Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0123)
DME Name Nitric oxide synthase endothelial (NOS3), Homo sapiens DME Info
UniProt ID
NOS3_HUMAN
EC Number    EC: 1.14.13.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.39
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Atrazine inhibits the drug-metabolizing activity of DME NOS3 [1]
                              Propazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00979   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Propazine inhibits the drug-metabolizing activity of DME NOS3 [2]
                              Simazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00980   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Simazine inhibits the expression of DME NOS3 [3]
                              Terbutylazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00981   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Terbutylazine inhibits the drug-metabolizing activity of DME NOS3 [4]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Endosulfan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01074   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Endosulfan up-regulates the expression of DME NOS3 [5]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Sodium bisulfide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00843   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Sodium bisulfide up-regulates the expression of DME NOS3 [6]
                              Toluene 2,4-diisocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01028   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Toluene 2,4-diisocyanate up-regulates the expression of DME NOS3 [7]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dichlorodiphenyl dichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00768   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Dichlorodiphenyl dichloroethylene up-regulates the expression of DME NOS3 [5]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Lead chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01506   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Lead chloride inhibits the drug-metabolizing activity of DME NOS3 [8]
                              25-hydroxycholesterol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01116   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 25-hydroxycholesterol inhibits the expression of DME NOS3 [9]
                              Caffeic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01232   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Caffeic acid up-regulates the expression of DME NOS3 [10]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Amurensin G Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01197   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Amurensin G up-regulates the expression of DME NOS3 [11]
                              Deguelin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01537   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Deguelin inhibits the drug-metabolizing activity of DME NOS3 [12]
                              Fructose Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00855   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Fructose inhibits the drug-metabolizing activity of DME NOS3 [13]
                              Phloretin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00883   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Phloretin inhibits the drug-metabolizing activity of DME NOS3 [14], [15]
                              Phlorhizin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01429   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Phlorhizin inhibits the drug-metabolizing activity of DME NOS3 [15]
                              Vanillic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00782   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Vanillic acid up-regulates the expression of DME NOS3 [16]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts induces the drug-metabolizing activity of DME NOS3 [17]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      32 Xenobiotics
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME NOS3 [18]
                              Atorvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00340   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Atorvastatin induces the drug-metabolizing activity of DME NOS3 [19]
                              Capsaicin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00178   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Capsaicin induces the drug-metabolizing activity of DME NOS3 [20]
                              Cocaine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00751   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cocaine hydrochloride inhibits the drug-metabolizing activity of DME NOS3 [21]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine up-regulates the expression of DME NOS3 [22], [23]
                              Decitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine up-regulates the expression of DME NOS3 [24]
                              Dexamethasone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone inhibits the drug-metabolizing activity of DME NOS3 [25]
                              Digitoxin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00402   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Digitoxin induces the drug-metabolizing activity of DME NOS3 [26]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol induces the drug-metabolizing activity of DME NOS3 [27]
                              Everolimus Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00191   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Everolimus inhibits the drug-metabolizing activity of DME NOS3 [28]
                              Fenofibrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00035   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fenofibrate induces the drug-metabolizing activity of DME NOS3 [29]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the drug-metabolizing activity of DME NOS3 [30]
                              Levamisole hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00305   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Levamisole hydrochloride inhibits the drug-metabolizing activity of DME NOS3 [31]
                              Lindane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane up-regulates the expression of DME NOS3 [5]
                              Methotrexate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate inhibits the drug-metabolizing activity of DME NOS3 [32]
                              Nebivolol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00370   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nebivolol up-regulates the expression of DME NOS3 [33]
                              Nicotine polacrilex Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex up-regulates the expression of DME NOS3 [34]
                              Paclitaxel Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00256   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Paclitaxel inhibits the drug-metabolizing activity of DME NOS3 [35]
                              Progesterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone up-regulates the expression of DME NOS3 [36], [37]
                              Rosuvastatin calcium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00255   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosuvastatin calcium induces the drug-metabolizing activity of DME NOS3 [38]
                              Simvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin up-regulates the expression of DME NOS3 [39]
                              Sirolimus Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00188   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sirolimus inhibits the expression of DME NOS3 [3]
                              Tacrolimus Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00254   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tacrolimus up-regulates the expression of DME NOS3 [40]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone induces the drug-metabolizing activity of DME NOS3 [41]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME NOS3 [10]
                              Calcium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00832   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Calcium induces the drug-metabolizing activity of DME NOS3 [42]
                              Cinnamic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01252   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Cinnamic acid up-regulates the expression of DME NOS3 [10]
                              Daidzein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00439   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Daidzein induces the drug-metabolizing activity of DME NOS3 [43]
                              Estriol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00457   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Estriol induces the drug-metabolizing activity of DME NOS3 [44]
                              Glycochenodeoxycholic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01318   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Glycochenodeoxycholic acid inhibits the drug-metabolizing activity of DME NOS3 [45], [46]
                              Linoleic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01367   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linoleic acid inhibits the expression of DME NOS3 [47]
                              Tanshinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00486   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Tanshinone up-regulates the expression of DME NOS3 [48]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Epigallocatechin gallate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate up-regulates the expression of DME NOS3 [49], [50]
                              Icariin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00654   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Icariin up-regulates the expression of DME NOS3 and leads to increasing the drug-metabolizing activity of this enzyme [51]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol induces the drug-metabolizing activity of DME NOS3 [52]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Calcimycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00604   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Calcimycin up-regulates the expression of DME NOS3 [46]
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A induces the drug-metabolizing activity of DME NOS3 [53]
                              Chlorogenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01246   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Chlorogenic acid up-regulates the expression of DME NOS3 [50]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the drug-metabolizing activity of DME NOS3 [54]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein induces the drug-metabolizing activity of DME NOS3 [43]
                              Puerarin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00648   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Puerarin up-regulates the expression of DME NOS3 [55]
                              Trichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00587   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Trichloroethylene induces the drug-metabolizing activity of DME NOS3 [56]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Cyanidin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01266   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Cyanidin up-regulates the expression of DME NOS3 [10]
                              Homocysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01331   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Homocysteine inhibits the drug-metabolizing activity of DME NOS3 [57]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME NOS3 [58]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME NOS3 [59]
                              Oleic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01412   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Oleic acid inhibits the expression of DME NOS3 [60]
                              Rosavin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01459   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Rosavin up-regulates the expression of DME NOS3 [61]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              7,8-diacetoxy-4-methylcoumarin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01171   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 7,8-diacetoxy-4-methylcoumarin induces the drug-metabolizing activity of DME NOS3 [62]
                              Egtazic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01286   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Egtazic acid inhibits the drug-metabolizing activity of DME NOS3 [45]
                              Protoporphyrin IX Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01440   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Protoporphyrin IX inhibits the drug-metabolizing activity of DME NOS3 [63]
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