Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0210)
DME Name Thioredoxin reductase TR1 (TXNRD1), Homo sapiens DME Info
UniProt ID
TRXR1_HUMAN
EC Number    EC: 1.8.1.9     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.8.1.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00971   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diquat up-regulates the expression of DME TXNRD1 [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              1,4-naphthoquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01089   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 1,4-naphthoquinone up-regulates the expression of DME TXNRD1 [2]
                              1,6-hexamethylene diisocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01093   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 1,6-hexamethylene diisocyanate up-regulates the expression of DME TXNRD1 [3]
                              2-butenal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01122   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-butenal up-regulates the expression of DME TXNRD1 [4]
                              2-methyl-4-isothiazolin-3-one Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00890   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-methyl-4-isothiazolin-3-one up-regulates the expression of DME TXNRD1 [5]
                              Acrolein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01186   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrolein inhibits the drug-metabolizing activity of DME TXNRD1 [6]
                              Allyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00852   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Allyl isothiocyanate inhibits the drug-metabolizing activity of DME TXNRD1 [7]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME TXNRD1 [8]
                              Chloropicrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin up-regulates the expression of DME TXNRD1 [3], [9]
                              Mercuric chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01508   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercuric chloride up-regulates the expression of DME TXNRD1 [10]
                              Nickel chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01397   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Nickel chloride up-regulates the expression of DME TXNRD1 [11], [12]
                              Uranium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00964   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Uranium up-regulates the expression of DME TXNRD1 [13]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form mRNA
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin up-regulates the expression of DME TXNRD1 [14]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME TXNRD1 [15]
                              Dimethyl nitrosamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01006   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Dimethyl nitrosamine up-regulates the expression of DME TXNRD1 [16]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME TXNRD1 [17]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone up-regulates the expression of DME TXNRD1 [18], [5]
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate up-regulates the expression of DME TXNRD1 [16], [19]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME TXNRD1 [20]
                              Sodium arsenate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01023   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Sodium arsenate up-regulates the expression of DME TXNRD1 [21]
                              Zinc oxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01032   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc oxide up-regulates the expression of DME TXNRD1 [22]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              N-hexane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01016   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation N-hexane up-regulates the expression of DME TXNRD1 [23]
                              7-aminocephalosporanic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01173   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 7-aminocephalosporanic acid up-regulates the expression of DME TXNRD1 [3]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME TXNRD1 [24]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Particulate matter Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter inhibits the expression of DME TXNRD1 [25], [26]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Benzyl isothiocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01217   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Benzyl isothiocyanate inhibits the drug-metabolizing activity of DME TXNRD1 [7]
                              Cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde induces the drug-metabolizing activity of DME TXNRD1 [27]
                              Gedunin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01311   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Gedunin up-regulates the expression of DME TXNRD1 [28]
                              Iberin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00789   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Iberin up-regulates the expression of DME TXNRD1 and leads to increasing the drug-metabolizing activity of this enzyme [29]
                              Isoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01553   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Isoflavone up-regulates the expression of DME TXNRD1 [30]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Plant extracts up-regulates the expression of DME TXNRD1 [31], [32]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      41 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen induces the drug-metabolizing activity of DME TXNRD1 [33]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME TXNRD1 [34]
                              Aspirin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin inhibits the expression of DME TXNRD1 [35]
                              Auranofin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00270   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Auranof DMEin inhibits the drug-metabolizing activity of DME TXNRD1 [36]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME TXNRD1 [37]
                              Azathioprine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine up-regulates the expression of DME TXNRD1 [38]
                              Bosentan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00148   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bosentan up-regulates the expression of DME TXNRD1 [39]
                              Caffeine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00218   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Caffeine inhibits the expression of DME TXNRD1 [40]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME TXNRD1 [41]
                              Cidofovir Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00132   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cidofovir up-regulates the expression of DME TXNRD1 [42]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the drug-metabolizing activity of DME TXNRD1 [36]
                              Copper Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00834   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper up-regulates the expression of DME TXNRD1 [43]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME TXNRD1 [44]
                              Cupric chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00407   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cupric chloride up-regulates the expression of DME TXNRD1 [45]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME TXNRD1 [46], [42]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME TXNRD1 [47]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME TXNRD1 [20]
                              Dronabinol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00115   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dronabinol up-regulates the expression of DME TXNRD1 [48]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME TXNRD1 [49]
                              Fenofibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00035   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenofibrate up-regulates the expression of DME TXNRD1 [42]
                              Ferric citrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00135   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ferric citrate up-regulates the expression of DME TXNRD1 [50]
                              Fluorouracil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00037   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluorouracil inhibits the expression of DME TXNRD1 [51]
                              Fulvestrant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00147   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fulvestrant inhibits the expression of DME TXNRD1 [49]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the expression of DME TXNRD1 [52]
                              Hydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone up-regulates the expression of DME TXNRD1 [53], [54]
                              Ifosfamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide up-regulates the expression of DME TXNRD1 [42]
                              Isoniazid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00224   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isoniazid up-regulates the expression of DME TXNRD1 [55]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME TXNRD1 [56]
                              Menadione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione up-regulates the expression of DME TXNRD1 [10]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate up-regulates the expression of DME TXNRD1 [57]
                              Raloxifene hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00126   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Raloxifene hydrochloride inhibits the expression of DME TXNRD1 [58]
                              Selenomethionine Se-75 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00324   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Selenomethionine Se-75 induces the drug-metabolizing activity of DME TXNRD1 [59]
                              Sorafenib tosylate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00325   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sorafenib tosylate up-regulates the expression of DME TXNRD1 [60]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME TXNRD1 [61]
                              Zinc acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00408   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Zinc acetate up-regulates the expression of DME TXNRD1 [62]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME TXNRD1 [20]
                              Chlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00442   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Chlorobenzene up-regulates the expression of DME TXNRD1 [63]
                              Clodronic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00465   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Clodronic acid up-regulates the expression of DME TXNRD1 [42]
                              Edetic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01285   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Edetic acid induces the drug-metabolizing activity of DME TXNRD1 [64]
                              Floxacillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00469   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Floxacillin up-regulates the expression of DME TXNRD1 [55]
                              Gamolenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00510   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Gamolenic acid up-regulates the expression of DME TXNRD1 [65]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Afimoxifene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00610   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Afimoxifene inhibits the expression of DME TXNRD1 [49]
                              Curcumin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin up-regulates the expression of DME TXNRD1 [66], [67]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol induces the drug-metabolizing activity of DME TXNRD1 [68]
                              Seocalcitol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00652   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Seocalcitol up-regulates the expression of DME TXNRD1 [62]
                              Sulforafan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan inhibits the expression of DME TXNRD1 [69]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Antimony Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00657   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Antimony up-regulates the expression of DME TXNRD1 [16]
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME TXNRD1 [70]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME TXNRD1 [40]
                              Phenethyl isothiocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00596   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Phenethyl isothiocyanate induces the drug-metabolizing activity of DME TXNRD1 [71]
                              STA-4783 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00629   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation STA-4783 up-regulates the expression of DME TXNRD1 [72]
                              ZIO-101 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00673   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation ZIO-101 up-regulates the expression of DME TXNRD1 [73]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Buthionine sulfoximine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01229   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Buthionine sulfoximine up-regulates the expression of DME TXNRD1 [74]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME TXNRD1 [20]
                              Ethaselen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01080   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Ethaselen inhibits the drug-metabolizing activity of DME TXNRD1 [75]
                              Methyl salicylate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01376   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Methyl salicylate up-regulates the expression of DME TXNRD1 [76]
                              Quercetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin up-regulates the expression of DME TXNRD1 [77]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite up-regulates the expression of DME TXNRD1 [78]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 up-regulates the expression of DME TXNRD1 [79]
                              Emodin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00692   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Emodin inhibits the expression of DME TXNRD1 [80]
                              Tripterine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00706   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Tripterine up-regulates the expression of DME TXNRD1 [81]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME TXNRD1 [20]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME TXNRD1 [82]
                              K-7174 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 up-regulates the expression of DME TXNRD1 [83]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Aurothioglucose Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00527   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Aurothioglucose inhibits the drug-metabolizing activity of DME TXNRD1 [36]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              7,8-diacetoxy-4-methylcoumarin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01171   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 7,8-diacetoxy-4-methylcoumarin up-regulates the expression of DME TXNRD1 [84]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME TXNRD1 [18], [85]
                              Chlorite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00807   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Chlorite inhibits the drug-metabolizing activity of DME TXNRD1 [86]
                              Isopropanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01128   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Isopropanol up-regulates the expression of DME TXNRD1 [20]
                              MG-132 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01219   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation MG-132 up-regulates the expression of DME TXNRD1 [78]
                              Mono-(2-ethylhexyl)phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01380   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Mono-(2-ethylhexyl)phthalate induces the drug-metabolizing activity of DME TXNRD1 [87]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Gold Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Gold inhibits the drug-metabolizing activity of DME TXNRD1 [88]
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