Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0425)
DME Name Methylsterol monooxygenase 1 (MSMO1), Homo sapiens DME Info
UniProt ID
MSMO1_HUMAN
EC Number    EC: 1.14.13.72     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.72
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the expression of DME MSMO1 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Fatostatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01299   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Fatostatin inhibits the expression of DME MSMO1 [2]
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME MSMO1 [3]
                              Nickel chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01397   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Nickel chloride inhibits the expression of DME MSMO1 [4]
                              Oxyquinoline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01419   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Oxyquinoline inhibits the expression of DME MSMO1 [5]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form mRNA
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin inhibits the expression of DME MSMO1 [6]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME MSMO1 [7]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate inhibits the expression of DME MSMO1 [3]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME MSMO1 [8], [9]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the drug-metabolizing activity of DME MSMO1 [10]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Ganoderic acid A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01310   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Ganoderic acid A inhibits the expression of DME MSMO1 [11]
                              Gedunin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01311   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Gedunin up-regulates the expression of DME MSMO1 [12]
                              Thapsigargin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00809   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Thapsigargin inhibits the expression of DME MSMO1 [13], [14]
                              Tunicamycin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01494   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Tunicamycin A inhibits the expression of DME MSMO1 [15]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      17 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME MSMO1 [16], [17]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the expression of DME MSMO1 [18], [19]
                              Azathioprine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine inhibits the expression of DME MSMO1 [20]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME MSMO1 [21], [22]
                              Capsaicin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00178   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Capsaicin up-regulates the expression of DME MSMO1 [23]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the expression of DME MSMO1 [24], [25]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME MSMO1 [26]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME MSMO1 [13], [27]
                              Decitabine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine inhibits the expression of DME MSMO1 [28]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME MSMO1 [29]
                              Indomethacin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin up-regulates the expression of DME MSMO1 [30]
                              Isotretinoin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00186   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isotretinoin inhibits the expression of DME MSMO1 [31]
                              Leflunomide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide inhibits the expression of DME MSMO1 [32]
                              Progesterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone induces the drug-metabolizing activity of DME MSMO1 [33]
                              Testosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone up-regulates the expression of DME MSMO1 [34]
                              Tretinoin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin inhibits the expression of DME MSMO1 [35]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME MSMO1 [36], [37]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol up-regulates the expression of DME MSMO1 [38]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME MSMO1 [39]
                              Lucanthone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00545   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Lucanthone up-regulates the expression of DME MSMO1 [40], [41]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Dihydrotestosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone up-regulates the expression of DME MSMO1 [42]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite up-regulates the expression of DME MSMO1 [43]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              MRK-003 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00721   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation MRK-003 inhibits the expression of DME MSMO1 [44]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME MSMO1 [45]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Archazolid B Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01205   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Archazolid B up-regulates the expression of DME MSMO1 [46]
                              PP242 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01436   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation PP242 inhibits the expression of DME MSMO1 [47]
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