Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0020)
DME Name Cytochrome P450 2B6 (CYP2B6), Homo sapiens DME Info
UniProt ID
CP2B6_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Azoxystrobin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00938   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Azoxystrobin induces the drug-metabolizing activity of DME CYP2B6 [1]
                              Cyproconazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00942   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Cyproconazole induces the drug-metabolizing activity of DME CYP2B6 [1]
                              Fluxapyroxad Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00950   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Fluxapyroxad induces the drug-metabolizing activity of DME CYP2B6 [1]
                              Prochloraz Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00955   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Prochloraz up-regulates the expression of DME CYP2B6 [2]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Atrazine induces the drug-metabolizing activity of DME CYP2B6 [3]
                              Diuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00973   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diuron up-regulates the expression of DME CYP2B6 [3]
                              Isoproturon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00975   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Isoproturon induces the drug-metabolizing activity of DME CYP2B6 [3]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:      18 Xenobiotics
                              Benfuracarb Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01039   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Benfuracarb induces the drug-metabolizing activity of DME CYP2B6 [3]
                              Carbofuran Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01597   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Carbofuran induces the drug-metabolizing activity of DME CYP2B6 [3]
                              Chlordecone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01598   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Chlordecone induces the drug-metabolizing activity of DME CYP2B6 [4]
                              Chlorfluazuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01043   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Chlorfluazuron induces the drug-metabolizing activity of DME CYP2B6 [3]
                              Cyhalothrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01600   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cyhalothrin inhibits the drug-metabolizing activity of DME CYP2B6 [5]
                              Cypermethrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01046   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cypermethrin induces the drug-metabolizing activity of DME CYP2B6 [4], [3]
                              Decamethrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01047   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Decamethrin inhibits the drug-metabolizing activity of DME CYP2B6 [5]
                              Dichlorodiphenyl dichloroethane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01048   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dichlorodiphenyl dichloroethane up-regulates the expression of DME CYP2B6 [6]
                              Dieldrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01051   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dieldrin induces the drug-metabolizing activity of DME CYP2B6 [4]
                              Endosulfan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01074   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Endosulfan induces the drug-metabolizing activity of DME CYP2B6 [7]
                              Fenitrothion Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01052   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenitrothion inhibits the drug-metabolizing activity of DME CYP2B6 [5]
                              Fenvalerate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01053   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Fenvalerate inhibits the drug-metabolizing activity of DME CYP2B6 [5]
                              Isomalathion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01058   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Isomalathion up-regulates the expression of DME CYP2B6 [8]
                              Monocrotophos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01062   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Monocrotophos up-regulates the expression of DME CYP2B6 [9]
                              Nonachlor Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01604   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Nonachlor up-regulates the expression of DME CYP2B6 [10]
                              Pentachlorophenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01605   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Pentachlorophenol up-regulates the expression of DME CYP2B6 [11]
                              Profenofos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01068   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Prof DMEenof DMEos inhibits the drug-metabolizing activity of DME CYP2B6 [12]
                              Pyrethrins Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01069   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Pyrethrins up-regulates the expression of DME CYP2B6 [13]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Chlorpyrifos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos inhibits the drug-metabolizing activity of DME CYP2B6 [5]
                              Fipronil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01302   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Fipronil up-regulates the expression of DME CYP2B6 [14], [15]
                              Ochratoxin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01407   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Ochratoxin A up-regulates the expression of DME CYP2B6 [16]
                              Perfluorodecanoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01018   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Perfluorodecanoic acid up-regulates the expression of DME CYP2B6 [17]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form Protein
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin inhibits the drug-metabolizing activity of DME CYP2B6 [18]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene up-regulates the expression of DME CYP2B6 [19]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME CYP2B6 [20]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Dichlorodiphenyl dichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00768   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Dichlorodiphenyl dichloroethylene up-regulates the expression of DME CYP2B6 [6]
                              Perfluorohexanoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00920   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Perfluorohexanoic acid up-regulates the expression of DME CYP2B6 [21]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Chlordan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01245   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Chlordan induces the drug-metabolizing activity of DME CYP2B6 [4]
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid up-regulates the expression of DME CYP2B6 [22]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the expression of DME CYP2B6 [23]
                              Pirinixic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01433   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Pirinixic acid induces the drug-metabolizing activity of DME CYP2B6 [24]
                              Tris(1,3-dichloro-2-propyl)phosphate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01031   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of DME CYP2B6 [25]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Tobacco smoke pollution Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution inhibits the drug-metabolizing activity of DME CYP2B6 [26]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:      16 Xenobiotics
                              5-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01518   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 5-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2B6 [27]
                              Baicalein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01212   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Baicalein up-regulates the expression of DME CYP2B6 [28]
                              Bergamottin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01527   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Bergamottin inhibits the drug-metabolizing activity of DME CYP2B6 (Ki = 5.2 microM) [29]
                              Bilirubin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00877   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Bilirubin up-regulates the expression of DME CYP2B6 [30]
                              Chrysin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00878   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Chrysin up-regulates the expression of DME CYP2B6 [28]
                              Clove oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01531   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Clove oil up-regulates the expression of DME CYP2B6 [31]
                              Galangin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01308   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Galangin up-regulates the expression of DME CYP2B6 [28]
                              Germacrone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01313   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Germacrone inhibits the drug-metabolizing activity of DME CYP2B6 [32]
                              Ginkgolide B Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00859   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Ginkgolide B up-regulates the expression of DME CYP2B6 [33]
                              Hyperforin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01335   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Hyperforin up-regulates the expression of DME CYP2B6 [34]
                              Isoxazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00786   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Isoxazole up-regulates the expression of DME CYP2B6 [35]
                              Lemongrass oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01557   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Lemongrass oil up-regulates the expression of DME CYP2B6 [31]
                              Methoxydimethyltryptamines Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01375   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Methoxydimethyltryptamines inhibits the drug-metabolizing activity of DME CYP2B6 [36]
                              Senecionine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01585   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Senecionine up-regulates the expression of DME CYP2B6 [37]
                              Steviol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00810   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Steviol up-regulates the expression of DME CYP2B6 [38], [39]
                              Walrycin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01498   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Walrycin A up-regulates the expression of DME CYP2B6 [40]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Basil oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01526   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Basil oil up-regulates the expression of DME CYP2B6 [31]
                              Caraway oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00759   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Caraway oil up-regulates the expression of DME CYP2B6 [31]
                              Cinnamon oil, bark Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01530   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Cinnamon oil, bark up-regulates the expression of DME CYP2B6 [31]
                              Coriander oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01533   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Coriander oil up-regulates the expression of DME CYP2B6 [31]
                              Ginkgo biloba extract Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01314   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Ginkgo biloba extract up-regulates the expression of DME CYP2B6 [33]
                              Juniperus communis oil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01556   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Juniperus communis oil up-regulates the expression of DME CYP2B6 [31]
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME CYP2B6 [41]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      49 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME CYP2B6 [42]
                              Amlodipine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00338   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amlodipine inhibits the drug-metabolizing activity of DME CYP2B6 [43]
                              Atorvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00340   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Atorvastatin up-regulates the expression of DME CYP2B6 [44]
                              Bosentan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00148   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bosentan up-regulates the expression of DME CYP2B6 [45], [46]
                              Cannabidiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00173   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cannabidiol inhibits the drug-metabolizing activity of DME CYP2B6 [47]
                              Carbamazepine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00011   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Carbamazepine induces the drug-metabolizing activity of DME CYP2B6 [48]
                              Cerivastatin sodium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00279   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cerivastatin sodium up-regulates the expression of DME CYP2B6 [44]
                              Cimetidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00015   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cimetidine inhibits the drug-metabolizing activity of DME CYP2B6 [49]
                              Clotrimazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00017   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clotrimazole up-regulates the expression of DME CYP2B6 and leads to increasing the drug-metabolizing activity of this enzyme [50]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME CYP2B6 [51]
                              Cyclophosphamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00018   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclophosphamide inhibits the expression of DME CYP2B6 and leads to decreasing the drug-metabolizing activity of this enzyme [52]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CYP2B6 [53]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME CYP2B6 and leads to increasing the drug-metabolizing activity of this enzyme [54]
                              Diethylstilbestrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00166   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diethylstilbestrol up-regulates the expression of DME CYP2B6 [35]
                              Dimethyl sulfoxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00001   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dimethyl sulfoxide up-regulates the expression of DME CYP2B6 [55]
                              Efavirenz Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00216   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Efavirenz inhibits the drug-metabolizing activity of DME CYP2B6 [27]
                              Erlotinib hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00157   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Erlotinib hydrochloride up-regulates the expression of DME CYP2B6 [56]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME CYP2B6 [57], [58]
                              Felodipine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00245   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Felodipine induces the drug-metabolizing activity of DME CYP2B6 [59]
                              Fluvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00359   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluvastatin up-regulates the expression of DME CYP2B6 [44]
                              Isradipine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00049   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isradipine induces the drug-metabolizing activity of DME CYP2B6 [59]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP2B6 [60]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME CYP2B6 [56]
                              Lindane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane induces the drug-metabolizing activity of DME CYP2B6 [4]
                              Malathion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00056   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Malathion up-regulates the expression of DME CYP2B6 [61]
                              Omeprazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00069   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Omeprazole induces the drug-metabolizing activity of DME CYP2B6 [62]
                              Orphenadrine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00314   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Orphenadrine hydrochloride inhibits the expression of DME CYP2B6 [63]
                              Paroxetine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00316   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Paroxetine hydrochloride inhibits the drug-metabolizing activity of DME CYP2B6 [64]
                              Pazopanib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00374   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pazopanib up-regulates the expression of DME CYP2B6 [65]
                              Phenobarbital Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00410   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenobarbital induces the drug-metabolizing activity of DME CYP2B6 [66]
                              Phenytoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00232   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenytoin up-regulates the expression of DME CYP2B6 [67]
                              Pimecrolimus Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00243   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pimecrolimus up-regulates the expression of DME CYP2B6 [68]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin induces the drug-metabolizing activity of DME CYP2B6 [69]
                              Ritonavir Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00160   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ritonavir induces the drug-metabolizing activity of DME CYP2B6 [70]
                              Rosiglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone induces the drug-metabolizing activity of DME CYP2B6 [71]
                              Selegiline hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00323   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Selegiline hydrochloride inhibits the expression of DME CYP2B6 [72]
                              Tamoxifen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00383   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tamoxifen induces the drug-metabolizing activity of DME CYP2B6 [73]
                              Teriflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00749   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Teriflunomide up-regulates the expression of DME CYP2B6 [74]
                              Thiabendazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00084   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Thiabendazole up-regulates the expression of DME CYP2B6 [75]
                              Thiotepa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00085   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Thiotepa inhibits the drug-metabolizing activity of DME CYP2B6 (Ki = 2.2 microM) [29]
                              Ticlopidine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00331   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ticlopidine hydrochloride inhibits the drug-metabolizing activity of DME CYP2B6 (IC50 = 0.6 microM) [76]
                              Tranylcypromine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00385   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tranylcypromine inhibits the drug-metabolizing activity of DME CYP2B6 (IC50 = 6.96 microM) [77]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone up-regulates the expression of DME CYP2B6 [78]
                              Vitamin D Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00747   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vitamin D induces the drug-metabolizing activity of DME CYP2B6 [79]
                              Apatinib Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00452   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Apatinib inhibits the drug-metabolizing activity of DME CYP2B6 [80]
                              Benidipine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00438   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benidipine induces the drug-metabolizing activity of DME CYP2B6 [59]
                              Ginkgolide A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01315   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Ginkgolide A up-regulates the expression of DME CYP2B6 [33]
                              Methoxychlor Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00446   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Methoxychlor inhibits the expression of DME CYP2B6 [81]
                              Perfluorobutane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00476   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Perfluorobutane up-regulates the expression of DME CYP2B6 [82]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Diethyltoluamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00582   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Diethyltoluamide up-regulates the expression of DME CYP2B6 [83], [15]
                              Oltipraz Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00605   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Oltipraz up-regulates the expression of DME CYP2B6 [84]
                              Triclosan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan up-regulates the expression of DME CYP2B6 [85]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Butyric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01230   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Butyric acid up-regulates the expression of DME CYP2B6 [86]
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME CYP2B6 [71]
                              Camptothecin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00597   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Camptothecin inhibits the expression of DME CYP2B6 [11]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Butylated hydroxytoluene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00601   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Butylated hydroxytoluene up-regulates the expression of DME CYP2B6 [87]
                              Carbendazim Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00598   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Carbendazim up-regulates the expression of DME CYP2B6 [3]
                              Epsilon-viniferin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00646   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Epsilon-viniferin inhibits the drug-metabolizing activity of DME CYP2B6 [88]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME CYP2B6 [89]
                              CP-778875 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01156   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation CP-778875 inhibits the drug-metabolizing activity of DME CYP2B6 [90]
                              Oleic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01412   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Oleic acid inhibits the expression of DME CYP2B6 [91]
                              GW-4064 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00735   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation GW-4064 inhibits the expression of DME CYP2B6 [92]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Phencyclidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01426   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Phencyclidine inhibits the drug-metabolizing activity of DME CYP2B6 (Ki = 10 microM) [29]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:      10 Xenobiotics
                              1,5-benzothiazepine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01090   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 1,5-benzothiazepine up-regulates the expression of DME CYP2B6 [93]
                              5-fluorotryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01159   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 5-fluorotryptamine inhibits the drug-metabolizing activity of DME CYP2B6 [27]
                              7-methyltryptamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01177   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 7-methyltryptamine inhibits the drug-metabolizing activity of DME CYP2B6 [27]
                              Avasimibe Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00804   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Avasimibe up-regulates the expression of DME CYP2B6 and leads to increasing the drug-metabolizing activity of this enzyme [94]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone induces the drug-metabolizing activity of DME CYP2B6 [95], [96]
                              CINPA1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01292   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation CINPA1 up-regulates the expression of DME CYP2B6 [97]
                              CITCO Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01165   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation CITCO induces the drug-metabolizing activity of DME CYP2B6 [98]
                              Clorgyline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00853   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Clorgyline inhibits the drug-metabolizing activity of DME CYP2B6 [99]
                              Farnesol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01298   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Farnesol up-regulates the expression of DME CYP2B6 [92]
                              FG-7142 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01301   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation FG-7142 up-regulates the expression of DME CYP2B6 [93]
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85 Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line. Toxicol Lett. 2008 Feb 15;176(3):230-8.
86 Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology. 2019 Jan 15;412:1-11.
87 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica. 2008 Jun;38(6):574-86.
88 Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 2003 Jul 18;73(9):1199-213.
89 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
90 Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha. Xenobiotica. 2013 Nov;43(11):963-72.
91 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
92 Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicol Appl Pharmacol. 2019 Feb 15;365:61-70.
93 Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett. 2011 Apr 25;202(2):148-54.
94 Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo. Drug Metab Dispos. 2004 Dec;32(12):1370-6.
95 Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers - a European Centre for Validation of Alternative Methods (ECVAM) - funded pre-validation study. Toxicol In Vitro. 2010 Feb;24(1):335-45.
96 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
97 Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Arch Toxicol. 2017 Jun;91(6):2375-2390.
98 Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. Arch Toxicol. 2015 Jan;89(1):57-72.
99 Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction. Chem Biol Interact. 2015 Mar 25;230:9-20.

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