Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0099)
DME Name Cholesterol desmolase (CYP11A1), Homo sapiens DME Info
UniProt ID
CP11A_HUMAN
EC Number    EC: 1.14.15.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2,4,6-trichlorophenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00962   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation 2,4,6-trichlorophenol inhibits the expression of DME CYP11A1 [1]
                              Hexachlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00951   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Hexachlorobenzene induces the drug-metabolizing activity of DME CYP11A1 [2]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine up-regulates the expression of DME CYP11A1 [3]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME CYP11A1 [4]
                              Pentabromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00904   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Pentabromophenol up-regulates the expression of DME CYP11A1 [5]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-bromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01121   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-bromophenol up-regulates the expression of DME CYP11A1 [6]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Dibutyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01275   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Dibutyl phthalate inhibits the expression of DME CYP11A1 [7]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME CYP11A1 [8]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME CYP11A1 [9]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Water pollutants chemical Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00924   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Water pollutants chemical induces the drug-metabolizing activity of DME CYP11A1 [10]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cholesteryl sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00911   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Cholesteryl sulfate inhibits the expression of DME CYP11A1 [11]
                              Walrycin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01498   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Walrycin A up-regulates the expression of DME CYP11A1 [12]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      12 Xenobiotics
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME CYP11A1 [13]
                              Diethylstilbestrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00166   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diethylstilbestrol inhibits the expression of DME CYP11A1 [14]
                              Dinoprostone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00260   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dinoprostone up-regulates the expression of DME CYP11A1 [15]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME CYP11A1 [14]
                              Hydrocortisone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00264   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrocortisone inhibits the drug-metabolizing activity of DME CYP11A1 [16]
                              Lindane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane inhibits the expression of DME CYP11A1 [17]
                              Mitotane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00064   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mitotane inhibits the drug-metabolizing activity of DME CYP11A1 [18]
                              Nicotine polacrilex Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex inhibits the expression of DME CYP11A1 [19], [20]
                              Perflubron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00104   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Perflubron up-regulates the expression of DME CYP11A1 [21]
                              Testosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone up-regulates the expression of DME CYP11A1 [22]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the drug-metabolizing activity of DME CYP11A1 [23]
                              Methoxychlor Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00446   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Methoxychlor induces the drug-metabolizing activity of DME CYP11A1 [24]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol up-regulates the expression of DME CYP11A1 [25]
                              Vanadyl sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00602   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Vanadyl sulfate up-regulates the expression of DME CYP11A1 [26], [27]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the drug-metabolizing activity of DME CYP11A1 [28], [29]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin up-regulates the expression of DME CYP11A1 [30]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the expression of DME CYP11A1 [31]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cyclic AMP Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01267   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Cyclic AMP induces the drug-metabolizing activity of DME CYP11A1 [29]
                              Dihydrotestosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone up-regulates the expression of DME CYP11A1 [32]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Antalarmin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00709   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Antalarmin inhibits the expression of DME CYP11A1 [33]
                              GW-3965 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01325   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GW-3965 inhibits the expression of DME CYP11A1 [34]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              3,3',4,5'-tetrahydroxystilbene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01133   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 3,3',4,5'-tetrahydroxystilbene inhibits the expression of DME CYP11A1 [35]
                              Astressin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01210   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Astressin inhibits the expression of DME CYP11A1 [33]
                              Go-6976 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01321   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Go-6976 up-regulates the expression of DME CYP11A1 [36]
      Other Chemical Compound(s) or Element(s)
                  Cosmetic Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-acetyltributylcitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01612   XEOTIC Info Gene Form mRNA
                                 Classification Cosmetic Additive
                                 DME Modulation 2-acetyltributylcitrate up-regulates the expression of DME CYP11A1 [30]
References
1 Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology. 2011 Apr 11;282(3):146-53.
2 Hexachlorobenzene and pentachlorobenzene accumulation, metabolism and effect on steroid secretion and on CYP11A1 and CYP19 expression in cultured human placental tissue. Reprod Toxicol. 2014 Jan;43:102-10.
3 A hierarchical testing strategy for micropollutants in drinking water regarding their potential endocrine-disrupting effects-towards health-related indicator values. Environ Sci Pollut Res Int. 2018 Feb;25(5):4051-4065.
4 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
5 Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China. Toxicol Lett. 2014 Jul 3;228(1):25-33.
6 Effects of brominated flame retardants and brominated dioxins on steroidogenesis in H295R human adrenocortical carcinoma cell line. Environ Toxicol Chem. 2007 Apr;26(4):764-72.
7 Dibutyl phthalate impairs steroidogenesis and a subset of LH-dependent genes in cultured human mural granulosa cell in vitro. Reprod Toxicol. 2017 Apr;69:13-18.
8 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARgama/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
9 Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells. Toxicol Appl Pharmacol. 2013 Dec 1;273(2):289-97.
10 Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils. Int Immunopharmacol. 2003 Oct;3(10-11):1519-28.
11 Inhibitory effects of cholesterol sulfate on progesterone production in human granulosa-like tumor cell line, KGN. Endocr J. 2008 Jul;55(3):575-81.
12 Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
13 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
14 Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
15 Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009 Feb;94(2):623-31.
16 Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure. Toxicol Lett. 2019 Mar 1;302:7-17.
17 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
18 Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. 2016 Mar;90(3):603-16.
19 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
20 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
21 Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett. 2013 Apr 26;218(3):253-9.
22 The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9.
23 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid acute administration diferentially change biochemical parameters in mice. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):331-4.
24 Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci. 2007 Jan;95(1):13-22.
25 Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells. Toxicology. 2016 Mar 28;350-352:1-14.
26 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
27 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
28 Does BPA alter steroid hormone synthesis in human granulosa cells in vitro? Hum Reprod. 2016 Jul;31(7):1562-9.
29 Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells. Biol Reprod. 2018 Feb 1;98(2):250-258.
30 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
31 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
32 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
33 Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells. J Clin Endocrinol Metab. 2005 Sep;90(9):5393-400.
34 Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists. Mol Hum Reprod. 2007 Jun;13(6):373-9.
35 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
36 Corticotropin-releasing hormone inhibits progesterone production in cultured human placental trophoblasts. J Mol Endocrinol. 2006 Dec;37(3):533-40.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.