Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0124)
DME Name Nitric oxide synthase inducible (NOS2), Homo sapiens DME Info
UniProt ID
NOS2_HUMAN
EC Number    EC: 1.14.13.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.39
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Polyhexamethyleneguanidine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00954   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Polyhexamethyleneguanidine up-regulates the expression of DME NOS2 [1]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Atrazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Atrazine inhibits the drug-metabolizing activity of DME NOS2 [2]
                              Propazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00979   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Propazine inhibits the drug-metabolizing activity of DME NOS2 [3]
                              Simazine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00980   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Simazine inhibits the expression of DME NOS2 [4]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME NOS2 [5]
                              Chlorpyrifos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos induces the drug-metabolizing activity of DME NOS2 [6]
                              Kaempferol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01353   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Kaempferol inhibits the drug-metabolizing activity of DME NOS2 [7]
                              Paraquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat induces the drug-metabolizing activity of DME NOS2 [8]
                              Toluene 2,4-diisocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01028   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Toluene 2,4-diisocyanate up-regulates the expression of DME NOS2 [9]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2-naphthylamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00896   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation 2-naphthylamine up-regulates the expression of DME NOS2 [10]
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene induces the drug-metabolizing activity of DME NOS2 [11], [12]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Lead chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01506   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Lead chloride inhibits the drug-metabolizing activity of DME NOS2 [13]
                              1-methyl-4-phenylpyridinium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01103   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 1-methyl-4-phenylpyridinium induces the drug-metabolizing activity of DME NOS2 [14]
                              25-hydroxycholesterol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01116   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 25-hydroxycholesterol up-regulates the expression of DME NOS2 [15]
                              Acetaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00872   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Acetaldehyde induces the drug-metabolizing activity of DME NOS2 [16]
                              Butyraldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00999   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Butyraldehyde up-regulates the expression of DME NOS2 [17]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate inhibits the expression of DME NOS2 [18]
                              Galactosamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00795   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Galactosamine up-regulates the expression of DME NOS2 [19]
                              Lithium chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01369   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Lithium chloride up-regulates the expression of DME NOS2 [20]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol up-regulates the expression of DME NOS2 [21]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Amphibole asbestos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00995   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Amphibole asbestos inhibits the drug-metabolizing activity of DME NOS2 [22]
                              Flavonoids Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00858   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Flavonoids induces the drug-metabolizing activity of DME NOS2 [23]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              7-Phloroeckol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01085   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 7-Phloroeckol inhibits the drug-metabolizing activity of DME NOS2 [24]
                              Amentoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01195   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Amentof DMElavone inhibits the drug-metabolizing activity of DME NOS2 [25]
                              Deguelin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01537   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Deguelin inhibits the drug-metabolizing activity of DME NOS2 [26]
                              Osajin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01570   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Osajin inhibits the drug-metabolizing activity of DME NOS2 [27]
                              Sulphoraphene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01590   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Sulphoraphene inhibits the expression of DME NOS2 and leads to decreasing the drug-metabolizing activity of this enzyme [28]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME NOS2 [29]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      34 Xenobiotics
                              Ammonia N-13 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00833   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ammonia N-13 up-regulates the expression of DME NOS2 [30]
                              Arsenic trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide induces the drug-metabolizing activity of DME NOS2 [31]
                              Aspirin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin induces the drug-metabolizing activity of DME NOS2 [32]
                              Beclomethasone dipropionate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00278   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Beclomethasone dipropionate inhibits the drug-metabolizing activity of DME NOS2 [33]
                              Capsaicin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00178   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Capsaicin induces the drug-metabolizing activity of DME NOS2 [34]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin induces the drug-metabolizing activity of DME NOS2 [35]
                              Copper Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00834   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper inhibits the drug-metabolizing activity of DME NOS2 [36]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME NOS2 [37]
                              Cyclosporine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine induces the drug-metabolizing activity of DME NOS2 [38]
                              Dexamethasone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone inhibits the expression of DME NOS2 [39]
                              Dimethyl sulfoxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00001   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dimethyl sulfoxide inhibits the expression of DME NOS2 [40]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride induces the drug-metabolizing activity of DME NOS2 [41], [42]
                              Estradiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol up-regulates the expression of DME NOS2 [43]
                              Etoposide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00121   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Etoposide induces the drug-metabolizing activity of DME NOS2 [44]
                              Fluorouracil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00037   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluorouracil induces the drug-metabolizing activity of DME NOS2 [45]
                              Fluvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00359   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluvastatin induces the drug-metabolizing activity of DME NOS2 [46]
                              Gadodiamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00268   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gadodiamide induces the drug-metabolizing activity of DME NOS2 [47]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide up-regulates the expression of DME NOS2 [48]
                              Isoproterenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00048   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isoproterenol inhibits the expression of DME NOS2 [49]
                              Lindane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane induces the drug-metabolizing activity of DME NOS2 [50]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate up-regulates the expression of DME NOS2 [51]
                              Naltrexone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00369   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Naltrexone inhibits the drug-metabolizing activity of DME NOS2 [52]
                              Nicotine polacrilex Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00312   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nicotine polacrilex up-regulates the expression of DME NOS2 [53]
                              Nitric oxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00228   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nitric oxide induces the drug-metabolizing activity of DME NOS2 [54]
                              Nitroglycerin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00068   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nitroglycerin inhibits the drug-metabolizing activity of DME NOS2 [55]
                              Nitroprusside Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00398   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Nitroprusside induces the drug-metabolizing activity of DME NOS2 [56]
                              Penicillamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00257   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Penicillamine induces the drug-metabolizing activity of DME NOS2 [57]
                              Progesterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone induces the drug-metabolizing activity of DME NOS2 [58]
                              Raloxifene hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00126   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Raloxifene hydrochloride inhibits the expression of DME NOS2 [59]
                              Rifampin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00223   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rifampin up-regulates the expression of DME NOS2 [60], [61]
                              Simvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin up-regulates the expression of DME NOS2 [4], [62]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone up-regulates the expression of DME NOS2 [63]
                              Valproic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00029   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Valproic acid inhibits the expression of DME NOS2 [64]
                              Vitamin D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00747   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vitamin D inhibits the drug-metabolizing activity of DME NOS2 [65]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A induces the drug-metabolizing activity of DME NOS2 [66]
                              Bufalin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00665   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bufalin inhibits the drug-metabolizing activity of DME NOS2 [67]
                              Ethanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol induces the drug-metabolizing activity of DME NOS2 [16]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the expression of DME NOS2 [68]
                              Pimagedine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00577   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Pimagedine inhibits the drug-metabolizing activity of DME NOS2 (IC50 = 101 microM) [69]
                              Puerarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00648   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Puerarin inhibits the expression of DME NOS2 [70]
                              Trichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00587   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Trichloroethylene up-regulates the expression of DME NOS2 [71]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Dieckol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01276   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dieckol inhibits the drug-metabolizing activity of DME NOS2 [24]
                              Lanthanum Chloride Hydroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00680   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Lanthanum Chloride Hydroxide up-regulates the expression of DME NOS2 [72]
                              LY-294002 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00580   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation LY-294002 induces the drug-metabolizing activity of DME NOS2 [12]
                              Palmitic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01420   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Palmitic acid up-regulates the expression of DME NOS2 [73]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the expression of DME NOS2 [74]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME NOS2 [75]
                              Spermine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00553   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Spermine up-regulates the expression of DME NOS2 [76]
                              Tetradecanoylphorbol acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00599   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Tetradecanoylphorbol acetate up-regulates the expression of DME NOS2 [77]
                              Trichostatin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01492   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Trichostatin A inhibits the expression of DME NOS2 [78]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME NOS2 [79]
                              GGTI-298 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00717   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation GGTI-298 induces the drug-metabolizing activity of DME NOS2 [46]
                              CR-3294 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01263   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation CR-3294 inhibits the expression of DME NOS2 [80]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              7,8-diacetoxy-4-methylcoumarin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01171   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 7,8-diacetoxy-4-methylcoumarin induces the drug-metabolizing activity of DME NOS2 [81]
                              Baohuoside I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01213   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Baohuoside I inhibits the drug-metabolizing activity of DME NOS2 [82]
                              Oxidopamine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01418   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Oxidopamine induces the drug-metabolizing activity of DME NOS2 [83]
                              PB28 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01101   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation PB28 induces the drug-metabolizing activity of DME NOS2 [84]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Gold induces the drug-metabolizing activity of DME NOS2 [85]
References
1 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013 Jun;72:69-82.
2 Triazine herbicides inhibit relaxin signaling and disrupt nitric oxide homeostasis. Toxicol Appl Pharmacol. 2016 Sep 15;307:10-18.
3 A biphasic effect of the fungicide prochloraz on aldosterone, but not cortisol, secretion in human adrenal H295R cells--underlying mechanisms. Toxicol Lett. 2009 Dec 15;191(2-3):174-80.
4 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015 Apr 18;16:315.
5 Cadmium induces transcription independently of intracellular calcium mobilization. PLoS One. 2011;6(6):e20542.
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29 Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways. Eur J Pharmacol. 2009 Oct 1;619(1-3):1-7.
30 Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. Metab Brain Dis. 2010 Mar;25(1):17-21.
31 The role of NF-B in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells. J Toxicol Sci. 2015 Jun;40(3):349-63.
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33 Correlation between change in pulmonary function and suppression of reactive nitrogen species production following steroid treatment in COPD. Thorax. 2003 Apr;58(4):299-305.
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35 Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food Chem Toxicol. 2018 Apr;114:227-236.
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41 Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res. 2005 Jan 15;65(2):516-25.
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44 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
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48 The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
49 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
50 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
51 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
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66 Bisphenol-A exposure induced neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Environ Int. 2019 Jun;127:324-332.
67 Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways. Environ Toxicol. 2015 Jan;30(1):74-82.
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71 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
72 Effects of the rare elements lanthanum and cerium on the growth of colorectal and hepatic cancer cell lines. Toxicol In Vitro. 2018 Feb;46:9-18.
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75 MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. Toxicol Lett. 2017 Aug 15;278:38-47.
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82 Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. Cancer Lett. 2009 Jul 18;280(1):93-100.
83 Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3550-4.
84 A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents. Toxicol In Vitro. 2011 Feb;25(1):222-30.
85 Effects of gold and silver nanoparticles in cultured human osteoarthritic chondrocytes. J Appl Toxicol. 2013 Dec;33(12):1506-13.

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