Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO03043)
Xenobiotics Name
Cytotoxic linear peptide IsCT
Xenobiotics Type
Amino Acid(s), Peptide(s) or Protein(s)
Classification
Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Salmonella enterica [1], [2]
Chloramphenicolase (chlR) DME Info Escherichia coli [1], [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Salmonella enterica [1], [2]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1], [2]
Glutamate racemase (MurI) DME Info Escherichia coli [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1], [2]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1], [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Salmonella enterica [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Salmonella enterica [1], [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1], [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1], [2]
Tyramine oxidase (tynA) DME Info Escherichia coli [1], [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1], [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Azoreductase (azoR) DME Info MIC = 4 microM [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info MIC = 4 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 4 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 2 microM [1], [2]
Chloramphenicolase (chlR) DME Info MIC = 4 microM [1], [2]
Glycoside hydrolase (cscA) DME Info MIC = 4 microM [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info MIC = 4 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 4 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 2 microM [1], [2]
Glutamate decarboxylase (gadB) DME Info MIC = 4 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 4 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 2 microM [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 4 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 4 microM [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC = 2 microM [1], [2]
N-ethylmaleimide reductase (nemA) DME Info MIC = 4 microM [1], [2]
NADPH-dependent oxidoreductase (nfrA) DME Info MIC = 2 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 4 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 2 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 4 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 2 microM [1], [2]
NADH dehydrogenase (nuoE) DME Info MIC = 4 microM [1], [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info MIC = 2 microM [1], [2]
Tyramine oxidase (tynA) DME Info MIC = 4 microM [1], [2]
Beta-glucuronidase (uidA) DME Info MIC = 4 microM [1], [2]
References
1 Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs. Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-9.
2 IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis. Biochem Biophys Res Commun. 2001 Aug 31;286(4):820-5.

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