Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0023)
DME Name Cytochrome P450 1B1 (CYP1B1), Homo sapiens DME Info
UniProt ID
CP1B1_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Prochloraz Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00955   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Prochloraz induces the drug-metabolizing activity of DME CYP1B1 [1]
                              Triadimefon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00958   XEOTIC Info Gene Form mRNA
                                 Classification Fungicide
                                 DME Modulation Triadimefon up-regulates the expression of DME CYP1B1 [2]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Diuron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00973   XEOTIC Info Gene Form mRNA
                                 Classification Herbicide
                                 DME Modulation Diuron up-regulates the expression of DME CYP1B1 [3]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01119   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine induces the drug-metabolizing activity of DME CYP1B1 [4]
                              Chloropicrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01247   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chloropicrin up-regulates the expression of DME CYP1B1 [5]
                              Chlorpyrifos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos up-regulates the expression of DME CYP1B1 [6]
                              Cycloheximide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01268   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cycloheximide up-regulates the expression of DME CYP1B1 [7]
                              Fatostatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01299   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Fatostatin inhibits the expression of DME CYP1B1 [8]
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME CYP1B1 [9]
                              Kaempferol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01353   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Kaempferol inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.047 microM) [10]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form mRNA
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin up-regulates the expression of DME CYP1B1 [11]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              1-nitropyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00893   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation 1-nitropyrene up-regulates the expression of DME CYP1B1 [12]
                              Benz(a)anthracenes Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00897   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Benz(a)anthracenes up-regulates the expression of DME CYP1B1 [13]
                              Benzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene induces the drug-metabolizing activity of DME CYP1B1 [14]
                              Benzo(c)phenanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00784   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(c)phenanthrene induces the drug-metabolizing activity of DME CYP1B1 [15]
                              Methylcholanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00899   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Methylcholanthrene up-regulates the expression of DME CYP1B1 [16]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              6-nitrochrysene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00794   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation 6-nitrochrysene up-regulates the expression of DME CYP1B1 [13]
                              Dichlorodiphenyl dichloroethylene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00768   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Dichlorodiphenyl dichloroethylene up-regulates the expression of DME CYP1B1 [17]
                              NCX-4040 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01394   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation NCX-4040 inhibits the drug-metabolizing activity of DME CYP1B1 [18]
                              Polychlorinated dibenzodioxin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00917   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Polychlorinated dibenzodioxin up-regulates the expression of DME CYP1B1 [19], [20]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              6-nitrobenzo(a)pyrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00913   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation 6-nitrobenzo(a)pyrene up-regulates the expression of DME CYP1B1 [13]
                              Butylbenzyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00998   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Butylbenzyl phthalate induces the drug-metabolizing activity of DME CYP1B1 [21]
                              Dibutyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01275   XEOTIC Info Gene Form Protein
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Dibutyl phthalate up-regulates the expression of DME CYP1B1 and leads to increasing the drug-metabolizing activity of this enzyme [17]
                              Dichloromethane Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03181   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Dichloromethane inhibits the drug-metabolizing activity of DME CYP1B1 [22]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate up-regulates the expression of DME CYP1B1 and leads to increasing the drug-metabolizing activity of this enzyme [17]
                              Ethyl benzene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01007   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Ethyl benzene inhibits the expression of DME CYP1B1 [23]
                              Glycidamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01009   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Glycidamide inhibits the expression of DME CYP1B1 [24]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form mRNA
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol inhibits the expression of DME CYP1B1 [25]
                              Fumonisin B1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00812   XEOTIC Info Gene Form Protein
                                 Classification Mycotoxin
                                 DME Modulation Fumonisin B1 induces the drug-metabolizing activity of DME CYP1B1 [26]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Coal tar Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00755   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Coal tar induces the drug-metabolizing activity of DME CYP1B1 [27]
                              Dietary carbohydrates Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00907   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Dietary carbohydrates up-regulates the expression of DME CYP1B1 [28]
                              Dust Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01284   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Dust inhibits the drug-metabolizing activity of DME CYP1B1 [29]
                              Particulate matter Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter inhibits the drug-metabolizing activity of DME CYP1B1 [30]
                              Tobacco smoke pollution Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution up-regulates the expression of DME CYP1B1 [31]
                              Vitallium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01511   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Vitallium up-regulates the expression of DME CYP1B1 [32]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:      32 Xenobiotics
                              5-hydroxyflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01161   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 5-hydroxyflavone inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.21 microM) [33]
                              7-hydroxyflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01176   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation 7-hydroxyflavone inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.25 microM) [33]
                              Acacetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01184   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Acacetin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.007 microM) [34]
                              Alizarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00993   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Alizarin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 0.5 microM) [33]
                              Aloe-emodin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01191   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Aloe-emodin inhibits the drug-metabolizing activity of DME CYP1B1 [35]
                              Alpha-naphthoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01192   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Alpha-naphthof DMElavone inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.0013 microM) [36]
                              Amentoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01195   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Amentof DMElavone inhibits the drug-metabolizing activity of DME CYP1B1 [37]
                              Apigenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01203   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Apigenin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.025 microM) [10]
                              Baicalein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01212   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Baicalein inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 0.26 microM) [38]
                              BDE-99 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00925   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation BDE-99 up-regulates the expression of DME CYP1B1 [39]
                              Bergamottin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01527   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Bergamottin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 587 microM) [33]
                              Biochanin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01222   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Biochanin A up-regulates the expression of DME CYP1B1 [40]
                              Chrysin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00878   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Chrysin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.024 microM) [10]
                              Chrysophanic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01528   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Chrysophanic acid inhibits the drug-metabolizing activity of DME CYP1B1 [35]
                              Diosmetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01281   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Diosmetin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.029 microM) [10]
                              Eupatorin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01541   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Eupatorin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 0.035 microM) [33], [38]
                              Flavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01304   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Flavone inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.6 microM) [33]
                              Galangin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01308   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Galangin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.003 microM) [33]
                              Imperatorin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01340   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Imperatorin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 1 microM) [33]
                              Indolo(3,2-B)carbazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01343   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Indolo(3,2-B)carbazole up-regulates the expression of DME CYP1B1 [41], [42]
                              Isoimperatorin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01554   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Isoimperatorin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 6 microM) [33]
                              Isopimpinellin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01555   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Isopimpinellin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 11 microM) [33]
                              Naringin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01391   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Naringin inhibits the drug-metabolizing activity of DME CYP1B1 [43]
                              Nobiletin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01566   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Nobiletin induces the drug-metabolizing activity of DME CYP1B1 [44]
                              Polycyclic aromatic hydrocarbon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00827   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Polycyclic aromatic hydrocarbon induces the drug-metabolizing activity of DME CYP1B1 [45], [46]
                              Pyrrolizidine alkaloid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01582   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Pyrrolizidine alkaloid up-regulates the expression of DME CYP1B1 [47]
                              Quercitrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01449   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Quercitrin inhibits the expression of DME CYP1B1 [48]
                              Sanguinarine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00865   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Sanguinarine induces the drug-metabolizing activity of DME CYP1B1 [49]
                              Scutellarein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01470   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Scutellarein inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 0.22 microM) [38]
                              Senecionine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01585   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Senecionine up-regulates the expression of DME CYP1B1 [50]
                              Steviol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00810   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Steviol up-regulates the expression of DME CYP1B1 [51]
                              Thapsigargin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00809   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Thapsigargin up-regulates the expression of DME CYP1B1 [48]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Grape seed proanthocyanidins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00758   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Grape seed proanthocyanidins inhibits the expression of DME CYP1B1 [52]
                              Plant extracts Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Plant extracts inhibits the drug-metabolizing activity of DME CYP1B1 [53], [54]
                  Traditional Medicine Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Jinfukang Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00760   XEOTIC Info Gene Form mRNA
                                 Classification Traditional Medicine
                                 DME Modulation Jinfukang up-regulates the expression of DME CYP1B1 [55]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      42 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME CYP1B1 [56]
                              Adefovir dipivoxil Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00745   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Adefovir dipivoxil up-regulates the expression of DME CYP1B1 [57]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME CYP1B1 [58]
                              Avobenzone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00411   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Avobenzone inhibits the expression of DME CYP1B1 [59]
                              Azacitidine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00102   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azacitidine up-regulates the expression of DME CYP1B1 [60], [61]
                              Belinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00193   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Belinostat up-regulates the expression of DME CYP1B1 [62]
                              Cidofovir Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00132   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cidofovir up-regulates the expression of DME CYP1B1 [57]
                              Cisplatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin up-regulates the expression of DME CYP1B1 [57], [63]
                              Copper sulfate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate up-regulates the expression of DME CYP1B1 [64], [65]
                              Cyclophosphamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00018   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclophosphamide inhibits the expression of DME CYP1B1 [66]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CYP1B1 [57]
                              Dasatinib Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00181   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dasatinib up-regulates the expression of DME CYP1B1 [67]
                              Dinoprostone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00260   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dinoprostone induces the drug-metabolizing activity of DME CYP1B1 [68]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride inhibits the expression of DME CYP1B1 [69]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 > 50 microM) [70]
                              Estrone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00091   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estrone inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 > 50 microM) [70]
                              Fulvestrant Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00147   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fulvestrant up-regulates the expression of DME CYP1B1 [40]
                              Hydrogen peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide up-regulates the expression of DME CYP1B1 [71]
                              Hydroquinone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00430   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydroquinone up-regulates the expression of DME CYP1B1 [72], [73]
                              Ifosfamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00046   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ifosfamide inhibits the expression of DME CYP1B1 [57]
                              Ketoconazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00251   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ketoconazole inhibits the drug-metabolizing activity of DME CYP1B1 [74]
                              Lansoprazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00052   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lansoprazole up-regulates the expression of DME CYP1B1 [75]
                              Leflunomide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide up-regulates the expression of DME CYP1B1 [76]
                              Menadione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00428   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menadione up-regulates the expression of DME CYP1B1 [77]
                              Metformin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00365   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Metformin inhibits the drug-metabolizing activity of DME CYP1B1 [78]
                              Omeprazole Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00069   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Omeprazole up-regulates the expression of DME CYP1B1 [79]
                              Panobinostat Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00372   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Panobinostat induces the drug-metabolizing activity of DME CYP1B1 [80]
                              Primaquine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00258   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Primaquine up-regulates the expression of DME CYP1B1 [81]
                              Progesterone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00094   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Progesterone inhibits the expression of DME CYP1B1 [82]
                              Rosiglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00380   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Rosiglitazone up-regulates the expression of DME CYP1B1 [83]
                              Sulindac Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00177   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulindac up-regulates the expression of DME CYP1B1 [84]
                              Tamoxifen Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00383   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tamoxifen up-regulates the expression of DME CYP1B1 [85]
                              Tretinoin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00253   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tretinoin induces the drug-metabolizing activity of DME CYP1B1 [86]
                              Troglitazone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00086   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Troglitazone up-regulates the expression of DME CYP1B1 [87]
                              Vorinostat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00079   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Vorinostat inhibits the expression of DME CYP1B1 [88], [62]
                              Biotin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01223   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Biotin up-regulates the expression of DME CYP1B1 and leads to increasing the drug-metabolizing activity of this enzyme [89]
                              Clodronic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00465   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Clodronic acid up-regulates the expression of DME CYP1B1 [57]
                              Daidzein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00439   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Daidzein inhibits the drug-metabolizing activity of DME CYP1B1 [90]
                              Diethyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01033   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Diethyl phthalate up-regulates the expression of DME CYP1B1 and leads to increasing the drug-metabolizing activity of this enzyme [17]
                              Formononetin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01306   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Formononetin up-regulates the expression of DME CYP1B1 [40]
                              Melatonin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00505   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Melatonin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 14 microM) [33]
                              Stevioside Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00448   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Stevioside induces the drug-metabolizing activity of DME CYP1B1 [91]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Afimoxifene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00610   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Afimoxifene inhibits the drug-metabolizing activity of DME CYP1B1 [92]
                              Curcumin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin inhibits the expression of DME CYP1B1 [93]
                              FK-435 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00640   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation FK-435 inhibits the drug-metabolizing activity of DME CYP1B1 [92]
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 55 microM) [94]
                              Triclosan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan induces the drug-metabolizing activity of DME CYP1B1 [95]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Isoquercitrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00644   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Isoquercitrin inhibits the drug-metabolizing activity of DME CYP1B1 [37]
                              Aminoflavone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00685   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Aminoflavone induces the drug-metabolizing activity of DME CYP1B1 [96]
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME CYP1B1 [97]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the drug-metabolizing activity of DME CYP1B1 [98]
                              MeIQx Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00609   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation MeIQx up-regulates the expression of DME CYP1B1 [4], [99]
                              Stemregenin 1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00677   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Stemregenin 1 inhibits the drug-metabolizing activity of DME CYP1B1 [100]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:      10 Xenobiotics
                              Dihydrotestosterone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00536   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dihydrotestosterone up-regulates the expression of DME CYP1B1 [101]
                              Epsilon-viniferin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00646   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Epsilon-viniferin inhibits the drug-metabolizing activity of DME CYP1B1 [102]
                              Fingolimod hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00554   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Fingolimod hydrochloride inhibits the expression of DME CYP1B1 [103]
                              Flavanone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00738   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Flavanone inhibits the drug-metabolizing activity of DME CYP1B1 [98]
                              Licochalcone A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01365   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Licochalcone A inhibits the expression of DME CYP1B1 [104]
                              Luteolin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00537   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Luteolin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.079 microM) [10]
                              Naringenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00573   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Naringenin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 3.656 microM) [10]
                              NSC 703786 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01107   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation NSC 703786 up-regulates the expression of DME CYP1B1 [105], [106]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.077 microM) [10], [107]
                              Sodium arsenite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite inhibits the drug-metabolizing activity of DME CYP1B1 [108]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Emodin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00692   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Emodin inhibits the drug-metabolizing activity of DME CYP1B1 [35]
                              Gardiquimod Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00722   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Gardiquimod inhibits the expression of DME CYP1B1 [109]
                              Isoliquiritigenin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00710   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Isoliquiritigenin up-regulates the expression of DME CYP1B1 [104]
                              Myricetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01384   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Myricetin inhibits the drug-metabolizing activity of DME CYP1B1 (Ki = 0.027 microM) [33], [38]
                              DMU-212 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01283   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation DMU-212 inhibits the drug-metabolizing activity of DME CYP1B1 [110]
                              Eugenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol inhibits the drug-metabolizing activity of DME CYP1B1 [111]
                              NSC-674495 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01400   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation NSC-674495 up-regulates the expression of DME CYP1B1 [73]
                              STO-609 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01476   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation STO-609 up-regulates the expression of DME CYP1B1 [51]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:      13 Xenobiotics
                              2'-hydroxychalcone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01126   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 2'-hydroxychalcone inhibits the drug-metabolizing activity of DME CYP1B1 [112]
                              2-ethynylnaphthalene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01125   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 2-ethynylnaphthalene inhibits the drug-metabolizing activity of DME CYP1B1 [113]
                              4-hydroxy-2-nonenal Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00869   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation 4-hydroxy-2-nonenal inhibits the expression of DME CYP1B1 [114]
                              6,7-dihydroxyflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01167   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 6,7-dihydroxyflavone inhibits the drug-metabolizing activity of DME CYP1B1 [98]
                              Benzyl selenocyanate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01218   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Benzyl selenocyanate inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.13 microM) [33]
                              Beta-naphthoflavone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01220   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Beta-naphthof DMElavone inhibits the drug-metabolizing activity of DME CYP1B1 [113], [98]
                              Butylparaben Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00930   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Butylparaben up-regulates the expression of DME CYP1B1 [115]
                              CL075 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01256   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation CL075 up-regulates the expression of DME CYP1B1 [116]
                              Coumestrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01261   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Coumestrol up-regulates the expression of DME CYP1B1 [117]
                              Ethyl isopropylamiloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01293   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Ethyl isopropylamiloride inhibits the drug-metabolizing activity of DME CYP1B1 [118]
                              G-1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01086   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation G-1 up-regulates the expression of DME CYP1B1 [119]
                              Phenylmercuric acetate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00818   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Phenylmercuric acetate up-regulates the expression of DME CYP1B1 [120]
                              Pifithrin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01431   XEOTIC Info Gene Form mRNA
                                 Classification Investigative Agent
                                 DME Modulation Pifithrin up-regulates the expression of DME CYP1B1 [62]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Naphthalene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00764   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Naphthalene inhibits the drug-metabolizing activity of DME CYP1B1 [121]
                              Pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00797   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Pyrene inhibits the drug-metabolizing activity of DME CYP1B1 (IC50 = 0.002 microM) [33]
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45 Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3ells by activation of oxidative stress and mitochondrial apoptosis. Chem Biol Interact. 2017 Sep 25;275:210-217.
46 Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process. J Hypertens. 2007 Mar;25(3):541-9.
47 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
48 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
49 PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
50 Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues. Toxicol Lett. 2005 Jul 28;158(1):50-60.
51 Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. Am J Clin Nutr. 2008 Jan;87(1):181-9.
52 Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. Mol Carcinog. 2010 May;49(5):450-63.
53 Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2. Mol Pharmacol. 2007 Mar;71(3):787-98.
54 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
55 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
56 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
57 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
58 Modulation of cellular response to arsenic trioxide toxicity by resveratrol. ACS Omega. 2018 May 31;3(5):5511-5515.
59 A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019 Jul;93(7):1903-1915.
60 Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. Toxicol Lett. 2003 Sep 30;144(2):247-56.
61 Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro. Arch Toxicol. 2017 Apr;91(4):1815-1832.
62 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
63 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
64 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
65 Copper induces the expression of cholesterogenic genes in human macrophages. Atherosclerosis. 2003 Jul;169(1):71-6.
66 Effect of cyclophosphamide on gene expression of cytochromes p450 and beta-actin in the HL-60 cell line. Eur J Pharmacol. 2002 Aug 9;449(3):197-205.
67 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
68 Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. Toxicol Sci. 2010 Apr;114(2):204-16.
69 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
70 Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5272-5276.
71 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
72 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
73 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
74 Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. Drug Metab Dispos. 2004 Jan;32(1):105-12.
75 Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics. Xenobiotica. 2003 Feb;33(2):107-18.
76 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
77 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
78 The human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) is irreversibly inhibited by inorganic (Hg2+) and organic mercury (CH3Hg+): mechanism and kinetics. FEBS Lett. 2010 Aug 4;584(15):3366-9.
79 Potential endocrine disrupting effect of ochratoxin A on human placental 3beta-hydroxysteroid dehydrogenase/isomerase in JEG-3 cells at levels relevant to human exposure. Reprod Toxicol. 2013 Jul;38:47-52.
80 Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling. Radiat Oncol. 2013 Mar 4;8:46.
81 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
82 Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
83 Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes. Toxicol Lett. 2015 Oct 1;238(1):43-53.
84 Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. Cancer Prev Res (Phila). 2013 Sep;6(9):886-97.
85 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
86 Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells. J Toxicol Sci. 2016 Feb;41(1):77-89.
87 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
88 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
89 Biotin supplementation increases expression of the cytochrome P450 1B1 gene in Jurkat cells, increasing the occurrence of single-stranded DNA breaks. J Nutr. 2004 Sep;134(9):2222-8.
90 Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover). J Agric Food Chem. 2004 Oct 20;52(21):6623-32.
91 Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation. Neurotoxicology. 2011 Mar;32(2):180-7.
92 Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites. Xenobiotica. 2002 Oct;32(10):863-78.
93 Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. J Pharm Pharmacol. 2007 Jun;59(6):857-62.
94 Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3243-3247.
95 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
96 Estrogen receptor alpha and aryl hydrocarbon receptor independent growth inhibitory effects of aminoflavone in breast cancer cells. BMC Cancer. 2014 May 20;14:344.
97 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
98 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20;23(12):1921-35.
99 Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
100 Sodium nitrite-induced oxidative stress causes membrane damage, protein oxidation, lipid peroxidation and alters major metabolic pathways in human erythrocytes. Toxicol In Vitro. 2015 Oct;29(7):1878-86.
101 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
102 Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 2003 Jul 18;73(9):1199-213.
103 Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells. Toxicol Lett. 2018 Jul;291:77-85.
104 Differential effects of Glycyrrhiza species on genotoxic estrogen metabolism: licochalcone A downregulates P450 1B1, whereas isoliquiritigenin stimulates it. Chem Res Toxicol. 2015 Aug 17;28(8):1584-94.
105 Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2(12):1265-72.
106 Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells. Drug Metab Dispos. 2004 Dec;32(12):1392-401.
107 Quinazoline derivatives as selective CYP1B1 inhibitors. Eur J Med Chem. 2017 Apr 21;130:320-327.
108 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
109 Selective IRAK4 inhibition attenuates disease in murine lupus models and demonstrates steroid sparing activity. J Immunol. 2017 Feb 1;198(3):1308-1319.
110 Resveratrol analogue 3,4,4',5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV-3 and A-2780 cancer cells. Toxicol Appl Pharmacol. 2012 Aug 15;263(1):53-60.
111 Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase. FEBS Lett. 2007 Feb 20;581(4):749-56.
112 Hydroxychalcones exhibit differential effects on XRE transactivation. Toxicology. 2005 Feb 14;207(2):303-13.
113 Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res Toxicol. 2009 Jul;22(7):1325-33.
114 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
115 Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells. Toxicol In Vitro. 2013 Aug;27(5):1467-75.
116 Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells. Arch Toxicol. 2017 May;91(5):2209-2221.
117 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
118 Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives. Biochem Pharmacol. 2004 May 1;67(9):1711-9.
119 G protein-coupled receptor 30 ligand G-1 increases aryl hydrocarbon receptor signalling by inhibition of tubulin assembly and cell cycle arrest in human MCF-7 cells. Arch Toxicol. 2016 Aug;90(8):1939-48.
120 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
121 Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36.

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