Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO04112)
Xenobiotics Name	Microcin E492
Xenobiotics Type	Amino Acid(s), Peptide(s) or Protein(s)
Classification	Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
	Azoreductase (azoR)	DME Info	Escherichia coli	[1]
	L,D-carboxypeptidase A (ldcA)	DME Info	Escherichia coli	[1]
	Beta-lactamase (blaB)	DME Info	Escherichia coli	[1]
	Beta-lactamase (blaB)	DME Info	Salmonella enterica	[1]
	Chloramphenicolase (chlR)	DME Info	Escherichia coli	[1]
	Glycoside hydrolase (cscA)	DME Info	Escherichia coli	[1]
	NADPH-dependent curcumin reductase (curA)	DME Info	Escherichia coli	[1]
	Unclear metabolic mechanism (DME-unclear)	DME Info	Escherichia coli	[1]
	Unclear metabolic mechanism (DME-unclear)	DME Info	Salmonella enterica	[1]
	Glutamate decarboxylase (gadB)	DME Info	Escherichia coli	[1]
	D-Lactate dehydrogenase (ldhA)	DME Info	Escherichia coli	[1]
	Molybdopterin-dependent enzyme (molD)	DME Info	Escherichia coli	[1]
	Glutamate racemase (MurI)	DME Info	Escherichia coli	[1]
	N-ethylmaleimide reductase (nemA)	DME Info	Escherichia coli	[1]
	Oxygen-insensitive NADPH nitroreductase A (nfsA)	DME Info	Escherichia coli	[1]
	Oxygen-insensitive NADPH nitroreductase A (nfsA)	DME Info	Salmonella enterica	[1]
	Oxygen-insensitive NADPH nitroreductase B (nfsB)	DME Info	Escherichia coli	[1]
	Oxygen-insensitive NADPH nitroreductase B (nfsB)	DME Info	Salmonella enterica	[1]
	NADH dehydrogenase (nuoE)	DME Info	Streptomyces griseus	[2]
	Tyramine oxidase (tynA)	DME Info	Escherichia coli	[1]
	Beta-glucuronidase (uidA)	DME Info	Escherichia coli	[1]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data	Azoreductase (azoR)	DME Info	MIC = 0.02 microM	[1]
	L,D-carboxypeptidase A (ldcA)	DME Info	MIC = 0.02 microM	[1]
	Beta-lactamase (blaB)	DME Info	MIC = 0.02 microM	[1]
	Beta-lactamase (blaB)	DME Info	MIC = 1.2 microM	[1]
	Chloramphenicolase (chlR)	DME Info	MIC = 0.02 microM	[1]
	Glycoside hydrolase (cscA)	DME Info	MIC = 0.02 microM	[1]
	NADPH-dependent curcumin reductase (curA)	DME Info	MIC = 0.02 microM	[1]
	Unclear metabolic mechanism (DME-unclear)	DME Info	MIC = 0.02 microM	[1]
	Unclear metabolic mechanism (DME-unclear)	DME Info	MIC = 1.2 microM	[1]
	Glutamate decarboxylase (gadB)	DME Info	MIC = 0.02 microM	[1]
	D-Lactate dehydrogenase (ldhA)	DME Info	MIC = 0.02 microM	[1]
	Molybdopterin-dependent enzyme (molD)	DME Info	MIC = 0.02 microM	[1]
	Glutamate racemase (MurI)	DME Info	MIC = 0.02 microM	[1]
	N-ethylmaleimide reductase (nemA)	DME Info	MIC = 0.02 microM	[1]
	Oxygen-insensitive NADPH nitroreductase A (nfsA)	DME Info	MIC = 0.02 microM	[1]
	Oxygen-insensitive NADPH nitroreductase A (nfsA)	DME Info	MIC = 1.2 microM	[1]
	Oxygen-insensitive NADPH nitroreductase B (nfsB)	DME Info	MIC = 0.02 microM	[1]
	Oxygen-insensitive NADPH nitroreductase B (nfsB)	DME Info	MIC = 1.2 microM	[1]
	NADH dehydrogenase (nuoE)	DME Info	MIC = 0.02 microM	[2]
	Tyramine oxidase (tynA)	DME Info	MIC = 0.02 microM	[1]
	Beta-glucuronidase (uidA)	DME Info	MIC = 0.02 microM	[1]

References
1	Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity. J Biol Chem. 2004 Jul 2;279(27):28233-42.
2	Microcin E492 forms ion channels in phospholipid bilayer membrane. FEBS Lett. 1993 Apr 26;321(2-3):145-8.

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