Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0088)
DME Name Glutathione S-transferase pi (GSTP1), Homo sapiens DME Info
UniProt ID
GSTP1_HUMAN
EC Number    EC: 2.5.1.18     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Captafol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00940   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Captafol inhibits the drug-metabolizing activity of DME GSTP1 [1]
                              Captan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00941   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Captan inhibits the drug-metabolizing activity of DME GSTP1 [1]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              2-dichlorobenzene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00886   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation 2-dichlorobenzene inhibits the drug-metabolizing activity of DME GSTP1 [2]
                              Monocrotophos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01062   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Monocrotophos up-regulates the expression of DME GSTP1 [3]
                              Parathion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01064   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Parathion induces the drug-metabolizing activity of DME GSTP1 [4]
                              Sulfotepp Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01608   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Sulfotepp inhibits the expression of DME GSTP1 [5]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              2-butenal Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01122   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-butenal inhibits the drug-metabolizing activity of DME GSTP1 [6]
                              Acrolein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01186   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrolein inhibits the drug-metabolizing activity of DME GSTP1 [6]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME GSTP1 [7]
                              Chloropicrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin inhibits the expression of DME GSTP1 [8]
                              Formaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde induces the drug-metabolizing activity of DME GSTP1 [9]
                              Kaempferol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01353   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Kaempferol inhibits the drug-metabolizing activity of DME GSTP1 [10]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dinophysistoxin 1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00813   XEOTIC Info Gene Form mRNA
                                 Classification Biotoxin
                                 DME Modulation Dinophysistoxin 1 up-regulates the expression of DME GSTP1 [11]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene induces the drug-metabolizing activity of DME GSTP1 [12]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone up-regulates the expression of DME GSTP1 [13]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              3-morpholinopropyl isothiocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01142   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 3-morpholinopropyl isothiocyanate induces the drug-metabolizing activity of DME GSTP1 [12]
                              Cumene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01003   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Cumene inhibits the drug-metabolizing activity of DME GSTP1 [2]
                              Ethyl benzene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01007   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Ethyl benzene inhibits the drug-metabolizing activity of DME GSTP1 [2]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Coal tar Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00755   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Coal tar up-regulates the expression of DME GSTP1 [14]
                              Flavonoids Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00858   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Flavonoids inhibits the expression of DME GSTP1 [15]
                              Polyphenols Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01578   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Polyphenols inhibits the expression of DME GSTP1 [16]
                              Tobacco smoke pollution Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution inhibits the expression of DME GSTP1 [17]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Alpha-naphthoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01192   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Alpha-naphthoflavone inhibits the expression of DME GSTP1 [18]
                              Benzyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01217   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Benzyl isothiocyanate inhibits the drug-metabolizing activity of DME GSTP1 [19]
                              Bilirubin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00877   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Bilirubin inhibits the expression of DME GSTP1 [20]
                              Cinnamic aldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde inhibits the drug-metabolizing activity of DME GSTP1 [6]
                              Galangin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01308   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Galangin inhibits the drug-metabolizing activity of DME GSTP1 [10]
                              Indioside D Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01552   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Indioside D induces the drug-metabolizing activity of DME GSTP1 [21]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Apple polyphenol extract Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00757   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Apple polyphenol extract up-regulates the expression of DME GSTP1 [22]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      28 Xenobiotics
                              Amitriptyline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00337   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amitriptyline inhibits the drug-metabolizing activity of DME GSTP1 [23]
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide up-regulates the expression of DME GSTP1 [24]
                              Celecoxib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00013   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Celecoxib up-regulates the expression of DME GSTP1 [25]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME GSTP1 [26]
                              Clomipramine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00285   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clomipramine hydrochloride inhibits the drug-metabolizing activity of DME GSTP1 [23]
                              Clozapine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00209   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clozapine inhibits the drug-metabolizing activity of DME GSTP1 [27]
                              Decitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine induces the drug-metabolizing activity of DME GSTP1 [28]
                              Dopamine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00290   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dopamine hydrochloride inhibits the drug-metabolizing activity of DME GSTP1 [29]
                              Doxepin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00354   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxepin inhibits the drug-metabolizing activity of DME GSTP1 [23]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride induces the drug-metabolizing activity of DME GSTP1 [30]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME GSTP1 [31]
                              Ethacrynic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00032   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ethacrynic acid inhibits the drug-metabolizing activity of DME GSTP1 in Human leukemia cell line (HL-60) (IC50 = 3.4 microM) [32]
                              Fluorouracil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00037   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluorouracil up-regulates the expression of DME GSTP1 [33]
                              Haloperidol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00045   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Haloperidol inhibits the expression of DME GSTP1 [34]
                              Hydralazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00362   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydralazine up-regulates the expression of DME GSTP1 [35]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the drug-metabolizing activity of DME GSTP1 [36]
                              Imipramine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00300   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Imipramine hydrochloride inhibits the drug-metabolizing activity of DME GSTP1 [23]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME GSTP1 [37]
                              Obeticholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00165   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Obeticholic acid inhibits the drug-metabolizing activity of DME GSTP1 [38]
                              Oxaliplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00207   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxaliplatin up-regulates the expression of DME GSTP1 [39]
                              Phenobarbital Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00410   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenobarbital inhibits the drug-metabolizing activity of DME GSTP1 [40]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin induces the drug-metabolizing activity of DME GSTP1 [41]
                              Selenomethionine Se-75 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00324   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Selenomethionine Se-75 induces the drug-metabolizing activity of DME GSTP1 [42]
                              Tetracycline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00200   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tetracycline inhibits the expression of DME GSTP1 [43]
                              Aclarubicin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00450   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Aclarubicin induces the drug-metabolizing activity of DME GSTP1 [30]
                              Artemisinine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00449   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Artemisinine inhibits the drug-metabolizing activity of DME GSTP1 [44]
                              Chlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00442   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Chlorobenzene induces the drug-metabolizing activity of DME GSTP1 [45]
                              Hemin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01328   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Hemin up-regulates the expression of DME GSTP1 [46]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin inhibits the drug-metabolizing activity of DME GSTP1 [6]
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the expression of DME GSTP1 [47]
                              Oltipraz Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00605   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Oltipraz up-regulates the expression of DME GSTP1 [48], [49]
                              SGX301 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00579   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation SGX301 inhibits the drug-metabolizing activity of DME GSTP1 [50]
                              Vitamin E Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00547   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Vitamin E up-regulates the expression of DME GSTP1 [51]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Butyric acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01230   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Butyric acid inhibits the expression of DME GSTP1 [52]
                              Artesunate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00540   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Artesunate inhibits the drug-metabolizing activity of DME GSTP1 [53]
                              Bufalin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00665   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bufalin inhibits the drug-metabolizing activity of DME GSTP1 [54]
                              Camptothecin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00597   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Camptothecin induces the drug-metabolizing activity of DME GSTP1 [55]
                              Glutathione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00542   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Glutathione inhibits the drug-metabolizing activity of DME GSTP1 [56]
                              Procysteine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00615   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Procysteine up-regulates the expression of DME GSTP1 and leads to increasing the drug-metabolizing activity of this enzyme [57]
                              Salvin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00614   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Salvin up-regulates the expression of DME GSTP1 [58], [59]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Eriodictyol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01290   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Eriodictyol inhibits the drug-metabolizing activity of DME GSTP1 [10]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the expression of DME GSTP1 [60]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME GSTP1 [61]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate up-regulates the expression of DME GSTP1 and leads to increasing the drug-metabolizing activity of this enzyme [62]
                              Xanthohumol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00636   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Xanthohumol up-regulates the expression of DME GSTP1 [63]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Eugenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol inhibits the drug-metabolizing activity of DME GSTP1 [64]
                              ICG-001 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 up-regulates the expression of DME GSTP1 [65]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              4-hydroxy-2-nonenal Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00869   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 4-hydroxy-2-nonenal inhibits the drug-metabolizing activity of DME GSTP1 [6]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone induces the drug-metabolizing activity of DME GSTP1 [66]
                              MG-132 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01219   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation MG-132 induces the drug-metabolizing activity of DME GSTP1 [67]
                              Oxidopamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01418   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Oxidopamine inhibits the drug-metabolizing activity of DME GSTP1 [68]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate induces the drug-metabolizing activity of DME GSTP1 [69]
                              WR-1065 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00801   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation WR-1065 inhibits the expression of DME GSTP1 [70]
      Other Chemical Compound(s) or Element(s)
                  Food Additive Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2-heptanone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00928   XEOTIC Info Gene Form Protein
                                 Classification Food Additive
                                 DME Modulation 2-heptanone inhibits the drug-metabolizing activity of DME GSTP1 [2]
                              4-propylphenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00929   XEOTIC Info Gene Form Protein
                                 Classification Food Additive
                                 DME Modulation 4-propylphenol inhibits the drug-metabolizing activity of DME GSTP1 [64]
References
1 Interaction of glutathione transferase P1-1 with captan and captafol. Biochem Pharmacol. 1996 Jul 12;52(1):43-8.
2 Study on the interaction between the skin detoxifying enzyme glutathione S-transferase and the substances listed in the CE/39/2000 rules with the "skin" annotation, finalized to the biological monitoring of exposed subjects. G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):523-6.
3 Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicol Appl Pharmacol. 2013 Apr 1;268(1):47-54.
4 Blockade of paclitaxel-induced thymidine phosphorylase expression can accelerate apoptosis in human prostate cancer cells. Cancer Res. 2004 Oct 15;64(20):7526-32.
5 A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55.
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