Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0110)
DME Name Glutathione reductase (GSR), Homo sapiens DME Info
UniProt ID
GSHR_HUMAN
EC Number    EC: 1.8.1.7     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.8.1.7
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Atrazine induces the drug-metabolizing activity of DME GSR [1]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Carbamate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00823   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Carbamate inhibits the drug-metabolizing activity of DME GSR [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Acrylamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01187   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylamide induces the drug-metabolizing activity of DME GSR [3]
                              Allyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00852   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Allyl isothiocyanate inhibits the drug-metabolizing activity of DME GSR [4]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium induces the drug-metabolizing activity of DME GSR [5]
                              Chlorpyrifos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos up-regulates the expression of DME GSR [6]
                              Glutaral Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01316   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Glutaral inhibits the drug-metabolizing activity of DME GSR [7]
                              Paraquat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat inhibits the expression of DME GSR [8]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the drug-metabolizing activity of DME GSR [9]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone induces the drug-metabolizing activity of DME GSR [10]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME GSR [11]
                              Pterostilbene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01441   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Pterostilbene inhibits the expression of DME GSR [12], [13]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              N-hexane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01016   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation N-hexane up-regulates the expression of DME GSR [14]
                              Chloric acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01001   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Chloric acid inhibits the drug-metabolizing activity of DME GSR [15]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tobacco smoke pollution Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution inhibits the drug-metabolizing activity of DME GSR [16]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Acylfulvene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01188   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Acylfulvene inhibits the drug-metabolizing activity of DME GSR [17]
                              Benzyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01217   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Benzyl isothiocyanate inhibits the drug-metabolizing activity of DME GSR [4]
                              Cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde up-regulates the expression of DME GSR [18]
                              Gallocatechol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01542   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Gallocatechol induces the drug-metabolizing activity of DME GSR [19]
                              Illudin S Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01339   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Illudin S inhibits the drug-metabolizing activity of DME GSR [17]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts induces the drug-metabolizing activity of DME GSR [20]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      21 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen up-regulates the expression of DME GSR [21]
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide up-regulates the expression of DME GSR [22], [23]
                              Azathioprine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine up-regulates the expression of DME GSR [24]
                              Bortezomib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00159   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bortezomib up-regulates the expression of DME GSR [25]
                              Carmustine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00012   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carmustine inhibits the drug-metabolizing activity of DME GSR (IC50 = 8.1 microM) [26]
                              Cidofovir Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00132   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cidofovir up-regulates the expression of DME GSR [27]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the drug-metabolizing activity of DME GSR [28]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME GSR [29]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME GSR [30]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME GSR [31]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME GSR [11]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide induces the drug-metabolizing activity of DME GSR [32]
                              Ifosfamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide up-regulates the expression of DME GSR [27]
                              Lindane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane up-regulates the expression of DME GSR [24]
                              Obeticholic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00165   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Obeticholic acid up-regulates the expression of DME GSR [33]
                              Pyrithione zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00399   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pyrithione zinc up-regulates the expression of DME GSR [34]
                              Testosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone induces the drug-metabolizing activity of DME GSR [35]
                              Tretinoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin induces the drug-metabolizing activity of DME GSR [36]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME GSR [11]
                              Clodronic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00465   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Clodronic acid up-regulates the expression of DME GSR [27]
                              Thiostrepton Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01485   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Thiostrepton induces the drug-metabolizing activity of DME GSR [37]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Epigallocatechin gallate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate induces the drug-metabolizing activity of DME GSR [19]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol up-regulates the expression of DME GSR [38]
                              Sulforafan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan up-regulates the expression of DME GSR [39]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME GSR [40]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the drug-metabolizing activity of DME GSR [41]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the expression of DME GSR [42]
                              Glutathione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00542   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Glutathione inhibits the drug-metabolizing activity of DME GSR [43]
                              MGI-114 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00625   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MGI-114 inhibits the drug-metabolizing activity of DME GSR [17]
                              Motexafin gadolinium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00541   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Motexafin gadolinium induces the drug-metabolizing activity of DME GSR [44]
                              Selenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00575   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Selenic acid up-regulates the expression of DME GSR [45]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Dihydrotestosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone up-regulates the expression of DME GSR [46]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME GSR [11]
                              Hexylresorcinol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01329   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Hexylresorcinol induces the drug-metabolizing activity of DME GSR [47]
                              Homocysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01331   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Homocysteine inhibits the drug-metabolizing activity of DME GSR [48]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite up-regulates the expression of DME GSR [49]
                              Thioctic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01483   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Thioctic acid up-regulates the expression of DME GSR [50]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Kolaviron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01358   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Kolaviron induces the drug-metabolizing activity of DME GSR [1]
                              Anethole trithione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00729   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Anethole trithione induces the drug-metabolizing activity of DME GSR [51]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME GSR [11]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME GSR [52]
                              K-7174 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 up-regulates the expression of DME GSR [53]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Chlorite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00807   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Chlorite inhibits the drug-metabolizing activity of DME GSR [54]
                              Indirubin-3'-monoxime Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01342   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Indirubin-3'-monoxime up-regulates the expression of DME GSR [55]
                              Isopropanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01128   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Isopropanol up-regulates the expression of DME GSR [11]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate induces the drug-metabolizing activity of DME GSR [56]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cupric oxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00840   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Cupric oxide inhibits the drug-metabolizing activity of DME GSR [57]
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