Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0398)
DME Name Small intestine reductase (AKR1B10), Homo sapiens DME Info
UniProt ID
AK1BA_HUMAN
EC Number    EC: 1.1.1.21     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.21
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00971   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diquat up-regulates the expression of DME AKR1B10 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              2-methyl-4-isothiazolin-3-one Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00890   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-methyl-4-isothiazolin-3-one up-regulates the expression of DME AKR1B10 [2]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME AKR1B10 [1], [3]
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME AKR1B10 [4]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              2-acetylaminofluorene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00894   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation 2-acetylaminofluorene up-regulates the expression of DME AKR1B10 [5]
                              2-amino-3-methylimidazo(4,5-f)quinoline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00895   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation 2-amino-3-methylimidazo(4,5-f)quinoline inhibits the expression of DME AKR1B10 [5]
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME AKR1B10 [6]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone up-regulates the expression of DME AKR1B10 [2]
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate up-regulates the expression of DME AKR1B10 [7]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME AKR1B10 [8]
                              Resorcinol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01453   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Resorcinol up-regulates the expression of DME AKR1B10 [9]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Lead chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01506   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Lead chloride up-regulates the expression of DME AKR1B10 [10]
                              N-hexane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01016   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation N-hexane up-regulates the expression of DME AKR1B10 [11]
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid up-regulates the expression of DME AKR1B10 [12]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME AKR1B10 [13]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME AKR1B10 [14]
                              Pirinixic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01433   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Pirinixic acid up-regulates the expression of DME AKR1B10 [15]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of DME AKR1B10 [16]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Particulate matter Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter inhibits the expression of DME AKR1B10 [17]
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution up-regulates the expression of DME AKR1B10 [18]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Anthranilic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00763   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Anthranilic acid up-regulates the expression of DME AKR1B10 [5]
                              Chrysin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00878   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Chrysin inhibits the drug-metabolizing activity of DME AKR1B10 [19]
                              Cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde up-regulates the expression of DME AKR1B10 [2]
                              Shogaol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01588   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Shogaol induces the drug-metabolizing activity of DME AKR1B10 [20], [21]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang up-regulates the expression of DME AKR1B10 [22]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      26 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME AKR1B10 [23], [24]
                              Amoxicillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00246   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amoxicillin up-regulates the expression of DME AKR1B10 [25]
                              Ampicillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00096   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ampicillin inhibits the expression of DME AKR1B10 [5], [26]
                              Azathioprine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine up-regulates the expression of DME AKR1B10 [5], [27]
                              Bortezomib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00159   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bortezomib induces the drug-metabolizing activity of DME AKR1B10 [28]
                              Chlorambucil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00014   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorambucil inhibits the expression of DME AKR1B10 [5]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME AKR1B10 [29], [22]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME AKR1B10 [30]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME AKR1B10 [31]
                              Diethylstilbestrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00166   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diethylstilbestrol up-regulates the expression of DME AKR1B10 [5]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME AKR1B10 [8]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride up-regulates the expression of DME AKR1B10 [32]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME AKR1B10 [33]
                              Fenofibrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00035   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenof DMEibrate inhibits the drug-metabolizing activity of DME AKR1B10 [34]
                              Fenofibric acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00138   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenof DMEibric acid inhibits the drug-metabolizing activity of DME AKR1B10 [34]
                              Gemfibrozil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00042   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gemfibrozil inhibits the drug-metabolizing activity of DME AKR1B10 [34]
                              Hydroquinone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone inhibits the expression of DME AKR1B10 [35]
                              Isoniazid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00224   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isoniazid up-regulates the expression of DME AKR1B10 [25]
                              Menadione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione up-regulates the expression of DME AKR1B10 [36]
                              Progesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone inhibits the drug-metabolizing activity of DME AKR1B10 [37]
                              Reserpine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00222   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Reserpine up-regulates the expression of DME AKR1B10 [26]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin up-regulates the expression of DME AKR1B10 [38]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the drug-metabolizing activity of DME AKR1B10 [39]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME AKR1B10 [8]
                              Ciprofibrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00494   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Ciprof DMEibrate inhibits the drug-metabolizing activity of DME AKR1B10 [34]
                              Floxacillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00469   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Floxacillin up-regulates the expression of DME AKR1B10 [25]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Exisulind Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00659   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Exisulind inhibits the drug-metabolizing activity of DME AKR1B10 [40]
                              Sorbinil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00630   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sorbinil inhibits the drug-metabolizing activity of DME AKR1B10 (IC50 = 9.6 microM) [41]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME AKR1B10 [8]
                              LY-294002 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00580   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation LY-294002 inhibits the drug-metabolizing activity of DME AKR1B10 [19]
                              Phenethyl caffeate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01233   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Phenethyl caffeate inhibits the drug-metabolizing activity of DME AKR1B10 (IC50 = 0.08 microM) [42]
                              SNK-860 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00628   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation SNK-860 inhibits the drug-metabolizing activity of DME AKR1B10 [43]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate inhibits the expression of DME AKR1B10 [44]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME AKR1B10 [45]
                              Zopolrestat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00688   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Zopolrestat inhibits the drug-metabolizing activity of DME AKR1B10 (IC50 = 0.62 microM) [41]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME AKR1B10 [2]
                              K-7174 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 up-regulates the expression of DME AKR1B10 [46]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              4-oxo-2-nonenal Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00870   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 4-oxo-2-nonenal inhibits the drug-metabolizing activity of DME AKR1B10 [47]
                              9,10-phenanthrenequinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00871   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 9,10-phenanthrenequinone up-regulates the expression of DME AKR1B10 [48]
                              Isopropanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01128   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Isopropanol up-regulates the expression of DME AKR1B10 [8]
                              MG-132 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01219   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation MG-132 up-regulates the expression of DME AKR1B10 [28]
      Other Chemical Compound(s) or Element(s)
                  Food Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Ethoxyquin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00934   XEOTIC Info Gene Form mRNA
                                 Classification Food Additive
                                 DME Modulation Ethoxyquin up-regulates the expression of DME AKR1B10 [49]
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              4-chloromercuribenzenesulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01151   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 4-chloromercuribenzenesulfonate inhibits the drug-metabolizing activity of DME AKR1B10 [50]
                              Ethyl acrylate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00783   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Ethyl acrylate up-regulates the expression of DME AKR1B10 [5]
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Gold up-regulates the expression of DME AKR1B10 [51]
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32 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
33 Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
34 Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers. Eur J Pharmacol. 2008 Apr 28;584(2-3):213-21.
35 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
36 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
37 Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicol Lett. 2016 Jan 22;243:56-66.
38 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
39 Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett. 2011 Oct 15;3(1):39-42.
40 Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem. 2011 Mar 24;54(6):1896-902.
41 Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem. 2010 Apr 1;18(7):2485-90.
42 Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. Eur J Med Chem. 2012 Feb;48:321-9.
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44 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation. Toxicol Sci. 2013 Mar;132(1):235-49.
45 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
46 A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
47 Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes. Chem Biol Interact. 2009 Mar 16;178(1-3):145-50.
48 Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):180-9.
49 Regulation of aldo-keto reductase AKR1B10 gene expression: involvement of transcription factor Nrf2. Chem Biol Interact. 2011 May 30;191(1-3):185-91.
50 Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein (AKR1B19) by oxidized glutathione and SH-reagents. Chem Biol Interact. 2013 Feb 25;202(1-3):146-52.
51 Gold nanoparticles induce serum amyloid A 1-Toll-like receptor 2 mediated NF-kB signaling in lung cells in vitro. Chem Biol Interact. 2018 Jun 1;289:81-89.

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