Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0095)
DME Name Metallothionein-2A (MT2A), Homo sapiens DME Info
UniProt ID
MT2_HUMAN
EC Number    EC: 1.8.5.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.8.5.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine up-regulates the expression of DME MT2A [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium induces the drug-metabolizing activity of DME MT2A [2]
                              Chloropicrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin inhibits the expression of DME MT2A [3]
                              Kaempferol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01353   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Kaempferol up-regulates the expression of DME MT2A [4]
                              Mercuric chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01508   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercuric chloride up-regulates the expression of DME MT2A [5]
                              Nickel chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01397   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Nickel chloride up-regulates the expression of DME MT2A [6], [7]
                              Uranium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00964   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Uranium up-regulates the expression of DME MT2A [8]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Azaspiracid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01502   XEOTIC Info Gene Form mRNA
                                 Classification Marine Algal Toxin
                                 DME Modulation Azaspiracid up-regulates the expression of DME MT2A [9]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME MT2A [10], [11]
                              Methylcholanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00899   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Methylcholanthrene up-regulates the expression of DME MT2A [12]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME MT2A [13]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate up-regulates the expression of DME MT2A [14]
                              Chromium nitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01002   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Chromium nitrate up-regulates the expression of DME MT2A [15]
                              Zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01512   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc up-regulates the expression of DME MT2A [16]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME MT2A [17]
                              Lead Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01505   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Lead up-regulates the expression of DME MT2A [18]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME MT2A [19]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Amphibole asbestos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00995   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Amphibole asbestos induces the drug-metabolizing activity of DME MT2A [20]
                              Dust Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01284   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Dust inhibits the expression of DME MT2A [21]
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter up-regulates the expression of DME MT2A [5]
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution induces the drug-metabolizing activity of DME MT2A [22]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Biochanin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01222   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Biochanin A up-regulates the expression of DME MT2A [4]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Grape seed proanthocyanidins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00758   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Grape seed proanthocyanidins inhibits the expression of DME MT2A [23]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      35 Xenobiotics
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide induces the drug-metabolizing activity of DME MT2A [24]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME MT2A [25]
                              Budesonide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00235   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Budesonide up-regulates the expression of DME MT2A [26]
                              Cidofovir Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00132   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cidofovir up-regulates the expression of DME MT2A [27]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME MT2A [27], [28]
                              Copper Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00834   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper up-regulates the expression of DME MT2A [29], [30]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME MT2A [31]
                              Cupric chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00407   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cupric chloride up-regulates the expression of DME MT2A [32], [33]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME MT2A [27]
                              Cytarabine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00097   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cytarabine inhibits the expression of DME MT2A [34]
                              Decitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine up-regulates the expression of DME MT2A [35]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME MT2A [36]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME MT2A [37]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME MT2A [38]
                              Dronabinol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00115   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dronabinol inhibits the expression of DME MT2A [39]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME MT2A [40], [41]
                              Ethinyl estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00267   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ethinyl estradiol up-regulates the expression of DME MT2A [42]
                              Gallium nitrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00136   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gallium nitrate induces the drug-metabolizing activity of DME MT2A [43]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide up-regulates the expression of DME MT2A [44]
                              Ifosfamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide up-regulates the expression of DME MT2A [27]
                              Menadione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione up-regulates the expression of DME MT2A [45]
                              Nitroprusside Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00398   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nitroprusside induces the drug-metabolizing activity of DME MT2A [46]
                              Oxaliplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00207   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxaliplatin inhibits the drug-metabolizing activity of DME MT2A [47]
                              Pyrithione zinc Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00399   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pyrithione zinc up-regulates the expression of DME MT2A [48]
                              Raloxifene hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00126   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Raloxifene hydrochloride up-regulates the expression of DME MT2A [49]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone up-regulates the expression of DME MT2A [50]
                              Urethane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane up-regulates the expression of DME MT2A [8]
                              Valproic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid induces the drug-metabolizing activity of DME MT2A [51]
                              Vincristine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00392   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vincristine up-regulates the expression of DME MT2A [45]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME MT2A [15]
                              Daidzein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00439   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Daidzein up-regulates the expression of DME MT2A [4]
                              Demecolcine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00466   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Demecolcine up-regulates the expression of DME MT2A [52]
                              Promegestone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00508   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Promegestone up-regulates the expression of DME MT2A [53]
                              Rotenone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00481   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Rotenone up-regulates the expression of DME MT2A [54]
                              Zinc sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00460   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Zinc sulfate up-regulates the expression of DME MT2A [44]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Copper histidine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00626   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Copper histidine up-regulates the expression of DME MT2A [55]
                              Diphenylcyclopropenone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00612   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Diphenylcyclopropenone up-regulates the expression of DME MT2A [15]
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the expression of DME MT2A [23]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Acyline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00674   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Acyline inhibits the expression of DME MT2A [56]
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME MT2A [57]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME MT2A [4]
                              Genistin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00645   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistin up-regulates the expression of DME MT2A [58]
                              Hydroxytamoxifen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00634   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Hydroxytamoxifen up-regulates the expression of DME MT2A [59]
                              Motexafin gadolinium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00541   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Motexafin gadolinium up-regulates the expression of DME MT2A [60]
                              MS-275 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 up-regulates the expression of DME MT2A [61]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Dihydrotestosterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone inhibits the expression of DME MT2A [62]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME MT2A [15]
                              Palmitic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01420   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Palmitic acid inhibits the expression of DME MT2A [63]
                              Quercetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin up-regulates the expression of DME MT2A [64]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME MT2A [65]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate up-regulates the expression of DME MT2A [66], [67]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 up-regulates the expression of DME MT2A [68]
                              GSK-J4 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01324   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GSK-J4 up-regulates the expression of DME MT2A [69]
                              K-7174 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 inhibits the expression of DME MT2A [70]
                              Vanillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00727   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Vanillin up-regulates the expression of DME MT2A [5]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Zomepirac glucuronide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00526   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Zomepirac glucuronide up-regulates the expression of DME MT2A [71]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              PCI-5002 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01423   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation PCI-5002 up-regulates the expression of DME MT2A [72]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate up-regulates the expression of DME MT2A [73]
                              Thioxotriazole copper(II) Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01081   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Thioxotriazole copper(II) up-regulates the expression of DME MT2A [74]
      Other Chemical Compound(s) or Element(s)
                  Cosmetic Additive Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Hydroxycitronellal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01334   XEOTIC Info Gene Form mRNA
                                 Classification Cosmetic Additive
                                 DME Modulation Hydroxycitronellal up-regulates the expression of DME MT2A [15]
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Cupric oxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00840   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Cupric oxide up-regulates the expression of DME MT2A [75]
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Gold up-regulates the expression of DME MT2A [76]
                              Tungsten Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00793   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Tungsten up-regulates the expression of DME MT2A [77]
References
1 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
2 Increased levels of metallothionein in placenta of smokers. Toxicology. 2005 Mar 1;208(1):133-9.
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