Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0009)
DME Name Cytochrome P450 2D6 (CYP2D6), Homo sapiens DME Info
UniProt ID
CP2D6_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Prochloraz Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00955   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Prochloraz inhibits the drug-metabolizing activity of DME CYP2D6 [1], [2]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Isoproturon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00975   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Isoproturon inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Cyhalothrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01600   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cyhalothrin inhibits the drug-metabolizing activity of DME CYP2D6 [4]
                              Cypermethrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01046   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cypermethrin inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                              Decamethrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01047   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Decamethrin inhibits the drug-metabolizing activity of DME CYP2D6 [4]
                              Fenvalerate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01053   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenvalerate inhibits the drug-metabolizing activity of DME CYP2D6 [4]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Chlorpyrifos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos inhibits the drug-metabolizing activity of DME CYP2D6 [4]
                              Fipronil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01302   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Fipronil inhibits the drug-metabolizing activity of DME CYP2D6 [5]
                              Salinomycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01467   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Salinomycin inhibits the drug-metabolizing activity of DME CYP2D6 [6]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME CYP2D6 [7]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diazinon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01274   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Diazinon up-regulates the expression of DME CYP2D6 [8]
                              Zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01512   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc up-regulates the expression of DME CYP2D6 [9]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cyclodextrins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00857   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Cyclodextrins inhibits the drug-metabolizing activity of DME CYP2D6 [10]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:      10 Xenobiotics
                              5-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01518   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 5-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2D6 [11]
                              Dihydrocapsaicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00802   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Dihydrocapsaicin inhibits the drug-metabolizing activity of DME CYP2D6 [12]
                              Eupatorin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01541   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Eupatorin inhibits the drug-metabolizing activity of DME CYP2D6 [13]
                              Germacrone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01313   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Germacrone inhibits the drug-metabolizing activity of DME CYP2D6 [14]
                              Inermin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01345   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Inermin inhibits the drug-metabolizing activity of DME CYP2D6 [15]
                              Isatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00880   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Isatin up-regulates the expression of DME CYP2D6 [16]
                              Mitragynine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01564   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Mitragynine up-regulates the expression of DME CYP2D6 [17]
                              Serpentine hydroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01586   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Serpentine hydroxide inhibits the expression of DME CYP2D6 [18]
                              Shikonin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01587   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Shikonin inhibits the drug-metabolizing activity of DME CYP2D6 [19]
                              Sophoranone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01472   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Sophoranone inhibits the expression of DME CYP2D6 [20]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME CYP2D6 [21]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      33 Xenobiotics
                              Amiodarone hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00277   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amiodarone hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 [22]
                              Amitriptyline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00337   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amitriptyline inhibits the drug-metabolizing activity of DME CYP2D6 [23]
                              Buprenorphine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00343   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Buprenorphine inhibits the drug-metabolizing activity of DME CYP2D6 [24]
                              Cannabidiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00173   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cannabidiol inhibits the drug-metabolizing activity of DME CYP2D6 [25]
                              Capsaicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00178   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Capsaicin inhibits the drug-metabolizing activity of DME CYP2D6 [12]
                              Cimetidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00015   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cimetidine inhibits the drug-metabolizing activity of DME CYP2D6 (Ki = 77 microM) [26]
                              Cinacalcet hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00282   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cinacalcet hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 0.05 microM) [27]
                              Dihydroergotamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00105   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dihydroergotamine inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                              Dopamine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00290   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dopamine hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                              Ethambutol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00357   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ethambutol inhibits the drug-metabolizing activity of DME CYP2D6 [28]
                              Fluoxetine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00358   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluoxetine inhibits the drug-metabolizing activity of DME CYP2D6 in Cellosaurus cell line BTI-Tn-5B1-4 (IC50 = 0.7 microM) [11]
                              Ivermectin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00244   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ivermectin inhibits the drug-metabolizing activity of DME CYP2D6 [29], [3]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 16.3 microM) [30]
                              Lindane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane inhibits the expression of DME CYP2D6 [31]
                              Nicardipine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00311   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicardipine hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 1.59 microM) [30]
                              Niclosamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00405   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Niclosamide inhibits the expression of DME CYP2D6 [32]
                              Paroxetine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00316   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Paroxetine hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 in Cellosaurus cell line BTI-Tn-5B1-4 (IC50 = 1 microM) [11]
                              Pentamidine isethionate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00317   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pentamidine isethionate inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 24.8 microM) [33]
                              Proguanil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00431   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Proguanil inhibits the expression of DME CYP2D6 [31]
                              Quinidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00225   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Quinidine inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 < 0.006 microM) [34]
                              Rosiglitazone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone inhibits the drug-metabolizing activity of DME CYP2D6 [35]
                              Terbinafine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00329   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Terbinafine hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 in Cellosaurus cell line BTI-Tn-5B1-4 (IC50 = 0.2 microM) [36]
                              Ticlopidine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00331   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ticlopidine hydrochloride inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 4.8 microM) [37]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME CYP2D6 [38]
                              Vitamin D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00747   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vitamin D inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                              Apatinib Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00452   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Apatinib inhibits the drug-metabolizing activity of DME CYP2D6 [39]
                              Benidipine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00438   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benidipine inhibits the drug-metabolizing activity of DME CYP2D6 [40]
                              Cinnamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01252   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cinnamic acid inhibits the drug-metabolizing activity of DME CYP2D6 [41]
                              Daidzein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00439   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Daidzein inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                              Formononetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01306   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Formononetin inhibits the drug-metabolizing activity of DME CYP2D6 [42]
                              Melarsoprol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00475   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Melarsoprol inhibits the drug-metabolizing activity of DME CYP2D6 [43], [44]
                              Raubasine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00480   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Raubasine inhibits the drug-metabolizing activity of DME CYP2D6 (Ki = 0.0033 microM) [45]
                              Sarpogrelate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00482   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Sarpogrelate inhibits the expression of DME CYP2D6 [46]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Manidipine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00567   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Manidipine inhibits the drug-metabolizing activity of DME CYP2D6 [47]
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the drug-metabolizing activity of DME CYP2D6 [29]
                              Triclosan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan up-regulates the expression of DME CYP2D6 [48]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Butyric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01230   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Butyric acid up-regulates the expression of DME CYP2D6 [49]
                              Ethanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol induces the drug-metabolizing activity of DME CYP2D6 [50]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Carbendazim Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00598   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Carbendazim inhibits the drug-metabolizing activity of DME CYP2D6 [4]
                              GSK-369796 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00679   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation GSK-369796 inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 3 microM) [51]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 18.8 microM) [30]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              1-aminobenzotriazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01099   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation 1-aminobenzotriazole inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 10.5 microM) [52]
                              HET-0016 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01396   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation HET-0016 inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 83.9 microM) [52]
                              Myricetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01384   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Myricetin inhibits the expression of DME CYP2D6 [53]
                              ICI-199441 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01337   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICI-199441 inhibits the drug-metabolizing activity of DME CYP2D6 (IC50 = 0.026 microM) [54]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              5-fluorotryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01159   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 5-fluorotryptamine inhibits the drug-metabolizing activity of DME CYP2D6 [11]
                              5-methoxyindole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01163   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 5-methoxyindole inhibits the drug-metabolizing activity of DME CYP2D6 [3]
                              7-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01177   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 7-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2D6 [11]
                              Beta-naphthoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone inhibits the expression of DME CYP2D6 [55]
                              DY-9760e Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01130   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation DY-9760e inhibits the drug-metabolizing activity of DME CYP2D6 [56]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Naphthalene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00764   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Naphthalene induces the drug-metabolizing activity of DME CYP2D6 [57]
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20 Cellular and molecular effects of prolonged low-level sodium arsenite exposure on human hepatic HepaRG cells. Toxicol Sci. 2018 Apr 1;162(2):676-687.
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32 Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015 Mar;135(3):712-20.
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36 A metoprolol-terbinafine combination induced bradycardia. Eur J Drug Metab Pharmacokinet. 2015 Sep;40(3):295-9.
37 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.
38 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
39 Evaluation of the inhibition effects of apatinib on human and rat cytochrome P450. Toxicol Lett. 2018 Nov;297:1-7.
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41 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
42 In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. Toxicol Lett. 2015 Nov 19;239(1):1-8.
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44 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
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48 Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line. Toxicol Lett. 2008 Feb 15;176(3):230-8.
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51 Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. J Med Chem. 2009 Mar 12;52(5):1408-15.
52 Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.
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