Interactions between Xenobiotics and DME (XEOTIC)
|
Fungicide(s), Herbicide(s) or Insecticide(s) |
Herbicide |
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|
Diquat |
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Induction |
XEOTIC ID |
XEO00971
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Herbicide |
DME Modulation |
Diquat up-regulates the expression of DME AKR1C2 |
[1] |
Diuron |
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Induction |
XEOTIC ID |
XEO00973
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Herbicide |
DME Modulation |
Diuron up-regulates the expression of DME AKR1C2 |
[2] |
Health or Environmental Toxicant(s) |
Acute Toxic Substance |
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|
Cadmium |
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Induction |
XEOTIC ID |
XEO01503
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Cadmium up-regulates the expression of DME AKR1C2 |
[1], [3] |
Chloropicrin |
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Induction |
XEOTIC ID |
XEO01247
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Chloropicrin up-regulates the expression of DME AKR1C2 |
[4] |
Formaldehyde |
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Induction |
XEOTIC ID |
XEO01305
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Formaldehyde up-regulates the expression of DME AKR1C2 |
[5], [6] |
Carcinogen |
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|
Benzo(a)pyrene |
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Induction |
XEOTIC ID |
XEO00898
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Carcinogen |
DME Modulation |
Benzo(a)pyrene up-regulates the expression of DME AKR1C2 |
[7] |
Ethyl methanesulfonate |
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Induction |
XEOTIC ID |
XEO00772
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Carcinogen |
DME Modulation |
Ethyl methanesulfonate up-regulates the expression of DME AKR1C2 |
[8] |
Environmental Pollutant |
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|
Antimony potassium tartrate |
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Induction |
XEOTIC ID |
XEO01201
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Environmental Pollutant |
DME Modulation |
Antimony potassium tartrate induces the drug-metabolizing activity of DME AKR1C2 |
[9] |
Health Hazard/Toxicant |
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|
Lead chloride |
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Induction |
XEOTIC ID |
XEO01506
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health and Environmental Toxicant |
DME Modulation |
Lead chloride up-regulates the expression of DME AKR1C2 |
[10] |
1-phenyl-1,2-propanedione |
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Induction |
XEOTIC ID |
XEO01105
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
1-phenyl-1,2-propanedione up-regulates the expression of DME AKR1C2 |
[6] |
Diethylhexyl phthalate |
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Induction |
XEOTIC ID |
XEO01004
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Diethylhexyl phthalate up-regulates the expression of DME AKR1C2 |
[11] |
Glycidamide |
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Induction |
XEOTIC ID |
XEO01009
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Glycidamide up-regulates the expression of DME AKR1C2 |
[12] |
Natural Product(s), Extract(s) or Medicine(s) |
Natural Mixture |
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|
Particulate matter |
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Induction |
XEOTIC ID |
XEO00919
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Mixture |
DME Modulation |
Particulate matter induces the drug-metabolizing activity of DME AKR1C2 |
[13] |
Tobacco smoke pollution |
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Induction |
XEOTIC ID |
XEO00821
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Mixture |
DME Modulation |
Tobacco smoke pollution up-regulates the expression of DME AKR1C2 |
[14] |
Natural Product |
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|
Gedunin |
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Induction |
XEOTIC ID |
XEO01311
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Product |
DME Modulation |
Gedunin up-regulates the expression of DME AKR1C2 |
[15] |
Linalool |
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Induction |
XEOTIC ID |
XEO01366
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Product |
DME Modulation |
Linalool up-regulates the expression of DME AKR1C2 |
[6] |
Octyl gallate |
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Inhibition |
XEOTIC ID |
XEO01408
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Product |
DME Modulation |
Octyl gallate inhibits the drug-metabolizing activity of DME AKR1C2 |
[16] |
Quinone |
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Induction |
XEOTIC ID |
XEO01450
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Product |
DME Modulation |
Quinone up-regulates the expression of DME AKR1C2 |
[17] |
Traditional Medicine |
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|
Jinfukang |
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Induction |
XEOTIC ID |
XEO00760
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Traditional Medicine |
DME Modulation |
Jinfukang up-regulates the expression of DME AKR1C2 |
[18] |
Pharmaceutical Agent(s) |
Approved/Marketed Drug |
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|
Acetaminophen |
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Inhibition |
XEOTIC ID |
XEO00217
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Acetaminophen inhibits the expression of DME AKR1C2 |
[19] |
Adefovir dipivoxil |
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Inhibition |
XEOTIC ID |
XEO00745
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Adefovir dipivoxil inhibits the expression of DME AKR1C2 |
[20] |
Ampicillin |
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Inhibition |
XEOTIC ID |
XEO00096
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Ampicillin inhibits the expression of DME AKR1C2 |
[17] |
Arsenic trioxide |
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Induction |
XEOTIC ID |
XEO00339
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Arsenic trioxide up-regulates the expression of DME AKR1C2 |
[21], [22] |
Aspirin |
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Inhibition |
XEOTIC ID |
XEO00213
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Aspirin inhibits the drug-metabolizing activity of DME AKR1C2 |
[23] |
Avobenzone |
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Induction |
XEOTIC ID |
XEO00411
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Avobenzone up-regulates the expression of DME AKR1C2 |
[24] |
Azathioprine |
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Induction |
XEOTIC ID |
XEO00007
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Azathioprine up-regulates the expression of DME AKR1C2 |
[7], [25] |
Chlorambucil |
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Inhibition |
XEOTIC ID |
XEO00014
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Chlorambucil inhibits the expression of DME AKR1C2 |
[7] |
Cisplatin |
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Inhibition |
XEOTIC ID |
XEO00334
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Cisplatin inhibits the expression of DME AKR1C2 |
[7] |
Cyclosporine |
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Induction |
XEOTIC ID |
XEO00241
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Cyclosporine up-regulates the expression of DME AKR1C2 |
[20] |
Diazepam |
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Inhibition |
XEOTIC ID |
XEO00024
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Diazepam inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 2.4 microM) |
[26], [27] |
Dienogest |
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Inhibition |
XEOTIC ID |
XEO00433
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Dienogest inhibits the expression of DME AKR1C2 |
[28] |
Doxorubicin hydrochloride |
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Inhibition |
XEOTIC ID |
XEO00292
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Doxorubicin hydrochloride inhibits the expression of DME AKR1C2 |
[29] |
Dutasteride |
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Induction |
XEOTIC ID |
XEO00192
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Dutasteride up-regulates the expression of DME AKR1C2 |
[30] |
Dydrogesterone |
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Inhibition |
XEOTIC ID |
XEO00403
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Dydrogesterone inhibits the drug-metabolizing activity of DME AKR1C2 |
[31] |
Estazolam |
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Inhibition |
XEOTIC ID |
XEO00031
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Estazolam inhibits the drug-metabolizing activity of DME AKR1C2 |
[27] |
Estradiol |
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Induction |
XEOTIC ID |
XEO00090
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Estradiol up-regulates the expression of DME AKR1C2 |
[32] |
Fenofibrate |
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Induction |
XEOTIC ID |
XEO00035
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Fenofibrate up-regulates the expression of DME AKR1C2 |
[20] |
Flurbiprofen sodium |
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Inhibition |
XEOTIC ID |
XEO00296
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Flurbiprofen sodium inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 32.5 microM) |
[33] |
Glipizide |
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Inhibition |
XEOTIC ID |
XEO00044
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Glipizide inhibits the drug-metabolizing activity of DME AKR1C2 |
[34] |
Glyburide |
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Inhibition |
XEOTIC ID |
XEO00247
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Glyburide inhibits the drug-metabolizing activity of DME AKR1C2 |
[34] |
Hydrogen peroxide |
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Induction |
XEOTIC ID |
XEO00388
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Hydrogen peroxide up-regulates the expression of DME AKR1C2 |
[35] |
Ibuprofen |
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Inhibition |
XEOTIC ID |
XEO00248
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Ibuprofen inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 42.4 microM) |
[33] |
Ifosfamide |
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Induction |
XEOTIC ID |
XEO00046
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Ifosfamide up-regulates the expression of DME AKR1C2 |
[20] |
Indomethacin |
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Inhibition |
XEOTIC ID |
XEO00047
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Indomethacin inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 36.53 microM) |
[36] |
Meclofenamic acid |
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Inhibition |
XEOTIC ID |
XEO00415
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Meclofenamic acid inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 8.74 microM) |
[33] |
Medroxyprogesterone acetate |
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Inhibition |
XEOTIC ID |
XEO00743
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Medroxyprogesterone acetate inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 1.6 microM) |
[26], [31] |
Menadione |
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Induction |
XEOTIC ID |
XEO00428
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Menadione up-regulates the expression of DME AKR1C2 |
[37] |
Naproxen |
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Inhibition |
XEOTIC ID |
XEO00156
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Naproxen inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 31.3 microM) |
[33] |
Urethane |
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Inhibition |
XEOTIC ID |
XEO00435
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Urethane inhibits the drug-metabolizing activity of DME AKR1C2 |
[38] |
Benzbromarone |
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Inhibition |
XEOTIC ID |
XEO00492
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Benzbromarone inhibits the drug-metabolizing activity of DME AKR1C2 |
[26] |
Clodronic acid |
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Induction |
XEOTIC ID |
XEO00465
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Clodronic acid up-regulates the expression of DME AKR1C2 |
[20] |
Cloxazolam |
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Inhibition |
XEOTIC ID |
XEO01258
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Cloxazolam inhibits the drug-metabolizing activity of DME AKR1C2 (Ki > 10 microM) |
[26] |
Flufenamic acid |
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Inhibition |
XEOTIC ID |
XEO00470
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Flufenamic acid inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 0.37 microM) |
[39] |
Flunitrazepam |
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Inhibition |
XEOTIC ID |
XEO00498
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Flunitrazepam inhibits the drug-metabolizing activity of DME AKR1C2 |
[27] |
Gliquidone |
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Inhibition |
XEOTIC ID |
XEO00501
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Gliquidone inhibits the drug-metabolizing activity of DME AKR1C2 |
[34] |
Glycyrrhetinic acid |
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Inhibition |
XEOTIC ID |
XEO01319
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Glycyrrhetinic acid inhibits the drug-metabolizing activity of DME AKR1C2 |
[26] |
Hexestrol |
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Inhibition |
XEOTIC ID |
XEO00769
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Hexestrol inhibits the drug-metabolizing activity of DME AKR1C2 |
[40], [26] |
Zinc sulfate |
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Induction |
XEOTIC ID |
XEO00460
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Zinc sulfate up-regulates the expression of DME AKR1C2 |
[35], [41] |
Drug in Phase 3 Clinical Trial |
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|
Nitrazepam |
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Inhibition |
XEOTIC ID |
XEO00550
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 3 |
DME Modulation |
Nitrazepam inhibits the drug-metabolizing activity of DME AKR1C2 |
[42] |
Sulforafan |
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Induction |
XEOTIC ID |
XEO01478
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 3 |
DME Modulation |
Sulforafan induces the drug-metabolizing activity of DME AKR1C2 |
[43] |
Vitamin E |
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Induction |
XEOTIC ID |
XEO00547
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 3 |
DME Modulation |
Vitamin E up-regulates the expression of DME AKR1C2 |
[44], [37] |
Drug in Phase 2 Clinical Trial |
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|
Salicylic acid |
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Induction |
XEOTIC ID |
XEO00546
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 2/3 |
DME Modulation |
Salicylic acid up-regulates the expression of DME AKR1C2 |
[45] |
MS-275 |
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Inhibition |
XEOTIC ID |
XEO00581
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
MS-275 inhibits the expression of DME AKR1C2 |
[46] |
Drug in Phase 1 Clinical Trial |
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|
Phenethyl caffeate |
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Inhibition |
XEOTIC ID |
XEO01233
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Phenethyl caffeate inhibits the drug-metabolizing activity of DME AKR1C2 (IC50 = 6 microM) |
[47] |
Quercetin |
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Inhibition |
XEOTIC ID |
XEO00538
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Quercetin inhibits the expression of DME AKR1C2 |
[48] |
Tetradecanoylphorbol acetate |
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Inhibition |
XEOTIC ID |
XEO00599
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Tetradecanoylphorbol acetate inhibits the expression of DME AKR1C2 |
[49] |
Preclinical/Patented Drug |
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|
(+)-JQ1 |
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Inhibition |
XEOTIC ID |
XEO00723
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug in Preclinical Study |
DME Modulation |
(+)-JQ1 inhibits the expression of DME AKR1C2 |
[50] |
Tripterine |
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Induction |
XEOTIC ID |
XEO00706
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug in Preclinical Study |
DME Modulation |
Tripterine up-regulates the expression of DME AKR1C2 |
[51], [52] |
Eugenol |
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Induction |
XEOTIC ID |
XEO00885
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
Eugenol up-regulates the expression of DME AKR1C2 |
[7] |
K-7174 |
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Induction |
XEOTIC ID |
XEO01348
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
K-7174 up-regulates the expression of DME AKR1C2 |
[53] |
Vanillin |
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Induction |
XEOTIC ID |
XEO00727
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
Vanillin up-regulates the expression of DME AKR1C2 |
[54] |
Drug Marketed but Withdrawn from Market |
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|
Phenolphthalein |
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Inhibition |
XEOTIC ID |
XEO00521
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but Withdrawn from Market |
DME Modulation |
Phenolphthalein inhibits the drug-metabolizing activity of DME AKR1C2 |
[55] |
Investigative Agent |
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|
Lithocholic acid |
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Inhibition |
XEOTIC ID |
XEO00787
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Investigative Agent |
DME Modulation |
Lithocholic acid inhibits the expression of DME AKR1C2 |
[56] |
Phenylmercuric acetate |
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Induction |
XEOTIC ID |
XEO00818
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Investigative Agent |
DME Modulation |
Phenylmercuric acetate induces the drug-metabolizing activity of DME AKR1C2 |
[57] |
Other Chemical Compound(s) or Element(s) |
Chemical Compound |
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|
1,10-phenanthroline |
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Inhibition |
XEOTIC ID |
XEO00766
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Chemical Compound |
DME Modulation |
1,10-phenanthroline inhibits the drug-metabolizing activity of DME AKR1C2 |
[26] |
Ethyl acrylate |
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Induction |
XEOTIC ID |
XEO00783
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Chemical Compound |
DME Modulation |
Ethyl acrylate up-regulates the expression of DME AKR1C2 |
[7] |
Gold |
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Induction |
XEOTIC ID |
XEO01504
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Chemical Compound |
DME Modulation |
Gold up-regulates the expression of DME AKR1C2 |
[58] |
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