Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO05120)
Xenobiotics Name
Thanatin
Xenobiotics Type
Amino Acid(s), Peptide(s) or Protein(s)
Classification
Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Klebsiella variicola [1], [2]
Beta-lactamase (blaB) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Salmonella enterica [1], [2]
Beta-lactamase (blaB) DME Info Klebsiella aerogenes [1], [2]
Beta-lactamase (blaB) DME Info Enterobacter cloacae [1], [2]
Metallo-beta-lactamase (blaM) DME Info Klebsiella pneumoniae [1], [2]
Beta-lactamase (blaB) DME Info Klebsiella pneumoniae [1], [2]
Cytidine deaminase (cdd) DME Info Escherichia coli [1], [2]
Cytidine deaminase (cdd) DME Info Klebsiella pneumoniae [1], [2]
Chloramphenicolase (chlR) DME Info Escherichia coli [1], [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1], [2]
Cytochrome P450 102A1 (cyp102) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 MEG (cyp106) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 21A2 (cyp21) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 BM3 (cypBM3) DME Info Bacillus megaterium [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Klebsiella pneumoniae [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Salmonella enterica [1], [2]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1], [2]
Beta-galactosidase (bgaB) DME Info Enterobacter cloacae [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info Klebsiella pneumoniae [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1], [2]
Methylthioribose kinase (mtnK) DME Info Klebsiella pneumoniae [1], [2]
S-adenosylhomocysteine nucleosidase (mtnN) DME Info Klebsiella pneumoniae [1], [2]
Glutamate racemase (MurI) DME Info Escherichia coli [1], [2]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1], [2]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Salmonella enterica [1], [2]
Nitroreductase (NTR) DME Info Enterobacter cloacae [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Salmonella enterica [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info Klebsiella pneumoniae [1], [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1], [2]
Glutamate racemase (MurI) DME Info Bacillus subtilis [1], [2]
Retro-nitroreductase (rNR) DME Info Enterobacter cloacae [1], [2]
Tyramine oxidase (tynA) DME Info Escherichia coli [1], [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1], [2]
Glutamate racemase (MurI) DME Info Bacillus pumilus [1], [2]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [1], [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Azoreductase (azoR) DME Info MIC = 0.3-0.6 microM [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info MIC = 0.3-0.6 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 0.6-1.2 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 0.3-0.6 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 0.6-1.2 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 0.6-1.2 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 1.2-2.5 microM [1], [2]
Metallo-beta-lactamase (blaM) DME Info MIC = 0.6-1.2 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 0.6-1.2 microM [1], [2]
Cytidine deaminase (cdd) DME Info MIC = 0.6-1.2 microM [1], [2]
Cytidine deaminase (cdd) DME Info MIC = 0.6-1.2 microM [1], [2]
Chloramphenicolase (chlR) DME Info MIC = 0.3-0.6 microM [1], [2]
Glycoside hydrolase (cscA) DME Info MIC = 0.3-0.6 microM [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info MIC = 0.3-0.6 microM [1], [2]
Cytochrome P450 102A1 (cyp102) DME Info MIC = 2.5-5 microM [1], [2]
Cytochrome P450 MEG (cyp106) DME Info MIC = 2.5-5 microM [1], [2]
Cytochrome P450 21A2 (cyp21) DME Info MIC = 2.5-5 microM [1], [2]
Cytochrome P450 BM3 (cypBM3) DME Info MIC = 2.5-5 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 0.3-0.6 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 0.6-1.2 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 0.6-1.2 microM [1], [2]
Glutamate decarboxylase (gadB) DME Info MIC = 0.3-0.6 microM [1], [2]
Beta-galactosidase (bgaB) DME Info MIC = 1.2-2.5 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 0.3-0.6 microM [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 0.6-1.2 microM [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 0.3-0.6 microM [1], [2]
Methylthioribose kinase (mtnK) DME Info MIC = 0.6-1.2 microM [1], [2]
S-adenosylhomocysteine nucleosidase (mtnN) DME Info MIC = 0.6-1.2 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 0.3-0.6 microM [1], [2]
N-ethylmaleimide reductase (nemA) DME Info MIC = 0.3-0.6 microM [1], [2]
NADPH-dependent nitroreductase (nfrA1) DME Info MIC = 2.5-5 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 0.3-0.6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 0.6-1.2 microM [1], [2]
Nitroreductase (NTR) DME Info MIC = 1.2-2.5 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 0.3-0.6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 0.6-1.2 microM [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC = 0.6-1.2 microM [1], [2]
NADH dehydrogenase (nuoE) DME Info MIC = 0.3-0.6 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 2.5-5 microM [1], [2]
Retro-nitroreductase (rNR) DME Info MIC = 1.2-2.5 microM [1], [2]
Tyramine oxidase (tynA) DME Info MIC = 0.3-0.6 microM [1], [2]
Beta-glucuronidase (uidA) DME Info MIC = 0.3-0.6 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 2.5-5 microM [1], [2]
General stress protein 14 (ywrO) DME Info MIC = 2.5-5 microM [1], [2]
References
1 Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5.
2 Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data. Eur J Biochem. 1998 Sep 1;256(2):404-10.

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