Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0147)
DME Name Cellular glutathione peroxidase (GPX1), Homo sapiens DME Info
UniProt ID
GPX1_HUMAN
EC Number    EC: 1.11.1.9     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Fludioxonil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00947   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Fludioxonil up-regulates the expression of DME GPX1 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Acrylamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01187   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylamide inhibits the expression of DME GPX1 [2]
                              Chloropicrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin inhibits the expression of DME GPX1 [3]
                              Cordycepin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01259   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cordycepin inhibits the expression of DME GPX1 [4]
                              Formaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde up-regulates the expression of DME GPX1 [5]
                              Mercury Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01509   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercury up-regulates the expression of DME GPX1 [6]
                              Ochratoxin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01407   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Ochratoxin A induces the drug-metabolizing activity of DME GPX1 [7], [8]
                              Paraquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat induces the drug-metabolizing activity of DME GPX1 [9]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Leptomycin B Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00906   XEOTIC Info Gene Form mRNA
                                 Classification Cytotoxin
                                 DME Modulation Leptomycin B up-regulates the expression of DME GPX1 [10]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME GPX1 [11]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate up-regulates the expression of DME GPX1 [5]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME GPX1 [12]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Pterostilbene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01441   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Pterostilbene up-regulates the expression of DME GPX1 [13]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid inhibits the expression of DME GPX1 [14]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Amphibole asbestos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00995   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Amphibole asbestos inhibits the drug-metabolizing activity of DME GPX1 [15]
                              Coal tar Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00755   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Coal tar up-regulates the expression of DME GPX1 [16]
                              Vitallium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01511   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Vitallium inhibits the expression of DME GPX1 [17], [18]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Biochanin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01222   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Biochanin A inhibits the expression of DME GPX1 [19]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tea extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01592   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Tea extracts up-regulates the expression of DME GPX1 [20]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      21 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME GPX1 [21]
                              Aminoglutethimide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00233   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aminoglutethimide induces the drug-metabolizing activity of DME GPX1 [22]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME GPX1 [23]
                              Auranofin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00270   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Auranofin induces the drug-metabolizing activity of DME GPX1 [24]
                              Bosentan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00148   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bosentan inhibits the expression of DME GPX1 [25]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME GPX1 [26]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME GPX1 [27]
                              Daunorubicin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00351   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Daunorubicin up-regulates the expression of DME GPX1 [28], [29]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride induces the drug-metabolizing activity of DME GPX1 [30]
                              Dronabinol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00115   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dronabinol induces the drug-metabolizing activity of DME GPX1 [31]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME GPX1 [32]
                              Etoposide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00121   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Etoposide up-regulates the expression of DME GPX1 [33]
                              Fluorouracil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00037   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluorouracil up-regulates the expression of DME GPX1 [34]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the drug-metabolizing activity of DME GPX1 [35]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate up-regulates the expression of DME GPX1 and leads to increasing the drug-metabolizing activity of this enzyme [36]
                              Omacor Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00194   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Omacor up-regulates the expression of DME GPX1 [37]
                              Pyridostigmine bromide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00100   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pyridostigmine bromide inhibits the expression of DME GPX1 [38]
                              Tretinoin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin inhibits the drug-metabolizing activity of DME GPX1 [39]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone up-regulates the expression of DME GPX1 [40]
                              Rotenone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00481   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Rotenone up-regulates the expression of DME GPX1 [41]
                              Silver nitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00511   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Silver nitrate up-regulates the expression of DME GPX1 [42]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the expression of DME GPX1 [43]
                              Fenretinide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00565   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Fenretinide induces the drug-metabolizing activity of DME GPX1 [44]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol up-regulates the expression of DME GPX1 [45]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME GPX1 and leads to decreasing the drug-metabolizing activity of this enzyme [46]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME GPX1 [47]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Homocysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01331   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Homocysteine inhibits the drug-metabolizing activity of DME GPX1 [48]
                              NS-398 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00583   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation NS-398 up-regulates the expression of DME GPX1 [49]
                              Thioctic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01483   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Thioctic acid induces the drug-metabolizing activity of DME GPX1 [50]
                              Thiomalates Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00655   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Thiomalates up-regulates the expression of DME GPX1 [51]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Emodin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00692   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Emodin up-regulates the expression of DME GPX1 [52]
                              Iodoacetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00696   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Iodoacetate inhibits the drug-metabolizing activity of DME GPX1 [53]
                              AM-251 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01194   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation AM-251 up-regulates the expression of DME GPX1 [54]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Nimesulide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00519   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Nimesulide inhibits the expression of DME GPX1 [55], [56]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Indirubin-3'-monoxime Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01342   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Indirubin-3'-monoxime inhibits the expression of DME GPX1 [57]
                              SB-431542 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01147   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation SB-431542 induces the drug-metabolizing activity of DME GPX1 [58]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Aluminum Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00839   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Aluminum inhibits the drug-metabolizing activity of DME GPX1 [59]
References
1 A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro. PLoS One. 2012;7(8):e42768.
2 Protective effect of carnosic acid against acrylamide-induced toxicity in RPE cells. Food Chem Toxicol. 2017 Oct;108(Pt B):543-553.
3 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
4 Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy. Toxicol In Vitro. 2018 Feb;46:113-121.
5 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
6 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
7 Transcriptional induction of CYP3A4 by o,p'-DDT in HepG2 cells. Toxicol Lett. 2005 May 16;157(1):41-7.
8 A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004 Dec 15;68(12):2347-58.
9 Aryl hydrocarbon receptor is an ozone sensor in human skin. J Invest Dermatol. 2009 Oct;129(10):2396-403.
10 Epigallocatechin-3-gallate enhances the therapeutic effects of leptomycin B on human lung cancer a549 cells. Oxid Med Cell Longev. 2015;2015:217304.
11 Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells. Food Chem Toxicol. 2019 Feb;124:349-358.
12 Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicol Lett. 2011 Aug 28;205(2):146-53.
13 Progestins regulate genes that can elicit both proliferative and antiproliferative effects in breast cancer cells. Oncol Rep. 2008 Jun;19(6):1627-34.
14 The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29.
15 Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos. Toxicol Sci. 2010 Dec;118(2):420-34.
16 Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo. Br J Dermatol. 2006 Aug;155(2):275-81.
17 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
18 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
19 Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts. Prostate. 2002 Aug 1;52(3):201-12.
20 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
21 Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
22 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
23 Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 Aug;27(8):1078-84.
24 Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis. Biochem J. 2011 May 15;436(1):123-32.
25 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
26 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
27 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
28 Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
29 Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
30 N-acetylcysteine enhances multidrug resistance-associated protein 1 mediated doxorubicin resistance. Eur J Clin Invest. 2004 Oct;34(10):683-9.
31 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
32 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
33 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
34 Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
35 Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE-/- mice. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):114-26.
36 Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
37 In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):216-24.
38 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
39 Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds. Chem Biol Interact. 2019 Aug 1;308:372-376.
40 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
41 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
42 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015 Apr 18;16:315.
43 Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU. Ai Zheng. 2008 Oct;27(10):1056-64.
44 Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress. Neoplasia. 2014 Sep;16(9):710-22.
45 Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor alpha and beta. J Cell Physiol. 2011 May;226(5):1334-9.
46 Prenatal nonylphenol and bisphenol A exposures and inflammation are determinants of oxidative/nitrative stress: a taiwanese cohort study. Environ Sci Technol. 2017 Jun 6;51(11):6422-6429.
47 A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells. Free Radic Res. 2008 Aug;42(8):746-53.
48 Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J Biol Chem. 2005 Apr 22;280(16):15518-25.
49 An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):64-71.
50 Thioredoxin reductase is the major selenoprotein expressed in human umbilical-vein endothelial cells and is regulated by protein kinase C. Biochem J. 1999 Aug 15;342 ( Pt 1):111-7.
51 Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element. J Nutr. 2003 Sep;133(9):2721-7.
52 Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells. Cell Res. 2005 Jul;15(7):511-22.
53 Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. Biochem J. 2001 Jan 1;353(Pt 1):91-100.
54 Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett. 2006 Mar 20;580(7):1733-9.
55 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
56 Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):131-49.
57 The effects of indirubin-3'-monoxime, a novel AHR ligand, on stress and toxicity-related gene/protein expression in human U937 cells undergoing differentiation and activation. J Immunotoxicol. 2006 Jan 1;3(1):1-10.
58 Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem. 2015 Apr 3;290(14):8834-48.
59 Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats. Biol Trace Elem Res. 2007 Jun;116(3):329-48.

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