Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0024)
DME Name Steroid 17-alpha-monooxygenase (CYP17A1), Homo sapiens DME Info
UniProt ID
CP17A_HUMAN
EC Number    EC: 1.14.99.9     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Oxygen paired donor oxidoreductase
EC: 1.14.99.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Benomyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00939   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Benomyl inhibits the expression of DME CYP17A1 and leads to decreasing the drug-metabolizing activity of this enzyme [1]
                              Prochloraz Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00955   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Prochloraz inhibits the drug-metabolizing activity of DME CYP17A1 [2]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bifenthrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01040   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Bifenthrin up-regulates the expression of DME CYP17A1 [3]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Enniatins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01289   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Enniatins inhibits the expression of DME CYP17A1 [4]
                              Pentabromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00904   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Pentabromophenol up-regulates the expression of DME CYP17A1 [5]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              2-bromophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01121   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-bromophenol up-regulates the expression of DME CYP17A1 [6]
                              Galaxolide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00984   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Galaxolide inhibits the drug-metabolizing activity of DME CYP17A1 [7]
                              p,p'-Hydroxy-DDT Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01110   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation p,p'-Hydroxy-DDT inhibits the drug-metabolizing activity of DME CYP17A1 [8]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid inhibits the expression of DME CYP17A1 [9]
                              Androstenedione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00874   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Androstenedione inhibits the expression of DME CYP17A1 [10]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol up-regulates the expression of DME CYP17A1 [11]
                              HT-2 toxin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01515   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation HT-2 toxin inhibits the expression of DME CYP17A1 [11]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Water pollutants chemical Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00924   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Water pollutants chemical up-regulates the expression of DME CYP17A1 [12]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Alpha-naphthoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01192   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Alpha-naphthoflavone inhibits the expression of DME CYP17A1 [13]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME CYP17A1 [14]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      24 Xenobiotics
                              Abiraterone acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00275   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Abiraterone acetate inhibits the drug-metabolizing activity of DME CYP17A1 (IC50 <= 0.011 microM) [15]
                              Albuterol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00004   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Albuterol induces the drug-metabolizing activity of DME CYP17A1 [16]
                              Aminoglutethimide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00233   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aminoglutethimide inhibits the drug-metabolizing activity of DME CYP17A1 (IC50 = 60 microM) [17]
                              Carbamazepine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine inhibits the drug-metabolizing activity of DME CYP17A1 [18]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CYP17A1 [19]
                              Dehydroepiandrosterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00393   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dehydroepiandrosterone inhibits the expression of DME CYP17A1 [10]
                              Dinoprostone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00260   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dinoprostone up-regulates the expression of DME CYP17A1 [20]
                              Duloxetine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00269   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Duloxetine hydrochloride inhibits the drug-metabolizing activity of DME CYP17A1 [15]
                              Flurbiprofen sodium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00296   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flurbiprof DMEen sodium inhibits the drug-metabolizing activity of DME CYP17A1 [21]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP17A1 (IC50 = 0.026 microM) [22]
                              Lamotrigine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00051   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lamotrigine inhibits the drug-metabolizing activity of DME CYP17A1 [18]
                              Levetiracetam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00187   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Levetiracetam inhibits the expression of DME CYP17A1 [23]
                              Mitotane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00064   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mitotane inhibits the expression of DME CYP17A1 [24]
                              Nicotine polacrilex Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex inhibits the expression of DME CYP17A1 [25]
                              Pioglitazone hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00319   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pioglitazone hydrochloride inhibits the expression of DME CYP17A1 [26]
                              Testosterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone inhibits the drug-metabolizing activity of DME CYP17A1 [27]
                              Testosterone undecanoate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00406   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone undecanoate inhibits the drug-metabolizing activity of DME CYP17A1 [28]
                              Tretinoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin up-regulates the expression of DME CYP17A1 [29]
                              Troglitazone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone inhibits the expression of DME CYP17A1 [30]
                              Valproic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid up-regulates the expression of DME CYP17A1 and leads to increasing the drug-metabolizing activity of this enzyme [31]
                              Venlafaxine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00137   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Venlafaxine hydrochloride inhibits the expression of DME CYP17A1 [32]
                              Cinnamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01252   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cinnamic acid inhibits the drug-metabolizing activity of DME CYP17A1 [33]
                              Fadrozole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00468   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Fadrozole inhibits the drug-metabolizing activity of DME CYP17A1 (IC50 > 5 microM) [34]
                              Pyruvic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00478   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Pyruvic acid up-regulates the expression of DME CYP17A1 [35]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the drug-metabolizing activity of DME CYP17A1 [36]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the drug-metabolizing activity of DME CYP17A1 [37], [38]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin up-regulates the expression of DME CYP17A1 [39]
                              TOK-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00672   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation TOK-001 inhibits the drug-metabolizing activity of DME CYP17A1 (IC50 = 0.3 microM) [40]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Antalarmin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00709   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Antalarmin inhibits the expression of DME CYP17A1 [41]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              3,3',4,5'-tetrahydroxystilbene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01133   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 3,3',4,5'-tetrahydroxystilbene inhibits the drug-metabolizing activity of DME CYP17A1 [42]
                              Astressin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01210   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Astressin inhibits the expression of DME CYP17A1 [41]
                              Pyrazolanthrone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01445   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Pyrazolanthrone induces the drug-metabolizing activity of DME CYP17A1 [43], [44]
      Other Chemical Compound(s) or Element(s)
                  Cosmetic Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-acetyltributylcitrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01612   XEOTIC Info Gene Form mRNA
                                 Classification Cosmetic Additive
                                 DME Modulation 2-acetyltributylcitrate inhibits the expression of DME CYP17A1 [39]
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