Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0233)
DME Name Aldo-keto reductase 1C2 (AKR1C2), Homo sapiens DME Info
UniProt ID
AK1C2_HUMAN
EC Number    EC: 1.1.1.357     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.357
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00971   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diquat up-regulates the expression of DME AKR1C2 [1]
                              Diuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00973   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diuron up-regulates the expression of DME AKR1C2 [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME AKR1C2 [1], [3]
                              Chloropicrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin up-regulates the expression of DME AKR1C2 [4]
                              Formaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde up-regulates the expression of DME AKR1C2 [5], [6]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME AKR1C2 [7]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate up-regulates the expression of DME AKR1C2 [8]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate induces the drug-metabolizing activity of DME AKR1C2 [9]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Lead chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01506   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Lead chloride up-regulates the expression of DME AKR1C2 [10]
                              1-phenyl-1,2-propanedione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01105   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 1-phenyl-1,2-propanedione up-regulates the expression of DME AKR1C2 [6]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME AKR1C2 [11]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME AKR1C2 [12]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter induces the drug-metabolizing activity of DME AKR1C2 [13]
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution up-regulates the expression of DME AKR1C2 [14]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Gedunin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01311   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Gedunin up-regulates the expression of DME AKR1C2 [15]
                              Linalool Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01366   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Linalool up-regulates the expression of DME AKR1C2 [6]
                              Octyl gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01408   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Octyl gallate inhibits the drug-metabolizing activity of DME AKR1C2 [16]
                              Quinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01450   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Quinone up-regulates the expression of DME AKR1C2 [17]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang up-regulates the expression of DME AKR1C2 [18]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      39 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME AKR1C2 [19]
                              Adefovir dipivoxil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00745   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Adefovir dipivoxil inhibits the expression of DME AKR1C2 [20]
                              Ampicillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00096   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ampicillin inhibits the expression of DME AKR1C2 [17]
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide up-regulates the expression of DME AKR1C2 [21], [22]
                              Aspirin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin inhibits the drug-metabolizing activity of DME AKR1C2 [23]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME AKR1C2 [24]
                              Azathioprine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine up-regulates the expression of DME AKR1C2 [7], [25]
                              Chlorambucil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00014   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorambucil inhibits the expression of DME AKR1C2 [7]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the expression of DME AKR1C2 [7]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME AKR1C2 [20]
                              Diazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00024   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diazepam inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 2.4 microM) [26], [27]
                              Dienogest Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00433   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dienogest inhibits the expression of DME AKR1C2 [28]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME AKR1C2 [29]
                              Dutasteride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00192   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dutasteride up-regulates the expression of DME AKR1C2 [30]
                              Dydrogesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00403   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dydrogesterone inhibits the drug-metabolizing activity of DME AKR1C2 [31]
                              Estazolam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00031   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estazolam inhibits the drug-metabolizing activity of DME AKR1C2 [27]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME AKR1C2 [32]
                              Fenofibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00035   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenofibrate up-regulates the expression of DME AKR1C2 [20]
                              Flurbiprofen sodium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00296   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flurbiprofen sodium inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 32.5 microM) [33]
                              Glipizide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00044   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glipizide inhibits the drug-metabolizing activity of DME AKR1C2 [34]
                              Glyburide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00247   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glyburide inhibits the drug-metabolizing activity of DME AKR1C2 [34]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide up-regulates the expression of DME AKR1C2 [35]
                              Ibuprofen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00248   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ibuprofen inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 42.4 microM) [33]
                              Ifosfamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide up-regulates the expression of DME AKR1C2 [20]
                              Indomethacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 36.53 microM) [36]
                              Meclofenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00415   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Meclofenamic acid inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 8.74 microM) [33]
                              Medroxyprogesterone acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00743   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Medroxyprogesterone acetate inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 1.6 microM) [26], [31]
                              Menadione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione up-regulates the expression of DME AKR1C2 [37]
                              Naproxen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00156   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Naproxen inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 31.3 microM) [33]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the drug-metabolizing activity of DME AKR1C2 [38]
                              Benzbromarone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00492   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzbromarone inhibits the drug-metabolizing activity of DME AKR1C2 [26]
                              Clodronic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00465   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Clodronic acid up-regulates the expression of DME AKR1C2 [20]
                              Cloxazolam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01258   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cloxazolam inhibits the drug-metabolizing activity of DME AKR1C2 (Ki > 10 microM) [26]
                              Flufenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00470   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flufenamic acid inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 0.37 microM) [39]
                              Flunitrazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00498   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flunitrazepam inhibits the drug-metabolizing activity of DME AKR1C2 [27]
                              Gliquidone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00501   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Gliquidone inhibits the drug-metabolizing activity of DME AKR1C2 [34]
                              Glycyrrhetinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01319   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Glycyrrhetinic acid inhibits the drug-metabolizing activity of DME AKR1C2 [26]
                              Hexestrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00769   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Hexestrol inhibits the drug-metabolizing activity of DME AKR1C2 [40], [26]
                              Zinc sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00460   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Zinc sulfate up-regulates the expression of DME AKR1C2 [35], [41]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Nitrazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00550   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Nitrazepam inhibits the drug-metabolizing activity of DME AKR1C2 [42]
                              Sulforafan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan induces the drug-metabolizing activity of DME AKR1C2 [43]
                              Vitamin E Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00547   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Vitamin E up-regulates the expression of DME AKR1C2 [44], [37]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Salicylic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00546   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Salicylic acid up-regulates the expression of DME AKR1C2 [45]
                              MS-275 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 inhibits the expression of DME AKR1C2 [46]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Phenethyl caffeate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01233   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Phenethyl caffeate inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 6 microM) [47]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the expression of DME AKR1C2 [48]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate inhibits the expression of DME AKR1C2 [49]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME AKR1C2 [50]
                              Tripterine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00706   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Tripterine up-regulates the expression of DME AKR1C2 [51], [52]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME AKR1C2 [7]
                              K-7174 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 up-regulates the expression of DME AKR1C2 [53]
                              Vanillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00727   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Vanillin up-regulates the expression of DME AKR1C2 [54]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Phenolphthalein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00521   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Phenolphthalein inhibits the drug-metabolizing activity of DME AKR1C2 [55]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Lithocholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00787   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Lithocholic acid inhibits the expression of DME AKR1C2 [56]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate induces the drug-metabolizing activity of DME AKR1C2 [57]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              1,10-phenanthroline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00766   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 1,10-phenanthroline inhibits the drug-metabolizing activity of DME AKR1C2 [26]
                              Ethyl acrylate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00783   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Ethyl acrylate up-regulates the expression of DME AKR1C2 [7]
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Gold up-regulates the expression of DME AKR1C2 [58]
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