General Information of Xenobiotics (ID: XEO04974)
Xenobiotics Name
Spinigerin
Xenobiotics Type
Amino Acid(s), Peptide(s) or Protein(s)
Classification
Peptide
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Azoreductase (azoR) DME Info Escherichia coli [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Klebsiella variicola [1], [2]
Beta-lactamase (blaB) DME Info Escherichia coli [1], [2]
Beta-lactamase (blaB) DME Info Salmonella enterica [1], [2]
Beta-lactamase (blaB) DME Info Klebsiella aerogenes [1], [2]
Metallo-beta-lactamase (blaM) DME Info Klebsiella pneumoniae [1], [2]
Beta-lactamase (blaB) DME Info Klebsiella pneumoniae [1], [2]
Cytidine deaminase (cdd) DME Info Escherichia coli [1], [2]
Cytidine deaminase (cdd) DME Info Klebsiella pneumoniae [1], [2]
Chloramphenicolase (chlR) DME Info Escherichia coli [1], [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1], [2]
Cytochrome P450 102A1 (cyp102) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 MEG (cyp106) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 21A2 (cyp21) DME Info Bacillus megaterium [1], [2]
Cytochrome P450 BM3 (cypBM3) DME Info Bacillus megaterium [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Klebsiella pneumoniae [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info Salmonella enterica [1], [2]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info Klebsiella pneumoniae [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1], [2]
Methylthioribose kinase (mtnK) DME Info Klebsiella pneumoniae [1], [2]
S-adenosylhomocysteine nucleosidase (mtnN) DME Info Klebsiella pneumoniae [1], [2]
Glutamate racemase (MurI) DME Info Escherichia coli [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1], [2]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Salmonella enterica [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Salmonella enterica [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info Klebsiella pneumoniae [1], [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1], [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1], [2]
Tyramine oxidase (tynA) DME Info Escherichia coli [1], [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1], [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Azoreductase (azoR) DME Info MIC = 3-6 microM [1], [2]
L,D-carboxypeptidase A (ldcA) DME Info MIC = 3-6 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 50-100 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 3-6 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 3-6 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 50-100 microM [1], [2]
Metallo-beta-lactamase (blaM) DME Info MIC = 50-100 microM [1], [2]
Beta-lactamase (blaB) DME Info MIC = 50-100 microM [1], [2]
Cytidine deaminase (cdd) DME Info MIC = 50-100 microM [1], [2]
Cytidine deaminase (cdd) DME Info MIC = 50-100 microM [1], [2]
Chloramphenicolase (chlR) DME Info MIC = 3-6 microM [1], [2]
Glycoside hydrolase (cscA) DME Info MIC = 3-6 microM [1], [2]
NADPH-dependent curcumin reductase (curA) DME Info MIC = 3-6 microM [1], [2]
Cytochrome P450 102A1 (cyp102) DME Info MIC = 0.8-1.5 microM [1], [2]
Cytochrome P450 MEG (cyp106) DME Info MIC = 0.8-1.5 microM [1], [2]
Cytochrome P450 21A2 (cyp21) DME Info MIC = 0.8-1.5 microM [1], [2]
Cytochrome P450 BM3 (cypBM3) DME Info MIC = 0.8-1.5 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 3-6 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 50-100 microM [1], [2]
Unclear metabolic mechanism (DME-unclear) DME Info MIC = 3-6 microM [1], [2]
Glutamate decarboxylase (gadB) DME Info MIC = 3-6 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 3-6 microM [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info MIC = 50-100 microM [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 50-100 microM [1], [2]
Molybdopterin-dependent enzyme (molD) DME Info MIC = 3-6 microM [1], [2]
Methylthioribose kinase (mtnK) DME Info MIC = 50-100 microM [1], [2]
S-adenosylhomocysteine nucleosidase (mtnN) DME Info MIC = 50-100 microM [1], [2]
Glutamate racemase (MurI) DME Info MIC = 3-6 microM [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC = 50-100 microM [1], [2]
N-ethylmaleimide reductase (nemA) DME Info MIC = 3-6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 3-6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info MIC = 3-6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 3-6 microM [1], [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info MIC = 3-6 microM [1], [2]
Arylamine N-acetyltransferase (NAT) DME Info MIC = 50-100 microM [1], [2]
NADH dehydrogenase (nuoE) DME Info MIC = 3-6 microM [1], [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info MIC = 50-100 microM [1], [2]
Tyramine oxidase (tynA) DME Info MIC = 3-6 microM [1], [2]
Beta-glucuronidase (uidA) DME Info MIC = 3-6 microM [1], [2]
References
1 Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect. J Biol Chem. 2001 Feb 9;276(6):4085-92.
2 Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation. Biopolymers. 2006 Feb 5;81(2):92-103.

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