Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0058)
DME Name Acetylcholinesterase (ACHE), Homo sapiens DME Info
UniProt ID
ACES_HUMAN
EC Number    EC: 3.1.1.7     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.7
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Alachlor Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00967   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Alachlor induces the drug-metabolizing activity of DME ACHE [1]
                              Bensulide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00970   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Bensulide inhibits the drug-metabolizing activity of DME ACHE [2]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:      28 Xenobiotics
                              Aldicarb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01037   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Aldicarb inhibits the drug-metabolizing activity of DME ACHE [3]
                              Arthodibrom Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01063   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Arthodibrom inhibits the drug-metabolizing activity of DME ACHE [4]
                              Azamethiphos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00799   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Azamethiphos inhibits the drug-metabolizing activity of DME ACHE [5]
                              Azinphosmethyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01038   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Azinphosmethyl inhibits the drug-metabolizing activity of DME ACHE [6], [7]
                              Carbamate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00823   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Carbamate inhibits the drug-metabolizing activity of DME ACHE [8]
                              Carbofuran Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01597   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Carbof DMEuran inhibits the drug-metabolizing activity of DME ACHE [3]
                              Chlorfenvinphos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01042   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Chlorfenvinphos inhibits the drug-metabolizing activity of DME ACHE [9]
                              Coumaphos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01599   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Coumaphos inhibits the drug-metabolizing activity of DME ACHE [2]
                              Demeton-S-methyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00887   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Demeton-S-methyl inhibits the drug-metabolizing activity of DME ACHE [10], [11]
                              Dichlorvos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01049   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dichlorvos inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.627 microM) [12]
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the drug-metabolizing activity of DME ACHE [9], [2]
                              Dimethoate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01073   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dimethoate inhibits the drug-metabolizing activity of DME ACHE [13]
                              Ethoprop Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01077   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Ethoprop inhibits the drug-metabolizing activity of DME ACHE [2]
                              Ethyl paraoxon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00882   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Ethyl paraoxon inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.01 microM) [14]
                              Fenamiphos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01078   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenamiphos inhibits the drug-metabolizing activity of DME ACHE [15]
                              Fenthion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00867   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenthion inhibits the drug-metabolizing activity of DME ACHE [16]
                              Heptenophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01056   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Heptenophos inhibits the drug-metabolizing activity of DME ACHE [9]
                              Isocarbophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01057   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Isocarbophos inhibits the drug-metabolizing activity of DME ACHE [17]
                              Methamidophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01059   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Methamidophos inhibits the drug-metabolizing activity of DME ACHE [18]
                              Methomyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01060   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Methomyl inhibits the drug-metabolizing activity of DME ACHE [19]
                              Mipafox Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01061   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Mipafox inhibits the drug-metabolizing activity of DME ACHE [20]
                              Parathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01064   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Parathion inhibits the expression of DME ACHE [21], [22]
                              Phorate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01076   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Phorate inhibits the drug-metabolizing activity of DME ACHE [23]
                              Phosphamidon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01066   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Phosphamidon inhibits the drug-metabolizing activity of DME ACHE [24]
                              Profenofos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01068   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Prof DMEenof DMEos inhibits the drug-metabolizing activity of DME ACHE [25]
                              Propoxur Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01607   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Propoxur inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.59 microM) [12]
                              Terbufos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01079   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Terbufos inhibits the drug-metabolizing activity of DME ACHE [26]
                              Trichlorfon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01072   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Trichlorfon inhibits the drug-metabolizing activity of DME ACHE [27]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Chlorpyrifos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos inhibits the drug-metabolizing activity of DME ACHE [2]
                              Dimethoxon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01615   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Dimethoxon inhibits the drug-metabolizing activity of DME ACHE [2]
                              Mercury Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01509   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercury up-regulates the expression of DME ACHE [28]
                              Sarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00779   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Sarin inhibits the drug-metabolizing activity of DME ACHE [18]
                              Soman Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00778   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Soman inhibits the expression of DME ACHE [29]
                              Thioflavin T Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01027   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Thiof DMElavin T inhibits the drug-metabolizing activity of DME ACHE [30]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene induces the drug-metabolizing activity of DME ACHE [31]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Bisphenol F Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00997   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Bisphenol F induces the drug-metabolizing activity of DME ACHE [32]
                              Diazinon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01274   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Diazinon inhibits the drug-metabolizing activity of DME ACHE (IC50 = 1.9 microM) [33]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid inhibits the drug-metabolizing activity of DME ACHE [34]
                              1-methyl-4-phenylpyridinium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01103   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 1-methyl-4-phenylpyridinium inhibits the drug-metabolizing activity of DME ACHE [35]
                              Acetaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00872   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Acetaldehyde inhibits the drug-metabolizing activity of DME ACHE [36]
                              Methylphosphonic difluoride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00900   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Methylphosphonic difluoride inhibits the expression of DME ACHE [37]
                  Neurotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tabun Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01596   XEOTIC Info Gene Form mRNA
                                 Classification Neurotoxin
                                 DME Modulation Tabun inhibits the expression of DME ACHE [38], [39]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Chebulinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01244   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Chebulinic acid inhibits the drug-metabolizing activity of DME ACHE [40]
                              Cryptotanshinone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01534   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cryptotanshinone inhibits the drug-metabolizing activity of DME ACHE (Ki = 6.41 microM) [41]
                              Hopeahainol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01333   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Hopeahainol A inhibits the drug-metabolizing activity of DME ACHE [42]
                              Tellimagrandin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01593   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Tellimagrandin I inhibits the expression of DME ACHE [43]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME ACHE [44], [45]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang inhibits the expression of DME ACHE [46]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      25 Xenobiotics
                              Chlorpromazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00280   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpromazine hydrochloride inhibits the drug-metabolizing activity of DME ACHE [47]
                              Choline C-11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00281   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Choline C-11 inhibits the drug-metabolizing activity of DME ACHE (IC50 = 3013.00602 microM) [48]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME ACHE [46]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME ACHE [49]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME ACHE [50]
                              Donepezil hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00289   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Donepezil hydrochloride inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.002 microM) [51]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride up-regulates the expression of DME ACHE [52], [53]
                              Edrophonium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00355   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Edrophonium inhibits the drug-metabolizing activity of DME ACHE [42], [54]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME ACHE [50]
                              Galantamine hydrobromide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00298   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Galantamine hydrobromide inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.1 microM) [55]
                              Imipramine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00300   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Imipramine hydrochloride inhibits the drug-metabolizing activity of DME ACHE [54]
                              Isoflurophate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00093   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isof DMElurophate inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.12 microM) [56]
                              Malathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00056   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Malathion inhibits the drug-metabolizing activity of DME ACHE [57]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate up-regulates the expression of DME ACHE [58]
                              Metoclopramide hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00307   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Metoclopramide hydrochloride inhibits the drug-metabolizing activity of DME ACHE (IC50 > 20 microM) [59]
                              Neostigmine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00065   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Neostigmine inhibits the drug-metabolizing activity of DME ACHE (IC50 = 2.4 microM) [60]
                              Pyridostigmine bromide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00100   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pyridostigmine bromide inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.35 microM) [61]
                              Ranitidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00379   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ranitidine inhibits the expression of DME ACHE [62]
                              Scopolamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00259   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Scopolamine induces the drug-metabolizing activity of DME ACHE [63]
                              Sulfonamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00424   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulfonamide inhibits the expression of DME ACHE [64]
                              Tacrine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00328   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tacrine hydrochloride inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.00316 microM) [65]
                              Bambuterol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00462   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Bambuterol inhibits the drug-metabolizing activity of DME ACHE (IC50 = 30 microM) [66], [67]
                              Huperzine A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00451   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Huperzine A inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.00054 microM) [68]
                              Obidoxime chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01406   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Obidoxime chloride inhibits the drug-metabolizing activity of DME ACHE [69]
                              Trimedoxime Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01493   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Trimedoxime inhibits the drug-metabolizing activity of DME ACHE (IC50 = 167 microM) [70]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Diethyltoluamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00582   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Diethyltoluamide inhibits the drug-metabolizing activity of DME ACHE [71]
                              Itopride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00570   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Itopride inhibits the drug-metabolizing activity of DME ACHE [54]
                              Physostigmine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00586   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Physostigmine inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.00043 microM) [72]
                              Physostigmine heptyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00616   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Physostigmine heptyl inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.005 microM) [73]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A induces the drug-metabolizing activity of DME ACHE [32], [74]
                              Ethanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol induces the drug-metabolizing activity of DME ACHE [75]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Aspartame Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01209   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Aspartame inhibits the drug-metabolizing activity of DME ACHE [76]
                              Homocysteine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01331   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Homocysteine induces the drug-metabolizing activity of DME ACHE [77]
                              Sodium arsenite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite inhibits the drug-metabolizing activity of DME ACHE [78]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              AM-2282 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00698   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation AM-2282 up-regulates the expression of DME ACHE [79]
                              HI-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01208   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation HI-6 inhibits the drug-metabolizing activity of DME ACHE [80], [81]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Amiridine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01196   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Amiridine inhibits the drug-metabolizing activity of DME ACHE (IC50 = 0.658 microM) [82]
                              Chlorite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00807   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Chlorite induces the drug-metabolizing activity of DME ACHE [83]
                              K075 compound Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01349   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation K075 compound inhibits the drug-metabolizing activity of DME ACHE [84]
                              Memoquin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01371   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Memoquin inhibits the drug-metabolizing activity of DME ACHE [85]
                              Methanethiosulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01374   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Methanethiosulfonate inhibits the expression of DME ACHE [86]
                              Russian VX Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01464   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Russian VX inhibits the expression of DME ACHE [87]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Phosphorous acids Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01019   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Phosphorous acids inhibits the drug-metabolizing activity of DME ACHE [88]
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