Interactions between Xenobiotics and DME (XEOTIC)
|
Fungicide(s), Herbicide(s) or Insecticide(s) |
Fungicide |
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|
2,4,5-trichlorophenol |
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Inhibition |
XEOTIC ID |
XEO00937
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Fungicide |
DME Modulation |
2,4,5-trichlorophenol inhibits the drug-metabolizing activity of DME CAT |
[1] |
Mancozeb |
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Inhibition |
XEOTIC ID |
XEO00953
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Fungicide |
DME Modulation |
Mancozeb inhibits the drug-metabolizing activity of DME CAT |
[2] |
Herbicide |
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|
Amitrole |
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Inhibition |
XEOTIC ID |
XEO00968
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Herbicide |
DME Modulation |
Amitrole inhibits the drug-metabolizing activity of DME CAT |
[3] |
Atrazine |
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Induction |
XEOTIC ID |
XEO00969
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Herbicide |
DME Modulation |
Atrazine induces the drug-metabolizing activity of DME CAT |
[4] |
Pesticide/Insecticide |
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|
Bifenthrin |
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Inhibition |
XEOTIC ID |
XEO01040
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Pesticide/Insecticide |
DME Modulation |
Bifenthrin inhibits the drug-metabolizing activity of DME CAT |
[5] |
Cyfluthrin |
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Inhibition |
XEOTIC ID |
XEO01045
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Pesticide/Insecticide |
DME Modulation |
Cyfluthrin inhibits the drug-metabolizing activity of DME CAT |
[6] |
Cypermethrin |
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Inhibition |
XEOTIC ID |
XEO01046
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Pesticide/Insecticide |
DME Modulation |
Cypermethrin inhibits the drug-metabolizing activity of DME CAT |
[7] |
Dimethoate |
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Induction |
XEOTIC ID |
XEO01073
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Pesticide/Insecticide |
DME Modulation |
Dimethoate induces the drug-metabolizing activity of DME CAT |
[8] |
Trichlorfon |
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Induction |
XEOTIC ID |
XEO01072
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Pesticide/Insecticide |
DME Modulation |
Trichlorfon up-regulates the expression of DME CAT |
[9] |
Health or Environmental Toxicant(s) |
Acute Toxic Substance |
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|
Acrylamide |
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Inhibition |
XEOTIC ID |
XEO01187
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Acute Toxic Substance |
DME Modulation |
Acrylamide inhibits the drug-metabolizing activity of DME CAT |
[10] |
Cadmium |
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Inhibition |
XEOTIC ID |
XEO01503
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Acute Toxic Substance |
DME Modulation |
Cadmium inhibits the drug-metabolizing activity of DME CAT |
[11] |
Chlorpyrifos |
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Induction |
XEOTIC ID |
XEO01248
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Acute Toxic Substance |
DME Modulation |
Chlorpyrifos induces the drug-metabolizing activity of DME CAT |
[12], [13] |
Cordycepin |
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Inhibition |
XEOTIC ID |
XEO01259
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Cordycepin inhibits the expression of DME CAT |
[14] |
Cyanoginosin LR |
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Inhibition |
XEOTIC ID |
XEO00965
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Acute Toxic Substance |
DME Modulation |
Cyanoginosin LR inhibits the drug-metabolizing activity of DME CAT |
[15] |
Mercuric chloride |
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Inhibition |
XEOTIC ID |
XEO01508
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Mercuric chloride inhibits the expression of DME CAT |
[16] |
Ochratoxin A |
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Induction |
XEOTIC ID |
XEO01407
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Ochratoxin A up-regulates the expression of DME CAT |
[17] |
Paraquat |
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Inhibition |
XEOTIC ID |
XEO01422
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Paraquat inhibits the expression of DME CAT |
[18], [19] |
Trinitrotoluene |
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Induction |
XEOTIC ID |
XEO01029
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Acute Toxic Substance |
DME Modulation |
Trinitrotoluene up-regulates the expression of DME CAT |
[20] |
Biotoxin |
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|
Cylindrospermopsin |
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Inhibition |
XEOTIC ID |
XEO00905
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Cyanotoxin |
DME Modulation |
Cylindrospermopsin inhibits the drug-metabolizing activity of DME CAT |
[21] |
Carcinogen |
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|
Benzo(a)pyrene |
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Inhibition |
XEOTIC ID |
XEO00898
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Carcinogen |
DME Modulation |
Benzo(a)pyrene inhibits the drug-metabolizing activity of DME CAT |
[22] |
Aflatoxin B1 |
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Inhibition |
XEOTIC ID |
XEO00806
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Carcinogen-mycotoxin |
DME Modulation |
Aflatoxin B1 inhibits the expression of DME CAT |
[23] |
Environmental Pollutant |
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|
Bisphenol F |
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Inhibition |
XEOTIC ID |
XEO00997
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Environmental Pollutant |
DME Modulation |
Bisphenol F inhibits the drug-metabolizing activity of DME CAT |
[24] |
Dichlorodiphenyl dichloroethylene |
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Inhibition |
XEOTIC ID |
XEO00768
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Environmental Pollutant |
DME Modulation |
Dichlorodiphenyl dichloroethylene inhibits the drug-metabolizing activity of DME CAT |
[25] |
Glyphosate |
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Induction |
XEOTIC ID |
XEO01320
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Environmental Pollutant |
DME Modulation |
Glyphosate induces the drug-metabolizing activity of DME CAT |
[26] |
Hexyl cinnamic aldehyde |
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Induction |
XEOTIC ID |
XEO00985
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Environmental Pollutant |
DME Modulation |
Hexyl cinnamic aldehyde up-regulates the expression of DME CAT |
[27] |
Pterostilbene |
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Induction |
XEOTIC ID |
XEO01441
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Environmental Pollutant |
DME Modulation |
Pterostilbene up-regulates the expression of DME CAT |
[28] |
Zinc |
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Inhibition |
XEOTIC ID |
XEO01512
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Environmental Pollutant |
DME Modulation |
Zinc inhibits the expression of DME CAT |
[29] |
Health Hazard/Toxicant |
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|
Perfluorooctane sulfonic acid |
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Induction |
XEOTIC ID |
XEO00921
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health and Environmental Toxicant |
DME Modulation |
Perfluorooctane sulfonic acid up-regulates the expression of DME CAT |
[30] |
Tetrachloroethylene |
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Inhibition |
XEOTIC ID |
XEO01026
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health and Environmental Toxicant |
DME Modulation |
Tetrachloroethylene inhibits the expression of DME CAT |
[31], [32] |
Acetaldehyde |
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Inhibition |
XEOTIC ID |
XEO00872
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Health Hazard |
DME Modulation |
Acetaldehyde inhibits the drug-metabolizing activity of DME CAT |
[33] |
Chloric acid |
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Inhibition |
XEOTIC ID |
XEO01001
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Health Hazard |
DME Modulation |
Chloric acid inhibits the drug-metabolizing activity of DME CAT |
[34] |
Diethylhexyl phthalate |
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Induction |
XEOTIC ID |
XEO01004
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Health Hazard |
DME Modulation |
Diethylhexyl phthalate induces the drug-metabolizing activity of DME CAT |
[35] |
Molybdenum trioxide |
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Inhibition |
XEOTIC ID |
XEO01014
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Molybdenum trioxide inhibits the expression of DME CAT |
[36] |
Pirinixic acid |
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Inhibition |
XEOTIC ID |
XEO01433
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Health Hazard |
DME Modulation |
Pirinixic acid inhibits the drug-metabolizing activity of DME CAT |
[2] |
Pyrogallol |
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Inhibition |
XEOTIC ID |
XEO01446
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Pyrogallol inhibits the expression of DME CAT |
[37] |
Styrene |
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Inhibition |
XEOTIC ID |
XEO01025
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Styrene inhibits the expression of DME CAT |
[38] |
Toluene |
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Inhibition |
XEOTIC ID |
XEO01489
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Toluene inhibits the expression of DME CAT |
[39] |
Zymosan |
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Induction |
XEOTIC ID |
XEO01501
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Health Hazard |
DME Modulation |
Zymosan up-regulates the expression of DME CAT |
[40] |
Mycotoxin |
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|
Deoxynivalenol |
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Induction |
XEOTIC ID |
XEO01514
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Mycotoxin |
DME Modulation |
Deoxynivalenol induces the drug-metabolizing activity of DME CAT |
[41] |
Natural Product(s), Extract(s) or Medicine(s) |
Natural Mixture |
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|
Agrochemicals |
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Induction |
XEOTIC ID |
XEO00888
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Mixture |
DME Modulation |
Agrochemicals induces the drug-metabolizing activity of DME CAT |
[26] |
Amphibole asbestos |
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Inhibition |
XEOTIC ID |
XEO00995
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Mixture |
DME Modulation |
Amphibole asbestos inhibits the drug-metabolizing activity of DME CAT |
[42] |
Dust |
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Inhibition |
XEOTIC ID |
XEO01284
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Mixture |
DME Modulation |
Dust inhibits the expression of DME CAT |
[43] |
Particulate matter |
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Inhibition |
XEOTIC ID |
XEO00919
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Mixture |
DME Modulation |
Particulate matter inhibits the expression of DME CAT |
[16] |
Tobacco smoke pollution |
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Inhibition |
XEOTIC ID |
XEO00821
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Mixture |
DME Modulation |
Tobacco smoke pollution inhibits the expression of DME CAT |
[44] |
Water pollutants chemical |
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Induction |
XEOTIC ID |
XEO00924
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Mixture |
DME Modulation |
Water pollutants chemical induces the drug-metabolizing activity of DME CAT |
[45] |
Natural Product |
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|
Apigenin |
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Inhibition |
XEOTIC ID |
XEO01203
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Product |
DME Modulation |
Apigenin inhibits the expression of DME CAT |
[46] |
Bilirubin |
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Inhibition |
XEOTIC ID |
XEO00877
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Product |
DME Modulation |
Bilirubin inhibits the expression of DME CAT |
[47] |
Dihydrocapsaicin |
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Induction |
XEOTIC ID |
XEO00802
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Product |
DME Modulation |
Dihydrocapsaicin induces the drug-metabolizing activity of DME CAT |
[48] |
Excavatolide B |
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Inhibition |
XEOTIC ID |
XEO01297
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Product |
DME Modulation |
Excavatolide B inhibits the drug-metabolizing activity of DME CAT |
[49] |
Ginsenoside |
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Inhibition |
XEOTIC ID |
XEO01547
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Product |
DME Modulation |
Ginsenoside inhibits the drug-metabolizing activity of DME CAT |
[50] |
Hesperetin |
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Inhibition |
XEOTIC ID |
XEO00856
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Natural Product |
DME Modulation |
Hesperetin inhibits the drug-metabolizing activity of DME CAT |
[51] |
Mangiferin |
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Induction |
XEOTIC ID |
XEO01370
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Natural Product |
DME Modulation |
Mangiferin up-regulates the expression of DME CAT |
[52] |
Plant Extract |
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|
Grape seed proanthocyanidins |
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Inhibition |
XEOTIC ID |
XEO00758
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Plant Extract |
DME Modulation |
Grape seed proanthocyanidins inhibits the expression of DME CAT |
[53] |
Plant extracts |
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Induction |
XEOTIC ID |
XEO01574
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Plant Extract |
DME Modulation |
Plant extracts up-regulates the expression of DME CAT |
[54] |
Tea extracts |
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Induction |
XEOTIC ID |
XEO01592
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Plant Extract |
DME Modulation |
Tea extracts induces the drug-metabolizing activity of DME CAT |
[55] |
Pharmaceutical Agent(s) |
Approved/Marketed Drug |
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|
Acetaminophen |
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Inhibition |
XEOTIC ID |
XEO00217
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Acetaminophen inhibits the expression of DME CAT |
[56] |
Acetylcysteine |
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Inhibition |
XEOTIC ID |
XEO00110
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Acetylcysteine inhibits the drug-metabolizing activity of DME CAT |
[57] |
Amikacin |
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Inhibition |
XEOTIC ID |
XEO00122
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Amikacin inhibits the drug-metabolizing activity of DME CAT |
[58] |
Amitriptyline |
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Inhibition |
XEOTIC ID |
XEO00337
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Amitriptyline inhibits the drug-metabolizing activity of DME CAT |
[59] |
Amphetamine |
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Inhibition |
XEOTIC ID |
XEO00023
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Amphetamine inhibits the drug-metabolizing activity of DME CAT |
[60] |
Arsenic trioxide |
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Inhibition |
XEOTIC ID |
XEO00339
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Arsenic trioxide inhibits the drug-metabolizing activity of DME CAT |
[61] |
Atorvastatin |
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Induction |
XEOTIC ID |
XEO00340
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Atorvastatin induces the drug-metabolizing activity of DME CAT |
[62] |
Beclomethasone dipropionate |
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Induction |
XEOTIC ID |
XEO00278
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Beclomethasone dipropionate induces the drug-metabolizing activity of DME CAT |
[63] |
Benzoyl peroxide |
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Induction |
XEOTIC ID |
XEO00389
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Benzoyl peroxide induces the drug-metabolizing activity of DME CAT |
[64] |
Bleomycin |
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Induction |
XEOTIC ID |
XEO00341
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Bleomycin induces the drug-metabolizing activity of DME CAT |
[65] |
Bosentan |
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Inhibition |
XEOTIC ID |
XEO00148
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Bosentan inhibits the expression of DME CAT |
[66] |
Celecoxib |
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Inhibition |
XEOTIC ID |
XEO00013
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Celecoxib inhibits the drug-metabolizing activity of DME CAT |
[67] |
Chloramphenicol |
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Induction |
XEOTIC ID |
XEO00220
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Chloramphenicol induces the drug-metabolizing activity of DME CAT |
[68] |
Chlorpromazine hydrochloride |
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Inhibition |
XEOTIC ID |
XEO00280
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Chlorpromazine hydrochloride inhibits the drug-metabolizing activity of DME CAT |
[69] |
Chlortetracycline |
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Inhibition |
XEOTIC ID |
XEO00201
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Chlortetracycline inhibits the drug-metabolizing activity of DME CAT |
[70] |
Cisplatin |
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Inhibition |
XEOTIC ID |
XEO00334
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Cisplatin inhibits the drug-metabolizing activity of DME CAT |
[71] |
Citalopram hydrobromide |
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Inhibition |
XEOTIC ID |
XEO00283
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Citalopram hydrobromide inhibits the drug-metabolizing activity of DME CAT |
[72] |
Clomipramine hydrochloride |
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Inhibition |
XEOTIC ID |
XEO00285
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Clomipramine hydrochloride inhibits the drug-metabolizing activity of DME CAT |
[59] |
Copper |
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Induction |
XEOTIC ID |
XEO00834
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Copper induces the drug-metabolizing activity of DME CAT |
[73] |
Copper sulfate |
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Inhibition |
XEOTIC ID |
XEO00117
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Copper sulfate inhibits the expression of DME CAT |
[74] |
Cyclosporine |
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Inhibition |
XEOTIC ID |
XEO00241
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Cyclosporine inhibits the expression of DME CAT |
[75] |
Dexamethasone |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00088
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Dexamethasone up-regulates the expression of DME CAT |
[76] |
Disulfiram |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00028
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Disulfiram up-regulates the expression of DME CAT |
[27] |
Doxorubicin hydrochloride |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00292
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Doxorubicin hydrochloride induces the drug-metabolizing activity of DME CAT |
[65] |
Dronabinol |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00115
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Dronabinol inhibits the expression of DME CAT |
[77] |
Etoposide |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00121
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Etoposide induces the drug-metabolizing activity of DME CAT |
[78] |
Fluvastatin |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00359
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Fluvastatin induces the drug-metabolizing activity of DME CAT |
[79] |
Gallium nitrate |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00136
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Gallium nitrate inhibits the expression of DME CAT |
[80] |
Heparin sodium |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00299
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Heparin sodium induces the drug-metabolizing activity of DME CAT |
[81] |
Hydrogen peroxide |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00388
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Hydrogen peroxide inhibits the drug-metabolizing activity of DME CAT |
[82] |
Leflunomide |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00053
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Leflunomide inhibits the expression of DME CAT |
[83] |
Lindane |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00740
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Lindane induces the drug-metabolizing activity of DME CAT |
[84] |
Malathion |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00056
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Malathion up-regulates the expression of DME CAT |
[85] |
Metformin |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00365
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Metformin inhibits the expression of DME CAT |
[86] |
Methimazole |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00176
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Methimazole inhibits the drug-metabolizing activity of DME CAT |
[87] |
Methotrexate |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00366
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Methotrexate up-regulates the expression of DME CAT |
[88] |
Oxaliplatin |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00207
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Oxaliplatin inhibits the expression of DME CAT |
[89] |
Oxytetracycline |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00202
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Oxytetracycline inhibits the expression of DME CAT |
[90] |
Phenobarbital |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00410
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Approved by US FDA |
DME Modulation |
Phenobarbital inhibits the drug-metabolizing activity of DME CAT |
[91], [92] |
Pravastatin |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00377
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Pravastatin up-regulates the expression of DME CAT |
[93] |
Propofol |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00075
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Propofol inhibits the expression of DME CAT |
[94] |
Pyridostigmine bromide |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00100
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Pyridostigmine bromide up-regulates the expression of DME CAT |
[95], [37] |
Raloxifene hydrochloride |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00126
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Raloxifene hydrochloride up-regulates the expression of DME CAT |
[31] |
Sodium nitrite |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00397
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Sodium nitrite inhibits the expression of DME CAT |
[96] |
Titanium dioxide |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00425
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Approved by US FDA |
DME Modulation |
Titanium dioxide inhibits the expression of DME CAT |
[97] |
Benzoic acid |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00447
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Benzoic acid inhibits the drug-metabolizing activity of DME CAT |
[98] |
Catechin |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO01239
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Catechin induces the drug-metabolizing activity of DME CAT |
[99] |
Citric acid |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01255
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Citric acid inhibits the drug-metabolizing activity of DME CAT |
[98] |
Dihydroartemisinin |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00454
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Dihydroartemisinin induces the drug-metabolizing activity of DME CAT |
[100] |
Linoleic acid |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO01367
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Linoleic acid induces the drug-metabolizing activity of DME CAT |
[101] |
Linsidomine |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01368
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Linsidomine inhibits the drug-metabolizing activity of DME CAT |
[102] |
Rotenone |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00481
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Rotenone induces the drug-metabolizing activity of DME CAT |
[103] |
Zinc chloride |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00444
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug Marketed but not Approved by US FDA |
DME Modulation |
Zinc chloride up-regulates the expression of DME CAT |
[29] |
Drug in Phase 3 Clinical Trial |
Click to Show/Hide the Full List of Xenobiotics: 3 Xenobiotics
|
Arsenic disulfide |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00994
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 3 |
DME Modulation |
Arsenic disulfide induces the drug-metabolizing activity of DME CAT |
[104] |
Epigallocatechin gallate |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00613
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 3 |
DME Modulation |
Epigallocatechin gallate induces the drug-metabolizing activity of DME CAT |
[99] |
Resveratrol |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00568
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 3 |
DME Modulation |
Resveratrol up-regulates the expression of DME CAT |
[105] |
Drug in Phase 2 Clinical Trial |
Click to Show/Hide the Full List of Xenobiotics: 7 Xenobiotics
|
Dehydroascorbic acid |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO01270
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 2/3 |
DME Modulation |
Dehydroascorbic acid induces the drug-metabolizing activity of DME CAT |
[106] |
Artesunate |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00540
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
Artesunate induces the drug-metabolizing activity of DME CAT |
[107], [108] |
Bisphenol A |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01226
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
Bisphenol A inhibits the drug-metabolizing activity of DME CAT |
[24] |
Ditiocarb |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00591
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
Ditiocarb inhibits the expression of DME CAT |
[109] |
Ethanol |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00539
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
Ethanol inhibits the drug-metabolizing activity of DME CAT |
[110] |
Genistein |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00557
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
Genistein induces the drug-metabolizing activity of DME CAT |
[111] |
Pimagedine |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00577
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 2 |
DME Modulation |
Pimagedine inhibits the expression of DME CAT |
[16] |
Drug in Phase 1 Clinical Trial |
Click to Show/Hide the Full List of Xenobiotics: 11 Xenobiotics
|
Piperine |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00635
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1/2 |
DME Modulation |
Piperine inhibits the drug-metabolizing activity of DME CAT |
[112] |
Adenosine triphosphate |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00535
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Adenosine triphosphate up-regulates the expression of DME CAT |
[113] |
Aica ribonucleotide |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO01190
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Aica ribonucleotide induces the drug-metabolizing activity of DME CAT |
[114] |
Dinitrochlorobenzene |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00571
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Dinitrochlorobenzene up-regulates the expression of DME CAT |
[27] |
Ferric oxide |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01008
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Ferric oxide inhibits the drug-metabolizing activity of DME CAT |
[115] |
Hexylresorcinol |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01329
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Hexylresorcinol inhibits the drug-metabolizing activity of DME CAT |
[116] |
Homocysteine |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01331
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Homocysteine inhibits the drug-metabolizing activity of DME CAT |
[117] |
Phenanthrene |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00574
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Phenanthrene up-regulates the expression of DME CAT |
[118] |
Quercetin |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00538
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Quercetin inhibits the drug-metabolizing activity of DME CAT |
[119] |
Sodium arsenite |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00632
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Sodium arsenite inhibits the drug-metabolizing activity of DME CAT |
[120], [121] |
Thioctic acid |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO01483
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Highest Clinical Status: Phase 1 |
DME Modulation |
Thioctic acid up-regulates the expression of DME CAT and leads to increasing the drug-metabolizing activity of this enzyme |
[122], [123] |
Preclinical/Patented Drug |
Click to Show/Hide the Full List of Xenobiotics: 8 Xenobiotics
|
Kolaviron |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO01358
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug in Preclinical Study |
DME Modulation |
Kolaviron induces the drug-metabolizing activity of DME CAT |
[4] |
Oleic acid |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01412
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug in Preclinical Study |
DME Modulation |
Oleic acid inhibits the expression of DME CAT |
[124] |
Tetramethylpyrazine |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00697
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Drug in Preclinical Study |
DME Modulation |
Tetramethylpyrazine up-regulates the expression of DME CAT |
[125] |
Trimidox |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00724
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug in Preclinical Study |
DME Modulation |
Trimidox induces the drug-metabolizing activity of DME CAT |
[126] |
Anethole trithione |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00729
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
Anethole trithione induces the drug-metabolizing activity of DME CAT |
[127] |
Eugenol |
Click to Show/Hide the Detail |
Induction |
XEOTIC ID |
XEO00885
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
Eugenol up-regulates the expression of DME CAT |
[27] |
ICG-001 |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01336
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
ICG-001 inhibits the expression of DME CAT |
[128] |
K-7174 |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01348
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Patented Pharmaceutical Agent |
DME Modulation |
K-7174 inhibits the expression of DME CAT |
[129] |
Drug Marketed but Withdrawn from Market |
Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
|
Oxalic acid |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO01417
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Drug Marketed but Withdrawn from Market |
DME Modulation |
Oxalic acid inhibits the drug-metabolizing activity of DME CAT |
[130] |
Investigative Agent |
Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
|
Aprindine |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00828
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Investigative Agent |
DME Modulation |
Aprindine inhibits the drug-metabolizing activity of DME CAT |
[59] |
Chlorite |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00807
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Investigative Agent |
DME Modulation |
Chlorite inhibits the drug-metabolizing activity of DME CAT |
[131] |
Other Chemical Compound(s) or Element(s) |
Chemical Compound |
Click to Show/Hide the Full List of Xenobiotics: 3 Xenobiotics
|
1,10-phenanthroline |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00766
XEOTIC Info
|
Gene Form |
mRNA |
Classification |
Chemical Compound |
DME Modulation |
1,10-phenanthroline inhibits the expression of DME CAT |
[132] |
Aluminum |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00839
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Chemical Compound |
DME Modulation |
Aluminum inhibits the drug-metabolizing activity of DME CAT |
[133] |
Cupric oxide |
Click to Show/Hide the Detail |
Inhibition |
XEOTIC ID |
XEO00840
XEOTIC Info
|
Gene Form |
Protein |
Classification |
Chemical Compound |
DME Modulation |
Cupric oxide inhibits the drug-metabolizing activity of DME CAT |
[115] |
|
|
|
|
|
|