Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0118)
DME Name Aldo-keto reductase 1C3 (AKR1C3), Homo sapiens DME Info
UniProt ID
AK1C3_HUMAN
EC Number    EC: 1.1.1.357     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.357
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00973   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diuron up-regulates the expression of DME AKR1C3 [1]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dicrotophos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01050   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dicrotophos inhibits the expression of DME AKR1C3 [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              2-butenal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01122   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-butenal up-regulates the expression of DME AKR1C3 [3]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME AKR1C3 [4]
                              Formaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde up-regulates the expression of DME AKR1C3 [5]
                              Ochratoxin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01407   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Ochratoxin A inhibits the drug-metabolizing activity of DME AKR1C3 [6]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME AKR1C3 [7]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate induces the drug-metabolizing activity of DME AKR1C3 [8]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME AKR1C3 [9]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              N-hexane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01016   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation N-hexane up-regulates the expression of DME AKR1C3 [10]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME AKR1C3 [11]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter induces the drug-metabolizing activity of DME AKR1C3 [12]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              2'-hydroxyflavanone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01127   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 2'-hydroxyflavanone inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 0.1 microM) [13]
                              7-hydroxycoumarin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01174   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 7-hydroxycoumarin induces the drug-metabolizing activity of DME AKR1C3 [14]
                              7-hydroxyflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01176   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 7-hydroxyflavone inhibits the drug-metabolizing activity of DME AKR1C3 [15]
                              Octyl gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01408   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Octyl gallate inhibits the drug-metabolizing activity of DME AKR1C3 [16]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang up-regulates the expression of DME AKR1C3 [17]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      45 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME AKR1C3 [18]
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide up-regulates the expression of DME AKR1C3 [19]
                              Aspirin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin inhibits the drug-metabolizing activity of DME AKR1C3 [20]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME AKR1C3 [21]
                              Bexarotene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00144   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bexarotene up-regulates the expression of DME AKR1C3 [22]
                              Bortezomib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00159   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bortezomib up-regulates the expression of DME AKR1C3 [23]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin induces the drug-metabolizing activity of DME AKR1C3 [24]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME AKR1C3 [25]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME AKR1C3 [26]
                              Dasatinib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00181   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dasatinib up-regulates the expression of DME AKR1C3 [27]
                              Desogestrel Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00432   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Desogestrel inhibits the drug-metabolizing activity of DME AKR1C3 [28]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME AKR1C3 [29]
                              Diazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00024   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diazepam inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 84 microM) [30], [31]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME AKR1C3 [9]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME AKR1C3 [32]
                              Dutasteride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00192   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dutasteride up-regulates the expression of DME AKR1C3 [33]
                              Dydrogesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00403   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dydrogesterone inhibits the drug-metabolizing activity of DME AKR1C3 [28]
                              Estazolam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00031   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estazolam inhibits the drug-metabolizing activity of DME AKR1C3 [31]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME AKR1C3 [34], [35]
                              Flurbiprofen sodium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00296   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flurbiprofen sodium inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 1.56 microM) [13]
                              Glimepiride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00043   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glimepiride inhibits the drug-metabolizing activity of DME AKR1C3 [36]
                              Glipizide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00044   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glipizide inhibits the drug-metabolizing activity of DME AKR1C3 [36]
                              Glyburide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00247   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Glyburide inhibits the drug-metabolizing activity of DME AKR1C3 [36]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide induces the drug-metabolizing activity of DME AKR1C3 [14]
                              Ibuprofen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00248   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ibuprofen inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 32.7 microM) [13]
                              Indomethacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00047   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Indomethacin inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 0.1 microM) [37]
                              Levonorgestrel Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00113   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Levonorgestrel inhibits the drug-metabolizing activity of DME AKR1C3 [28]
                              Meclofenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00415   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Meclofenamic acid inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 0.54 microM) [13]
                              Medroxyprogesterone acetate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00743   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Medroxyprogesterone acetate inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 0.28 microM) [38]
                              Naproxen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00156   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Naproxen inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 0.48 microM) [39]
                              Progesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone inhibits the expression of DME AKR1C3 [40]
                              Simvastatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin inhibits the expression of DME AKR1C3 [41]
                              Sulindac Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00177   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulindac inhibits the drug-metabolizing activity of DME AKR1C3 [42]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the expression of DME AKR1C3 [43]
                              Vorinostat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00079   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vorinostat inhibits the expression of DME AKR1C3 [44], [45]
                              Benzbromarone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00492   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzbromarone inhibits the drug-metabolizing activity of DME AKR1C3 [30]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME AKR1C3 [9]
                              Bromazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00458   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Bromazepam inhibits the drug-metabolizing activity of DME AKR1C3 [31]
                              Cloxazolam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01258   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cloxazolam inhibits the drug-metabolizing activity of DME AKR1C3 (Ki = 1.5 microM) [30], [31]
                              Flufenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00470   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flufenamic acid inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 0.05 microM) [46]
                              Flunitrazepam Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00498   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Flunitrazepam inhibits the drug-metabolizing activity of DME AKR1C3 [31]
                              Gliclazide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00500   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Gliclazide inhibits the drug-metabolizing activity of DME AKR1C3 [36]
                              Gliquidone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00501   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Gliquidone inhibits the drug-metabolizing activity of DME AKR1C3 [36]
                              Glycyrrhetinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01319   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Glycyrrhetinic acid inhibits the drug-metabolizing activity of DME AKR1C3 [30]
                              Hexestrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00769   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Hexestrol inhibits the drug-metabolizing activity of DME AKR1C3 [30]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Dinaciclib Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00678   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Dinaciclib inhibits the drug-metabolizing activity of DME AKR1C3 [47]
                              NVP-BKM120 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00675   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation NVP-BKM120 inhibits the drug-metabolizing activity of DME AKR1C3 [31]
                              Seocalcitol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00652   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Seocalcitol induces the drug-metabolizing activity of DME AKR1C3 [48], [49]
                              Triclosan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan inhibits the expression of DME AKR1C3 [50]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Butyric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01230   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Butyric acid up-regulates the expression of DME AKR1C3 [7]
                              Colforsin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00606   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Colforsin inhibits the expression of DME AKR1C3 [51]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Tolfenamic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00556   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1/2
                                 DME Modulation Tolfenamic acid inhibits the drug-metabolizing activity of DME AKR1C3 (Ki = 0.008 microM) [52]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME AKR1C3 [9]
                              Naringenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00573   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Naringenin inhibits the drug-metabolizing activity of DME AKR1C3 [53]
                              Phenethyl caffeate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01233   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Phenethyl caffeate inhibits the drug-metabolizing activity of DME AKR1C3 (IC50 = 1.7 microM) [52]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME AKR1C3 [54], [55]
                              Trichostatin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01492   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Trichostatin A up-regulates the expression of DME AKR1C3 [56]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME AKR1C3 [9]
                              GSK-J4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01324   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GSK-J4 inhibits the expression of DME AKR1C3 [57]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME AKR1C3 [58]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              4-hydroxy-2-nonenal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00869   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 4-hydroxy-2-nonenal induces the drug-metabolizing activity of DME AKR1C3 [14]
                              9,10-phenanthrenequinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00871   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 9,10-phenanthrenequinone induces the drug-metabolizing activity of DME AKR1C3 [59]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone up-regulates the expression of DME AKR1C3 [60]
                              Isopropanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01128   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Isopropanol up-regulates the expression of DME AKR1C3 [9]
                              MG-132 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01219   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation MG-132 up-regulates the expression of DME AKR1C3 [23], [24]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate up-regulates the expression of DME AKR1C3 and leads to increasing the drug-metabolizing activity of this enzyme [61], [62]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              1,10-phenanthroline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00766   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 1,10-phenanthroline inhibits the drug-metabolizing activity of DME AKR1C3 [30]
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Gold up-regulates the expression of DME AKR1C3 [63]
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