Jun 17;32(6):1165-1177.
38 In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. Int J Mol Sci. 2011;12(3):2077-87.
39 Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor. Chem Biol Interact. 2008 Sep 25;175(1-3):231-4.
40 In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450. Toxicol In Vitro. 2011 Jun;25(4):890-6.
41 A biphasic effect of the fungicide prochloraz on aldosterone, but not cortisol, secretion in human adrenal H295R cells--underlying mechanisms. Toxicol Lett. 2009 Dec 15;191(2-3):174-80.
42 Antiandrogenic mechanisms of pesticides in human LNCaP prostate and H295R adrenocortical carcinoma cells. Toxicol Sci. 2015 Jan;143(1):126-35.
43 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
44 Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. J Med Chem. 2014 Oct 9;57(19):8167-79.
45 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
46 Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors. Eur J Med Chem. 2011 Aug;46(8):3250-7.
47 The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9.
48 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
49 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
50 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
51 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
52 Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase. Eur J Med Chem. 2017 Jan 27;126:61-71.
53 Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation. J Pharmacol Exp Ther. 2015 Feb;352(2):315-24.
54 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
55 In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases. Chem Biol Interact. 2011 Apr 25;190(2-3):79-83.
56 Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets. Mol Carcinog. 2004 Oct;41(2):108-119.
57 Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):138-48.
58 Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett. 2011 Oct 10;206(2):178-88.
59 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
60 Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicol Lett. 2016 Nov 16;262:114-122.
61 Xenobiotic CAR activators induce Dlk1-Dio3 locus noncoding RNA expression in mouse liver. Toxicol Sci. 2017 Aug 1;158(2):367-378.
62 Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia. Methods Find Exp Clin Pharmacol. 1997 May;19(4):245-51.
63 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.

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