Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0109)
DME Name Superoxide dismutase 1 (SOD1), Homo sapiens DME Info
UniProt ID
SODC_HUMAN
EC Number    EC: 1.15.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Superoxide radical acceptor oxidoreductase
Superoxide radical acceptor oxidoreductase
EC: 1.15.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Atrazine inhibits the expression of DME SOD1 [1]
                              Monomethylarsonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00982   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Monomethylarsonic acid induces the drug-metabolizing activity of DME SOD1 [2]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Decamethrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01047   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Decamethrin inhibits the drug-metabolizing activity of DME SOD1 [3]
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the expression of DME SOD1 [4]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Acrylamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01187   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylamide inhibits the expression of DME SOD1 [5]
                              Cadmium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium inhibits the drug-metabolizing activity of DME SOD1 [6]
                              Chloropicrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin up-regulates the expression of DME SOD1 [7]
                              Cordycepin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01259   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cordycepin inhibits the expression of DME SOD1 [8]
                              Kaempferol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01353   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Kaempferol induces the drug-metabolizing activity of DME SOD1 [9]
                              Nickel chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01397   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Nickel chloride up-regulates the expression of DME SOD1 [10]
                              Okadaic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01409   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Okadaic acid inhibits the expression of DME SOD1 [11]
                              Paraquat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat inhibits the expression of DME SOD1 [12]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the drug-metabolizing activity of DME SOD1 [3]
                              Aflatoxin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 up-regulates the expression of DME SOD1 [13]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Dichlorodiphenyl dichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00768   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Dichlorodiphenyl dichloroethylene induces the drug-metabolizing activity of DME SOD1 [14]
                              Glyphosate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01320   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Glyphosate inhibits the drug-metabolizing activity of DME SOD1 [15]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME SOD1 [16]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              CD-437 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01241   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation CD-437 inhibits the expression of DME SOD1 [17]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Amphibole asbestos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00995   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Amphibole asbestos inhibits the drug-metabolizing activity of DME SOD1 [18]
                              Particulate matter Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter inhibits the expression of DME SOD1 [19]
                              Tobacco smoke pollution Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution inhibits the drug-metabolizing activity of DME SOD1 [20]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Apocarotenal Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01523   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Apocarotenal inhibits the expression of DME SOD1 [21]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Grape seed proanthocyanidins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00758   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Grape seed proanthocyanidins inhibits the expression of DME SOD1 [22]
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Plant extracts up-regulates the expression of DME SOD1 [23]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      34 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the drug-metabolizing activity of DME SOD1 [24]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME SOD1 [25]
                              Benzoyl peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00389   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Benzoyl peroxide induces the drug-metabolizing activity of DME SOD1 [26]
                              Beta carotene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00401   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Beta carotene inhibits the expression of DME SOD1 [21]
                              Bleomycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00341   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bleomycin induces the drug-metabolizing activity of DME SOD1 [27]
                              Bosentan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00148   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bosentan inhibits the expression of DME SOD1 [28]
                              Carmustine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00012   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carmustine inhibits the drug-metabolizing activity of DME SOD1 [29]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin induces the drug-metabolizing activity of DME SOD1 [30]
                              Clofibrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00016   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clofibrate inhibits the expression of DME SOD1 [31]
                              Cocaine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00751   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cocaine hydrochloride inhibits the expression of DME SOD1 [32]
                              Copper Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00834   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper inhibits the drug-metabolizing activity of DME SOD1 [33], [34]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME SOD1 [35]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME SOD1 [16]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride induces the drug-metabolizing activity of DME SOD1 [27]
                              Epinephrine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00265   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Epinephrine induces the drug-metabolizing activity of DME SOD1 [36]
                              Fulvestrant Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00147   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fulvestrant up-regulates the expression of DME SOD1 [37]
                              Gallium nitrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00136   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gallium nitrate inhibits the expression of DME SOD1 [38]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the drug-metabolizing activity of DME SOD1 [39], [40]
                              Hydroquinone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone inhibits the drug-metabolizing activity of DME SOD1 [41]
                              Medroxyprogesterone acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00743   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Medroxyprogesterone acetate up-regulates the expression of DME SOD1 [42]
                              Mitomycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00089   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mitomycin up-regulates the expression of DME SOD1 [43]
                              Penicillamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00257   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Penicillamine inhibits the drug-metabolizing activity of DME SOD1 [44]
                              Pioglitazone hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00319   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pioglitazone hydrochloride up-regulates the expression of DME SOD1 [19]
                              Raloxifene hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00126   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Raloxifene hydrochloride up-regulates the expression of DME SOD1 [12]
                              Rosiglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone up-regulates the expression of DME SOD1 [45]
                              Trientine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00332   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Trientine hydrochloride inhibits the drug-metabolizing activity of DME SOD1 [46]
                              Troglitazone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone inhibits the drug-metabolizing activity of DME SOD1 [47]
                              Undecylenic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00426   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Undecylenic acid inhibits the expression of DME SOD1 [48]
                              Aclarubicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00450   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Aclarubicin inhibits the drug-metabolizing activity of DME SOD1 [49]
                              Bezafibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00493   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Bezafibrate induces the drug-metabolizing activity of DME SOD1 [50]
                              Chlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00442   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Chlorobenzene induces the drug-metabolizing activity of DME SOD1 [51]
                              Dihydroartemisinin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00454   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Dihydroartemisinin induces the drug-metabolizing activity of DME SOD1 [52]
                              Linsidomine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01368   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linsidomine inhibits the drug-metabolizing activity of DME SOD1 [53]
                              Thiostrepton Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01485   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Thiostrepton induces the drug-metabolizing activity of DME SOD1 [54]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Fenretinide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00565   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Fenretinide induces the drug-metabolizing activity of DME SOD1 [55]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol up-regulates the expression of DME SOD1 [56], [57]
                              Sulforafan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan up-regulates the expression of DME SOD1 [58]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A induces the drug-metabolizing activity of DME SOD1 [59]
                              Camptothecin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00597   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Camptothecin induces the drug-metabolizing activity of DME SOD1 [60]
                              Carbon monoxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00572   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Carbon monoxide inhibits the drug-metabolizing activity of DME SOD1 [61]
                              Ditiocarb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00591   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ditiocarb inhibits the drug-metabolizing activity of DME SOD1 [62]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein up-regulates the expression of DME SOD1 [63]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Adenosine triphosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00535   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Adenosine triphosphate induces the drug-metabolizing activity of DME SOD1 [64]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME SOD1 [16]
                              Quercetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin up-regulates the expression of DME SOD1 [65]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME SOD1 [66]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate induces the drug-metabolizing activity of DME SOD1 [67], [68]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME SOD1 [69]
                              Manumycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00713   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Manumycin inhibits the drug-metabolizing activity of DME SOD1 [70]
                              Eugenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol inhibits the drug-metabolizing activity of DME SOD1 [71]
                              GW-7604 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01326   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GW-7604 up-regulates the expression of DME SOD1 [37]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME SOD1 [72]
                              K-7174 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 inhibits the expression of DME SOD1 [73]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Danthron Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00516   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Danthron inhibits the drug-metabolizing activity of DME SOD1 [74]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              9,10-phenanthrenequinone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00871   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 9,10-phenanthrenequinone inhibits the drug-metabolizing activity of DME SOD1 [75]
                              Chlorite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00807   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Chlorite induces the drug-metabolizing activity of DME SOD1 [76]
                              Thioxotriazole copper(II) Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01081   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Thioxotriazole copper(II) up-regulates the expression of DME SOD1 [77]
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