Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0006)
DME Name	Cytochrome P450 1A1 (CYP1A1), Homo sapiens	DME Info
UniProt ID	CP1A1_HUMAN
EC Number	EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Fungicide(s), Herbicide(s) or Insecticide(s)
Fungicide		Click to Show/Hide the Full List of Xenobiotics: 9 Xenobiotics
Azoxystrobin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00938 XEOTIC Info		Gene Form	Protein
Classification	Fungicide
DME Modulation	Azoxystrobin induces the drug-metabolizing activity of DME CYP1A1				[1]
Cyproconazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00942 XEOTIC Info		Gene Form	mRNA
Classification	Fungicide
DME Modulation	Cyproconazole up-regulates the expression of DME CYP1A1				[2]
Cyprodinil		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00943 XEOTIC Info		Gene Form	Protein
Classification	Fungicide
DME Modulation	Cyprodinil induces the drug-metabolizing activity of DME CYP1A1				[3]
Enilconazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00944 XEOTIC Info		Gene Form	Protein
Classification	Fungicide
DME Modulation	Enilconazole induces the drug-metabolizing activity of DME CYP1A1				[4], [5]
Epoxiconazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00945 XEOTIC Info		Gene Form	Protein
Classification	Fungicide
DME Modulation	Epoxiconazole induces the drug-metabolizing activity of DME CYP1A1				[2]
Flusilazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00948 XEOTIC Info		Gene Form	mRNA
Classification	Fungicide
DME Modulation	Flusilazole up-regulates the expression of DME CYP1A1				[6]
Hexachlorobenzene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00951 XEOTIC Info		Gene Form	Protein
Classification	Fungicide
DME Modulation	Hexachlorobenzene up-regulates the expression of DME CYP1A1 and leads to increasing the drug-metabolizing activity of this enzyme				[7]
Propiconazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00956 XEOTIC Info		Gene Form	mRNA
Classification	Fungicide
DME Modulation	Propiconazole up-regulates the expression of DME CYP1A1				[8]
Tebuconazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00957 XEOTIC Info		Gene Form	mRNA
Classification	Fungicide
DME Modulation	Tebuconazole up-regulates the expression of DME CYP1A1				[9], [10]
Herbicide		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Diuron		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00973 XEOTIC Info		Gene Form	Protein
Classification	Herbicide
DME Modulation	Diuron induces the drug-metabolizing activity of DME CYP1A1				[11], [1]
Monomethylarsonic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00982 XEOTIC Info		Gene Form	mRNA
Classification	Herbicide
DME Modulation	Monomethylarsonic acid up-regulates the expression of DME CYP1A1				[12]
Pesticide/Insecticide		Click to Show/Hide the Full List of Xenobiotics: 9 Xenobiotics
Decamethrin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01047 XEOTIC Info		Gene Form	mRNA
Classification	Pesticide/Insecticide
DME Modulation	Decamethrin up-regulates the expression of DME CYP1A1				[13]
Dicrotophos		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01050 XEOTIC Info		Gene Form	mRNA
Classification	Pesticide/Insecticide
DME Modulation	Dicrotophos up-regulates the expression of DME CYP1A1				[14]
Endosulfan		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01074 XEOTIC Info		Gene Form	Protein
Classification	Pesticide/Insecticide
DME Modulation	Endosulfan inhibits the drug-metabolizing activity of DME CYP1A1				[15]
Fenitrothion		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01052 XEOTIC Info		Gene Form	Protein
Classification	Pesticide/Insecticide
DME Modulation	Fenitrothion inhibits the drug-metabolizing activity of DME CYP1A1				[16]
Monocrotophos		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01062 XEOTIC Info		Gene Form	Protein
Classification	Pesticide/Insecticide
DME Modulation	Monocrotophos induces the drug-metabolizing activity of DME CYP1A1				[17]
Parathion		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01064 XEOTIC Info		Gene Form	mRNA
Classification	Pesticide/Insecticide
DME Modulation	Parathion up-regulates the expression of DME CYP1A1				[18]
Pentachlorophenol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01605 XEOTIC Info		Gene Form	mRNA
Classification	Pesticide/Insecticide
DME Modulation	Pentachlorophenol up-regulates the expression of DME CYP1A1				[19], [20]
Piperonyl butoxide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00889 XEOTIC Info		Gene Form	Protein
Classification	Pesticide/Insecticide
DME Modulation	Piperonyl butoxide induces the drug-metabolizing activity of DME CYP1A1				[21]
Profenofos		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01068 XEOTIC Info		Gene Form	Protein
Classification	Pesticide/Insecticide
DME Modulation	Prof DMEenof DMEos inhibits the drug-metabolizing activity of DME CYP1A1				[22]
Health or Environmental Toxicant(s)
Acute Toxic Substance		Click to Show/Hide the Full List of Xenobiotics: 20 Xenobiotics
1,4-naphthoquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01089 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	1,4-naphthoquinone up-regulates the expression of DME CYP1A1				[23]
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01108 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole induces the drug-metabolizing activity of DME CYP1A1				[24]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01119 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine induces the drug-metabolizing activity of DME CYP1A1				[25]
2-methyl-4-isothiazolin-3-one		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00890 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	2-methyl-4-isothiazolin-3-one up-regulates the expression of DME CYP1A1				[26]
Anisomycin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01199 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Anisomycin up-regulates the expression of DME CYP1A1				[27]
Cacodylic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01231 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Cacodylic acid up-regulates the expression of DME CYP1A1 and leads to increasing the drug-metabolizing activity of this enzyme				[28]
Cadmium		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01503 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Cadmium up-regulates the expression of DME CYP1A1				[29]
Chlorpyrifos		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01248 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Chlorpyrifos inhibits the drug-metabolizing activity of DME CYP1A1				[1], [16]
Cycloheximide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01268 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Cycloheximide up-regulates the expression of DME CYP1A1				[30]
Cynaropicrin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01269 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Cynaropicrin up-regulates the expression of DME CYP1A1				[31]
Ellipticine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01288 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Ellipticine induces the drug-metabolizing activity of DME CYP1A1				[32]
Enniatins		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01289 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Enniatins up-regulates the expression of DME CYP1A1				[33]
Fipronil		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01302 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Fipronil up-regulates the expression of DME CYP1A1				[34], [35]
Formaldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01305 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Formaldehyde up-regulates the expression of DME CYP1A1				[36]
Kaempferol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01353 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Kaempferol inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.632 microM)				[37]
Mercuric chloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01508 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Mercuric chloride inhibits the expression of DME CYP1A1				[38]
Morin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01381 XEOTIC Info		Gene Form	Protein
Classification	Acute Toxic Substance
DME Modulation	Morin induces the drug-metabolizing activity of DME CYP1A1				[39]
Nickel chloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01397 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Nickel chloride inhibits the expression of DME CYP1A1				[40], [41]
Ochratoxin A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01407 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Ochratoxin A up-regulates the expression of DME CYP1A1				[42]
Trinitrotoluene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01029 XEOTIC Info		Gene Form	mRNA
Classification	Acute Toxic Substance
DME Modulation	Trinitrotoluene up-regulates the expression of DME CYP1A1				[43]
Biotoxin		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Cylindrospermopsin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00905 XEOTIC Info		Gene Form	mRNA
Classification	Cyanotoxin
DME Modulation	Cylindrospermopsin up-regulates the expression of DME CYP1A1				[44]
8-prenylnaringenin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01179 XEOTIC Info		Gene Form	Protein
Classification	Cytotoxin
DME Modulation	8-prenylnaringenin inhibits the drug-metabolizing activity of DME CYP1A1				[45]
Carcinogen		Click to Show/Hide the Full List of Xenobiotics: 8 Xenobiotics
2-amino-3-methylimidazo(4,5-f)quinoline		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00895 XEOTIC Info		Gene Form	mRNA
Classification	Carcinogen
DME Modulation	2-amino-3-methylimidazo(4,5-f)quinoline up-regulates the expression of DME CYP1A1				[46]
2-naphthylamine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00896 XEOTIC Info		Gene Form	mRNA
Classification	Carcinogen
DME Modulation	2-naphthylamine up-regulates the expression of DME CYP1A1				[47]
Benz(a)anthracenes		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00897 XEOTIC Info		Gene Form	mRNA
Classification	Carcinogen
DME Modulation	Benz(a)anthracenes up-regulates the expression of DME CYP1A1				[48]
Benzo(a)pyrene		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00898 XEOTIC Info		Gene Form	Protein
Classification	Carcinogen
DME Modulation	Benzo(a)pyrene inhibits the drug-metabolizing activity of DME CYP1A1				[49]
Methylcholanthrene		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00899 XEOTIC Info		Gene Form	Protein
Classification	Carcinogen
DME Modulation	Methylcholanthrene inhibits the drug-metabolizing activity of DME CYP1A1				[50], [51]
Polychlorinated biphenyls		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00776 XEOTIC Info		Gene Form	mRNA
Classification	Carcinogen
DME Modulation	Polychlorinated biphenyls up-regulates the expression of DME CYP1A1				[52]
Aflatoxin B1		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00806 XEOTIC Info		Gene Form	mRNA
Classification	Carcinogen-mycotoxin
DME Modulation	Aflatoxin B1 up-regulates the expression of DME CYP1A1				[53]
Aflatoxin M1		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00816 XEOTIC Info		Gene Form	mRNA
Classification	Carcinogen-mycotoxin
DME Modulation	Aflatoxin M1 up-regulates the expression of DME CYP1A1				[54]
Environmental Pollutant		Click to Show/Hide the Full List of Xenobiotics: 11 Xenobiotics
2-tert-butylhydroquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01129 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	2-tert-butylhydroquinone induces the drug-metabolizing activity of DME CYP1A1				[55], [56]
3,4',5-trimethoxystilbene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01135 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	3,4',5-trimethoxystilbene induces the drug-metabolizing activity of DME CYP1A1				[57]
6-nitrochrysene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00794 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	6-nitrochrysene up-regulates the expression of DME CYP1A1				[48]
Bisphenol F		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00997 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	Bisphenol F induces the drug-metabolizing activity of DME CYP1A1				[58]
Diarylpropionitrile		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01273 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	Diarylpropionitrile up-regulates the expression of DME CYP1A1				[59]
Diazinon		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01274 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	Diazinon induces the drug-metabolizing activity of DME CYP1A1				[1]
Naphthenic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01015 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	Naphthenic acid up-regulates the expression of DME CYP1A1				[60]
NCX-4040		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01394 XEOTIC Info		Gene Form	Protein
Classification	Environmental Pollutant
DME Modulation	NCX-4040 inhibits the drug-metabolizing activity of DME CYP1A1				[61]
Polychlorinated dibenzodioxin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00917 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	Polychlorinated dibenzodioxin up-regulates the expression of DME CYP1A1				[62]
Pterostilbene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01441 XEOTIC Info		Gene Form	mRNA
Classification	Environmental Pollutant
DME Modulation	Pterostilbene up-regulates the expression of DME CYP1A1				[63]
Phthalic anhydride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01614 XEOTIC Info		Gene Form	mRNA
Classification	Plasticizer
DME Modulation	Phthalic anhydride up-regulates the expression of DME CYP1A1				[38]
Health Hazard/Toxicant		Click to Show/Hide the Full List of Xenobiotics: 13 Xenobiotics
2,3,4,4'5-pentachlorobiphenyl		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01111 XEOTIC Info		Gene Form	mRNA
Classification	Health and Environmental Toxicant
DME Modulation	2,3,4,4'5-pentachlorobiphenyl up-regulates the expression of DME CYP1A1				[64]
6-nitrobenzo(a)pyrene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00913 XEOTIC Info		Gene Form	mRNA
Classification	Health and Environmental Toxicant
DME Modulation	6-nitrobenzo(a)pyrene up-regulates the expression of DME CYP1A1				[48]
Butylbenzyl phthalate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00998 XEOTIC Info		Gene Form	Protein
Classification	Health and Environmental Toxicant
DME Modulation	Butylbenzyl phthalate induces the drug-metabolizing activity of DME CYP1A1				[65]
Iprodione		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00851 XEOTIC Info		Gene Form	mRNA
Classification	Health and Environmental Toxicant
DME Modulation	Iprodione up-regulates the expression of DME CYP1A1				[66]
1-phenyl-1,2-propanedione		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01105 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	1-phenyl-1,2-propanedione up-regulates the expression of DME CYP1A1				[36]
2-methylindole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00989 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	2-methylindole induces the drug-metabolizing activity of DME CYP1A1				[62]
Butyraldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00999 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Butyraldehyde up-regulates the expression of DME CYP1A1				[67], [68]
Diethylhexyl phthalate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01004 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Diethylhexyl phthalate induces the drug-metabolizing activity of DME CYP1A1				[69]
Glycidamide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01009 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Glycidamide inhibits the expression of DME CYP1A1				[70]
Lead		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01505 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Lead up-regulates the expression of DME CYP1A1				[29]
Pirinixic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01433 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Pirinixic acid induces the drug-metabolizing activity of DME CYP1A1				[71]
Pyridine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00850 XEOTIC Info		Gene Form	Protein
Classification	Health Hazard
DME Modulation	Pyridine up-regulates the expression of DME CYP1A1 and leads to increasing the drug-metabolizing activity of this enzyme				[72]
Tris(1,3-dichloro-2-propyl)phosphate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01031 XEOTIC Info		Gene Form	mRNA
Classification	Health Hazard
DME Modulation	Tris(1,3-dichloro-2-propyl)phosphate up-regulates the expression of DME CYP1A1				[73]
Mycotoxin		Click to Show/Hide the Full List of Xenobiotics: 4 Xenobiotics
Aurofusarin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00935 XEOTIC Info		Gene Form	Protein
Classification	Fungal Toxin
DME Modulation	Aurofusarin induces the drug-metabolizing activity of DME CYP1A1				[74]
Deoxynivalenol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01514 XEOTIC Info		Gene Form	mRNA
Classification	Mycotoxin
DME Modulation	Deoxynivalenol up-regulates the expression of DME CYP1A1				[75]
HT-2 toxin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01515 XEOTIC Info		Gene Form	mRNA
Classification	Mycotoxin
DME Modulation	HT-2 toxin up-regulates the expression of DME CYP1A1				[75]
Puromycin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00808 XEOTIC Info		Gene Form	mRNA
Classification	Mycotoxin
DME Modulation	Puromycin up-regulates the expression of DME CYP1A1				[76]
Natural Product(s), Extract(s) or Medicine(s)
Natural Mixture		Click to Show/Hide the Full List of Xenobiotics: 8 Xenobiotics
Amphibole asbestos		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00995 XEOTIC Info		Gene Form	Protein
Classification	Natural Mixture
DME Modulation	Amphibole asbestos inhibits the drug-metabolizing activity of DME CYP1A1				[77]
Coal ash		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00916 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Coal ash up-regulates the expression of DME CYP1A1				[78]
Coal tar		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00755 XEOTIC Info		Gene Form	Protein
Classification	Natural Mixture
DME Modulation	Coal tar induces the drug-metabolizing activity of DME CYP1A1				[79], [80]
Dust		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01284 XEOTIC Info		Gene Form	Protein
Classification	Natural Mixture
DME Modulation	Dust inhibits the drug-metabolizing activity of DME CYP1A1				[81]
Flavonoids		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00858 XEOTIC Info		Gene Form	Protein
Classification	Natural Mixture
DME Modulation	Flavonoids induces the drug-metabolizing activity of DME CYP1A1				[82]
Particulate matter		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00919 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Particulate matter up-regulates the expression of DME CYP1A1				[83], [84]
Polyphenols		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01578 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Polyphenols up-regulates the expression of DME CYP1A1				[85]
Tobacco smoke pollution		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00821 XEOTIC Info		Gene Form	mRNA
Classification	Natural Mixture
DME Modulation	Tobacco smoke pollution up-regulates the expression of DME CYP1A1				[86], [87]
Natural Product		Click to Show/Hide the Full List of Xenobiotics: 51 Xenobiotics
15,16-dihydrotanshinone I		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01517 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	15,16-dihydrotanshinone I induces the drug-metabolizing activity of DME CYP1A1				[88]
5-hydroxyflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01161 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	5-hydroxyflavone inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 4.03 microM)				[89]
6',7'-dihydroxybergamottin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01166 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	6',7'-dihydroxybergamottin inhibits the drug-metabolizing activity of DME CYP1A1				[90]
7-hydroxyflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01176 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	7-hydroxyflavone inhibits the drug-metabolizing activity of DME CYP1A1				[91]
Acacetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01184 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Acacetin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.08 microM)				[92]
Alizarin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00993 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Alizarin inhibits the drug-metabolizing activity of DME CYP1A1				[93]
Allocryptopine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01519 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Allocryptopine up-regulates the expression of DME CYP1A1				[94]
Aloe-emodin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01191 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Aloe-emodin inhibits the drug-metabolizing activity of DME CYP1A1				[95]
Alpha-naphthoflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01192 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Alpha-naphthoflavone inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.01 microM)				[96]
Annomontine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01521 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Annomontine up-regulates the expression of DME CYP1A1				[97]
Apigenin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01203 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Apigenin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.427 microM)				[37]
Baicalein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01212 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Baicalein inhibits the drug-metabolizing activity of DME CYP1A1 (Ki = 1.22 microM)				[98]
BDE-99		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00925 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	BDE-99 up-regulates the expression of DME CYP1A1				[99]
Bilirubin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00877 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Bilirubin induces the drug-metabolizing activity of DME CYP1A1				[100]
Biochanin A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01222 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Biochanin A induces the drug-metabolizing activity of DME CYP1A1				[101]
Chrysin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00878 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Chrysin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.153 microM)				[37]
Chrysophanic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01528 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Chrysophanic acid inhibits the drug-metabolizing activity of DME CYP1A1				[95]
Cinnamic aldehyde		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01253 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Cinnamic aldehyde up-regulates the expression of DME CYP1A1				[26]
Cryptotanshinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01534 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Cryptotanshinone induces the drug-metabolizing activity of DME CYP1A1				[88]
Cyanidin 3-O-glucoside		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01535 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Cyanidin 3-O-glucoside inhibits the drug-metabolizing activity of DME CYP1A1				[102]
Diosmetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01281 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Diosmetin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.14 microM)				[37]
Eupatorin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01541 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Eupatorin inhibits the drug-metabolizing activity of DME CYP1A1 (Ki = 0.21 microM)				[98]
Flavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01304 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Flavone inhibits the drug-metabolizing activity of DME CYP1A1				[91]
Galangin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01308 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Galangin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.077 microM)				[37]
Gedunin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01311 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Gedunin inhibits the expression of DME CYP1A1				[103]
Genkwanin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01546 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Genkwanin inhibits the drug-metabolizing activity of DME CYP1A1 (Ki > 2.34 microM)				[98]
Gossypetin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01322 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Gossypetin up-regulates the expression of DME CYP1A1				[104]
Heptanal		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01011 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Heptanal up-regulates the expression of DME CYP1A1				[67]
Hyperforin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01335 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Hyperforin inhibits the drug-metabolizing activity of DME CYP1A1				[105]
Indolo(3,2-B)carbazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01343 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Indolo(3,2-B)carbazole up-regulates the expression of DME CYP1A1				[106]
Isoflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01553 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Isof DMElavone inhibits the drug-metabolizing activity of DME CYP1A1				[107]
Ligustilide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01558 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Ligustilide up-regulates the expression of DME CYP1A1				[108]
Limonene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01559 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Limonene up-regulates the expression of DME CYP1A1				[36]
Linalool		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01366 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Linalool up-regulates the expression of DME CYP1A1				[36]
Naringin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01391 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Naringin inhibits the drug-metabolizing activity of DME CYP1A1				[109]
Nobiletin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01566 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Nobiletin induces the drug-metabolizing activity of DME CYP1A1				[110], [111]
Pelargonidin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01424 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Pelargonidin up-regulates the expression of DME CYP1A1				[112]
Protopine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01581 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Protopine up-regulates the expression of DME CYP1A1				[113]
Puag-haad		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01442 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Puag-haad up-regulates the expression of DME CYP1A1				[76]
Purpurin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01443 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Purpurin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 5.5 microM)				[114]
Quinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01450 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Quinone up-regulates the expression of DME CYP1A1				[115], [116]
Robinetin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01458 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Robinetin induces the drug-metabolizing activity of DME CYP1A1				[117]
Rutecarpine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01462 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Rutecarpine induces the drug-metabolizing activity of DME CYP1A1				[118]
Rutin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01463 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Rutin up-regulates the expression of DME CYP1A1				[118]
Sanguinarine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00865 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Sanguinarine inhibits the expression of DME CYP1A1				[119]
Scutellarein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01470 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Scutellarein inhibits the drug-metabolizing activity of DME CYP1A1 (Ki = 1.64 microM)				[98]
Senecionine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01585 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Senecionine induces the drug-metabolizing activity of DME CYP1A1				[120]
Skatole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00777 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Skatole up-regulates the expression of DME CYP1A1				[121]
Steviol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00810 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Steviol induces the drug-metabolizing activity of DME CYP1A1				[122]
Taxifolin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01591 XEOTIC Info		Gene Form	Protein
Classification	Natural Product
DME Modulation	Taxifolin induces the drug-metabolizing activity of DME CYP1A1				[123]
Walrycin A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01498 XEOTIC Info		Gene Form	mRNA
Classification	Natural Product
DME Modulation	Walrycin A up-regulates the expression of DME CYP1A1				[124]
Plant Extract		Click to Show/Hide the Full List of Xenobiotics: 4 Xenobiotics
Grape seed proanthocyanidins		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00758 XEOTIC Info		Gene Form	mRNA
Classification	Plant Extract
DME Modulation	Grape seed proanthocyanidins inhibits the expression of DME CYP1A1				[125]
Green tea extract AR25		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01549 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Green tea extract AR25 inhibits the drug-metabolizing activity of DME CYP1A1				[126]
Mangifera indica extract		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00826 XEOTIC Info		Gene Form	mRNA
Classification	Plant Extract
DME Modulation	Mangifera indica extract up-regulates the expression of DME CYP1A1				[127]
Plant extracts		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01574 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Plant extracts inhibits the drug-metabolizing activity of DME CYP1A1				[128]
Pharmaceutical Agent(s)
Approved/Marketed Drug		Click to Show/Hide the Full List of Xenobiotics: 79 Xenobiotics
Acetaminophen		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00217 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Acetaminophen inhibits the expression of DME CYP1A1				[129]
Albendazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00003 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Albendazole induces the drug-metabolizing activity of DME CYP1A1				[130], [131]
Amlodipine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00338 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Amlodipine inhibits the drug-metabolizing activity of DME CYP1A1				[132]
Ampicillin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00096 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Ampicillin inhibits the expression of DME CYP1A1				[133]
Arsenic trioxide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00339 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Arsenic trioxide up-regulates the expression of DME CYP1A1				[134], [135]
Avobenzone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00411 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Avobenzone up-regulates the expression of DME CYP1A1				[136]
Azacitidine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00102 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Azacitidine up-regulates the expression of DME CYP1A1				[137], [138]
Calcitriol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00184 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Calcitriol up-regulates the expression of DME CYP1A1				[139]
Cannabidiol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00173 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Cannabidiol inhibits the drug-metabolizing activity of DME CYP1A1 (Ki = 0.15 microM)				[114]
Carbamazepine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00011 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Carbamazepine inhibits the drug-metabolizing activity of DME CYP1A1				[140]
Cidofovir		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00132 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Cidofovir inhibits the expression of DME CYP1A1				[141]
Cimetidine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00015 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Cimetidine inhibits the drug-metabolizing activity of DME CYP1A1				[142]
Cisplatin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00334 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Cisplatin inhibits the expression of DME CYP1A1				[141], [143]
Clobetasol propionate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00284 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Clobetasol propionate up-regulates the expression of DME CYP1A1				[144]
Clofibrate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00016 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Clofibrate up-regulates the expression of DME CYP1A1				[145]
Copper sulfate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00117 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Copper sulfate up-regulates the expression of DME CYP1A1				[146]
Cyclosporine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00241 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Cyclosporine inhibits the expression of DME CYP1A1				[147], [141]
Dapsone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00019 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dapsone induces the drug-metabolizing activity of DME CYP1A1				[131]
Decitabine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00168 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Decitabine up-regulates the expression of DME CYP1A1				[148]
Dexamethasone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00088 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dexamethasone inhibits the drug-metabolizing activity of DME CYP1A1				[149]
Diclofenac		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00352 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Diclofenac induces the drug-metabolizing activity of DME CYP1A1				[1]
Diethylstilbestrol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00166 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Diethylstilbestrol inhibits the expression of DME CYP1A1				[150]
Dihydroergotamine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00105 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Dihydroergotamine induces the drug-metabolizing activity of DME CYP1A1				[151]
Dronabinol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00115 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Dronabinol inhibits the expression of DME CYP1A1				[152]
Esomeprazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00070 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Esomeprazole up-regulates the expression of DME CYP1A1				[153]
Estradiol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00090 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Estradiol inhibits the drug-metabolizing activity of DME CYP1A1				[154]
Ethacrynic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00032 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Ethacrynic acid up-regulates the expression of DME CYP1A1				[155]
Ethinyl estradiol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00267 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Ethinyl estradiol inhibits the expression of DME CYP1A1				[156]
Etoposide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00121 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Etoposide induces the drug-metabolizing activity of DME CYP1A1				[32]
Felodipine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00245 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Felodipine up-regulates the expression of DME CYP1A1				[157]
Fulvestrant		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00147 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Fulvestrant up-regulates the expression of DME CYP1A1				[59], [158]
Hydrogen peroxide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00388 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Hydrogen peroxide up-regulates the expression of DME CYP1A1				[159]
Hydroquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00430 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Hydroquinone up-regulates the expression of DME CYP1A1				[160], [161]
Ifosfamide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00046 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Ifosfamide inhibits the expression of DME CYP1A1				[141]
Isoproterenol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00048 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Isoproterenol inhibits the expression of DME CYP1A1				[162]
Isradipine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00049 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Isradipine up-regulates the expression of DME CYP1A1				[157]
Itraconazole		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00250 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Itraconazole inhibits the drug-metabolizing activity of DME CYP1A1				[163]
Ketoconazole		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00251 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Ketoconazole inhibits the drug-metabolizing activity of DME CYP1A1				[164]
Lansoprazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00052 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Lansoprazole induces the drug-metabolizing activity of DME CYP1A1				[165], [166]
Leflunomide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00053 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Leflunomide up-regulates the expression of DME CYP1A1				[167]
Losartan		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00364 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Losartan up-regulates the expression of DME CYP1A1				[168]
Mebendazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00057 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Mebendazole induces the drug-metabolizing activity of DME CYP1A1				[169]
Medroxyprogesterone acetate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00743 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Medroxyprogesterone acetate induces the drug-metabolizing activity of DME CYP1A1				[170]
Mycophenolic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00163 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Mycophenolic acid induces the drug-metabolizing activity of DME CYP1A1				[171]
Nelfinavir mesylate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00310 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Nelfinavir mesylate up-regulates the expression of DME CYP1A1				[172]
Nicardipine hydrochloride		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00311 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Nicardipine hydrochloride up-regulates the expression of DME CYP1A1				[173]
Niclosamide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00405 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Niclosamide up-regulates the expression of DME CYP1A1				[41]
Nicotine polacrilex		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00312 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Nicotine polacrilex induces the drug-metabolizing activity of DME CYP1A1				[174]
Omeprazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00069 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Omeprazole up-regulates the expression of DME CYP1A1				[175], [176]
Permethrin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00123 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Permethrin up-regulates the expression of DME CYP1A1				[177]
Phenytoin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00232 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Phenytoin up-regulates the expression of DME CYP1A1				[178]
Primaquine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00258 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Primaquine up-regulates the expression of DME CYP1A1				[124]
Rabeprazole		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00378 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Rabeprazole induces the drug-metabolizing activity of DME CYP1A1				[179]
Rifampin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00223 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Rifampin induces the drug-metabolizing activity of DME CYP1A1				[180]
Ritonavir		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00160 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Ritonavir up-regulates the expression of DME CYP1A1				[181]
Rosiglitazone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00380 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Rosiglitazone induces the drug-metabolizing activity of DME CYP1A1				[182], [183]
Semaxanib		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00409 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Semaxanib up-regulates the expression of DME CYP1A1				[184]
Sulindac		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00177 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Sulindac induces the drug-metabolizing activity of DME CYP1A1				[185]
Sunitinib		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00382 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Sunitinib induces the drug-metabolizing activity of DME CYP1A1				[186], [187]
Tamoxifen		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00383 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Tamoxifen up-regulates the expression of DME CYP1A1				[188]
Tretinoin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00253 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Tretinoin inhibits the expression of DME CYP1A1				[189], [190]
Troglitazone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00086 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Troglitazone up-regulates the expression of DME CYP1A1				[191]
Urethane		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00435 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Urethane inhibits the expression of DME CYP1A1				[192]
Valproic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00029 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Valproic acid up-regulates the expression of DME CYP1A1				[119]
Zoledronic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00140 XEOTIC Info		Gene Form	mRNA
Classification	Drug Approved by US FDA
DME Modulation	Zoledronic acid up-regulates the expression of DME CYP1A1				[193]
Amodiaquine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00489 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Amodiaquine induces the drug-metabolizing activity of DME CYP1A1				[131]
Benidipine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00438 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Benidipine inhibits the drug-metabolizing activity of DME CYP1A1				[132]
Berberine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00463 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Berberine inhibits the drug-metabolizing activity of DME CYP1A1				[194]
Bezafibrate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00493 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Bezafibrate up-regulates the expression of DME CYP1A1				[145]
Daidzein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00439 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Daidzein inhibits the drug-metabolizing activity of DME CYP1A1				[154]
Formononetin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01306 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Formononetin up-regulates the expression of DME CYP1A1				[158]
Indigo carmine		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00933 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Indigo carmine induces the drug-metabolizing activity of DME CYP1A1				[151]
Melatonin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00505 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Melatonin inhibits the drug-metabolizing activity of DME CYP1A1 (Ki = 59 microM)				[114]
Stevioside		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00448 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Stevioside induces the drug-metabolizing activity of DME CYP1A1				[195]
Tanshinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00486 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Tanshinone up-regulates the expression of DME CYP1A1				[196], [197]
Thiazolidinedione		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00835 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Thiazolidinedione inhibits the expression of DME CYP1A1				[145]
Thiostrepton		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01485 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Thiostrepton inhibits the drug-metabolizing activity of DME CYP1A1				[198]
Thymol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00487 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Thymol up-regulates the expression of DME CYP1A1				[199]
Tranilast		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00509 XEOTIC Info		Gene Form	mRNA
Classification	Drug Marketed but not Approved by US FDA
DME Modulation	Tranilast up-regulates the expression of DME CYP1A1				[200]
Drug in Phase 3 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 9 Xenobiotics
Afimoxifene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00610 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Afimoxifene up-regulates the expression of DME CYP1A1				[59]
Curcumin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00683 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Curcumin inhibits the drug-metabolizing activity of DME CYP1A1				[201], [202]
Diethyltoluamide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00582 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Diethyltoluamide up-regulates the expression of DME CYP1A1				[35]
Domperidone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00548 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Domperidone up-regulates the expression of DME CYP1A1				[203]
Endoxifen		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00671 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Endoxifen up-regulates the expression of DME CYP1A1				[204]
Epigallocatechin gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00613 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 3
DME Modulation	Epigallocatechin gallate inhibits the expression of DME CYP1A1				[205]
Oltipraz		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00605 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Oltipraz induces the drug-metabolizing activity of DME CYP1A1				[206]
Resveratrol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00568 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Resveratrol inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 34 microM)				[207]
SGX301		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00579 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	SGX301 inhibits the drug-metabolizing activity of DME CYP1A1				[105]
Drug in Phase 2 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 13 Xenobiotics
Acteoside		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00647 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2/3
DME Modulation	Acteoside up-regulates the expression of DME CYP1A1				[208]
Butyric acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01230 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2/3
DME Modulation	Butyric acid up-regulates the expression of DME CYP1A1				[209]
Isoquercitrin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00644 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2/3
DME Modulation	Isoquercitrin inhibits the drug-metabolizing activity of DME CYP1A1				[210]
Aminoflavone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00685 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Aminoflavone induces the drug-metabolizing activity of DME CYP1A1				[211]
Bisphenol A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01226 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Bisphenol A induces the drug-metabolizing activity of DME CYP1A1				[212], [58]
Delphinidin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00619 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Delphinidin inhibits the drug-metabolizing activity of DME CYP1A1				[213]
Fisetin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01303 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	Fisetin up-regulates the expression of DME CYP1A1				[104]
Genistein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00557 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Genistein inhibits the drug-metabolizing activity of DME CYP1A1				[91], [154]
Lucanthone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00545 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	Lucanthone up-regulates the expression of DME CYP1A1				[214]
MeIQx		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00609 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	MeIQx up-regulates the expression of DME CYP1A1				[46]
MS-275		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00581 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	MS-275 up-regulates the expression of DME CYP1A1				[38]
Phenethyl isothiocyanate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00596 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2
DME Modulation	Phenethyl isothiocyanate induces the drug-metabolizing activity of DME CYP1A1				[215]
Sulindac sulfide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00656 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 2
DME Modulation	Sulindac sulfide up-regulates the expression of DME CYP1A1				[216]
Drug in Phase 1 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 19 Xenobiotics
Carbendazim		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00598 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Carbendazim induces the drug-metabolizing activity of DME CYP1A1				[217], [1]
Carvacrol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01237 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Carvacrol up-regulates the expression of DME CYP1A1				[108]
Dihydrotestosterone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00536 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Dihydrotestosterone up-regulates the expression of DME CYP1A1				[218]
Dinitrochlorobenzene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00571 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Dinitrochlorobenzene up-regulates the expression of DME CYP1A1				[36]
Ellagic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01287 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Ellagic acid inhibits the expression of DME CYP1A1				[205]
Epsilon-viniferin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00646 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Epsilon-viniferin inhibits the drug-metabolizing activity of DME CYP1A1				[219]
Fingolimod hydrochloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00554 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Fingolimod hydrochloride inhibits the expression of DME CYP1A1				[220]
Flavanone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00738 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Flavanone inhibits the drug-metabolizing activity of DME CYP1A1				[91]
HK-001		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00637 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	HK-001 up-regulates the expression of DME CYP1A1				[108]
Kynurenic acid		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01359 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Kynurenic acid induces the drug-metabolizing activity of DME CYP1A1				[221]
Luteolin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00537 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Luteolin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 1.249 microM)				[37]
Naringenin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00573 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Naringenin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 15.167 microM)				[37]
NSC 703786		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01107 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	NSC 703786 induces the drug-metabolizing activity of DME CYP1A1				[222], [223]
O(6)-benzylguanine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01405 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	O(6)-benzylguanine inhibits the drug-metabolizing activity of DME CYP1A1				[224]
Phenanthrene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00574 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Phenanthrene up-regulates the expression of DME CYP1A1				[177]
Quercetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00538 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Quercetin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 1.191 microM)				[37], [96]
R-76713		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00662 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	R-76713 up-regulates the expression of DME CYP1A1				[124]
Sodium arsenite		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00632 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Sodium arsenite inhibits the drug-metabolizing activity of DME CYP1A1				[225]
Trichostatin A		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01492 XEOTIC Info		Gene Form	mRNA
Classification	Highest Clinical Status: Phase 1
DME Modulation	Trichostatin A up-regulates the expression of DME CYP1A1				[226]
Preclinical/Patented Drug		Click to Show/Hide the Full List of Xenobiotics: 16 Xenobiotics
(+)-JQ1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00723 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	(+)-JQ1 inhibits the expression of DME CYP1A1				[227]
Baicalin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00702 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Baicalin induces the drug-metabolizing activity of DME CYP1A1				[228]
Beta-carboline		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00701 XEOTIC Info		Gene Form	mRNA
Classification	Drug in Preclinical Study
DME Modulation	Beta-carboline up-regulates the expression of DME CYP1A1				[97]
Cannabidiol dimethyl ether		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01234 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Cannabidiol dimethyl ether inhibits the drug-metabolizing activity of DME CYP1A1				[229]
Emodin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00692 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Emodin inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 12.25 microM)				[114]
Harmaline		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00693 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Harmaline inhibits the drug-metabolizing activity of DME CYP1A1				[230]
Myricetin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01384 XEOTIC Info		Gene Form	Protein
Classification	Drug in Preclinical Study
DME Modulation	Myricetin inhibits the drug-metabolizing activity of DME CYP1A1 (Ki = 0.37 microM)				[98]
DMU-212		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01283 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	DMU-212 inhibits the drug-metabolizing activity of DME CYP1A1				[231], [232]
Eugenol		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00885 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	Eugenol inhibits the drug-metabolizing activity of DME CYP1A1				[233]
Ferulic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00730 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	Ferulic acid inhibits the drug-metabolizing activity of DME CYP1A1				[202]
GW-3965		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01325 XEOTIC Info		Gene Form	mRNA
Classification	Patented Pharmaceutical Agent
DME Modulation	GW-3965 up-regulates the expression of DME CYP1A1				[234]
Harmine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00732 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	Harmine inhibits the drug-metabolizing activity of DME CYP1A1				[235]
NSC-674495		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01400 XEOTIC Info		Gene Form	Protein
Classification	Patented Pharmaceutical Agent
DME Modulation	NSC-674495 induces the drug-metabolizing activity of DME CYP1A1				[236]
STO-609		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01476 XEOTIC Info		Gene Form	mRNA
Classification	Patented Pharmaceutical Agent
DME Modulation	STO-609 up-regulates the expression of DME CYP1A1				[237]
TO-901317		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01487 XEOTIC Info		Gene Form	mRNA
Classification	Patented Pharmaceutical Agent
DME Modulation	TO-901317 up-regulates the expression of DME CYP1A1				[86], [87]
WAY-169916		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01499 XEOTIC Info		Gene Form	mRNA
Classification	Patented Pharmaceutical Agent
DME Modulation	WAY-169916 inhibits the expression of DME CYP1A1				[238]
Drug Marketed but Withdrawn from Market		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Cantharidin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00531 XEOTIC Info		Gene Form	Protein
Classification	Drug Marketed but Withdrawn from Market
DME Modulation	Cantharidin induces the drug-metabolizing activity of DME CYP1A1				[239]
Investigative Agent		Click to Show/Hide the Full List of Xenobiotics: 21 Xenobiotics
1,2-naphthoquinone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00868 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	1,2-naphthoquinone up-regulates the expression of DME CYP1A1				[23]
2'-hydroxychalcone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01126 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	2'-hydroxychalcone inhibits the drug-metabolizing activity of DME CYP1A1				[240]
3'-methoxy-4'-nitroflavone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01139 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	3'-methoxy-4'-nitroflavone induces the drug-metabolizing activity of DME CYP1A1				[241]
3,3',4,5'-tetrahydroxystilbene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01133 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	3,3',4,5'-tetrahydroxystilbene induces the drug-metabolizing activity of DME CYP1A1				[57]
4'-bromoflavone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01150 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	4'-bromoflavone up-regulates the expression of DME CYP1A1				[242]
4-chlorophenylbiguanide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01152 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	4-chlorophenylbiguanide induces the drug-metabolizing activity of DME CYP1A1				[131]
6,7-dihydroxyflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01167 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	6,7-dihydroxyflavone inhibits the drug-metabolizing activity of DME CYP1A1				[91]
AG-1879		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00770 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	AG-1879 induces the drug-metabolizing activity of DME CYP1A1				[243]
Benzyl selenocyanate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01218 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Benzyl selenocyanate inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.1 microM)				[114]
Beta-naphthoflavone		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01220 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Beta-naphthof DMElavone inhibits the drug-metabolizing activity of DME CYP1A1 (IC50 = 0.054 microM)				[89]
Cloflucarban		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00909 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Cloflucarban induces the drug-metabolizing activity of DME CYP1A1				[1]
Ethyl isopropylamiloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01293 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Ethyl isopropylamiloride inhibits the drug-metabolizing activity of DME CYP1A1				[244]
Farnesol		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01298 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Farnesol up-regulates the expression of DME CYP1A1				[26]
Furafylline		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01307 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Furafylline inhibits the drug-metabolizing activity of DME CYP1A1 (Ki > 200 microM)				[245]
G-1		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01086 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	G-1 up-regulates the expression of DME CYP1A1				[246]
Indirubin-3'-monoxime		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01342 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Indirubin-3'-monoxime up-regulates the expression of DME CYP1A1				[247]
Mono-(2-ethylhexyl)phthalate		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01380 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Mono-(2-ethylhexyl)phthalate induces the drug-metabolizing activity of DME CYP1A1				[248]
Pifithrin		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01431 XEOTIC Info		Gene Form	mRNA
Classification	Investigative Agent
DME Modulation	Pifithrin up-regulates the expression of DME CYP1A1				[38]
Pyrazolanthrone		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01445 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Pyrazolanthrone induces the drug-metabolizing activity of DME CYP1A1				[249]
Rhein		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01455 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Rhein inhibits the drug-metabolizing activity of DME CYP1A1				[250]
SB-202190		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO01146 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	SB-202190 induces the drug-metabolizing activity of DME CYP1A1				[24]
Other Chemical Compound(s) or Element(s)
Chemical Compound		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Naphthalene		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00764 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	Naphthalene induces the drug-metabolizing activity of DME CYP1A1				[251]
Pyridine N-oxide		Click to Show/Hide the Detail			Induction
XEOTIC ID	XEO00791 XEOTIC Info		Gene Form	mRNA
Classification	Chemical Compound
DME Modulation	Pyridine N-oxide up-regulates the expression of DME CYP1A1				[252]

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