Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0154)
DME Name Asparagine synthetase (ASNS), Homo sapiens DME Info
UniProt ID
ASNS_HUMAN
EC Number    EC: 6.3.5.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Carbon-nitrogen ligase
EC: 6.3.5.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine up-regulates the expression of DME ASNS [1]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Boron compound Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00824   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Boron compound up-regulates the expression of DME ASNS [2]
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the expression of DME ASNS [3]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Formaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde up-regulates the expression of DME ASNS [4]
                              Nickel chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01397   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Nickel chloride up-regulates the expression of DME ASNS [5], [6]
                              Ochratoxin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01407   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Ochratoxin A inhibits the drug-metabolizing activity of DME ASNS [7]
                              Trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01490   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride up-regulates the expression of DME ASNS [8]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              1-nitropyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00893   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation 1-nitropyrene up-regulates the expression of DME ASNS [9]
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME ASNS [10]
                              Dimethyl nitrosamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01006   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Dimethyl nitrosamine up-regulates the expression of DME ASNS [11]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME ASNS [12], [13]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diazinon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01274   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Diazinon up-regulates the expression of DME ASNS [10]
                              Sodium arsenate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01023   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Sodium arsenate up-regulates the expression of DME ASNS [14]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              1-methyl-4-phenylpyridinium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01103   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 1-methyl-4-phenylpyridinium induces the drug-metabolizing activity of DME ASNS [15]
                              Butyraldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00999   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Butyraldehyde up-regulates the expression of DME ASNS [16]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME ASNS [17], [18]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              BDE-99 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00925   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation BDE-99 up-regulates the expression of DME ASNS [19]
                              Nobiletin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01566   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Nobiletin up-regulates the expression of DME ASNS [20]
                              Tunicamycin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01494   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Tunicamycin A up-regulates the expression of DME ASNS [21]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      53 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen up-regulates the expression of DME ASNS [22]
                              Adefovir dipivoxil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00745   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Adefovir dipivoxil inhibits the expression of DME ASNS [18]
                              Amiodarone hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00277   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amiodarone hydrochloride up-regulates the expression of DME ASNS [23], [24]
                              Amitriptyline Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00337   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amitriptyline up-regulates the expression of DME ASNS [23]
                              Ampicillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00096   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ampicillin inhibits the expression of DME ASNS [13]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME ASNS [25]
                              Avobenzone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone inhibits the expression of DME ASNS [26]
                              Azathioprine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine inhibits the expression of DME ASNS [27]
                              Belinostat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00193   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Belinostat inhibits the expression of DME ASNS [28]
                              Bexarotene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00144   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bexarotene inhibits the expression of DME ASNS [29]
                              Caffeine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00218   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Caffeine inhibits the expression of DME ASNS [30]
                              Chlorpromazine hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00280   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpromazine hydrochloride up-regulates the expression of DME ASNS [24]
                              Cidofovir Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00132   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cidofovir up-regulates the expression of DME ASNS [18]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME ASNS [31]
                              Clomipramine hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00285   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clomipramine hydrochloride up-regulates the expression of DME ASNS [24]
                              Clozapine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00209   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clozapine up-regulates the expression of DME ASNS [32], [24]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME ASNS [33]
                              Cyclophosphamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00018   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclophosphamide inhibits the expression of DME ASNS [10]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME ASNS [22]
                              Dasatinib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00181   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dasatinib up-regulates the expression of DME ASNS [34]
                              Dexamethasone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone inhibits the expression of DME ASNS [35]
                              Diclofenac Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00352   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diclofenac inhibits the expression of DME ASNS [27]
                              Doxepin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00354   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxepin up-regulates the expression of DME ASNS [23]
                              Erythromycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00111   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Erythromycin inhibits the expression of DME ASNS [24]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME ASNS [36]
                              Fenofibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00035   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenofibrate up-regulates the expression of DME ASNS [18]
                              Flecainide acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00294   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flecainide acetate up-regulates the expression of DME ASNS [32], [24]
                              Fluoxetine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00358   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluoxetine up-regulates the expression of DME ASNS [23]
                              Fulvestrant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00147   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fulvestrant inhibits the expression of DME ASNS [37]
                              Haloperidol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00045   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Haloperidol inhibits the expression of DME ASNS [24]
                              Hydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone up-regulates the expression of DME ASNS [38]
                              Ibuprofen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00248   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ibuprofen up-regulates the expression of DME ASNS [18]
                              Ifosfamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide up-regulates the expression of DME ASNS [18]
                              Imipramine hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00300   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Imipramine hydrochloride up-regulates the expression of DME ASNS [23], [32]
                              Indomethacin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin up-regulates the expression of DME ASNS [39]
                              Ketoconazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole up-regulates the expression of DME ASNS [32], [24]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME ASNS [40]
                              Lindane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane up-regulates the expression of DME ASNS [10]
                              Loratadine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00055   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Loratadine induces the drug-metabolizing activity of DME ASNS [41]
                              Oxaliplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00207   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxaliplatin inhibits the drug-metabolizing activity of DME ASNS [42]
                              Phenobarbital Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00410   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenobarbital inhibits the drug-metabolizing activity of DME ASNS [43]
                              Prednisolone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00219   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Prednisolone inhibits the expression of DME ASNS [44]
                              Progesterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone induces the drug-metabolizing activity of DME ASNS [45], [46]
                              Quinidine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00225   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Quinidine up-regulates the expression of DME ASNS [47]
                              Raloxifene hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00126   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Raloxifene hydrochloride inhibits the expression of DME ASNS [13]
                              Sotalol hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00326   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sotalol hydrochloride inhibits the expression of DME ASNS [48]
                              Sulindac Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00177   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulindac induces the drug-metabolizing activity of DME ASNS [49]
                              Tetracycline Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00200   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tetracycline up-regulates the expression of DME ASNS [50]
                              Thioridazine hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00330   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Thioridazine hydrochloride up-regulates the expression of DME ASNS and leads to increasing the drug-metabolizing activity of this enzyme [51]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME ASNS [52]
                              Zoledronic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00140   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Zoledronic acid inhibits the expression of DME ASNS [28]
                              Clodronic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00465   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Clodronic acid inhibits the expression of DME ASNS [18]
                              Rotenone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00481   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Rotenone up-regulates the expression of DME ASNS [53]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Afimoxifene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00610   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Afimoxifene inhibits the expression of DME ASNS [37]
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the drug-metabolizing activity of DME ASNS [54]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME ASNS [55], [35]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein induces the drug-metabolizing activity of DME ASNS [56]
                              Lucanthone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00545   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Lucanthone inhibits the drug-metabolizing activity of DME ASNS [57]
                              MS-275 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 inhibits the expression of DME ASNS [28]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Ellagic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01287   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Ellagic acid up-regulates the expression of DME ASNS [58]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite up-regulates the expression of DME ASNS [59]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 up-regulates the expression of DME ASNS [60], [61]
                              ICG-001 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 up-regulates the expression of DME ASNS [62]
                              K-7174 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 up-regulates the expression of DME ASNS [63]
                              NSC-668394 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01403   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation NSC-668394 induces the drug-metabolizing activity of DME ASNS [64]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Zimeldine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00525   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Zimeldine induces the drug-metabolizing activity of DME ASNS [65]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME ASNS [24]
                              Metribolone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01378   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Metribolone inhibits the expression of DME ASNS [27]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate up-regulates the expression of DME ASNS [66]
                              Thioxotriazole copper(II) Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01081   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Thioxotriazole copper(II) up-regulates the expression of DME ASNS [67]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cupric oxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00840   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Cupric oxide up-regulates the expression of DME ASNS [68]
                              Pentanal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01034   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Pentanal up-regulates the expression of DME ASNS [69]
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