Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0419)
DME Name Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2), Homo sapiens DME Info
UniProt ID
DHI2_HUMAN
EC Number    EC: 1.1.1.B40     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.B40
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine up-regulates the expression of DME HSD11B2 [1]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dicrotophos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos up-regulates the expression of DME HSD11B2 [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium inhibits the expression of DME HSD11B2 and leads to decreasing the drug-metabolizing activity of this enzyme [3], [4]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME HSD11B2 [5]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              p,p'-Hydroxy-DDT Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01110   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation p,p'-Hydroxy-DDT inhibits the drug-metabolizing activity of DME HSD11B2 [6]
                              Sodium arsenate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01023   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Sodium arsenate inhibits the drug-metabolizing activity of DME HSD11B2 [7]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Dibutyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01275   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Dibutyl phthalate inhibits the drug-metabolizing activity of DME HSD11B2 [8]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME HSD11B2 [9]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              18alpha-glycyrrhetinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01098   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 18alpha-glycyrrhetinic acid inhibits the drug-metabolizing activity of DME HSD11B2 in Human embryonic kidney 293 cell (HEK293) (IC50 = 0.0012 microM) [10]
                              Baicalein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01212   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Baicalein induces the drug-metabolizing activity of DME HSD11B2 [11]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      25 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME HSD11B2 [12]
                              Azathioprine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine inhibits the expression of DME HSD11B2 [13]
                              Caffeine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00218   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Caffeine inhibits the expression of DME HSD11B2 and leads to decreasing the drug-metabolizing activity of this enzyme [14]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME HSD11B2 [15]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME HSD11B2 [16]
                              Cosyntropin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00335   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cosyntropin inhibits the drug-metabolizing activity of DME HSD11B2 [17]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME HSD11B2 [18]
                              Danazol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00118   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Danazol inhibits the drug-metabolizing activity of DME HSD11B2 [19]
                              Decitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine up-regulates the expression of DME HSD11B2 [20]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone induces the drug-metabolizing activity of DME HSD11B2 [21]
                              Dinoprost Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00183   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dinoprost inhibits the drug-metabolizing activity of DME HSD11B2 [22]
                              Dinoprostone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00260   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dinoprostone inhibits the drug-metabolizing activity of DME HSD11B2 [22]
                              Disulfiram Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram inhibits the drug-metabolizing activity of DME HSD11B2 [23]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the drug-metabolizing activity of DME HSD11B2 [24]
                              Fluoxymesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00098   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluoxymesterone inhibits the drug-metabolizing activity of DME HSD11B2 [19]
                              Hydrocortisone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00264   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrocortisone inhibits the drug-metabolizing activity of DME HSD11B2 [25]
                              Indomethacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin inhibits the drug-metabolizing activity of DME HSD11B2 [22]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME HSD11B2 [26]
                              Mifepristone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00127   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mifepristone induces the drug-metabolizing activity of DME HSD11B2 [27]
                              Nicotine polacrilex Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex up-regulates the expression of DME HSD11B2 [28], [29]
                              Progesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone inhibits the drug-metabolizing activity of DME HSD11B2 [30]
                              Testosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone up-regulates the expression of DME HSD11B2 [31]
                              Valproic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid up-regulates the expression of DME HSD11B2 [32], [33]
                              Zoledronic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00140   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Zoledronic acid inhibits the drug-metabolizing activity of DME HSD11B2 [34]
                              Carbenoxolone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01236   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Carbenoxolone inhibits the drug-metabolizing activity of DME HSD11B2 [35], [36]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the drug-metabolizing activity of DME HSD11B2 [37]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin induces the drug-metabolizing activity of DME HSD11B2 [38]
                              Ditiocarb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00591   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ditiocarb inhibits the drug-metabolizing activity of DME HSD11B2 [23]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the drug-metabolizing activity of DME HSD11B2 [38]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME HSD11B2 [39]
                              Leukotriene B4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00643   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Leukotriene B4 inhibits the drug-metabolizing activity of DME HSD11B2 [22], [11]
                              MS-275 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 up-regulates the expression of DME HSD11B2 [40], [41]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Sodium arsenite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite inhibits the drug-metabolizing activity of DME HSD11B2 [42]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME HSD11B2 [43]
                              AA-861 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00689   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation AA-861 induces the drug-metabolizing activity of DME HSD11B2 [11]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Pyrrolidine dithiocarbamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01447   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Pyrrolidine dithiocarbamic acid inhibits the expression of DME HSD11B2 [44]
                              Tributyltin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01491   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Tributyltin inhibits the drug-metabolizing activity of DME HSD11B2 [45]
References
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