Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0090)
DME Name Catalase (CAT), Homo sapiens DME Info
UniProt ID
CATA_HUMAN
EC Number    EC: 1.11.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2,4,5-trichlorophenol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00937   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation 2,4,5-trichlorophenol inhibits the drug-metabolizing activity of DME CAT [1]
                              Mancozeb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00953   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Mancozeb inhibits the drug-metabolizing activity of DME CAT [2]
                  Herbicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Amitrole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00968   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Amitrole inhibits the drug-metabolizing activity of DME CAT [3]
                              Atrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00969   XEOTIC Info Gene Form Protein
                                 Classification Herbicide
                                 DME Modulation Atrazine induces the drug-metabolizing activity of DME CAT [4]
                  Pesticide/Insecticide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Bifenthrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01040   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Bifenthrin inhibits the drug-metabolizing activity of DME CAT [5]
                              Cyfluthrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01045   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cyfluthrin inhibits the drug-metabolizing activity of DME CAT [6]
                              Cypermethrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01046   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Cypermethrin inhibits the drug-metabolizing activity of DME CAT [7]
                              Dimethoate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01073   XEOTIC Info Gene Form Protein
                                 Classification Pesticide/Insecticide
                                 DME Modulation Dimethoate induces the drug-metabolizing activity of DME CAT [8]
                              Trichlorfon Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01072   XEOTIC Info Gene Form mRNA
                                 Classification Pesticide/Insecticide
                                 DME Modulation Trichlorfon up-regulates the expression of DME CAT [9]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Acrylamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01187   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Acrylamide inhibits the drug-metabolizing activity of DME CAT [10]
                              Cadmium Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium inhibits the drug-metabolizing activity of DME CAT [11]
                              Chlorpyrifos Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01248   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Chlorpyrifos induces the drug-metabolizing activity of DME CAT [12], [13]
                              Cordycepin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01259   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cordycepin inhibits the expression of DME CAT [14]
                              Cyanoginosin LR Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00965   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Cyanoginosin LR inhibits the drug-metabolizing activity of DME CAT [15]
                              Mercuric chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01508   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Mercuric chloride inhibits the expression of DME CAT [16]
                              Ochratoxin A Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01407   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Ochratoxin A up-regulates the expression of DME CAT [17]
                              Paraquat Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01422   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Paraquat inhibits the expression of DME CAT [18], [19]
                              Trinitrotoluene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01029   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Trinitrotoluene up-regulates the expression of DME CAT [20]
                  Biotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Cylindrospermopsin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00905   XEOTIC Info Gene Form Protein
                                 Classification Cyanotoxin
                                 DME Modulation Cylindrospermopsin inhibits the drug-metabolizing activity of DME CAT [21]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Benzo(a)pyrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00898   XEOTIC Info Gene Form Protein
                                 Classification Carcinogen
                                 DME Modulation Benzo(a)pyrene inhibits the drug-metabolizing activity of DME CAT [22]
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME CAT [23]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Bisphenol F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00997   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Bisphenol F inhibits the drug-metabolizing activity of DME CAT [24]
                              Dichlorodiphenyl dichloroethylene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00768   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Dichlorodiphenyl dichloroethylene inhibits the drug-metabolizing activity of DME CAT [25]
                              Glyphosate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01320   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Glyphosate induces the drug-metabolizing activity of DME CAT [26]
                              Hexyl cinnamic aldehyde Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00985   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Hexyl cinnamic aldehyde up-regulates the expression of DME CAT [27]
                              Pterostilbene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01441   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Pterostilbene up-regulates the expression of DME CAT [28]
                              Zinc Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01512   XEOTIC Info Gene Form mRNA
                                 Classification Environmental Pollutant
                                 DME Modulation Zinc inhibits the expression of DME CAT [29]
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              Perfluorooctane sulfonic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00921   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Perfluorooctane sulfonic acid up-regulates the expression of DME CAT [30]
                              Tetrachloroethylene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01026   XEOTIC Info Gene Form mRNA
                                 Classification Health and Environmental Toxicant
                                 DME Modulation Tetrachloroethylene inhibits the expression of DME CAT [31], [32]
                              Acetaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00872   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Acetaldehyde inhibits the drug-metabolizing activity of DME CAT [33]
                              Chloric acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01001   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Chloric acid inhibits the drug-metabolizing activity of DME CAT [34]
                              Diethylhexyl phthalate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01004   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Diethylhexyl phthalate induces the drug-metabolizing activity of DME CAT [35]
                              Molybdenum trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01014   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Molybdenum trioxide inhibits the expression of DME CAT [36]
                              Pirinixic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01433   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Pirinixic acid inhibits the drug-metabolizing activity of DME CAT [2]
                              Pyrogallol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01446   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Pyrogallol inhibits the expression of DME CAT [37]
                              Styrene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01025   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Styrene inhibits the expression of DME CAT [38]
                              Toluene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01489   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Toluene inhibits the expression of DME CAT [39]
                              Zymosan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01501   XEOTIC Info Gene Form mRNA
                                 Classification Health Hazard
                                 DME Modulation Zymosan up-regulates the expression of DME CAT [40]
                  Mycotoxin Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Deoxynivalenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01514   XEOTIC Info Gene Form Protein
                                 Classification Mycotoxin
                                 DME Modulation Deoxynivalenol induces the drug-metabolizing activity of DME CAT [41]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Agrochemicals Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00888   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Agrochemicals induces the drug-metabolizing activity of DME CAT [26]
                              Amphibole asbestos Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00995   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Amphibole asbestos inhibits the drug-metabolizing activity of DME CAT [42]
                              Dust Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01284   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Dust inhibits the expression of DME CAT [43]
                              Particulate matter Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter inhibits the expression of DME CAT [16]
                              Tobacco smoke pollution Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution inhibits the expression of DME CAT [44]
                              Water pollutants chemical Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00924   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Water pollutants chemical induces the drug-metabolizing activity of DME CAT [45]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Apigenin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01203   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Apigenin inhibits the expression of DME CAT [46]
                              Bilirubin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00877   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Bilirubin inhibits the expression of DME CAT [47]
                              Dihydrocapsaicin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00802   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Dihydrocapsaicin induces the drug-metabolizing activity of DME CAT [48]
                              Excavatolide B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01297   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Excavatolide B inhibits the drug-metabolizing activity of DME CAT [49]
                              Ginsenoside Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01547   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Ginsenoside inhibits the drug-metabolizing activity of DME CAT [50]
                              Hesperetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00856   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Hesperetin inhibits the drug-metabolizing activity of DME CAT [51]
                              Mangiferin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01370   XEOTIC Info Gene Form mRNA
                                 Classification Natural Product
                                 DME Modulation Mangiferin up-regulates the expression of DME CAT [52]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Grape seed proanthocyanidins Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00758   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Grape seed proanthocyanidins inhibits the expression of DME CAT [53]
                              Plant extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01574   XEOTIC Info Gene Form mRNA
                                 Classification Plant Extract
                                 DME Modulation Plant extracts up-regulates the expression of DME CAT [54]
                              Tea extracts Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01592   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Tea extracts induces the drug-metabolizing activity of DME CAT [55]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:      53 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME CAT [56]
                              Acetylcysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00110   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetylcysteine inhibits the drug-metabolizing activity of DME CAT [57]
                              Amikacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00122   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amikacin inhibits the drug-metabolizing activity of DME CAT [58]
                              Amitriptyline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00337   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amitriptyline inhibits the drug-metabolizing activity of DME CAT [59]
                              Amphetamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00023   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amphetamine inhibits the drug-metabolizing activity of DME CAT [60]
                              Arsenic trioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00339   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Arsenic trioxide inhibits the drug-metabolizing activity of DME CAT [61]
                              Atorvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00340   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Atorvastatin induces the drug-metabolizing activity of DME CAT [62]
                              Beclomethasone dipropionate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00278   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Beclomethasone dipropionate induces the drug-metabolizing activity of DME CAT [63]
                              Benzoyl peroxide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00389   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Benzoyl peroxide induces the drug-metabolizing activity of DME CAT [64]
                              Bleomycin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00341   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bleomycin induces the drug-metabolizing activity of DME CAT [65]
                              Bosentan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00148   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Bosentan inhibits the expression of DME CAT [66]
                              Celecoxib Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00013   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Celecoxib inhibits the drug-metabolizing activity of DME CAT [67]
                              Chloramphenicol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00220   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chloramphenicol induces the drug-metabolizing activity of DME CAT [68]
                              Chlorpromazine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00280   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlorpromazine hydrochloride inhibits the drug-metabolizing activity of DME CAT [69]
                              Chlortetracycline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00201   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chlortetracycline inhibits the drug-metabolizing activity of DME CAT [70]
                              Cisplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00334   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cisplatin inhibits the drug-metabolizing activity of DME CAT [71]
                              Citalopram hydrobromide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00283   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Citalopram hydrobromide inhibits the drug-metabolizing activity of DME CAT [72]
                              Clomipramine hydrochloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00285   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clomipramine hydrochloride inhibits the drug-metabolizing activity of DME CAT [59]
                              Copper Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00834   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper induces the drug-metabolizing activity of DME CAT [73]
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the expression of DME CAT [74]
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME CAT [75]
                              Dexamethasone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00088   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dexamethasone up-regulates the expression of DME CAT [76]
                              Disulfiram Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00028   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Disulfiram up-regulates the expression of DME CAT [27]
                              Doxorubicin hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00292   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Doxorubicin hydrochloride induces the drug-metabolizing activity of DME CAT [65]
                              Dronabinol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00115   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dronabinol inhibits the expression of DME CAT [77]
                              Etoposide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00121   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Etoposide induces the drug-metabolizing activity of DME CAT [78]
                              Fluvastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00359   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Fluvastatin induces the drug-metabolizing activity of DME CAT [79]
                              Gallium nitrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00136   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Gallium nitrate inhibits the expression of DME CAT [80]
                              Heparin sodium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00299   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Heparin sodium induces the drug-metabolizing activity of DME CAT [81]
                              Hydrogen peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00388   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Hydrogen peroxide inhibits the drug-metabolizing activity of DME CAT [82]
                              Leflunomide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00053   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Leflunomide inhibits the expression of DME CAT [83]
                              Lindane Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00740   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Lindane induces the drug-metabolizing activity of DME CAT [84]
                              Malathion Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00056   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Malathion up-regulates the expression of DME CAT [85]
                              Metformin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00365   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Metformin inhibits the expression of DME CAT [86]
                              Methimazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00176   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methimazole inhibits the drug-metabolizing activity of DME CAT [87]
                              Methotrexate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00366   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Methotrexate up-regulates the expression of DME CAT [88]
                              Oxaliplatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00207   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxaliplatin inhibits the expression of DME CAT [89]
                              Oxytetracycline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00202   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxytetracycline inhibits the expression of DME CAT [90]
                              Phenobarbital Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00410   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenobarbital inhibits the drug-metabolizing activity of DME CAT [91], [92]
                              Pravastatin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00377   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pravastatin up-regulates the expression of DME CAT [93]
                              Propofol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00075   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Propofol inhibits the expression of DME CAT [94]
                              Pyridostigmine bromide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00100   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Pyridostigmine bromide up-regulates the expression of DME CAT [95], [37]
                              Raloxifene hydrochloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00126   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Raloxifene hydrochloride up-regulates the expression of DME CAT [31]
                              Sodium nitrite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00397   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sodium nitrite inhibits the expression of DME CAT [96]
                              Titanium dioxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00425   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Titanium dioxide inhibits the expression of DME CAT [97]
                              Benzoic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00447   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Benzoic acid inhibits the drug-metabolizing activity of DME CAT [98]
                              Catechin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01239   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Catechin induces the drug-metabolizing activity of DME CAT [99]
                              Citric acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01255   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Citric acid inhibits the drug-metabolizing activity of DME CAT [98]
                              Dihydroartemisinin Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00454   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Dihydroartemisinin induces the drug-metabolizing activity of DME CAT [100]
                              Linoleic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01367   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linoleic acid induces the drug-metabolizing activity of DME CAT [101]
                              Linsidomine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01368   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Linsidomine inhibits the drug-metabolizing activity of DME CAT [102]
                              Rotenone Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00481   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Rotenone induces the drug-metabolizing activity of DME CAT [103]
                              Zinc chloride Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00444   XEOTIC Info Gene Form mRNA
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Zinc chloride up-regulates the expression of DME CAT [29]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Arsenic disulfide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00994   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Arsenic disulfide induces the drug-metabolizing activity of DME CAT [104]
                              Epigallocatechin gallate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate induces the drug-metabolizing activity of DME CAT [99]
                              Resveratrol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol up-regulates the expression of DME CAT [105]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Dehydroascorbic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01270   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2/3
                                 DME Modulation Dehydroascorbic acid induces the drug-metabolizing activity of DME CAT [106]
                              Artesunate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00540   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Artesunate induces the drug-metabolizing activity of DME CAT [107], [108]
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the drug-metabolizing activity of DME CAT [24]
                              Ditiocarb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00591   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ditiocarb inhibits the expression of DME CAT [109]
                              Ethanol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00539   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Ethanol inhibits the drug-metabolizing activity of DME CAT [110]
                              Genistein Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein induces the drug-metabolizing activity of DME CAT [111]
                              Pimagedine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00577   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Pimagedine inhibits the expression of DME CAT [16]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:      11 Xenobiotics
                              Piperine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00635   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1/2
                                 DME Modulation Piperine inhibits the drug-metabolizing activity of DME CAT [112]
                              Adenosine triphosphate Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00535   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Adenosine triphosphate up-regulates the expression of DME CAT [113]
                              Aica ribonucleotide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01190   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Aica ribonucleotide induces the drug-metabolizing activity of DME CAT [114]
                              Dinitrochlorobenzene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00571   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Dinitrochlorobenzene up-regulates the expression of DME CAT [27]
                              Ferric oxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01008   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Ferric oxide inhibits the drug-metabolizing activity of DME CAT [115]
                              Hexylresorcinol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01329   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Hexylresorcinol inhibits the drug-metabolizing activity of DME CAT [116]
                              Homocysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01331   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Homocysteine inhibits the drug-metabolizing activity of DME CAT [117]
                              Phenanthrene Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00574   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Phenanthrene up-regulates the expression of DME CAT [118]
                              Quercetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00538   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Quercetin inhibits the drug-metabolizing activity of DME CAT [119]
                              Sodium arsenite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00632   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Sodium arsenite inhibits the drug-metabolizing activity of DME CAT [120], [121]
                              Thioctic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01483   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Thioctic acid up-regulates the expression of DME CAT and leads to increasing the drug-metabolizing activity of this enzyme [122], [123]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Kolaviron Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01358   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Kolaviron induces the drug-metabolizing activity of DME CAT [4]
                              Oleic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01412   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Oleic acid inhibits the expression of DME CAT [124]
                              Tetramethylpyrazine Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00697   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation Tetramethylpyrazine up-regulates the expression of DME CAT [125]
                              Trimidox Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00724   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Trimidox induces the drug-metabolizing activity of DME CAT [126]
                              Anethole trithione Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00729   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Anethole trithione induces the drug-metabolizing activity of DME CAT [127]
                              Eugenol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00885   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Eugenol up-regulates the expression of DME CAT [27]
                              ICG-001 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01336   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation ICG-001 inhibits the expression of DME CAT [128]
                              K-7174 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01348   XEOTIC Info Gene Form mRNA
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation K-7174 inhibits the expression of DME CAT [129]
                  Drug Marketed but Withdrawn from Market Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Oxalic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01417   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but Withdrawn from Market
                                 DME Modulation Oxalic acid inhibits the drug-metabolizing activity of DME CAT [130]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Aprindine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00828   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Aprindine inhibits the drug-metabolizing activity of DME CAT [59]
                              Chlorite Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00807   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Chlorite inhibits the drug-metabolizing activity of DME CAT [131]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              1,10-phenanthroline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00766   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation 1,10-phenanthroline inhibits the expression of DME CAT [132]
                              Aluminum Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00839   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Aluminum inhibits the drug-metabolizing activity of DME CAT [133]
                              Cupric oxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00840   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Cupric oxide inhibits the drug-metabolizing activity of DME CAT [115]
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