Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00574)
Xenobiotics Name
Phenanthrene
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
995
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Beta-lactamase (blaB) DME Info Serratia marcescens [1]
Azoreductase (azoR) DME Info Escherichia coli [1]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [1]
Beta-lactamase (blaB) DME Info Klebsiella variicola [1]
Beta-lactamase (blaB) DME Info Escherichia coli [1]
Beta-lactamase (blaB) DME Info Klebsiella aerogenes [1]
Metallo-beta-lactamase (blaM) DME Info Klebsiella pneumoniae [1]
Beta-lactamase (blaB) DME Info Klebsiella pneumoniae [1]
Cytidine deaminase (cdd) DME Info Escherichia coli [1]
Cytidine deaminase (cdd) DME Info Klebsiella pneumoniae [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [1]
Glycoside hydrolase (cscA) DME Info Escherichia coli [1]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [1]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [1]
Unclear metabolic mechanism (DME-unclear) DME Info Klebsiella pneumoniae [1]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [1]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [1]
Molybdopterin-dependent enzyme (molD) DME Info Klebsiella pneumoniae [1]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [1]
Methylthioribose kinase (mtnK) DME Info Klebsiella pneumoniae [1]
S-adenosylhomocysteine nucleosidase (mtnN) DME Info Klebsiella pneumoniae [1]
Glutamate racemase (MurI) DME Info Escherichia coli [1]
Arylamine N-acetyltransferase (NAT) DME Info Serratia marcescens [1]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [1]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [1]
Arylamine N-acetyltransferase (NAT) DME Info Klebsiella pneumoniae [1]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [1]
Beta-glucuronidase (uidA) DME Info Escherichia coli [1]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [2]
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
References
1 Inhibition of quorum sensing mediated biofilm development and virulence in uropathogens by Hyptis suaveolens. Antonie Van Leeuwenhoek. 2015 Apr;107(4):1095-106.
2 Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology. 2011 Oct 9;288(1-3):8-17.
3 Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine-related genes in vitro and in vivo. Environ Toxicol Chem. 2013 Feb;32(2):353-60.
4 The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29.

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