Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0216)
DME Name Putrescine acetyltransferase (SSAT1), Homo sapiens DME Info
UniProt ID
SAT1_HUMAN
EC Number    EC: 2.3.1.57     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.57
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine up-regulates the expression of DME SAT1 [1]
                              Diquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00971   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diquat up-regulates the expression of DME SAT1 [2]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the expression of DME SAT1 [3]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME SAT1 [2]
                              Formaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde up-regulates the expression of DME SAT1 [4]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME SAT1 [5]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate up-regulates the expression of DME SAT1 [4]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME SAT1 [6]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME SAT1 [7]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME SAT1 [8]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dust Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01284   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Dust up-regulates the expression of DME SAT1 [9]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Quercitrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01449   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Quercitrin inhibits the expression of DME SAT1 [10]
                              Stallimycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01474   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Stallimycin up-regulates the expression of DME SAT1 [11], [12]
                              Thapsigargin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00809   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Thapsigargin induces the drug-metabolizing activity of DME SAT1 [13]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      21 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen up-regulates the expression of DME SAT1 [14], [15]
                              Aspirin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin up-regulates the expression of DME SAT1 and leads to increasing the drug-metabolizing activity of this enzyme [16]
                              Belinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00193   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Belinostat up-regulates the expression of DME SAT1 [17], [18]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME SAT1 [19], [20]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME SAT1 [21]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME SAT1 [22], [23]
                              Diethylstilbestrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00166   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diethylstilbestrol inhibits the expression of DME SAT1 [24]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME SAT1 [25]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME SAT1 [26]
                              Fluorouracil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00037   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluorouracil up-regulates the expression of DME SAT1 [27]
                              Folic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00404   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Folic acid up-regulates the expression of DME SAT1 [28]
                              Gemcitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00361   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gemcitabine up-regulates the expression of DME SAT1 [29]
                              Ibuprofen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00248   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ibuprofen up-regulates the expression of DME SAT1 [16]
                              Indomethacin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin up-regulates the expression of DME SAT1 [16]
                              Irinotecan hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00301   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Irinotecan hydrochloride up-regulates the expression of DME SAT1 [30]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME SAT1 [31]
                              Oxaliplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00207   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxaliplatin induces the drug-metabolizing activity of DME SAT1 [32]
                              Panobinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00372   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Panobinostat up-regulates the expression of DME SAT1 [33]
                              Vincristine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00392   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vincristine up-regulates the expression of DME SAT1 [34]
                              Vorinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00079   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vorinostat up-regulates the expression of DME SAT1 [35], [17]
                              Demecolcine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00466   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Demecolcine up-regulates the expression of DME SAT1 [4]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              AM-80 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00622   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation AM-80 up-regulates the expression of DME SAT1 [36]
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME SAT1 [37]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the expression of DME SAT1 [24]
                              STA-4783 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00629   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation STA-4783 up-regulates the expression of DME SAT1 [38]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Dihydrotestosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone up-regulates the expression of DME SAT1 [39]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME SAT1 [40]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 up-regulates the expression of DME SAT1 [41]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME SAT1 [40]
                              K-7174 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 up-regulates the expression of DME SAT1 [42]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Coumestrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01261   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Coumestrol inhibits the expression of DME SAT1 [43]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate induces the drug-metabolizing activity of DME SAT1 [44]
                              Thioxotriazole copper(II) Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01081   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Thioxotriazole copper(II) up-regulates the expression of DME SAT1 [19]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cupric oxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00840   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Cupric oxide up-regulates the expression of DME SAT1 [45]
References
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