Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0224)
DME Name HMG-CoA reductase (HMGCR), Homo sapiens DME Info
UniProt ID
HMDH_HUMAN
EC Number    EC: 1.1.1.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.34
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the expression of DME HMGCR [1]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Enniatins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01289   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Enniatins inhibits the expression of DME HMGCR [2]
                              Fatostatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01299   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Fatostatin inhibits the drug-metabolizing activity of DME HMGCR [3], [4]
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME HMGCR [5]
                              Okadaic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01409   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Okadaic acid inhibits the expression of DME HMGCR [6]
                              Oxyquinoline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01419   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Oxyquinoline inhibits the drug-metabolizing activity of DME HMGCR [7]
                              Pentabromophenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00904   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Pentabromophenol inhibits the expression of DME HMGCR [8]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Dinophysistoxin 1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00813   XEOTIC Info Gene Form mRNA
                                 Classification Biotoxin
                                 DME Modulation Dinophysistoxin 1 inhibits the expression of DME HMGCR [9]
                              Azaspiracid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01502   XEOTIC Info Gene Form mRNA
                                 Classification Marine Algal Toxin
                                 DME Modulation Azaspiracid up-regulates the expression of DME HMGCR [9]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the expression of DME HMGCR [10]
                              Dimethyl nitrosamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01006   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Dimethyl nitrosamine inhibits the expression of DME HMGCR [11]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate inhibits the expression of DME HMGCR [5]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME HMGCR [12], [13]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              PF-429242 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01425   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation PF-429242 inhibits the drug-metabolizing activity of DME HMGCR [14]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Eucalyptol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01296   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Eucalyptol inhibits the drug-metabolizing activity of DME HMGCR [15]
                              Triparacresyl phosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01030   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Triparacresyl phosphate up-regulates the expression of DME HMGCR [16]
                              25-hydroxycholesterol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01116   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 25-hydroxycholesterol inhibits the drug-metabolizing activity of DME HMGCR in Human hepatocellular carcinoma cell line (HepG2) (IC50 = 0.3 microM) [17]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of DME HMGCR [18]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol inhibits the expression of DME HMGCR [19]
                              HT-2 toxin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01515   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation HT-2 toxin inhibits the expression of DME HMGCR [19]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Artemisic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01524   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Artemisic acid inhibits the drug-metabolizing activity of DME HMGCR [20]
                              Betulin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01221   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Betulin inhibits the drug-metabolizing activity of DME HMGCR [21]
                              Cholesterol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01250   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cholesterol inhibits the drug-metabolizing activity of DME HMGCR [22]
                              Ganoderic acid A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01310   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Ganoderic acid A inhibits the expression of DME HMGCR [23]
                              Geraniol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01312   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Geraniol inhibits the drug-metabolizing activity of DME HMGCR [24]
                              Linalool Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01366   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Linalool inhibits the drug-metabolizing activity of DME HMGCR [15]
                              Stigmasterol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01611   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Stigmasterol up-regulates the expression of DME HMGCR [25]
                              Thapsigargin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00809   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Thapsigargin inhibits the expression of DME HMGCR [26], [27]
                              Tunicamycin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01494   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Tunicamycin A inhibits the expression of DME HMGCR [28]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Coconut oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01532   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Coconut oil up-regulates the expression of DME HMGCR [29]
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts induces the drug-metabolizing activity of DME HMGCR [30], [31]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang inhibits the expression of DME HMGCR [32]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      32 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME HMGCR [33]
                              Atorvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00340   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Atorvastatin up-regulates the expression of DME HMGCR and leads to increasing the drug-metabolizing activity of this enzyme [34]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME HMGCR [35]
                              Azathioprine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00007   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azathioprine inhibits the expression of DME HMGCR [36]
                              Caffeine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00218   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Caffeine induces the drug-metabolizing activity of DME HMGCR [37]
                              Carbamazepine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine inhibits the expression of DME HMGCR [38]
                              Chlorpromazine hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00280   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpromazine hydrochloride up-regulates the expression of DME HMGCR [39]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the expression of DME HMGCR [40]
                              Clofibrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00016   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clof DMEibrate inhibits the drug-metabolizing activity of DME HMGCR [41]
                              Clozapine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00209   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clozapine induces the drug-metabolizing activity of DME HMGCR [42]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME HMGCR [43]
                              Crizotinib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00195   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Crizotinib up-regulates the expression of DME HMGCR [44]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME HMGCR [45]
                              Ezetimibe Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00155   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ezetimibe induces the drug-metabolizing activity of DME HMGCR [46]
                              Fluvastatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00359   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluvastatin inhibits the drug-metabolizing activity of DME HMGCR (IC50 = 0.000353 microM) [47]
                              Haloperidol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00045   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Haloperidol induces the drug-metabolizing activity of DME HMGCR [42]
                              Hydrocortisone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00264   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrocortisone inhibits the expression of DME HMGCR [48]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide up-regulates the expression of DME HMGCR [49]
                              Isotretinoin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00186   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isotretinoin inhibits the expression of DME HMGCR [50]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the expression of DME HMGCR [51]
                              Lovastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00262   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lovastatin up-regulates the expression of DME HMGCR [52]
                              Menadione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione inhibits the expression of DME HMGCR [53]
                              Methimazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00176   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methimazole inhibits the expression of DME HMGCR [54]
                              Olanzapine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00226   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Olanzapine up-regulates the expression of DME HMGCR [6]
                              Piroxicam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00204   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Piroxicam inhibits the drug-metabolizing activity of DME HMGCR [55]
                              Pravastatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00377   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pravastatin inhibits the drug-metabolizing activity of DME HMGCR (IC50 = 0.005591 microM) [56], [47]
                              Progesterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone induces the drug-metabolizing activity of DME HMGCR [57]
                              Risperidone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00077   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Risperidone induces the drug-metabolizing activity of DME HMGCR [58]
                              Simvastatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin inhibits the drug-metabolizing activity of DME HMGCR (IC50 = 0.0009 microM) [59]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone induces the drug-metabolizing activity of DME HMGCR [60]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME HMGCR [61]
                              Bezafibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00493   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Bezafibrate induces the drug-metabolizing activity of DME HMGCR [62]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Copper histidine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00626   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Copper histidine up-regulates the expression of DME HMGCR [63]
                              Curcumin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin up-regulates the expression of DME HMGCR [64]
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the expression of DME HMGCR [65]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME HMGCR and leads to increasing the drug-metabolizing activity of this enzyme [66]
                              Colforsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin up-regulates the expression of DME HMGCR [51], [67]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the drug-metabolizing activity of DME HMGCR [68]
                              MS-275 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 inhibits the expression of DME HMGCR [69]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Dihydrotestosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone up-regulates the expression of DME HMGCR [70]
                              Fingolimod hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00554   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Fingolimod hydrochloride up-regulates the expression of DME HMGCR [71]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the expression of DME HMGCR [72]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              GW-4064 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00735   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GW-4064 up-regulates the expression of DME HMGCR [73]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME HMGCR [74]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Phenylpropanolamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00529   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Phenylpropanolamine up-regulates the expression of DME HMGCR [75]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:      10 Xenobiotics
                              27-hydroxycholesterol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01117   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 27-hydroxycholesterol inhibits the drug-metabolizing activity of DME HMGCR [22]
                              Arachidonic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00876   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Arachidonic acid inhibits the expression of DME HMGCR [76]
                              Archazolid B Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01205   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Archazolid B up-regulates the expression of DME HMGCR [77]
                              Beta-naphthoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone inhibits the expression of DME HMGCR [78], [79]
                              Farnesol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01298   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Farnesol inhibits the drug-metabolizing activity of DME HMGCR [80]
                              Metribolone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01378   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Metribolone induces the drug-metabolizing activity of DME HMGCR [81]
                              Mevalonic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01379   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Mevalonic acid inhibits the expression of DME HMGCR [82]
                              Mono-(2-ethylhexyl)phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01380   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Mono-(2-ethylhexyl)phthalate up-regulates the expression of DME HMGCR [83]
                              NSC-305787 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01200   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation NSC-305787 induces the drug-metabolizing activity of DME HMGCR [84]
                              Phenylmercuric acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate inhibits the expression of DME HMGCR [75]
References
1 Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
2 An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicol Lett. 2015 Mar 4;233(2):84-94.
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4 Fatostatin suppresses growth and enhances apoptosis by blocking SREBP-regulated metabolic pathways in endometrial carcinoma. Oncol Rep. 2018 Apr;39(4):1919-1929.
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