Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0005)
DME Name Cytochrome P450 2A6 (CYP2A6), Homo sapiens DME Info
UniProt ID
CP2A6_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cyproconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00942   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Cyproconazole inhibits the drug-metabolizing activity of DME CYP2A6 [1]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine up-regulates the expression of DME CYP2A6 [2]
                              Clofibric acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01257   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Clof DMEibric acid inhibits the drug-metabolizing activity of DME CYP2A6 [3]
                              Diuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00973   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diuron up-regulates the expression of DME CYP2A6 [2]
                              Isoproturon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00975   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Isoproturon up-regulates the expression of DME CYP2A6 [2]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:      10 Xenobiotics
                              Chlorfluazuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01043   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Chlorfluazuron up-regulates the expression of DME CYP2A6 [2]
                              Cyhalothrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01600   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cyhalothrin up-regulates the expression of DME CYP2A6 [2]
                              Cypermethrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01046   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cypermethrin up-regulates the expression of DME CYP2A6 [2]
                              Decamethrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01047   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Decamethrin up-regulates the expression of DME CYP2A6 [2]
                              Fenitrothion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01052   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenitrothion up-regulates the expression of DME CYP2A6 [2]
                              Fenvalerate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01053   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenvalerate up-regulates the expression of DME CYP2A6 [2]
                              Parathion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01064   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Parathion induces the drug-metabolizing activity of DME CYP2A6 [4]
                              Phenthoate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01065   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Phenthoate induces the drug-metabolizing activity of DME CYP2A6 [5]
                              Profenofos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01068   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Profenofos induces the drug-metabolizing activity of DME CYP2A6 [6]
                              Tebufenozide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01070   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Tebufenozide up-regulates the expression of DME CYP2A6 [7]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Chlorpyrifos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos up-regulates the expression of DME CYP2A6 [2]
                              Cycloheximide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01268   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cycloheximide inhibits the drug-metabolizing activity of DME CYP2A6 [8]
                              Fipronil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01302   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Fipronil up-regulates the expression of DME CYP2A6 [9]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form mRNA
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin inhibits the expression of DME CYP2A6 [10]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene induces the drug-metabolizing activity of DME CYP2A6 [11]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME CYP2A6 [12]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone up-regulates the expression of DME CYP2A6 [13]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Alpha-linolenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00873   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Alpha-linolenic acid induces the drug-metabolizing activity of DME CYP2A6 [14]
                              Coumarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00879   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Coumarin inhibits the drug-metabolizing activity of DME CYP2A6 [15]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution induces the drug-metabolizing activity of DME CYP2A6 [16]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              5-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01518   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 5-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2A6 [17]
                              Alizarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00993   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Alizarin inhibits the drug-metabolizing activity of DME CYP2A6 [18]
                              Bilirubin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00877   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Bilirubin inhibits the drug-metabolizing activity of DME CYP2A6 [8]
                              Isatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00880   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Isatin up-regulates the expression of DME CYP2A6 [19]
                              Purpurin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01443   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Purpurin inhibits the drug-metabolizing activity of DME CYP2A6 [20]
                              Safrole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01583   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Safrole inhibits the drug-metabolizing activity of DME CYP2A6 [21]
                              Skatole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00777   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Skatole inhibits the expression of DME CYP2A6 [22]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      26 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME CYP2A6 [23]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME CYP2A6 [24]
                              Carbamazepine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine up-regulates the expression of DME CYP2A6 [25]
                              Chlorpromazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00280   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpromazine hydrochloride inhibits the drug-metabolizing activity of DME CYP2A6 [26]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CYP2A6 [27]
                              Desipramine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00022   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Desipramine inhibits the drug-metabolizing activity of DME CYP2A6 [26]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone induces the drug-metabolizing activity of DME CYP2A6 [28], [29]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME CYP2A6 [30], [31]
                              Felodipine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00245   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Felodipine induces the drug-metabolizing activity of DME CYP2A6 [32]
                              Fluphenazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00295   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluphenazine hydrochloride inhibits the drug-metabolizing activity of DME CYP2A6 [26]
                              Irinotecan hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00301   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Irinotecan hydrochloride inhibits the drug-metabolizing activity of DME CYP2A6 [33]
                              Isradipine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00049   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isradipine induces the drug-metabolizing activity of DME CYP2A6 [32]
                              Methoxsalen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00062   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methoxsalen inhibits the drug-metabolizing activity of DME CYP2A6 (Ki = 0.25 microM) [34]
                              Nicotine polacrilex Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex up-regulates the expression of DME CYP2A6 [35]
                              Obeticholic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00165   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Obeticholic acid up-regulates the expression of DME CYP2A6 [36]
                              Permethrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00123   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Permethrin up-regulates the expression of DME CYP2A6 [37]
                              Phenobarbital Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00410   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenobarbital induces the drug-metabolizing activity of DME CYP2A6 [38]
                              Pilocarpine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00092   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pilocarpine inhibits the drug-metabolizing activity of DME CYP2A6 (Ki = 3 microM) [34]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin up-regulates the expression of DME CYP2A6 [39], [40]
                              Testosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone up-regulates the expression of DME CYP2A6 [41]
                              Thioridazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00330   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Thioridazine hydrochloride inhibits the expression of DME CYP2A6 [42], [43]
                              Tranylcypromine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00385   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tranylcypromine inhibits the drug-metabolizing activity of DME CYP2A6 (Ki = 0.13 microM) [34]
                              Valproic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid up-regulates the expression of DME CYP2A6 [44]
                              Benidipine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00438   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benidipine induces the drug-metabolizing activity of DME CYP2A6 [32]
                              Cinnamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01252   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cinnamic acid inhibits the drug-metabolizing activity of DME CYP2A6 [45]
                              Linoleic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01367   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linoleic acid induces the drug-metabolizing activity of DME CYP2A6 [14]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Afimoxifene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00610   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Afimoxifene inhibits the expression of DME CYP2A6 [46]
                              Diethyltoluamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00582   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Diethyltoluamide up-regulates the expression of DME CYP2A6 [47], [9]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME CYP2A6 [48]
                              Ditiocarb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00591   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ditiocarb inhibits the drug-metabolizing activity of DME CYP2A6 [49]
                              Ethanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol induces the drug-metabolizing activity of DME CYP2A6 [50]
                              Phenethyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00596   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Phenethyl isothiocyanate inhibits the drug-metabolizing activity of DME CYP2A6 (Ki = 1.7 microM) [34]
                              Tryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00576   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Tryptamine inhibits the drug-metabolizing activity of DME CYP2A6 (Ki = 1.7 microM) [34]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Carbendazim Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00598   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Carbendazim up-regulates the expression of DME CYP2A6 [2]
                              Epsilon-viniferin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00646   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Epsilon-viniferin inhibits the drug-metabolizing activity of DME CYP2A6 [51]
                              Quercetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin induces the drug-metabolizing activity of DME CYP2A6 [52]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Oleic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01412   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Oleic acid up-regulates the expression of DME CYP2A6 [53]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              7-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01177   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 7-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2A6 [17]
                              Benzyl selenocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01218   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Benzyl selenocyanate inhibits the drug-metabolizing activity of DME CYP2A6 [54]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME CYP2A6 [55]
                              CITCO Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01165   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation CITCO up-regulates the expression of DME CYP2A6 [56]
      Other Chemical Compound(s) or Element(s)
                  Food Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Stearic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01475   XEOTIC Info Gene Form Protein
                                 Classification Food Additive
                                 DME Modulation Stearic acid induces the drug-metabolizing activity of DME CYP2A6 [57]
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