Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0097)
DME Name Quinone reductase 1 (NQO1), Homo sapiens DME Info
UniProt ID
NQO1_HUMAN
EC Number    EC: 1.6.5.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
NADH/NADPH oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.6.5.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Polyhexamethyleneguanidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00954   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Polyhexamethyleneguanidine inhibits the expression of DME NQO1 [1]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Diquat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00971   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Diquat induces the drug-metabolizing activity of DME NQO1 [2]
                              Monomethylarsonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00982   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Monomethylarsonic acid induces the drug-metabolizing activity of DME NQO1 [3]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:      17 Xenobiotics
                              1,6-hexamethylene diisocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01093   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 1,6-hexamethylene diisocyanate up-regulates the expression of DME NQO1 [4]
                              2-methyl-4-isothiazolin-3-one Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00890   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-methyl-4-isothiazolin-3-one up-regulates the expression of DME NQO1 [5]
                              Acrolein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01186   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrolein induces the drug-metabolizing activity of DME NQO1 [6]
                              Acrylamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01187   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylamide inhibits the expression of DME NQO1 [7]
                              Acrylonitrile Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00992   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylonitrile induces the drug-metabolizing activity of DME NQO1 [8]
                              Cacodylic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01231   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cacodylic acid up-regulates the expression of DME NQO1 and leads to increasing the drug-metabolizing activity of this enzyme [9]
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium induces the drug-metabolizing activity of DME NQO1 [2]
                              Catechol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01240   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Catechol up-regulates the expression of DME NQO1 [10]
                              Chloropicrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin up-regulates the expression of DME NQO1 [4], [11]
                              Cyanoginosin LR Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00965   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cyanoginosin LR induces the drug-metabolizing activity of DME NQO1 [12]
                              Cynaropicrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01269   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cynaropicrin up-regulates the expression of DME NQO1 [13]
                              Mercuric chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01508   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercuric chloride up-regulates the expression of DME NQO1 [14]
                              Ochratoxin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01407   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Ochratoxin A inhibits the drug-metabolizing activity of DME NQO1 [15]
                              Paraquat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat inhibits the expression of DME NQO1 [16]
                              Plumbagin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01435   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Plumbagin up-regulates the expression of DME NQO1 [17]
                              Sarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00779   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Sarin inhibits the expression of DME NQO1 [18]
                              Usnic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01497   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Usnic acid up-regulates the expression of DME NQO1 [19]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene induces the drug-metabolizing activity of DME NQO1 [20], [21]
                              Ethyl methanesulfonate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate up-regulates the expression of DME NQO1 [22]
                              Methylcholanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00899   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Methylcholanthrene induces the drug-metabolizing activity of DME NQO1 [23]
                              Polychlorinated biphenyls Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00776   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Polychlorinated biphenyls up-regulates the expression of DME NQO1 [17]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              2-tert-butylhydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01129   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation 2-tert-butylhydroquinone induces the drug-metabolizing activity of DME NQO1 [24]
                              Antimony potassium tartrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01201   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Antimony potassium tartrate induces the drug-metabolizing activity of DME NQO1 [25]
                              Demethoxycurcumin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01271   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Demethoxycurcumin induces the drug-metabolizing activity of DME NQO1 [26]
                              Diazinon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01274   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Diazinon up-regulates the expression of DME NQO1 [27]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME NQO1 [28]
                              Pterostilbene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01441   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Pterostilbene up-regulates the expression of DME NQO1 [29]
                              Sodium arsenate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01023   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Sodium arsenate up-regulates the expression of DME NQO1 [30]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              N-hexane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01016   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation N-hexane induces the drug-metabolizing activity of DME NQO1 [31]
                              Thiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00884   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Thiram up-regulates the expression of DME NQO1 [32]
                              1-methyl-4-phenylpyridinium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01103   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation 1-methyl-4-phenylpyridinium induces the drug-metabolizing activity of DME NQO1 [33]
                              3-morpholinopropyl isothiocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01142   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 3-morpholinopropyl isothiocyanate up-regulates the expression of DME NQO1 [20]
                              7-aminocephalosporanic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01173   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation 7-aminocephalosporanic acid up-regulates the expression of DME NQO1 [4]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME NQO1 [34]
                              Glycidamide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide up-regulates the expression of DME NQO1 [35]
                              Lead Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01505   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Lead up-regulates the expression of DME NQO1 [36]
                              Molybdenum trioxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01014   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Molybdenum trioxide up-regulates the expression of DME NQO1 [37], [38]
                              Pyruvaldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01448   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Pyruvaldehyde up-regulates the expression of DME NQO1 [39]
                              Toluene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01489   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Toluene up-regulates the expression of DME NQO1 [40]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Coal tar Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00755   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Coal tar up-regulates the expression of DME NQO1 [41], [42]
                              Dust Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01284   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Dust up-regulates the expression of DME NQO1 [43]
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter up-regulates the expression of DME NQO1 [44]
                              Polyphenols Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01578   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Polyphenols up-regulates the expression of DME NQO1 [17]
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution up-regulates the expression of DME NQO1 [45]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:      14 Xenobiotics
                              Cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde induces the drug-metabolizing activity of DME NQO1 [46]
                              Cyanidin 3-O-glucoside Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01535   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Cyanidin 3-O-glucoside up-regulates the expression of DME NQO1 [47], [48]
                              Daphnetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01536   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Daphnetin induces the drug-metabolizing activity of DME NQO1 [49]
                              Genipin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01545   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Genipin induces the drug-metabolizing activity of DME NQO1 [50]
                              Glucobrassicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01548   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Glucobrassicin inhibits the drug-metabolizing activity of DME NQO1 [51]
                              Guggulsterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01579   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Guggulsterone up-regulates the expression of DME NQO1 [52]
                              Hesperetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00856   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Hesperetin induces the drug-metabolizing activity of DME NQO1 [53]
                              Isoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01553   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Isoflavone up-regulates the expression of DME NQO1 [54], [55]
                              Ligustilide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01558   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Ligustilide up-regulates the expression of DME NQO1 [56]
                              Linalool Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01366   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Linalool up-regulates the expression of DME NQO1 [57]
                              Quinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01450   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Quinone up-regulates the expression of DME NQO1 [16]
                              Sanguinarine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00865   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Sanguinarine inhibits the expression of DME NQO1 [18]
                              Sesquiterpene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00814   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Sesquiterpene up-regulates the expression of DME NQO1 [58]
                              Taxifolin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01591   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Taxifolin induces the drug-metabolizing activity of DME NQO1 [59]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Angelicae sinensis extract Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00825   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Angelicae sinensis extract up-regulates the expression of DME NQO1 [60]
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts induces the drug-metabolizing activity of DME NQO1 [61]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      49 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the drug-metabolizing activity of DME NQO1 [62]
                              Adefovir dipivoxil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00745   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Adefovir dipivoxil inhibits the expression of DME NQO1 [63]
                              Amoxicillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00246   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amoxicillin up-regulates the expression of DME NQO1 [64]
                              Ampicillin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00096   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ampicillin up-regulates the expression of DME NQO1 [65]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME NQO1 [66]
                              Aspirin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00213   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Aspirin induces the drug-metabolizing activity of DME NQO1 [67]
                              Avobenzone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone up-regulates the expression of DME NQO1 [68]
                              Belinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00193   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Belinostat up-regulates the expression of DME NQO1 [44]
                              Bortezomib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00159   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bortezomib up-regulates the expression of DME NQO1 [69]
                              Bosentan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00148   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bosentan up-regulates the expression of DME NQO1 [70]
                              Capsaicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00178   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Capsaicin inhibits the drug-metabolizing activity of DME NQO1 [71]
                              Cidofovir Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00132   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cidofovir inhibits the expression of DME NQO1 [63]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin induces the drug-metabolizing activity of DME NQO1 [72]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME NQO1 [73], [74]
                              Daunorubicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00351   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Daunorubicin inhibits the drug-metabolizing activity of DME NQO1 [75]
                              Decitabine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00168   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Decitabine up-regulates the expression of DME NQO1 [76]
                              Deferoxamine mesylate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00286   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Deferoxamine mesylate inhibits the expression of DME NQO1 [77]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME NQO1 [78]
                              Diclofenac Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00352   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Diclofenac induces the drug-metabolizing activity of DME NQO1 [79]
                              Dicumarol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00203   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dicumarol inhibits the drug-metabolizing activity of DME NQO1 (IC50 = 0.0026 microM) [80]
                              Dimethyl fumarate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00172   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dimethyl fumarate induces the drug-metabolizing activity of DME NQO1 [81], [82]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME NQO1 [28]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride up-regulates the expression of DME NQO1 [83]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the drug-metabolizing activity of DME NQO1 [84]
                              Etoposide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00121   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Etoposide up-regulates the expression of DME NQO1 [85]
                              Ferric citrate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00135   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ferric citrate induces the drug-metabolizing activity of DME NQO1 [86]
                              Flurbiprofen sodium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00296   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flurbiprofen sodium induces the drug-metabolizing activity of DME NQO1 [79]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the drug-metabolizing activity of DME NQO1 [87]
                              Hydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone up-regulates the expression of DME NQO1 and leads to increasing the drug-metabolizing activity of this enzyme [88]
                              Ifosfamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide inhibits the expression of DME NQO1 [63]
                              Irinotecan hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00301   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Irinotecan hydrochloride inhibits the expression of DME NQO1 [89]
                              Isoniazid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00224   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Isoniazid up-regulates the expression of DME NQO1 [64]
                              Ivermectin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00244   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ivermectin inhibits the drug-metabolizing activity of DME NQO1 [75]
                              Ketoconazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole induces the drug-metabolizing activity of DME NQO1 [90]
                              Lapatinib ditosylate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00304   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lapatinib ditosylate up-regulates the expression of DME NQO1 [91]
                              Metformin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00365   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Metformin inhibits the drug-metabolizing activity of DME NQO1 [92]
                              Mifepristone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00127   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Mifepristone inhibits the drug-metabolizing activity of DME NQO1 [93]
                              Penicillin G Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00437   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Penicillin G up-regulates the expression of DME NQO1 [94]
                              Penicillin V Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00099   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Penicillin V up-regulates the expression of DME NQO1 [95]
                              Rosiglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone induces the drug-metabolizing activity of DME NQO1 [96], [97]
                              Simvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00125   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Simvastatin up-regulates the expression of DME NQO1 [98]
                              Sulindac Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00177   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulindac induces the drug-metabolizing activity of DME NQO1 [99]
                              Tretinoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin up-regulates the expression of DME NQO1 [100]
                              Urethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00435   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Urethane inhibits the expression of DME NQO1 [101]
                              Benzoic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid up-regulates the expression of DME NQO1 [28]
                              Clodronic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00465   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Clodronic acid inhibits the expression of DME NQO1 [63]
                              Daidzein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00439   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Daidzein inhibits the expression of DME NQO1 [102]
                              Hemin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01328   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Hemin induces the drug-metabolizing activity of DME NQO1 [103]
                              Linoleic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01367   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linoleic acid up-regulates the expression of DME NQO1 [104]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin induces the drug-metabolizing activity of DME NQO1 [105]
                              LY-353381 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00847   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation LY-353381 up-regulates the expression of DME NQO1 [106]
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the expression of DME NQO1 [107]
                              Sulforafan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01478   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Sulforafan induces the drug-metabolizing activity of DME NQO1 [108]
                              Vitamin E Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00547   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Vitamin E up-regulates the expression of DME NQO1 [109]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              Butyric acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01230   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Butyric acid induces the drug-metabolizing activity of DME NQO1 [21]
                              Phenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00558   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Phenol up-regulates the expression of DME NQO1 [110], [111]
                              Andrographolide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00543   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Andrographolide induces the drug-metabolizing activity of DME NQO1 [112]
                              Bisphenol A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A up-regulates the expression of DME NQO1 [113]
                              Chlorogenic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01246   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Chlorogenic acid up-regulates the expression of DME NQO1 [62]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the expression of DME NQO1 [114]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the expression of DME NQO1 [102]
                              MS-275 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00581   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MS-275 up-regulates the expression of DME NQO1 [44]
                              Phenethyl isothiocyanate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00596   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Phenethyl isothiocyanate up-regulates the expression of DME NQO1 [115]
                              Sulindac sulfide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00656   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Sulindac sulfide up-regulates the expression of DME NQO1 [116]
                              ZIO-101 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00673   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation ZIO-101 induces the drug-metabolizing activity of DME NQO1 [117]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME NQO1 [28]
                              Ellagic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01287   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Ellagic acid induces the drug-metabolizing activity of DME NQO1 [118]
                              Naringenin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00573   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Naringenin induces the drug-metabolizing activity of DME NQO1 [119]
                              Quercetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin induces the drug-metabolizing activity of DME NQO1 [120]
                              Sodium arsenite Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite induces the drug-metabolizing activity of DME NQO1 [121]
                              Thioctic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01483   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Thioctic acid induces the drug-metabolizing activity of DME NQO1 [122], [123]
                              Xanthohumol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00636   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Xanthohumol induces the drug-metabolizing activity of DME NQO1 [124]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 induces the drug-metabolizing activity of DME NQO1 [125]
                              Esculetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01291   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Esculetin up-regulates the expression of DME NQO1 and leads to increasing the drug-metabolizing activity of this enzyme [126]
                              Isoliquiritigenin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00710   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Isoliquiritigenin induces the drug-metabolizing activity of DME NQO1 [127]
                              Bay 11-7085 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01214   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Bay 11-7085 up-regulates the expression of DME NQO1 [128]
                              CP-673,451 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01262   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation CP-673,451 inhibits the expression of DME NQO1 [129]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol induces the drug-metabolizing activity of DME NQO1 [130]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              4'-bromoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01150   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 4'-bromoflavone induces the drug-metabolizing activity of DME NQO1 [131]
                              4-hydroxy-2-nonenal Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00869   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 4-hydroxy-2-nonenal induces the drug-metabolizing activity of DME NQO1 [132]
                              9,10-phenanthrenequinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00871   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 9,10-phenanthrenequinone induces the drug-metabolizing activity of DME NQO1 [132]
                              Aluminum maltolate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01193   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Aluminum maltolate inhibits the drug-metabolizing activity of DME NQO1 [133]
                              Beta-naphthoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthoflavone induces the drug-metabolizing activity of DME NQO1 [134]
                              ES-936 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01162   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation ES-936 inhibits the drug-metabolizing activity of DME NQO1 [135], [136]
                              GW9662 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01123   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation GW9662 up-regulates the expression of DME NQO1 [128]
                              Isopropanol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01128   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Isopropanol up-regulates the expression of DME NQO1 [28]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate up-regulates the expression of DME NQO1 and leads to increasing the drug-metabolizing activity of this enzyme [137]
                              Sirtinol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01471   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Sirtinol up-regulates the expression of DME NQO1 [138]
                              TIMBD Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01148   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation TIMBD induces the drug-metabolizing activity of DME NQO1 [139]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Gold Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01504   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Gold up-regulates the expression of DME NQO1 [140]
References
1 Ethanol extract of Hedyotis diffusa willd upregulates G0/G1 phase arrest and induces apoptosis in human leukemia cells by modulating caspase cascade signaling and altering associated genes expression was assayed by cDNA microarray. Environ Toxicol. 2015 Sep;30(10):1162-77.
2 Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity. Toxicol In Vitro. 2011 Apr;25(3):613-22.
3 Panax ginseng methabolit (GIM-1) prevents oxidative stress and apoptosis in human Sertoli cells exposed to Monobutyl-phthalate (MBP). Reprod Toxicol. 2019 Jun;86:68-75.
4 Gene expressions changes in bronchial epithelial cells: markers for respiratory sensitizers and exploration of the NRF2 pathway. Toxicol In Vitro. 2014 Mar;28(2):209-17.
5 The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
6 Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers. Chem Biol Interact. 2010 Feb 12;183(3):416-24.
7 Protective effect of carnosic acid against acrylamide-induced toxicity in RPE cells. Food Chem Toxicol. 2017 Oct;108(Pt B):543-553.
8 Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals. Drug Metab Dispos. 1997 Feb;25(2):175-81.
9 Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med. 2014 Feb;67:171-87.
10 Transcriptional regulation of the human NAD(P)H:quinone oxidoreductase (NQO1) gene by monofunctional inducers. Biochim Biophys Acta. 1996 Jun 3;1307(1):104-10.
11 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
12 Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. Chem Res Toxicol. 2010 Sep 20;23(9):1477-84.
13 Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway. Toxicol Lett. 2015 Apr 16;234(2):74-80.
14 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
15 Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3. Chem Biol Interact. 2019 Apr 1;302:101-107.
16 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
17 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013 Jun;72:69-82.
18 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
19 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
20 Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message. Toxicol Sci. 2010 Aug;116(2):549-61.
21 Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology. 2019 Jan 15;412:1-11.
22 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
23 Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro. Arch Toxicol. 2017 Apr;91(4):1815-1832.
24 The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017 Jul 15;387:17-26.
25 Parallel responses of human epidermal keratinocytes to inorganic SbIII and AsIII. Environ Chem. 2016;13(6):963-970.
26 Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. Pancreas. 2009 May;38(4):454-60.
27 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
28 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
29 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
30 RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells. Sci Rep. 2018 Apr 27;8(1):6668.
31 Cell-specific and dose-dependent effects of PAHs on proliferation, cell cycle, and apoptosis protein expression and hormone secretion by placental cell lines. Toxicol Lett. 2017 Oct 5;280:10-19.
32 Preparation of cardiovascular disease-related genes microarray and its application in exploring ligustrazine-induced changes in endothelial gene expression. Pol J Pharmacol. 2004 Jul-Aug;56(4):427-33.
33 Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death Dis. 2014 May 8;5:e1222.
34 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARgama/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
35 Expression profile of human cells in culture exposed to glycidamide, a reactive metabolite of the heat-induced food carcinogen acrylamide. Toxicology. 2007 Oct 30;240(1-2):111-24.
36 Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase. Toxicology. 2012 Jan 27;291(1-3):113-21.
37 Mitotane exhibits dual effects on steroidogenic enzymes gene transcription under basal and cAMP-stimulating microenvironments in NCI-H295 cells. Toxicology. 2012 Aug 16;298(1-3):14-23.
38 Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):281-9.
39 Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011 Jun 10;203(2):135-41.
40 Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures. Food Chem Toxicol. 2019 Mar;125:252-270.
41 Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest. 2013 Feb;123(2):917-27.
42 Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo. Br J Dermatol. 2006 Aug;155(2):275-81.
43 Differential response of Mono Mac 6, BEAS-2B, and Jurkat cells to indoor dust. Environ Health Perspect. 2007 Sep;115(9):1325-32.
44 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
45 Cytoprotective effect of alpha-lipoic acid on paraquat-exposed human bronchial epithelial cells via activation of nuclear factor erythroid related factor-2 pathway. Biol Pharm Bull. 2013;36(5):802-11.
46 Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. 2008 Aug 15;45(4):385-95.
47 Palmitate-induced endothelial dysfunction is attenuated by cyanidin-3-O-glucoside through modulation of Nrf2/Bach1 and NF-B pathways. Toxicol Lett. 2015 Dec 15;239(3):152-60.
48 Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-alpha and exerts protective effects via Nrf2 pathway activation. Toxicol Lett. 2016 Dec 15;264:51-58.
49 Daphnetin activates the Nrf2-dependent antioxidant response to prevent arsenic-induced oxidative insult in human lung epithelial cells. Chem Biol Interact. 2019 Apr 1;302:93-100.
50 Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17. J Neural Transm (Vienna). 2014 Jun;121(6):601-10.
51 Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. Biol Chem. 2010 Nov;391(11):1281-93.
52 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
53 Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact. 2019 Aug 1;308:269-278.
54 Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr. 2007 Apr;137(4):964-72.
55 Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells. J Nutr. 2006 Jan;136(1):75-82.
56 Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2. Food Chem Toxicol. 2018 Nov;121:631-638.
57 Editor's highlight: fragrance allergens linalool and limonene allylic hydroperoxides in skin allergy: Mechanisms of action focusing on transcription factor Nrf2. Toxicol Sci. 2018 Jan 1;161(1):139-148.
58 Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines. Lung Cancer. 2007 Jan;55(1):35-42.
59 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
60 Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. PLoS One. 2011 Mar 28;6(3):e18278.
61 Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar;35(3):419-27.
62 Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway. Toxicol Sci. 2018 Mar 1;162(1):99-112.
63 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
64 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
65 Evaluation of the sensitizing potential of antibiotics in vitro using the human cell lines THP-1 and MUTZ-LC and primary monocyte-derived dendritic cells. Toxicol Appl Pharmacol. 2012 Aug 1;262(3):283-92.
66 miR-155/BACH1 signaling pathway in human lung adenocarcinoma cell death induced by arsenic trioxide. Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Nov;48(6):828-833.
67 Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chem Res Toxicol. 2012 Dec 17;25(12):2725-36.
68 A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019 Jul;93(7):1903-1915.
69 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
70 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
71 Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target. Antioxid Redox Signal. 2007 Dec;9(12):2087-98.
72 Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity. Toxicol Lett. 2016 Jan 22;243:22-30.
73 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
74 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
75 High-throughput library screening identifies two novel NQO1 inducers in human lung cells. Am J Respir Cell Mol Biol. 2012 Mar;46(3):365-71.
76 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
77 Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol. 2003 Dec;64(6):1485-93.
78 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
79 Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism. Arch Toxicol. 1995;69(10):684-9.
80 Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56.
81 Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
82 Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one, in cellular and in vivo models of pulmonary oxidative stress. J Pharmacol Exp Ther. 2017 Oct;363(1):114-125.
83 RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
84 Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
85 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
86 Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells. Toxicol Lett. 2018 Oct 1;295:179-186.
87 Hydrogen peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity. Toxicol Lett. 2014 Aug 4;228(3):179-91.
88 A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8150-5.
89 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
90 Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect. J Invest Dermatol. 2012 Jan;132(1):59-68.
91 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
92 Does mercury promote lipid peroxidation? An in vitro study concerning mercury, copper, and iron in peroxidation of low-density lipoprotein. Biol Trace Elem Res. 2004 Nov;101(2):117-32.
93 Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics. 2007 Jan;7(1):47-63.
94 Induction of proinflammatory cytokines and C-reactive protein in human macrophage cell line U937 exposed to air pollution particulates. Environ Health Perspect. 2005 Nov;113(11):1536-41.
95 Alteration of peripheral blood monocyte gene expression in humans following diesel exhaust inhalation. Inhal Toxicol. 2012 Feb;24(3):172-81.
96 Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver. Drug Metab Dispos. 2012 Mar;40(3):474-80.
97 Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes. Pharm Res. 2005 Jan;22(1):71-8.
98 Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015 Mar 1;24(5):1374-89.
99 CYP3A5 mRNA degradation by nonsense-mediated mRNA decay. Mol Pharmacol. 2005 Sep;68(3):808-15.
100 Comparison of cellular and transcriptomic effects between electronic cigarette vapor and cigarette smoke in human bronchial epithelial cells. Toxicol In Vitro. 2017 Dec;45(Pt 3):417-425.
101 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
102 Phytoestrogens modulate the expression of 17alpha-estradiol metabolizing enzymes in cultured MCF-7 cells. Adv Exp Med Biol. 2008;617:625-32.
103 The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth. Toxicol Appl Pharmacol. 2019 Jul 1;374:77-85.
104 10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress. Toxicol Appl Pharmacol. 2016 Apr 1;296:1-9.
105 Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):726-35.
106 Prediction of aryl hydrocarbon receptor-mediated enzyme induction of drugs and chemicals by mRNA quantification. Chem Res Toxicol. 1998 Dec;11(12):1447-52.
107 Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells. Toxicology. 2016 Mar 28;350-352:1-14.
108 Profiling of bisphenol S towards nuclear receptors activities in human reporter cell lines. Toxicol Lett. 2017 Nov 5;281:10-19.
109 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
110 Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci. 2010 Aug;116(2):422-32.
111 Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica. 2004 Jul;34(7):619-32.
112 Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway. Toxicology. 2018 Mar 1;396-397:1-12.
113 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
114 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
115 Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes. Toxicology. 2013 Jun 7;308:129-37.
116 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142.
117 The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells. Leukemia. 2013 Nov;27(11):2220-8.
118 Antioxidant action of ellagic acid ameliorates paraquat-induced A549 cytotoxicity. Biol Pharm Bull. 2013;36(4):609-15.
119 Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases. Chem Biol Interact. 2013 Feb 25;202(1-3):195-203.
120 Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes. Biometals. 2010 Apr;23(2):339-54.
121 Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):309-17.
122 Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation. Chem Biol Interact. 2010 Mar 30;184(3):413-22.
123 Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFB p65 signal pathway. Toxicol In Vitro. 2015 Oct;29(7):1766-78.
124 Role of neprilysin in airway inflammation induced by diesel exhaust emissions. Res Rep Health Eff Inst. 2011 Jun;(159):3-40.
125 Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. J Immunol. 2014 May 15;192(10):4913-4920.
126 Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):130-6.
127 Induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) by Glycyrrhiza species used for women's health: differential effects of the michael acceptors isoliquiritigenin and licochalcone A. Chem Res Toxicol. 2015 Nov 16;28(11):2130-41.
128 Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening. J Biol Chem. 2012 Sep 21;287(39):33001-13.
129 Inhibition of PDGFR by CP-673451 induces apoptosis and increases cisplatin cytotoxicity in NSCLC cells via inhibiting the Nrf2-mediated defense mechanism. Toxicol Lett. 2018 Oct 1;295:88-98.
130 Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase. FEBS Lett. 2007 Feb 20;581(4):749-56.
131 Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Mol Cancer Ther. 2007 Sep;6(9):2418-28.
132 Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chem Biol Interact. 2018 Jan 5;279:10-20.
133 Aluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53. PLoS One. 2014 May 30;9(5):e98409.
134 Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes. Food Chem Toxicol. 2013 Jan;51:202-9.
135 Dicoumarol relieves serum withdrawal-induced G0/1 blockade in HL-60 cells through a superoxide-dependent mechanism. Biochem Pharmacol. 2005 Jun 1;69(11):1613-25.
136 Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells. J Pharmacol Exp Ther. 2011 Mar;336(3):874-80.
137 Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58.
138 Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. Chem Biol Interact. 2013 Jun 25;204(1):28-38.
139 Antioxidant activities of novel resveratrol analogs in breast cancer. J Biochem Mol Toxicol. 2018 Jan;32(1).
140 Gold nanoparticles induce serum amyloid A 1-Toll-like receptor 2 mediated NF-kB signaling in lung cells in vitro. Chem Biol Interact. 2018 Jun 1;289:81-89.

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