Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0004)
DME Name UDP-glucuronosyltransferase 1A1 (UGT1A1), Homo sapiens DME Info
UniProt ID
UD11_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tebuconazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00957   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Tebuconazole up-regulates the expression of DME UGT1A1 [1]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Clofibric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01257   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Clofibric acid up-regulates the expression of DME UGT1A1 [2]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Endosulfan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01074   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Endosulfan up-regulates the expression of DME UGT1A1 [3]
                              Parathion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01064   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Parathion induces the drug-metabolizing activity of DME UGT1A1 [4], [5]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01119   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine up-regulates the expression of DME UGT1A1 [6], [7]
                              Cycloheximide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01268   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cycloheximide inhibits the expression of DME UGT1A1 [8]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form mRNA
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin up-regulates the expression of DME UGT1A1 [9]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME UGT1A1 and leads to increasing the drug-metabolizing activity of this enzyme [10]
                              Methylcholanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00899   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Methylcholanthrene induces the drug-metabolizing activity of DME UGT1A1 [11]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME UGT1A1 [12]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bisphenol F Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00997   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Bisphenol F induces the drug-metabolizing activity of DME UGT1A1 [13]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Pirinixic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01433   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Pirinixic acid up-regulates the expression of DME UGT1A1 [14], [15]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Flavonoids Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00858   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Flavonoids induces the drug-metabolizing activity of DME UGT1A1 [16]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Amentoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01195   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Amentof DMElavone inhibits the drug-metabolizing activity of DME UGT1A1 [17]
                              Apigenin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01203   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Apigenin up-regulates the expression of DME UGT1A1 [18], [19]
                              Bilirubin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00877   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Bilirubin inhibits the drug-metabolizing activity of DME UGT1A1 [20]
                              Chrysin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00878   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Chrysin induces the drug-metabolizing activity of DME UGT1A1 [21], [22]
                              Ginkgolide B Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00859   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Ginkgolide B up-regulates the expression of DME UGT1A1 [23]
                              Hyperforin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01335   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Hyperforin up-regulates the expression of DME UGT1A1 [24]
                              Ligustilide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01558   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Ligustilide up-regulates the expression of DME UGT1A1 [25]
                              Mangiferin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01370   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Mangiferin up-regulates the expression of DME UGT1A1 [26]
                              Notoginsenoside R1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01567   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Notoginsenoside R1 induces the drug-metabolizing activity of DME UGT1A1 [27]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Ginkgo biloba extract Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01314   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Ginkgo biloba extract up-regulates the expression of DME UGT1A1 [23]
                              Turmeric extract Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00756   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Turmeric extract up-regulates the expression of DME UGT1A1 [28]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      36 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the drug-metabolizing activity of DME UGT1A1 [29]
                              Caffeine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00218   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Caffeine up-regulates the expression of DME UGT1A1 [30]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME UGT1A1 [31], [32]
                              Carbamazepine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine induces the drug-metabolizing activity of DME UGT1A1 [33]
                              Clozapine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00209   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clozapine up-regulates the expression of DME UGT1A1 [30]
                              Decitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine up-regulates the expression of DME UGT1A1 [34]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone induces the drug-metabolizing activity of DME UGT1A1 [35]
                              Diclofenac Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00352   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diclof DMEenac inhibits the drug-metabolizing activity of DME UGT1A1 (Ki = 52 microM) [36]
                              Diflunisal Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00026   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diflunisal inhibits the drug-metabolizing activity of DME UGT1A1 [29]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the drug-metabolizing activity of DME UGT1A1 [37]
                              Fenofibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00035   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenofibrate up-regulates the expression of DME UGT1A1 [38]
                              Fenofibric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00138   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenofibric acid up-regulates the expression of DME UGT1A1 [2]
                              Fulvestrant Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00147   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fulvestrant up-regulates the expression of DME UGT1A1 [8]
                              Furosemide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00040   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Furosemide up-regulates the expression of DME UGT1A1 [30]
                              Gemfibrozil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00042   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gemfibrozil up-regulates the expression of DME UGT1A1 [2]
                              Indomethacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin inhibits the drug-metabolizing activity of DME UGT1A1 [29]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME UGT1A1 in Human embryonic kidney 293 cell (HEK293) (IC50 = 13 microM) [39]
                              Ketoprofen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00050   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoprof DMEen inhibits the drug-metabolizing activity of DME UGT1A1 [29]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME UGT1A1 [40]
                              Naproxen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00156   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Naproxen inhibits the drug-metabolizing activity of DME UGT1A1 [41]
                              Nilotinib hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00274   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nilotinib hydrochloride inhibits the drug-metabolizing activity of DME UGT1A1 [42]
                              Omeprazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00069   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Omeprazole up-regulates the expression of DME UGT1A1 [43]
                              Phenytoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00232   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenytoin up-regulates the expression of DME UGT1A1 [44]
                              Pioglitazone hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00319   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pioglitazone hydrochloride up-regulates the expression of DME UGT1A1 [45]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin up-regulates the expression of DME UGT1A1 [46], [47]
                              Rosiglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone up-regulates the expression of DME UGT1A1 [48]
                              Sulindac Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00177   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulindac induces the drug-metabolizing activity of DME UGT1A1 [49]
                              Testosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00095   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Testosterone induces the drug-metabolizing activity of DME UGT1A1 [50]
                              Ticlopidine hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00331   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ticlopidine hydrochloride up-regulates the expression of DME UGT1A1 [51], [52]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone up-regulates the expression of DME UGT1A1 [53]
                              Valproic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid up-regulates the expression of DME UGT1A1 [54]
                              Daidzein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00439   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Daidzein induces the drug-metabolizing activity of DME UGT1A1 [55]
                              Flunitrazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00498   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flunitrazepam inhibits the drug-metabolizing activity of DME UGT1A1 [20]
                              Ginkgolide A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01315   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Ginkgolide A up-regulates the expression of DME UGT1A1 [23]
                              Tocotrienol beta Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00455   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Tocotrienol beta induces the drug-metabolizing activity of DME UGT1A1 [56]
                              Tocotrienol delta Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00456   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Tocotrienol delta up-regulates the expression of DME UGT1A1 [57]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin up-regulates the expression of DME UGT1A1 [58]
                              Exisulind Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00659   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Exisulind up-regulates the expression of DME UGT1A1 [59], [60]
                              Sulforafan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan up-regulates the expression of DME UGT1A1 [61]
                              Triclosan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan up-regulates the expression of DME UGT1A1 [62]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Butyric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01230   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Butyric acid up-regulates the expression of DME UGT1A1 [63]
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A induces the drug-metabolizing activity of DME UGT1A1 [13]
                              Bisphenol B Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00588   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol B up-regulates the expression of DME UGT1A1 [64]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the drug-metabolizing activity of DME UGT1A1 [65], [55]
                              Hydroxytamoxifen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00634   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Hydroxytamoxifen inhibits the expression of DME UGT1A1 [8]
                              MeIQx Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00609   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MeIQx up-regulates the expression of DME UGT1A1 [6], [7]
                              Sulindac sulfide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00656   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Sulindac sulfide induces the drug-metabolizing activity of DME UGT1A1 [66]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Hymecromone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00555   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1/2
                                 DME Modulation Hymecromone induces the drug-metabolizing activity of DME UGT1A1 [42]
                              Quercetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin up-regulates the expression of DME UGT1A1 [67]
                              Trichostatin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01492   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Trichostatin A up-regulates the expression of DME UGT1A1 [68]
                              Xanthohumol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00636   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Xanthohumol up-regulates the expression of DME UGT1A1 [69], [70]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME UGT1A1 [71]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME UGT1A1 and leads to increasing the drug-metabolizing activity of this enzyme [10]
                              Niflumic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00829   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Niflumic acid inhibits the drug-metabolizing activity of DME UGT1A1 in Human embryonic kidney 293 cell (HEK293) (IC50 = 13 microM) [39]
                              Pregnenolone carbonitrile Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01437   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Pregnenolone carbonitrile up-regulates the expression of DME UGT1A1 [72]
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6 Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells. Food Chem Toxicol. 2012 Mar;50(3-4):949-55.
7 Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food Chem Toxicol. 2013 Sep;59:386-94.
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9 Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells. Toxicol In Vitro. 2013 Sep;27(6):1809-19.
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11 Organophosphate pesticides increase the expression of alpha glutathione S-transferase in HepG2 cells. Toxicol In Vitro. 2011 Dec;25(8):2074-9.
12 Adipose tissue stem cell-derived hepatic progenies as an in vitro model for genotoxicity testing. Arch Toxicol. 2018 May;92(5):1893-1903.
13 Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells. Sci Total Environ. 2019 Oct 15;687:267-276.
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18 Structure-dependent modulation of aryl hydrocarbon receptor-mediated activities by flavonoids. Toxicol Sci. 2018 Jul 1;164(1):205-217.
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20 Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos. 2004 Sep;25(6):243-52.
21 Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos. 2000 Sep;28(9):1077-82.
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23 Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
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25 Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2. Food Chem Toxicol. 2018 Nov;121:631-638.
26 Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology. 2007 May;28(3):478-89.
27 Enhancement of cancer stem-like and epithelial-mesenchymal transdifferentiation property in oral epithelial cells with long-term nicotine exposure: reversal by targeting SNAIL. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):459-69.
28 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
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30 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.
31 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
32 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
33 Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol Pharmacol. 2016 Sep;90(3):265-74.
34 Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney. Drug Metab Dispos. 2013 Oct;41(10):1738-43.
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36 UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther. 2005 Apr;106(1):97-132.
37 Effects of beta-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9. Biopharm Drug Dispos. 2004 Nov;25(8):339-44.
38 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
39 Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos. 2011 Feb;39(2):322-9.
40 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
41 Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chem Biol Interact. 2015 Jun 5;234:114-25.
42 Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Food Chem Toxicol. 2016 Apr;90:112-22.
43 In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):216-24.
44 Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology. 2004 Oct;40(4):951-60.
45 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
46 Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes. Drug Metab Dispos. 2007 May;35(5):699-703.
47 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
48 A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform. Toxicol In Vitro. 2019 Oct;60:347-358.
49 A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55.
50 Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line. Toxicol Appl Pharmacol. 2011 Apr 1;252(1):18-27.
51 Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
52 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
53 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
54 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
55 Isoflavones modulate the glucuronidation of estradiol in human liver microsomes. Carcinogenesis. 2005 Dec;26(12):2172-8.
56 Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. Biol Reprod. 1999 Jul;61(1):40-5.
57 Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr. 2008 Apr;138(4):667-73.
58 Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. Biol Pharm Bull. 2006 Jul;29(7):1476-9.
59 Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos. 2008 Dec;36(12):2556-63.
60 Low level occupational exposure to styrene: its effects on DNA damage and DNA repair. Int J Hyg Environ Health. 2011 Mar;214(2):127-37.
61 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
62 Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line. Toxicol Lett. 2008 Feb 15;176(3):230-8.
63 Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology. 2019 Jan 15;412:1-11.
64 Bisphenol A and its analogues activate human pregnane X receptor. Environ Health Perspect. 2012 Mar;120(3):399-405.
65 Effects of endocrine disruptors on genes associated with 17beta-estradiol metabolism and excretion. Steroids. 2008 Nov;73(12):1242-51.
66 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142.
67 Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells. Food Chem Toxicol. 2018 Aug;118:880-888.
68 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
69 Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. J Immunol. 2006 Sep 1;177(5):3477-83.
70 Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L671-9.
71 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
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