Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0197)
DME Name Aldo-keto reductase 1C1 (AKR1C1), Homo sapiens DME Info
UniProt ID
AK1C1_HUMAN
EC Number    EC: 1.1.1.149     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.149
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00971   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diquat up-regulates the expression of DME AKR1C1 [1]
                              Diuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00973   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diuron up-regulates the expression of DME AKR1C1 [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2-butenal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01122   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-butenal up-regulates the expression of DME AKR1C1 [3]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME AKR1C1 [1]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME AKR1C1 [4]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate up-regulates the expression of DME AKR1C1 [5]
                              Methylcholanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00899   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Methylcholanthrene up-regulates the expression of DME AKR1C1 and leads to increasing the drug-metabolizing activity of this enzyme [6]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone up-regulates the expression of DME AKR1C1 [7], [8]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME AKR1C1 [9]
                              Sodium arsenate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01023   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Sodium arsenate up-regulates the expression of DME AKR1C1 [10]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Dibutyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01275   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Dibutyl phthalate up-regulates the expression of DME AKR1C1 [11]
                              Lead chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01506   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Lead chloride up-regulates the expression of DME AKR1C1 [12]
                              N-hexane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01016   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation N-hexane up-regulates the expression of DME AKR1C1 [13]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME AKR1C1 [14]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME AKR1C1 [15]
                              Medazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00881   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Medazepam inhibits the drug-metabolizing activity of DME AKR1C1 [16]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME AKR1C1 [17], [18]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution up-regulates the expression of DME AKR1C1 [19]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              7-hydroxyflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01176   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 7-hydroxyflavone inhibits the drug-metabolizing activity of DME AKR1C1 [20]
                              Anthranilic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00763   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Anthranilic acid inhibits the drug-metabolizing activity of DME AKR1C1 [21]
                              Cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde up-regulates the expression of DME AKR1C1 [22]
                              Gedunin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01311   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Gedunin up-regulates the expression of DME AKR1C1 [23]
                              Geraniol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01312   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Geraniol up-regulates the expression of DME AKR1C1 [8]
                              Octyl gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01408   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Octyl gallate inhibits the expression of DME AKR1C1 [24]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang up-regulates the expression of DME AKR1C1 [25]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      45 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen up-regulates the expression of DME AKR1C1 [26]
                              Amiodarone hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00277   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amiodarone hydrochloride up-regulates the expression of DME AKR1C1 [27]
                              Aspirin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin inhibits the drug-metabolizing activity of DME AKR1C1 [28]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME AKR1C1 [29]
                              Azathioprine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine up-regulates the expression of DME AKR1C1 [30]
                              Bexarotene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00144   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bexarotene up-regulates the expression of DME AKR1C1 [31]
                              Bortezomib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00159   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bortezomib up-regulates the expression of DME AKR1C1 [32]
                              Calcitriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol up-regulates the expression of DME AKR1C1 [33], [34]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME AKR1C1 [35], [25]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME AKR1C1 [36]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME AKR1C1 [37]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME AKR1C1 [38]
                              Diazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00024   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diazepam inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 5.6 microM) [39], [40]
                              Dienogest Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00433   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dienogest inhibits the expression of DME AKR1C1 [41]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME AKR1C1 [9]
                              Dutasteride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00192   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dutasteride up-regulates the expression of DME AKR1C1 [42]
                              Dydrogesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00403   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dydrogesterone inhibits the drug-metabolizing activity of DME AKR1C1 [43]
                              Estazolam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00031   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estazolam inhibits the drug-metabolizing activity of DME AKR1C1 [40]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME AKR1C1 [44]
                              Ethacrynic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00032   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ethacrynic acid up-regulates the expression of DME AKR1C1 [7]
                              Flurbiprofen sodium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00296   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flurbiprofen sodium inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 > 100 microM) [45]
                              Glimepiride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00043   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glimepiride inhibits the drug-metabolizing activity of DME AKR1C1 [46]
                              Glipizide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00044   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glipizide inhibits the drug-metabolizing activity of DME AKR1C1 [46]
                              Glyburide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00247   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glyburide inhibits the drug-metabolizing activity of DME AKR1C1 [46]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide up-regulates the expression of DME AKR1C1 [7]
                              Ibuprofen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00248   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ibuprofen inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 > 100 microM) [45]
                              Indomethacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 130 microM) [47]
                              Leflunomide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide inhibits the expression of DME AKR1C1 [48]
                              Meclofenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00415   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Meclofenamic acid inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 3.16 microM) [45], [49]
                              Medroxyprogesterone acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00743   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Medroxyprogesterone acetate inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 0.7 microM) [39], [43]
                              Naproxen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00156   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Naproxen inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 > 100 microM) [45]
                              Simvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin up-regulates the expression of DME AKR1C1 [50]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the drug-metabolizing activity of DME AKR1C1 [51], [52]
                              Ursodeoxycholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00119   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ursodeoxycholic acid inhibits the drug-metabolizing activity of DME AKR1C1 [53]
                              Vitamin D Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00747   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vitamin D up-regulates the expression of DME AKR1C1 [54]
                              Vorinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00079   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vorinostat up-regulates the expression of DME AKR1C1 [54]
                              Benzbromarone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00492   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzbromarone inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 0.048 microM) [55]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME AKR1C1 [9]
                              Cloxazolam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01258   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cloxazolam inhibits the drug-metabolizing activity of DME AKR1C1 (Ki > 10 microM) [39]
                              Flufenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00470   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flufenamic acid inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 0.98 microM) [56], [39]
                              Flunitrazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00498   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flunitrazepam inhibits the drug-metabolizing activity of DME AKR1C1 [40]
                              Gamolenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00510   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Gamolenic acid up-regulates the expression of DME AKR1C1 [57]
                              Gliquidone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00501   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Gliquidone inhibits the drug-metabolizing activity of DME AKR1C1 [46]
                              Glycyrrhetinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01319   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Glycyrrhetinic acid inhibits the drug-metabolizing activity of DME AKR1C1 [39]
                              Hexestrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00769   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Hexestrol inhibits the drug-metabolizing activity of DME AKR1C1 [56], [39]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Fenretinide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00565   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Fenretinide up-regulates the expression of DME AKR1C1 [58]
                              Seocalcitol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00652   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Seocalcitol induces the drug-metabolizing activity of DME AKR1C1 [59]
                              Sulforafan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan up-regulates the expression of DME AKR1C1 [60]
                              Triclosan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan inhibits the drug-metabolizing activity of DME AKR1C1 [61]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              4-phenylbutyric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00584   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation 4-phenylbutyric acid up-regulates the expression of DME AKR1C1 [62]
                              MS-275 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 inhibits the expression of DME AKR1C1 [63]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME AKR1C1 [9]
                              Methyl salicylate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01376   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Methyl salicylate up-regulates the expression of DME AKR1C1 [5]
                              Naringenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00573   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Naringenin inhibits the drug-metabolizing activity of DME AKR1C1 [64]
                              Phenethyl caffeate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01233   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Phenethyl caffeate inhibits the drug-metabolizing activity of DME AKR1C1 (IC50 = 13 microM) [47]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite up-regulates the expression of DME AKR1C1 [65]
                              Trichostatin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01492   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Trichostatin A up-regulates the expression of DME AKR1C1 [66]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME AKR1C1 [9]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Phenolphthalein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00521   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Phenolphthalein inhibits the drug-metabolizing activity of DME AKR1C1 [67]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              3,7-dihydroxyflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01137   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 3,7-dihydroxyflavone inhibits the drug-metabolizing activity of DME AKR1C1 [20]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME AKR1C1 [68]
                              Farnesol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01298   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Farnesol up-regulates the expression of DME AKR1C1 [8]
                              Fenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01300   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Fenamic acid inhibits the drug-metabolizing activity of DME AKR1C1 [28]
                              Isopropanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01128   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Isopropanol up-regulates the expression of DME AKR1C1 [9]
                              Lithocholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00787   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Lithocholic acid inhibits the drug-metabolizing activity of DME AKR1C1 [69]
                              MG-132 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01219   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation MG-132 up-regulates the expression of DME AKR1C1 [32], [35]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              1,10-phenanthroline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00766   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 1,10-phenanthroline inhibits the drug-metabolizing activity of DME AKR1C1 [56], [39]
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