Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0114)
DME Name	Prostaglandin G/H synthase 2 (COX-2), Homo sapiens	DME Info
UniProt ID	PGH2_HUMAN
EC Number	EC: 1.14.99.1 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Oxygen paired donor oxidoreductase EC: 1.14.99.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Fungicide(s), Herbicide(s) or Insecticide(s)
Fungicide		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Hexachlorobenzene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00951 XEOTIC Info		Gene Form	Protein
Classification	Fungicide
DME Modulation	Hexachlorobenzene induces the drug-metabolizing activity of DME PTGS2				[1]
Polyhexamethyleneguanidine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00954 XEOTIC Info		Gene Form	mRNA
Classification	Fungicide
DME Modulation	Polyhexamethyleneguanidine up-regulates the expression of DME PTGS2				[2]
Herbicide		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Diuron		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00973 XEOTIC Info		Gene Form	mRNA
Classification	Herbicide
DME Modulation	Diuron up-regulates the expression of DME PTGS2				[3]
Pesticide/Insecticide		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Boron compound		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00824 XEOTIC Info		Gene Form	mRNA
Classification	Pesticide/Insecticide
DME Modulation	Boron compound inhibits the expression of DME PTGS2				[4]
Dichlorodiphenyl dichloroethane		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01048 XEOTIC Info		Gene Form	Protein
Classification	Pesticide/Insecticide
DME Modulation	Dichlorodiphenyl dichloroethane induces the drug-metabolizing activity of DME PTGS2				[5]
Health or Environmental Toxicant(s)
Acute Toxic Substance		Click to Show/Hide the Full List of Xenobiotics: 19 Xenobiotics
1,4-naphthoquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01089 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	1,4-naphthoquinone up-regulates the expression of DME PTGS2				[6]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01119 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine induces the drug-metabolizing activity of DME PTGS2				[7]
2-methyl-4-isothiazolin-3-one		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00890 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	2-methyl-4-isothiazolin-3-one up-regulates the expression of DME PTGS2				[8]
5-(N,N-hexamethylene)amiloride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01157 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	5-(N,N-hexamethylene)amiloride up-regulates the expression of DME PTGS2				[9]
Acrolein		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01186 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Acrolein induces the drug-metabolizing activity of DME PTGS2				[10]
Antimycin A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01202 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Antimycin A induces the drug-metabolizing activity of DME PTGS2				[11]
Brucine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01228 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Brucine inhibits the drug-metabolizing activity of DME PTGS2				[12], [13]
Cadmium		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01503 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Cadmium induces the drug-metabolizing activity of DME PTGS2				[14]
Chloropicrin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01247 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Chloropicrin inhibits the expression of DME PTGS2				[15]
Chlorpyrifos		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01248 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Chlorpyrifos induces the drug-metabolizing activity of DME PTGS2				[16], [17]
Diacetyl		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00931 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Diacetyl inhibits the expression of DME PTGS2				[18]
Enniatins		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01289 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Enniatins inhibits the expression of DME PTGS2				[19]
Formaldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01305 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Formaldehyde up-regulates the expression of DME PTGS2				[20], [21]
Kaempferol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01353 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Kaempferol inhibits the drug-metabolizing activity of DME PTGS2 in Spodoptera frugiperda (Sf21) cell (IC50 > 100 microM)				[22]
Nickel chloride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01397 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Nickel chloride induces the drug-metabolizing activity of DME PTGS2				[23]
Ochratoxin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01407 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Ochratoxin A inhibits the drug-metabolizing activity of DME PTGS2				[24]
Okadaic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01409 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Okadaic acid up-regulates the expression of DME PTGS2				[25]
Paraquat		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01422 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Paraquat induces the drug-metabolizing activity of DME PTGS2				[26]
Pyranoprofen		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01444 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Pyranoprofen up-regulates the expression of DME PTGS2				[27]
Biotoxin		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Melitten		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00817 XEOTIC Info		Gene Form	mRNA
Classification	Biotoxin
DME Modulation	Melitten up-regulates the expression of DME PTGS2				[28]
Carcinogen		Click to Show/Hide the Full List of Xenobiotics: 3 Xenobiotics
Benzo(a)pyrene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00898 XEOTIC Info		Gene Form	Protein
Classification	Carcinogen
DME Modulation	Benzo(a)pyrene induces the drug-metabolizing activity of DME PTGS2				[29], [30]
Methylcholanthrene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00899 XEOTIC Info		Gene Form	Protein
Classification	Carcinogen
DME Modulation	Methylcholanthrene induces the drug-metabolizing activity of DME PTGS2				[31]
Aflatoxin B1		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00806 XEOTIC Info		Gene Form	Protein
Classification	Carcinogen-mycotoxin
DME Modulation	Aflatoxin B1 induces the drug-metabolizing activity of DME PTGS2				[32]
Environmental Pollutant		Click to Show/Hide the Full List of Xenobiotics: 5 Xenobiotics
Acenaphthenequinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01185 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	Acenaphthenequinone induces the drug-metabolizing activity of DME PTGS2				[33]
Dichlorodiphenyl dichloroethylene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00768 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	Dichlorodiphenyl dichloroethylene induces the drug-metabolizing activity of DME PTGS2				[5], [34]
Resorcinol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01453 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	Resorcinol inhibits the drug-metabolizing activity of DME PTGS2				[35]
Tetrabromobisphenol A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00926 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	Tetrabromobisphenol A up-regulates the expression of DME PTGS2				[36]
Zinc		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01512 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	Zinc up-regulates the expression of DME PTGS2				[37]
Health Hazard/Toxicant		Click to Show/Hide the Full List of Xenobiotics: 16 Xenobiotics
Lead nitrate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01507 XEOTIC Info		Gene Form	Protein
Classification	Health and Environmental Toxicant
DME Modulation	Lead nitrate induces the drug-metabolizing activity of DME PTGS2				[38], [39]
Perfluorooctane sulfonic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00921 XEOTIC Info		Gene Form	Protein
Classification	Health and Environmental Toxicant
DME Modulation	Perfluorooctane sulfonic acid induces the drug-metabolizing activity of DME PTGS2				[40]
Thiram		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00884 XEOTIC Info		Gene Form	Protein
Classification	Health and Environmental Toxicant
DME Modulation	Thiram induces the drug-metabolizing activity of DME PTGS2				[41]
3-methylquercetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01141 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	3-methylquercetin inhibits the drug-metabolizing activity of DME PTGS2				[42]
9,10-anthraquinone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01180 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	9,10-anthraquinone inhibits the drug-metabolizing activity of DME PTGS2				[43]
Acetaldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00872 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Acetaldehyde up-regulates the expression of DME PTGS2				[44]
Alpha-linolenic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00873 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Alpha-linolenic acid up-regulates the expression of DME PTGS2				[45]
Butyraldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00999 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Butyraldehyde up-regulates the expression of DME PTGS2				[46]
Diethylhexyl phthalate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01004 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Diethylhexyl phthalate inhibits the expression of DME PTGS2				[47]
Lead		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01505 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Lead induces the drug-metabolizing activity of DME PTGS2				[48]
Lithium chloride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01369 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Lithium chloride induces the drug-metabolizing activity of DME PTGS2				[49]
Pirinixic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01433 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Pirinixic acid induces the drug-metabolizing activity of DME PTGS2				[50]
Styrene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01025 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Styrene induces the drug-metabolizing activity of DME PTGS2				[51]
Tris(1,3-dichloro-2-propyl)phosphate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01031 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME PTGS2				[52]
Zeranol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00963 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Zeranol up-regulates the expression of DME PTGS2				[53]
Zymosan		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01501 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Zymosan up-regulates the expression of DME PTGS2				[54]
Mycotoxin		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Deoxynivalenol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01514 XEOTIC Info		Gene Form	Protein
Classification	Mycotoxin
DME Modulation	Deoxynivalenol induces the drug-metabolizing activity of DME PTGS2				[55]
Oligomycins		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01516 XEOTIC Info		Gene Form	Protein
Classification	Mycotoxin
DME Modulation	Oligomycins induces the drug-metabolizing activity of DME PTGS2				[56]
Natural Product(s), Extract(s) or Medicine(s)
Natural Mixture		Click to Show/Hide the Full List of Xenobiotics: 7 Xenobiotics
Amphibole asbestos		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00995 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Amphibole asbestos up-regulates the expression of DME PTGS2				[57]
Coal tar		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00755 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Coal tar up-regulates the expression of DME PTGS2				[58]
Dust		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01284 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Dust up-regulates the expression of DME PTGS2				[59]
Particulate matter		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00919 XEOTIC Info		Gene Form	Protein
Classification	Natural Mixture
DME Modulation	Particulate matter inhibits the drug-metabolizing activity of DME PTGS2				[60]
Tobacco smoke pollution		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00821 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Tobacco smoke pollution up-regulates the expression of DME PTGS2				[61]
Viper venoms		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00892 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Viper venoms up-regulates the expression of DME PTGS2				[62]
Vitallium		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01511 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Vitallium up-regulates the expression of DME PTGS2				[63]
Natural Product		Click to Show/Hide the Full List of Xenobiotics: 16 Xenobiotics
4-oxoretinoic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01154 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	4-oxoretinoic acid inhibits the expression of DME PTGS2				[64]
7-Phloroeckol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01085 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	7-Phloroeckol inhibits the drug-metabolizing activity of DME PTGS2				[65]
Alpha-naphthoflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01192 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Alpha-naphthoflavone inhibits the expression of DME PTGS2				[66]
Amentoflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01195 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Amentof DMElavone inhibits the drug-metabolizing activity of DME PTGS2				[67]
Avarol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01525 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Avarol inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 2.3 microM)				[68]
BDE-99		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00925 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	BDE-99 up-regulates the expression of DME PTGS2				[69]
Cannabidiolic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00803 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Cannabidiolic acid inhibits the expression of DME PTGS2				[70]
Chrysin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00878 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Chrysin up-regulates the expression of DME PTGS2				[71]
Cinnamic aldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01253 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Cinnamic aldehyde up-regulates the expression of DME PTGS2				[8]
Deguelin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01537 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Deguelin inhibits the drug-metabolizing activity of DME PTGS2				[72]
Gallic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01309 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Gallic acid inhibits the drug-metabolizing activity of DME PTGS2				[73]
Honokiol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01332 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Honokiol inhibits the drug-metabolizing activity of DME PTGS2				[74]
Obacunone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01568 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Obacunone inhibits the drug-metabolizing activity of DME PTGS2				[75]
Senecionine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01585 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Senecionine up-regulates the expression of DME PTGS2				[76]
Sulphoraphene		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01590 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Sulphoraphene inhibits the expression of DME PTGS2				[77]
Tamarixetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01479 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Tamarixetin inhibits the drug-metabolizing activity of DME PTGS2				[78]
Plant Extract		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Plant extracts		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01574 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Plant extracts induces the drug-metabolizing activity of DME PTGS2				[79]
Traditional Medicine		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Chan su		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01243 XEOTIC Info		Gene Form	Protein
Classification	Traditional Medicine
DME Modulation	Chan su inhibits the drug-metabolizing activity of DME PTGS2				[80]
Jinfukang		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00760 XEOTIC Info		Gene Form	mRNA
Classification	Traditional Medicine
DME Modulation	Jinfukang inhibits the expression of DME PTGS2				[81]
Pharmaceutical Agent(s)
Approved/Marketed Drug		Click to Show/Hide the Full List of Xenobiotics: 76 Xenobiotics
Acetaminophen		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00217 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Acetaminophen inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 141 microM)				[82]
Acetylcysteine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00110 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Acetylcysteine inhibits the expression of DME PTGS2				[83]
Alitretinoin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00167 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Alitretinoin inhibits the expression of DME PTGS2				[64]
Amiodarone hydrochloride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00277 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Amiodarone hydrochloride up-regulates the expression of DME PTGS2				[84]
Arsenic trioxide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00339 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Arsenic trioxide inhibits the drug-metabolizing activity of DME PTGS2				[85]
Aspirin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00213 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Aspirin inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 100 microM)				[86]
Azathioprine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00007 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Azathioprine inhibits the expression of DME PTGS2				[87]
Boniva		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00391 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Boniva inhibits the drug-metabolizing activity of DME PTGS2				[88]
Bortezomib		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00159 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Bortezomib up-regulates the expression of DME PTGS2				[89]
Bupivacaine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00342 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Bupivacaine up-regulates the expression of DME PTGS2				[90]
Busulfan		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00010 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Busulfan up-regulates the expression of DME PTGS2				[91]
Caffeine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00218 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Caffeine inhibits the drug-metabolizing activity of DME PTGS2				[92]
Calcitriol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00184 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Calcitriol up-regulates the expression of DME PTGS2				[93]
Cannabidiol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00173 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Cannabidiol induces the drug-metabolizing activity of DME PTGS2				[94]
Capecitabine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00133 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Capecitabine inhibits the drug-metabolizing activity of DME PTGS2				[95]
Celecoxib		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00013 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Celecoxib inhibits the drug-metabolizing activity of DME PTGS2 (IC50 < 0.3 microM)				[96], [97]
Cisplatin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00334 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Cisplatin inhibits the drug-metabolizing activity of DME PTGS2				[98]
Copper		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00834 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Copper induces the drug-metabolizing activity of DME PTGS2				[99]
Deferoxamine mesylate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00286 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Deferoxamine mesylate induces the drug-metabolizing activity of DME PTGS2				[100], [101]
Dexamethasone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00088 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dexamethasone inhibits the drug-metabolizing activity of DME PTGS2				[102], [103]
Diclofenac		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00352 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Diclof DMEenac inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.005 microM)				[104], [105]
Dienogest		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00433 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dienogest inhibits the drug-metabolizing activity of DME PTGS2				[106]
Dinoprostone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00260 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dinoprostone induces the drug-metabolizing activity of DME PTGS2				[107], [108]
Docetaxel		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00153 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Docetaxel up-regulates the expression of DME PTGS2				[109]
Donepezil hydrochloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00289 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Donepezil hydrochloride inhibits the drug-metabolizing activity of DME PTGS2				[110]
Doxorubicin hydrochloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00292 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Doxorubicin hydrochloride inhibits the drug-metabolizing activity of DME PTGS2				[111]
Dronabinol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00115 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dronabinol induces the drug-metabolizing activity of DME PTGS2				[112]
Estradiol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00090 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Estradiol induces the drug-metabolizing activity of DME PTGS2				[7]
Ethinyl estradiol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00267 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Ethinyl estradiol up-regulates the expression of DME PTGS2				[113]
Etodolac		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00034 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Etodolac inhibits the drug-metabolizing activity of DME PTGS2 in Spodoptera frugiperda (Sf21) cell (IC50 = 0.561 microM)				[114]
Etoposide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00121 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Etoposide induces the drug-metabolizing activity of DME PTGS2				[115]
Fluorouracil		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00037 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Fluorouracil inhibits the drug-metabolizing activity of DME PTGS2				[116]
Flurbiprofen sodium		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00296 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Flurbiprof DMEen sodium inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.01 microM)				[117], [118]
Hydrogen peroxide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00388 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Hydrogen peroxide induces the drug-metabolizing activity of DME PTGS2				[119], [120]
Hydroquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00430 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Hydroquinone up-regulates the expression of DME PTGS2				[121]
Ibuprofen		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00248 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Ibuprof DMEen inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.1 microM)				[122]
Imatinib mesylate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00151 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Imatinib mesylate inhibits the drug-metabolizing activity of DME PTGS2				[73]
Indomethacin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00047 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Indomethacin inhibits the drug-metabolizing activity of DME PTGS2 (IC50 < 0.2 microM)				[123]
Isotretinoin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00186 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Isotretinoin inhibits the expression of DME PTGS2				[64]
Lovastatin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00262 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Lovastatin inhibits the drug-metabolizing activity of DME PTGS2				[124], [125]
Manganese chloride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00434 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Manganese chloride up-regulates the expression of DME PTGS2				[126]
Medroxyprogesterone acetate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00743 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Medroxyprogesterone acetate inhibits the drug-metabolizing activity of DME PTGS2				[127]
Meloxicam		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00205 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Meloxicam inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.16 microM)				[128]
Methamphetamine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00108 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Methamphetamine up-regulates the expression of DME PTGS2				[129]
Methotrexate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00366 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Methotrexate inhibits the drug-metabolizing activity of DME PTGS2				[130]
Metoprolol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00367 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Metoprolol inhibits the drug-metabolizing activity of DME PTGS2				[131]
Naproxen		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00156 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Naproxen inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 1010 microM)				[132]
Nebivolol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00370 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Nebivolol inhibits the drug-metabolizing activity of DME PTGS2				[133]
Niacinamide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00419 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Niacinamide up-regulates the expression of DME PTGS2				[134]
Nicotine polacrilex		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00312 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Nicotine polacrilex up-regulates the expression of DME PTGS2				[135]
Nitroprusside		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00398 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Nitroprusside induces the drug-metabolizing activity of DME PTGS2				[136]
Paclitaxel		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00256 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Paclitaxel inhibits the expression of DME PTGS2				[137]
Paroxetine hydrochloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00316 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Paroxetine hydrochloride inhibits the expression of DME PTGS2				[138]
Progesterone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00094 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Progesterone inhibits the expression of DME PTGS2				[87]
Raloxifene hydrochloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00126 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Raloxifene hydrochloride inhibits the expression of DME PTGS2				[139]
Rivastigmine tartrate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00321 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Rivastigmine tartrate inhibits the drug-metabolizing activity of DME PTGS2				[119]
Rofecoxib		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00078 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Rof DMEecoxib inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.001 microM)				[140]
Simvastatin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00125 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Simvastatin inhibits the expression of DME PTGS2				[141]
Sodium fluoride F-18		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00422 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Sodium fluoride F-18 up-regulates the expression of DME PTGS2				[142]
Sulindac		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00177 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Sulindac inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 8.8 microM)				[143]
Temozolomide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00082 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Temozolomide inhibits the drug-metabolizing activity of DME PTGS2				[144]
Thalidomide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00083 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Thalidomide inhibits the expression of DME PTGS2				[145]
Titanium dioxide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00425 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Titanium dioxide up-regulates the expression of DME PTGS2				[146]
Tretinoin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00253 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Tretinoin induces the drug-metabolizing activity of DME PTGS2				[147]
Troglitazone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00086 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Troglitazone inhibits the drug-metabolizing activity of DME PTGS2				[148]
Valdecoxib		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00150 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Valdecoxib inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.005 microM)				[149]
Valproic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00029 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Valproic acid up-regulates the expression of DME PTGS2				[150]
Vinorelbine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00394 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Vinorelbine inhibits the expression of DME PTGS2				[62]
Zoledronic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00140 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Zoledronic acid inhibits the expression of DME PTGS2				[151]
Chlorobenzene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00442 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Chlorobenzene induces the drug-metabolizing activity of DME PTGS2				[152]
Etoricoxib		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00497 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Etoricoxib inhibits the drug-metabolizing activity of DME PTGS2 in Chinese hamster ovary (CHO) cell (IC50 = 0.081 microM)				[153]
Flufenamic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00470 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Flufenamic acid induces the drug-metabolizing activity of DME PTGS2				[154]
Gamolenic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00510 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Gamolenic acid up-regulates the expression of DME PTGS2				[45]
Glucosamine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00502 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Glucosamine induces the drug-metabolizing activity of DME PTGS2				[155]
Lumiracoxib		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00504 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Lumiracoxib inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.007 microM)				[118]
Sodium salicylate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00483 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Sodium salicylate up-regulates the expression of DME PTGS2				[156]
Drug in Phase 3 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 7 Xenobiotics
Curcumin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00683 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Curcumin inhibits the drug-metabolizing activity of DME PTGS2				[116]
Epigallocatechin gallate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00613 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Epigallocatechin gallate induces the drug-metabolizing activity of DME PTGS2				[157]
Fenretinide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00565 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Fenretinide up-regulates the expression of DME PTGS2				[158]
Folfox		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00844 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Folfox inhibits the drug-metabolizing activity of DME PTGS2				[116]
Resveratrol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00568 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Resveratrol inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.75 microM)				[159]
Seocalcitol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00652 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Seocalcitol up-regulates the expression of DME PTGS2				[37]
Tetrathiomolybdate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00642 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Tetrathiomolybdate up-regulates the expression of DME PTGS2				[160]
Drug in Phase 2 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 11 Xenobiotics
Butyric acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01230 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2/3
DME Modulation	Butyric acid up-regulates the expression of DME PTGS2				[161], [162]
Arecoline		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00578 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Arecoline induces the drug-metabolizing activity of DME PTGS2				[163]
Bisphenol A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01226 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Bisphenol A induces the drug-metabolizing activity of DME PTGS2				[164]
Bufalin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00665 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Bufalin inhibits the drug-metabolizing activity of DME PTGS2				[165]
Colforsin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00606 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	Colforsin up-regulates the expression of DME PTGS2				[166]
Ethanol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00539 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Ethanol induces the drug-metabolizing activity of DME PTGS2				[167]
Genistein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00557 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Genistein inhibits the drug-metabolizing activity of DME PTGS2				[168], [169]
JBT-101		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00641 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	JBT-101 up-regulates the expression of DME PTGS2				[170]
Sphingosine 1-phosphate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00650 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Sphingosine 1-phosphate induces the drug-metabolizing activity of DME PTGS2				[171]
Sulindac sulfide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00656 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Sulindac sulfide inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.1 microM)				[172]
Taurocholic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00589 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	Taurocholic acid up-regulates the expression of DME PTGS2				[173]
Drug in Phase 1 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 13 Xenobiotics
Dieckol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01276 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Dieckol inhibits the drug-metabolizing activity of DME PTGS2				[65]
Dihydrosphingosine 1-phosphate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01277 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Dihydrosphingosine 1-phosphate induces the drug-metabolizing activity of DME PTGS2				[174]
Dinitrochlorobenzene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00571 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Dinitrochlorobenzene up-regulates the expression of DME PTGS2				[175], [176]
Gold sodium thiomalate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00533 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Gold sodium thiomalate inhibits the expression of DME PTGS2				[87]
Homocysteine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01331 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Homocysteine up-regulates the expression of DME PTGS2				[177]
LY-294002		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00580 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	LY-294002 inhibits the drug-metabolizing activity of DME PTGS2				[178]
NS-398		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00583 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	NS-398 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.001 microM)				[140]
NSC 703786		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01107 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	NSC 703786 up-regulates the expression of DME PTGS2				[179]
Quercetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00538 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Quercetin inhibits the drug-metabolizing activity of DME PTGS2 in Spodoptera frugiperda (Sf21) cell (IC50 = 28.6 microM)				[22]
SC-58125		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00623 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	SC-58125 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.05 microM)				[180]
Sodium arsenite		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00632 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Sodium arsenite inhibits the drug-metabolizing activity of DME PTGS2				[181]
Tetradecanoylphorbol acetate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00599 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Tetradecanoylphorbol acetate up-regulates the expression of DME PTGS2				[182]
Trichostatin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01492 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Trichostatin A inhibits the expression of DME PTGS2				[183]
Preclinical/Patented Drug		Click to Show/Hide the Full List of Xenobiotics: 19 Xenobiotics
(+)-JQ1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00723 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	(+)-JQ1 inhibits the expression of DME PTGS2				[184]
1-(1-naphthyl)piperazine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01084 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	1-(1-naphthyl)piperazine up-regulates the expression of DME PTGS2				[185]
3,3',4,4',5,5'-hexahydroxystilbene		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01132 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	3,3',4,4',5,5'-hexahydroxystilbene inhibits the drug-metabolizing activity of DME PTGS2				[186]
Anandamide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01198 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Anandamide induces the drug-metabolizing activity of DME PTGS2				[112]
DuP-697		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00690 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	DuP-697 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 < 0.2 microM)				[123]
Edelfosine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00687 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Edelfosine induces the drug-metabolizing activity of DME PTGS2				[187]
Embelin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00691 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Embelin inhibits the drug-metabolizing activity of DME PTGS2				[188]
FT-1050		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00712 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	FT-1050 up-regulates the expression of DME PTGS2				[189]
Gardiquimod		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00722 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	Gardiquimod up-regulates the expression of DME PTGS2				[190]
ICI-118551		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00704 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	ICI-118551 inhibits the drug-metabolizing activity of DME PTGS2				[191]
Isoliquiritigenin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00710 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Isoliquiritigenin inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 130 microM)				[192]
JTE-522		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00707 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	JTE-522 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.085 microM)				[193]
L-745337		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00715 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	L-745337 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.02 microM)				[180]
Oleic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01412 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	Oleic acid up-regulates the expression of DME PTGS2				[25]
SC-58236		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00718 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	SC-58236 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.00045 microM)				[194]
CR-3294		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01263 XEOTIC Info		Gene Form	mRNA
Classification	Patented Pharmaceutical Agent
DME Modulation	CR-3294 inhibits the expression of DME PTGS2				[195]
Erastin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00737 XEOTIC Info		Gene Form	mRNA
Classification	Patented Pharmaceutical Agent
DME Modulation	Erastin up-regulates the expression of DME PTGS2				[196]
Ferulic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00730 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	Ferulic acid inhibits the drug-metabolizing activity of DME PTGS2				[197]
SC-560		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01468 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	SC-560 inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 6.3 microM)				[198]
Drug Marketed but Withdrawn from Market		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Flupenthixol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00528 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but Withdrawn from Market
DME Modulation	Flupenthixol inhibits the drug-metabolizing activity of DME PTGS2				[199]
Nimesulide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00519 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but Withdrawn from Market
DME Modulation	Nimesulide inhibits the drug-metabolizing activity of DME PTGS2 (IC50 = 0.015 microM)				[200]
Investigative Agent		Click to Show/Hide the Full List of Xenobiotics: 21 Xenobiotics
1,2-naphthoquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00868 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	1,2-naphthoquinone up-regulates the expression of DME PTGS2				[201]
15d-PGJ2		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01096 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	15d-PGJ2 induces the drug-metabolizing activity of DME PTGS2				[202]
27-hydroxycholesterol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01117 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	27-hydroxycholesterol induces the drug-metabolizing activity of DME PTGS2				[203]
3,4,5,4'-tetrahydroxystilbene		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01134 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	3,4,5,4'-tetrahydroxystilbene inhibits the expression of DME PTGS2				[204]
7,8-diacetoxy-4-methylcoumarin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01171 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	7,8-diacetoxy-4-methylcoumarin inhibits the drug-metabolizing activity of DME PTGS2				[205]
7,8-diacetoxy-4-methylthiocoumarin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01172 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	7,8-diacetoxy-4-methylthiocoumarin inhibits the drug-metabolizing activity of DME PTGS2				[205]
AG-1879		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00770 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	AG-1879 inhibits the drug-metabolizing activity of DME PTGS2				[178]
Arachidonic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00876 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Arachidonic acid induces the drug-metabolizing activity of DME PTGS2				[206], [207]
Archazolid B		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01205 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Archazolid B up-regulates the expression of DME PTGS2				[208]
Baohuoside I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01213 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Baohuoside I inhibits the drug-metabolizing activity of DME PTGS2				[209]
Ciglitazone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00767 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Ciglitazone up-regulates the expression of DME PTGS2 and leads to increasing the drug-metabolizing activity of this enzyme				[108]
Indomethacin phenethylamide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01344 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Indomethacin phenethylamide inhibits the drug-metabolizing activity of DME PTGS2				[210]
Lithocholic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00787 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Lithocholic acid induces the drug-metabolizing activity of DME PTGS2				[211]
MG-132		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01219 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	MG-132 up-regulates the expression of DME PTGS2				[71]
Mono-(2-ethylhexyl)phthalate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01380 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Mono-(2-ethylhexyl)phthalate induces the drug-metabolizing activity of DME PTGS2				[212]
N-formylmethionine leucyl-phenylalanine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01395 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	N-formylmethionine leucyl-phenylalanine up-regulates the expression of DME PTGS2				[213], [214]
Niflumic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00829 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Niflumic acid up-regulates the expression of DME PTGS2				[215], [216]
Oxidopamine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01418 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Oxidopamine up-regulates the expression of DME PTGS2				[217]
Rhein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01455 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Rhein inhibits the expression of DME PTGS2				[218]
RSL3 compound		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01461 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	RSL3 compound up-regulates the expression of DME PTGS2				[219]
Tributyltin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01491 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Tributyltin up-regulates the expression of DME PTGS2				[220]
Other Chemical Compound(s) or Element(s)
Food Additive		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Stearic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01475 XEOTIC Info		Gene Form	mRNA
Classification	Food Additive
DME Modulation	Stearic acid up-regulates the expression of DME PTGS2				[221], [222]
Chemical Compound		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Dinitrofluorobenzene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00774 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	Dinitrofluorobenzene induces the drug-metabolizing activity of DME PTGS2				[223]
Nickel sulfide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00796 XEOTIC Info		Gene Form	mRNA
Classification	Chemical Compound
DME Modulation	Nickel sulfide up-regulates the expression of DME PTGS2				[224], [225]

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