General Information of Xenobiotics (ID: XEO02680)
Xenobiotics Name
P18 analogue C-8
Xenobiotics Type
Amino Acid(s), Peptide(s) or Protein(s)
Classification
Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1]
Beta-lactamase (blaB) DME Info Escherichia coli [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [1]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1]
Cytochrome P450 102A1 (cyp102) DME Info Bacillus megaterium [1]
Cytochrome P450 MEG (cyp106) DME Info Bacillus megaterium [1]
Cytochrome P450 21A2 (cyp21) DME Info Bacillus megaterium [1]
Cytochrome P450 BM3 (cypBM3) DME Info Bacillus megaterium [1]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1]
Glutamate racemase (MurI) DME Info Escherichia coli [1]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [1]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [1]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1]
Glutamate racemase (MurI) DME Info Bacillus subtilis [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [1]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1]
Glutamate racemase (MurI) DME Info Bacillus pumilus [1]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [1]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Azoreductase (azoR) DME Info MIC = 6.25 microM [1]
L,D-carboxypeptidase A (ldcA) DME Info MIC = 6.25 microM [1]
Beta-lactamase (blaB) DME Info MIC = 6.25 microM [1]
Chloramphenicolase (chlR) DME Info MIC = 6.25 microM [1]
Glycoside hydrolase (cscA) DME Info MIC = 6.25 microM [1]
NADPH-dependent curcumin reductase (curA) DME Info MIC = 6.25 microM [1]
Cytochrome P450 102A1 (cyp102) DME Info MIC = 3.125 microM [1]
Cytochrome P450 MEG (cyp106) DME Info MIC = 3.125 microM [1]
Cytochrome P450 21A2 (cyp21) DME Info MIC = 3.125 microM [1]
Cytochrome P450 BM3 (cypBM3) DME Info MIC = 3.125 microM [1]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 6.25 microM [1]
Glutamate decarboxylase (gadB) DME Info MIC = 6.25 microM [1]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 6.25 microM [1]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 6.25 microM [1]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 6.25 microM [1]
Glutamate racemase (MurI) DME Info MIC = 6.25 microM [1]
Arylamine N-acetyltransferase (NAT) DME Info MIC = 6.25 microM [1]
N-ethylmaleimide reductase (nemA) DME Info MIC = 6.25 microM [1]
NADPH-dependent oxidoreductase (nfrA) DME Info MIC = 6.25 microM [1]
NADPH-dependent nitroreductase (nfrA1) DME Info MIC = 1.56 microM [1]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 6.25 microM [1]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 6.25 microM [1]
NADH dehydrogenase (nuoE) DME Info MIC = 6.25 microM [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info MIC = 6.25 microM [1]
Glutamate racemase (MurI) DME Info MIC = 1.56 microM [1]
Tyramine oxidase (tynA) DME Info MIC = 6.25 microM [1]
Beta-glucuronidase (uidA) DME Info MIC = 6.25 microM [1]
Glutamate racemase (MurI) DME Info MIC = 1.56 microM [1]
General stress protein 14 (ywrO) DME Info MIC = 1.56 microM [1]
References
1 Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14.

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