Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0013)
DME Name Cytochrome P450 2E1 (CYP2E1), Homo sapiens DME Info
UniProt ID
CP2E1_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Carbon tetrachloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01000   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Carbon tetrachloride inhibits the drug-metabolizing activity of DME CYP2E1 in Cellosaurus cell line BTI-Tn-5B1-4 (IC50 = 11 microM) [1]
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cyproconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00942   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Cyproconazole inhibits the expression of DME CYP2E1 [2]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Amitrole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00968   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Amitrole inhibits the drug-metabolizing activity of DME CYP2E1 [3]
                              Isoproturon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00975   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Isoproturon inhibits the drug-metabolizing activity of DME CYP2E1 [4]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Chlorfluazuron Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01043   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Chlorfluazuron inhibits the drug-metabolizing activity of DME CYP2E1 [4]
                              Cypermethrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01046   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cypermethrin inhibits the drug-metabolizing activity of DME CYP2E1 [4]
                              Endosulfan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01074   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Endosulfan inhibits the drug-metabolizing activity of DME CYP2E1 [5]
                              Fenitrothion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01052   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenitrothion inhibits the drug-metabolizing activity of DME CYP2E1 [4]
                              Fenvalerate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01053   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenvalerate inhibits the drug-metabolizing activity of DME CYP2E1 [4]
                              Monocrotophos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01062   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Monocrotophos up-regulates the expression of DME CYP2E1 [6]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01119   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine up-regulates the expression of DME CYP2E1 [7]
                              Acrylamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01187   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylamide induces the drug-metabolizing activity of DME CYP2E1 [8]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME CYP2E1 [9]
                              Chlorpyrifos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos inhibits the drug-metabolizing activity of DME CYP2E1 [4]
                              Fipronil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01302   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Fipronil inhibits the expression of DME CYP2E1 [10]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME CYP2E1 [11]
                              Dimethyl nitrosamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01006   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Dimethyl nitrosamine inhibits the drug-metabolizing activity of DME CYP2E1 [12]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate inhibits the expression of DME CYP2E1 [13]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME CYP2E1 [14], [15]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Alpha-linolenic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00873   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Alpha-linolenic acid inhibits the drug-metabolizing activity of DME CYP2E1 [16]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the expression of DME CYP2E1 [17]
                              Dimethyl formamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01279   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Dimethyl formamide induces the drug-metabolizing activity of DME CYP2E1 [18]
                              Pyridine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00850   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Pyridine up-regulates the expression of DME CYP2E1 [19]
                              Toluene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01489   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Toluene up-regulates the expression of DME CYP2E1 [20]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Vitallium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01511   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Vitallium inhibits the expression of DME CYP2E1 [21], [22]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              5-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01518   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 5-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2E1 [23]
                              Alizarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00993   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Alizarin inhibits the drug-metabolizing activity of DME CYP2E1 [24]
                              Apigenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01203   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Apigenin inhibits the drug-metabolizing activity of DME CYP2E1 [25]
                              Baicalein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01212   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Baicalein inhibits the drug-metabolizing activity of DME CYP2E1 [25]
                              Diosmetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01281   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Diosmetin inhibits the drug-metabolizing activity of DME CYP2E1 [26]
                              Isatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00880   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Isatin up-regulates the expression of DME CYP2E1 [27]
                              Purpurin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01443   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Purpurin inhibits the drug-metabolizing activity of DME CYP2E1 [28]
                              Senecionine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01585   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Senecionine induces the drug-metabolizing activity of DME CYP2E1 [29]
                              Skatole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00777   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Skatole inhibits the expression of DME CYP2E1 [30]
                              Taxifolin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01591   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Taxifolin inhibits the expression of DME CYP2E1 [31]
                              Walrycin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01498   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Walrycin A up-regulates the expression of DME CYP2E1 [32]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Ginkgo biloba extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01314   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Ginkgo biloba extract inhibits the drug-metabolizing activity of DME CYP2E1 [33]
                              Grape seed proanthocyanidins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00758   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Grape seed proanthocyanidins inhibits the drug-metabolizing activity of DME CYP2E1 [34]
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME CYP2E1 [35]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      27 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the drug-metabolizing activity of DME CYP2E1 [36]
                              Chlorpromazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00280   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpromazine hydrochloride inhibits the drug-metabolizing activity of DME CYP2E1 [37]
                              Cimetidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00015   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cimetidine inhibits the drug-metabolizing activity of DME CYP2E1 [38]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CYP2E1 [39]
                              Desipramine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00022   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Desipramine inhibits the drug-metabolizing activity of DME CYP2E1 [37]
                              Diclofenac Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00352   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diclof DMEenac inhibits the drug-metabolizing activity of DME CYP2E1 [40]
                              Dimethyl sulfoxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00001   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dimethyl sulfoxide induces the drug-metabolizing activity of DME CYP2E1 [41]
                              Disulfiram Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram inhibits the drug-metabolizing activity of DME CYP2E1 [42]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol induces the drug-metabolizing activity of DME CYP2E1 [43]
                              Ethambutol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00357   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ethambutol inhibits the drug-metabolizing activity of DME CYP2E1 [44]
                              Ferric citrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00135   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ferric citrate up-regulates the expression of DME CYP2E1 [45]
                              Fluphenazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00295   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluphenazine hydrochloride inhibits the drug-metabolizing activity of DME CYP2E1 [37]
                              Fomepizole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00039   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fomepizole inhibits the drug-metabolizing activity of DME CYP2E1 [12]
                              Hydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone induces the drug-metabolizing activity of DME CYP2E1 [46]
                              Isoniazid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00224   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isoniazid induces the drug-metabolizing activity of DME CYP2E1 [41]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP2E1 [47]
                              Lindane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane inhibits the expression of DME CYP2E1 [48]
                              Malathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00056   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Malathion inhibits the drug-metabolizing activity of DME CYP2E1 [49]
                              Obeticholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00165   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Obeticholic acid inhibits the expression of DME CYP2E1 [50]
                              Phenytoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00232   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenytoin induces the drug-metabolizing activity of DME CYP2E1 [51], [52]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin induces the drug-metabolizing activity of DME CYP2E1 [53], [54]
                              Tenofovir Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00384   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tenof DMEovir inhibits the drug-metabolizing activity of DME CYP2E1 [55]
                              Thioridazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00330   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Thioridazine hydrochloride inhibits the drug-metabolizing activity of DME CYP2E1 [56]
                              Cinnamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01252   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cinnamic acid inhibits the drug-metabolizing activity of DME CYP2E1 [57]
                              Linoleic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01367   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linoleic acid inhibits the drug-metabolizing activity of DME CYP2E1 [16]
                              S-adenosylmethionine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01466   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation S-adenosylmethionine inhibits the expression of DME CYP2E1 [58]
                              Thiostrepton Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01485   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Thiostrepton inhibits the drug-metabolizing activity of DME CYP2E1 [59]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Chlormethiazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00593   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Chlormethiazole inhibits the drug-metabolizing activity of DME CYP2E1 [23], [60]
                              Satraplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00663   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Satraplatin inhibits the expression of DME CYP2E1 [61]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Carbon monoxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00572   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Carbon monoxide inhibits the drug-metabolizing activity of DME CYP2E1 [62]
                              Ditiocarb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00591   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ditiocarb inhibits the drug-metabolizing activity of DME CYP2E1 (IC50 = 0.85 microM) [63]
                              Ethanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol up-regulates the expression of DME CYP2E1 and leads to increasing the drug-metabolizing activity of this enzyme [64]
                              Phenethyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00596   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Phenethyl isothiocyanate inhibits the drug-metabolizing activity of DME CYP2E1 (Ki = 11 microM) [65]
                              Trichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00587   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Trichloroethylene up-regulates the expression of DME CYP2E1 [66]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Epsilon-viniferin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00646   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Epsilon-viniferin inhibits the drug-metabolizing activity of DME CYP2E1 [67]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate up-regulates the expression of DME CYP2E1 [68]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              1-aminobenzotriazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01099   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation 1-aminobenzotriazole inhibits the drug-metabolizing activity of DME CYP2E1 [47]
                              HI-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01208   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation HI-6 inhibits the drug-metabolizing activity of DME CYP2E1 [69]
                              Oleic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01412   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Oleic acid up-regulates the expression of DME CYP2E1 [70]
                              Proadifen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01438   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Proadifen inhibits the expression of DME CYP2E1 [71]
                              Chir-99021 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00736   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Chir-99021 up-regulates the expression of DME CYP2E1 and leads to increasing the drug-metabolizing activity of this enzyme [72]
                              GW-4064 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00735   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GW-4064 inhibits the expression of DME CYP2E1 [73]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              5-fluorotryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01159   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 5-fluorotryptamine inhibits the drug-metabolizing activity of DME CYP2E1 [23]
                              7-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01177   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 7-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2E1 [23]
                              Arachidonic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00876   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Arachidonic acid inhibits the drug-metabolizing activity of DME CYP2E1 [16]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone induces the drug-metabolizing activity of DME CYP2E1 [74]
                              Farnesol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01298   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Farnesol inhibits the expression of DME CYP2E1 [73]
      Other Chemical Compound(s) or Element(s)
                  Food Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Stearic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01475   XEOTIC Info Gene Form Protein
                                 Classification Food Additive
                                 DME Modulation Stearic acid induces the drug-metabolizing activity of DME CYP2E1 [75]
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Aniline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02228   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Aniline inhibits the drug-metabolizing activity of DME CYP2E1 [76], [63]
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