Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0222)
DME Name Beta-HSD adrenal and gonadal type (HSD3B2), Homo sapiens DME Info
UniProt ID
3BHS2_HUMAN
EC Number    EC: 1.1.1.145     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.145
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bifenthrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01040   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Bifenthrin up-regulates the expression of DME HSD3B2 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Enniatins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01289   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Enniatins inhibits the expression of DME HSD3B2 [2]
                              Pentabromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00904   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Pentabromophenol up-regulates the expression of DME HSD3B2 [3]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2-bromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01121   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-bromophenol up-regulates the expression of DME HSD3B2 [4]
                              Galaxolide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00984   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Galaxolide inhibits the drug-metabolizing activity of DME HSD3B2 [5]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid up-regulates the expression of DME HSD3B2 [6]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol up-regulates the expression of DME HSD3B2 [7]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Water pollutants chemical Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00924   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Water pollutants chemical induces the drug-metabolizing activity of DME HSD3B2 [8]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      13 Xenobiotics
                              Carbamazepine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine inhibits the drug-metabolizing activity of DME HSD3B2 [9]
                              Copper Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00834   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper up-regulates the expression of DME HSD3B2 [10]
                              Dinoprostone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00260   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dinoprostone up-regulates the expression of DME HSD3B2 [11]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME HSD3B2 [12]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the expression of DME HSD3B2 [13]
                              Lamotrigine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00051   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lamotrigine inhibits the drug-metabolizing activity of DME HSD3B2 [9]
                              Levetiracetam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00187   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Levetiracetam inhibits the expression of DME HSD3B2 [14]
                              Lindane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane inhibits the expression of DME HSD3B2 [15]
                              Mitotane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00064   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mitotane inhibits the drug-metabolizing activity of DME HSD3B2 [16]
                              Pioglitazone hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00319   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pioglitazone hydrochloride inhibits the drug-metabolizing activity of DME HSD3B2 [17]
                              Topiramate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00189   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Topiramate inhibits the expression of DME HSD3B2 [18]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME HSD3B2 [19]
                              Cinnamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01252   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cinnamic acid inhibits the drug-metabolizing activity of DME HSD3B2 [20]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Torcetrapib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00627   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Torcetrapib up-regulates the expression of DME HSD3B2 [21]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the drug-metabolizing activity of DME HSD3B2 [22]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin up-regulates the expression of DME HSD3B2 [23]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cyclic AMP Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01267   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Cyclic AMP up-regulates the expression of DME HSD3B2 [24]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              3,3',4,5'-tetrahydroxystilbene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01133   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 3,3',4,5'-tetrahydroxystilbene inhibits the expression of DME HSD3B2 [25]
                              Tributyltin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01491   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Tributyltin inhibits the expression of DME HSD3B2 [26]
      Other Chemical Compound(s) or Element(s)
                  Cosmetic Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-acetyltributylcitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01612   XEOTIC Info Gene Form mRNA
                                 Classification Cosmetic Additive
                                 DME Modulation 2-acetyltributylcitrate up-regulates the expression of DME HSD3B2 [23]
References
1 Disruption of the hormonal network and the enantioselectivity of bifenthrin in trophoblast: maternal-fetal health risk of chiral pesticides. Environ Sci Technol. 2014 Jul 15;48(14):8109-16.
2 An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicol Lett. 2015 Mar 4;233(2):84-94.
3 Transcriptome analysis of airborne PM2.5-induced detrimental effects on human keratinocytes. Toxicol Lett. 2017 May 5;273:26-35.
4 Effects of brominated flame retardants and brominated dioxins on steroidogenesis in H295R human adrenocortical carcinoma cell line. Environ Toxicol Chem. 2007 Apr;26(4):764-72.
5 Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells. Chemosphere. 2013 Jan;90(3):1227-35.
6 Modulation of signal transduction pathways in lymphocytes due to sub-lethal toxicity of chlorinated phenol. Toxicol Lett. 2008 Jun 10;179(1):23-8.
7 An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicol Lett. 2012 Nov 15;214(3):268-78.
8 Mannose-containing molecular patterns are strong inducers of cyclooxygenase-2 expression and prostaglandin E2 production in human macrophages. J Immunol. 2005 Jun 15;174(12):8154-62.
9 Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
10 High copper levels in follicular fluid affect follicle development in polycystic ovary syndrome patients: population-based and in vitro studies. Toxicol Appl Pharmacol. 2019 Feb 15;365:101-111.
11 Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009 Feb;94(2):623-31.
12 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
13 The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicol Environ Saf. 2006 Nov;65(3):293-305.
14 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
15 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
16 In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox. J Appl Toxicol. 2004 Mar-Apr;24(2):143-6.
17 Human and rodent carboxylesterases: immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. Drug Metab Dispos. 2002 May;30(5):541-7.
18 Systems toxicology assessment of the biological impact of a candidate modified risk tobacco product on human organotypic oral epithelial cultures. Chem Res Toxicol. 2016 Aug 15;29(8):1252-69.
19 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
20 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
21 Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: a systems toxicology assessment. Food Chem Toxicol. 2018 May;115:109-126.
22 Does BPA alter steroid hormone synthesis in human granulosa cells in vitro? Hum Reprod. 2016 Jul;31(7):1562-9.
23 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
24 Inhibitory effects of cholesterol sulfate on progesterone production in human granulosa-like tumor cell line, KGN. Endocr J. 2008 Jul;55(3):575-81.
25 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
26 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.

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