Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0137)
DME Name Thymidylate synthase (TYMS), Homo sapiens DME Info
UniProt ID
TYSY_HUMAN
EC Number    EC: 2.1.1.45     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.45
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine inhibits the expression of DME TYMS [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium induces the drug-metabolizing activity of DME TYMS [2]
                              Mercury Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01509   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercury up-regulates the expression of DME TYMS [3]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME TYMS [4], [5]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate up-regulates the expression of DME TYMS [6]
                              Methylcholanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00899   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Methylcholanthrene up-regulates the expression of DME TYMS and leads to increasing the drug-metabolizing activity of this enzyme [7]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME TYMS [8], [9]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate up-regulates the expression of DME TYMS [10]
                              Zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01512   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc up-regulates the expression of DME TYMS [11]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              1-methyl-4-phenylpyridinium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01103   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 1-methyl-4-phenylpyridinium inhibits the expression of DME TYMS [12]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of DME TYMS [13]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              14-deoxy-11,12-didehydroandrographolide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01095   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation 14-deoxy-11,12-didehydroandrographolide inhibits the expression of DME TYMS [14]
                              Gambogic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01543   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Gambogic acid inhibits the expression of DME TYMS [15]
                              Geraniol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01312   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Geraniol inhibits the expression of DME TYMS [16]
                              Phytoestrogen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00860   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Phytoestrogen up-regulates the expression of DME TYMS [3]
                              Thapsigargin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00809   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Thapsigargin inhibits the expression of DME TYMS [17], [18]
                              Wogonin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01500   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Wogonin up-regulates the expression of DME TYMS [19]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME TYMS [20]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      31 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME TYMS [21]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME TYMS [22], [23]
                              Azathioprine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine inhibits the expression of DME TYMS [24]
                              Belinostat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00193   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Belinostat inhibits the expression of DME TYMS [25]
                              Bicalutamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00009   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bicalutamide inhibits the drug-metabolizing activity of DME TYMS [26]
                              Calcitriol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol inhibits the expression of DME TYMS [27]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin induces the drug-metabolizing activity of DME TYMS [28]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME TYMS [29]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME TYMS [30]
                              Docetaxel Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00153   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Docetaxel inhibits the drug-metabolizing activity of DME TYMS [31]
                              Dronabinol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00115   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dronabinol inhibits the expression of DME TYMS [32]
                              Erlotinib hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00157   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Erlotinib hydrochloride inhibits the drug-metabolizing activity of DME TYMS [33]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME TYMS [34]
                              Fluorouracil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00037   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluorouracil inhibits the drug-metabolizing activity of DME TYMS [35], [36]
                              Gefitinib Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00152   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gefitinib inhibits the drug-metabolizing activity of DME TYMS [37], [33]
                              Malathion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00056   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Malathion inhibits the drug-metabolizing activity of DME TYMS [38]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate up-regulates the expression of DME TYMS [39]
                              Mitomycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00089   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mitomycin up-regulates the expression of DME TYMS [40]
                              Oxaliplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00207   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxaliplatin inhibits the drug-metabolizing activity of DME TYMS [41]
                              Paclitaxel Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00256   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Paclitaxel up-regulates the expression of DME TYMS [42]
                              Palbociclib Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00190   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Palbociclib inhibits the expression of DME TYMS [43]
                              Pemetrexed Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00211   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pemetrexed inhibits the drug-metabolizing activity of DME TYMS (IC50 = 11 microM) [44]
                              Progesterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone up-regulates the expression of DME TYMS [45], [46]
                              Simvastatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin inhibits the expression of DME TYMS [47]
                              Sirolimus Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00188   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sirolimus inhibits the expression of DME TYMS [48]
                              Temsirolimus Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00229   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Temsirolimus inhibits the drug-metabolizing activity of DME TYMS [49], [50]
                              Testosterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone inhibits the drug-metabolizing activity of DME TYMS [51]
                              Troglitazone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone inhibits the expression of DME TYMS [52]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the expression of DME TYMS [53]
                              Vorinostat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00079   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vorinostat inhibits the expression of DME TYMS [54]
                              Raltitrexed Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00479   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Raltitrexed inhibits the drug-metabolizing activity of DME TYMS (IC50 = 0.26 microM) [55]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Nolatrexed Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00682   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Nolatrexed inhibits the drug-metabolizing activity of DME TYMS (Ki = 0.015 microM) [56]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol induces the drug-metabolizing activity of DME TYMS [57]
                              Triclosan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan inhibits the drug-metabolizing activity of DME TYMS [58], [59]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Antimony Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00657   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Antimony up-regulates the expression of DME TYMS [10]
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME TYMS [60]
                              Camptothecin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00597   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Camptothecin up-regulates the expression of DME TYMS [28]
                              FdUMP(10) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00590   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation FdUMP(10) inhibits the drug-metabolizing activity of DME TYMS [61]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME TYMS [62]
                              PF-00299804 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00592   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation PF-00299804 inhibits the expression of DME TYMS [63]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Betulinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00611   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1/2
                                 DME Modulation Betulinic acid inhibits the drug-metabolizing activity of DME TYMS [33]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the expression of DME TYMS [64]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate up-regulates the expression of DME TYMS [65], [63]
                              Trichostatin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01492   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Trichostatin A inhibits the expression of DME TYMS [66], [67]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME TYMS [68]
                              GSK-J4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01324   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GSK-J4 inhibits the expression of DME TYMS [69]
                              K-7174 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 inhibits the expression of DME TYMS [70]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Phenolphthalein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00521   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Phenolphthalein inhibits the drug-metabolizing activity of DME TYMS (Ki = 1.2 microM) [71]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              AG-1879 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00770   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation AG-1879 inhibits the drug-metabolizing activity of DME TYMS [72]
                              Coumestrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01261   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Coumestrol up-regulates the expression of DME TYMS [34]
                              NU2058 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01404   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation NU2058 inhibits the drug-metabolizing activity of DME TYMS [73]
References
1 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
2 Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+. Cell Signal. 2003 Nov;15(11):1059-70.
3 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
4 Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett. 2011 Oct 10;206(2):178-88.
5 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
6 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
7 Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. Drug Metab Dispos. 2001 Sep;29(9):1229-35.
8 Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
9 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
10 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
11 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
12 Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death Dis. 2014 May 8;5:e1222.
13 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
14 Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells. Food Chem Toxicol. 2012 Feb;50(2):431-44.
15 Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. Toxicology. 2009 Feb 4;256(1-2):135-40.
16 Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 2004 Nov 8;215(1):53-9.
17 The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko. Toxicol Sci. 2012 Jan;125(1):310-7.
18 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
19 Induction of cytochromes P-450 1A1 and 1B1 by motorcycle exhaust particulate in human breast cancer MCF-7 cells. J Toxicol Environ Health A. 2002 Oct 11;65(19):1401-17.
20 Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. J Steroid Biochem Mol Biol. 2005 May;95(1-5):129-36.
21 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
22 Arsenic trioxide suppresses thymidylate synthase in 5-FU-resistant colorectal cancer cell line HT29 In Vitro re-sensitizing cells to 5-FU. Anticancer Res. 2010 Apr;30(4):1157-62.
23 Downregulation of thymidylate synthase with arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Jun;44(6):2093-102.
24 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
25 Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs. 2009 Sep;20(8):682-92.
26 Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26(55):7611-9.
27 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
28 Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
29 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
30 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
31 Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines. Int J Cancer. 2006 Aug 15;119(4):783-91.
32 Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncol. 2008;47(6):1062-70.
33 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
34 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
35 Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemother Pharmacol. 2003 Jul;52(1):1-12.
36 Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br J Cancer. 2007 Mar 12;96(5):769-75.
37 Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase. Mol Cancer Ther. 2008 Mar;7(3):599-606.
38 Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Food Chem Toxicol. 2016 Apr;90:112-22.
39 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
40 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
41 High-affinity binding of fatty acyl-CoAs and peroxisome proliferator-CoA esters to glutathione S-transferases effect on enzymatic activity. Eur J Biochem. 1999 Nov;266(1):143-50.
42 Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB. Toxicol Appl Pharmacol. 2015 Jul 15;286(2):92-101.
43 Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer. 2009 Nov;45(16):2882-92.
44 Design, Synthesis, and Biological Activities of Classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic Acid and Its 6-methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents J Med Chem. 2003 Feb 13;46(4):591-600.
45 Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11;280(45):37547-57.
46 Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol Pharmacol. 2016 Sep;90(3):265-74.
47 Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015 Mar 1;24(5):1374-89.
48 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015 Apr 18;16:315.
49 Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chem Biol Interact. 2013 Mar 25;203(1):77-80.
50 Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. Chem Biol Interact. 2013 Mar 25;203(1):67-71.
51 Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54.
52 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
53 Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq. Toxicol In Vitro. 2018 Feb;46:178-188.
54 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
55 Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline. Eur J Med Chem. 2013 Jun;64:401-9.
56 Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. J Med Chem. 1993 Mar 19;36(6):733-46.
57 Effects of calcitonin, risedronate, and raloxifene on erythrocyte antioxidant enzyme activity, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Arch Med Res. 2007 Feb;38(2):196-205.
58 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
59 Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands. Environ Sci. 2005;12(4):219-30.
60 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
61 Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):401-10.
62 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
63 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
64 Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicol In Vitro. 2015 Oct;29(7):1669-82.
65 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
66 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
67 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
68 The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. Oncogene. 2016 Feb 18;35(7):833-45.
69 Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018 Feb 16;293(7):2422-2437.
70 A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
71 Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67.
72 Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling. Oncogene. 2008 Dec 4;27(57):7212-22.
73 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.

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