General Information of Drug Metabolite (DM) (ID: DM009999)
DM Name
Unclear
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
#NAME? DMEN252 Unclear - Unclear BP-12941 [1]
Acyl-CoA thioesterase 13 (ACOT13) DME0516 Hydrolysis - Hydrolysis Hydroxybutyryl-CoA [2]
Alcohol dehydrogenase 1C1 (ADH1C1) DMEN408 Unclear - Unclear Ethanol [3]
Alcohol dehydrogenase 1C2 (ADH1C2) DMEN409 Unclear - Unclear Ethanol [3]
Alcohol dehydrogenase class-I beta (ADH1B) DME0128 Unclear - Unclear Ethanol [3]
Aldehyde dehydrogenase 1 (ALDH1) DME0286 Unclear - Unclear Decanal [4]
Aldehyde oxidase (AOX1) DME0052 Unclear - Unclear Lenvatinib mesylate [5]
Aldehyde oxidase (AOX1) DME0052 Oxidation - Oxidationn XL-147 [6] , [7]
Aldehyde oxidase (AOX1) DME0052 Oxidation - 2-hydroxylation FYX-051 [8]
Aldo-keto reductase 1C3 (AKR1C3) DME0118 Oxidation - Oxidationn Indan-1-ol [9]
Aldo-keto reductase 1D1 (AKR1D1) DME0400 Hydrolysis - Hydrolysis Hydroxy-cholesten-one [2]
Aldo-keto reductases (AKR) DMEN063 Reduction - Reduction Telaprevir [10]
Aldo-keto reductases (AKR) DMEN063 Reduction - Reduction Brexanolone [11]
Alpha-galactosidase (melA) DME1714 Unclear - Unclear Melibiose [12]
Aminoglycoside 3'-phosphotransferase (aphA) DMEN326 Unclear - Unclear Sisomicin [13]
Aminoglycoside adenylyltransferase (aadA1a) DME1632 Conjugation - O-Adenosine conjugation Spectinomycin [14]
Angiotensin-converting enzyme 2 (ACE2) DME0446 Hydrolysis - Hydrolysis TXA-127 [15]
Aromatase (CYP19A1) DME0002 Unclear - Unclear Ethanol [16]
Arylamine N-acetyltransferase (NAT) DME1102 Unclear - Unclear Dihydralazine [17]
Beta-glycosidase (glyB) DME1677 Unclear - Unclear K-6015 [18]
Beta-mannosidase (manB) DME1195 Unclear - Unclear Mannotetraose [19]
Beta-mannosidase (manB) DME1195 Unclear - Unclear Man-b-4MU [19]
Beta-mannosidase (manB) DME1195 Unclear - Unclear W-201259 [19]
Brain form hexokinase (HK1) DME0476 Unclear - Unclear ANW-43980 [20]
Carboxyl ester lipase (CEL) DME0568 Hydrolysis - Hydrolysis Estol-1581 [21]
Carboxypeptidase A4 (CPA4) DME0593 Other reaction - Degradation GTPL-989 [22]
Copper amine oxidase (AOC3) DME0405 Unclear - Unclear Phenylethylamine [23]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME0199 Reduction - Reduction Dehydrocorticosterone [24]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME0419 Reduction - Reduction Dehydrocorticosterone [24]
Cyclic ADP-ribose hydrolase 1 (CD38) DME0538 Unclear - Unclear FT-0654944 [25]
CYTOCHROME CYP141 (CYP141) DMEN245 Unclear - Unclear Ramosetron [26]
Cytochrome P450 124 (cyp124) DME1234 Oxidation - Oxidationn Provitamin D3 [27]
Cytochrome P450 1A1 (CYP1A1) DME0006 Unclear - Unclear Sudan I [28]
Cytochrome P450 1A1 (CYP1A1) DME0006 Unclear - Unclear TMC-120 [29]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear Enasidenib [30]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear MRTX849 [31]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear MLN-8054 [32]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear Ramosetron [26] , [33]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear Dihydralazine [34]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear Bromazepam [35]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear RO-408757 [36]
Cytochrome P450 1A2 (CYP1A2) DME0003 Unclear - Unclear Rasagiline mesylate [37]
Cytochrome P450 1A2 (CYP1A2) DME0003 Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [38] , [39]
Cytochrome P450 2A13 (CYP2A13) DME0030 Unclear - Unclear BRN-3548355 [40]
Cytochrome P450 2A6 (CYP2A6) DME0005 Unclear - Unclear Lidocaine [16]
Cytochrome P450 2A6 (CYP2A6) DME0005 Unclear - Unclear Chloroxylenol [16]
Cytochrome P450 2B6 (CYP2B6) DME0020 Unclear - Unclear MRTX849 [31]
Cytochrome P450 2B6 (CYP2B6) DME0020 Oxidation - Oxidationn Voxelotor [41]
Cytochrome P450 2B6 (CYP2B6) DME0020 Unclear - Unclear Trifarotene [42]
Cytochrome P450 2B6 (CYP2B6) DME0020 Unclear - Unclear Clotiazepam [43]
Cytochrome P450 2B6 (CYP2B6) DME0020 Oxidation - Thiono-Oxidation Disulfiram [44]
Cytochrome P450 2B6 (CYP2B6) DME0020 Unclear - Unclear AV-650 [45]
Cytochrome P450 2B6 (CYP2B6) DME0020 Unclear - Unclear Lidocaine [46]
Cytochrome P450 2C18 (CYP2C18) DME0017 Unclear - Unclear Clotiazepam [43]
Cytochrome P450 2C18 (CYP2C18) DME0017 Unclear - Unclear Lidocaine [16]
Cytochrome P450 2C8 (CYP2C8) DME0018 Unclear - Unclear MRTX849 [31]
Cytochrome P450 2C8 (CYP2C8) DME0018 Unclear - Unclear Trifarotene [42]
Cytochrome P450 2C8 (CYP2C8) DME0018 Unclear - Unclear BNP-1350 [47]
Cytochrome P450 2C8 (CYP2C8) DME0018 Unclear - Unclear AZD-2014 [48]
Cytochrome P450 2C8 (CYP2C8) DME0018 Unclear - Unclear Relugolix [49]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear MRTX849 [31]
Cytochrome P450 2C9 (CYP2C9) DME0019 Oxidation - Oxidationn Voxelotor [41]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Gliquidone [50]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Trifarotene [42]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Lidocaine [16]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Iclaprim [51]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Dicumarol [52]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Leflunomide [53]
Cytochrome P450 2C9 (CYP2C9) DME0019 Unclear - Unclear Sitaxentan [54]
Cytochrome P450 2C9 (CYP2C9) DME0019 Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [38] , [39]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear MRTX849 [31]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Gliquidone [50]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Chloroxylenol [16]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear BNP-1350 [47]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Ramosetron [26]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear E-7070 [55]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Iclaprim [51]
Cytochrome P450 2D6 (CYP2D6) DME0009 Conjugation - Glucuronidation Upadacitinib [56]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Lorpiprazole [57]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Letermovir [58]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Lidocaine [59]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Pyrantel [60]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Remoxipride [16]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Repinotan [61]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Esmirtazapine [62]
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - Hydrolyzationn Guanoxan [16]
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - N-desethylation CBL-0102 [63]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Bromazepam [35]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Bupranolol [64]
Cytochrome P450 2D6 (CYP2D6) DME0009 Unclear - Unclear Revefenacin [65]
Cytochrome P450 2E1 (CYP2E1) DME0013 Oxidation - Thiono-Oxidation Disulfiram [44]
Cytochrome P450 2E1 (CYP2E1) DME0013 Unclear - Unclear Chloroxylenol [16]
Cytochrome P450 2E1 (CYP2E1) DME0013 Unclear - Unclear Y-100032 [66]
Cytochrome P450 2J2 (CYP2J2) DME0031 Oxidation - Hydrolyzationn Infigratinib [67] , [68]
Cytochrome P450 3A (CYP3A) DMEN065 Unclear - Unclear Grazoprevir [69]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Enasidenib [30]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear MRTX849 [31]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidationn Voxelotor [41]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Gliquidone [50]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Trifarotene [42]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Clotiazepam [43]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Thiono-Oxidation Disulfiram [44]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear BNP-1350 [47]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear PT2977 [70]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear AZD-2014 [48]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Hydrolyzationn Infigratinib [67] , [68]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Sulfoxidation Disulfiram [44]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Isavuconazonium [71]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Isavuconazole [72] , [71]
Cytochrome P450 3A4 (CYP3A4) DME0001 Conjugation - Glucuronidation Upadacitinib [56]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Lorpiprazole [57]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Lenacapavir [73]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Iclaprim [51]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear MLN-8054 [32]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidation Albendazole [74]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - O-Demethylations Alfuzosin hydrochloride [75]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - N-Dealkylation Alfuzosin hydrochloride [75]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidation Alfuzosin hydrochloride [75]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidation Exemestane [76] , [77]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Fedratinib hydrochloride [78] , [79] , [80]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Fingolimod [81]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Fingolimod hydrochloride [81]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Lefamulin [82] , [83] , [84]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Lenvatinib mesylate [85]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Letermovir [86]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Levonorgestrel [87]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Pretomanid [88]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Telaprevir [10]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Temsirolimus [89]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Elbasvir [90]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Deamination Oxazepam [91]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Selinexor [92]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Leflunomide [93]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Avapritinib [94]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Mitapivat [95]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Selpercatinib [96]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Methylergometrine [97]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Clotrimazole [98]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Imiquimod [16]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Halcinonide [99]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear CTK1G9578 [100]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Manidipine 2HCl [101]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear GBR-12909 [102]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear GW-873140 [103]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Hydrolyzationn Miocamycin [104]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear LY-2940680 [105] , [106]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidationn ZK-299 [107]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Tianeptine [108]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear NSC-9705 [22]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Dienogest [109]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Dihydralazine [110]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Ergometrine [111]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Ergonovine maleate [111]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear BC-3781 [112]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear RO-408757 [36]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear BMS-275183 [113]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Hydroxylation MK-3118 [114]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Voxilaprevir [115]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Rifaximin [116]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Conivaptan hydrochloride [117]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear Fluprednisolone [118]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [38] , [39]
Cytochrome P450 3A5 (CYP3A5) DME0012 Oxidation - Oxidationn Voxelotor [41]
Cytochrome P450 3A5 (CYP3A5) DME0012 Oxidation - Thiono-Oxidation Disulfiram [44]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear AZD-2014 [48]
Cytochrome P450 3A5 (CYP3A5) DME0012 Oxidation - Sulfoxidation Disulfiram [44]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Isavuconazonium [71]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Isavuconazole [72] , [71]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Docetaxel [119]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Finasteride [119]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Letermovir [86]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Levonorgestrel [87]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear Levomethadyl acetate hydrochloride [119]
Cytochrome P450 3A5 (CYP3A5) DME0012 Unclear - Unclear TMC-120 [29]
Cytochrome P450 3A5 (CYP3A5) DME0012 Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [38] , [39]
Cytochrome P450 3A7 (CYP3A7) DME0015 Unclear - Unclear Docetaxel [119]
Cytochrome P450 3A7 (CYP3A7) DME0015 Unclear - Unclear Fentanyl citrate [119]
Cytochrome P450 3A7 (CYP3A7) DME0015 Unclear - Unclear Finasteride [119]
Cytochrome P450 3A7 (CYP3A7) DME0015 Unclear - Unclear Temsirolimus [119]
Cytochrome P450 3A7 (CYP3A7) DME0015 Unclear - Unclear Levomethadyl acetate hydrochloride [119]
Cytochrome P450 3A7 (CYP3A7) DME0015 Unclear - Unclear Prasterone sulfate [120]
Cytosolic 5'-nucleotidase II (NT5C2) DME0482 Unclear - Unclear Inosine [121] , [122]
Dimethylaniline oxidase 3 (FMO3) DME0039 Unclear - Unclear AV-650 [45]
Dimethylaniline oxidase 3 (FMO3) DME0039 Unclear - Unclear Fedratinib hydrochloride [79]
Dipeptidyl peptidase IV (DPP4) DME0133 Oxidation - Degradation Liraglutide [123]
dispepetidase (DPT) DMEN363 Unclear - Unclear BP-12941 [1]
Folylpolyglutamate synthetase (fpgS) DME1239 Unclear - Unclear DACTHF [124]
Friedreich ataxia protein (FXN) DME0416 Unclear - Unclear Ferrum metallicum [125]
Gamma-glutamylcyclotransferase 2 (CHAC2) DME0450 Unclear - Unclear ANW-43980 [126]
Gamma-glutamyltranspeptidase 1 (GGT1) DME0498 Unclear - Unclear Glutathiol [127]
Gamma-glutamyltranspeptidase 5 (GGT5) DME0432 Unclear - Unclear Glutathiol [127]
glucose 1,6-P2 phosphatase (GLP) DMEN341 Unclear - Unclear Glucose-bisphosphate [128]
Glutathione peroxidase 6 (GPX6) DME0610 Unclear - Unclear ANW-43980 [20]
Glutathione S-transferase alpha-1 (GSTA1) DME0011 Unclear - Unclear Selinexor [129]
Glyceraldehyde-3-phosphate dehydrogenase (gap) DME1052 Unclear - Unclear CERC-801 [130]
Hyaluronidase-1 (HYAL1) DMEN354 Unclear - Unclear Hyaluronan [131]
Inositol polyphosphate 4-phosphatase I (INPP4A) DME0525 Unclear - Unclear DMI-bisphosphate [132]
Insulin-degrading enzyme (IDE) DME0494 Unclear - Unclear Insulin [133]
L-arabinose isomerase (araA) DME1053 Unclear - Unclear CERC-801 [134]
L-arabinose isomerase (araA) DME1053 Unclear - Unclear CERC-801 [135]
L-malate:NADP(+) oxidoreductase (maeB) DME1471 Unclear - Unclear Malate [136] , [137]
Lactate dehydrogenase C (LDHC) DME0503 Unclear - Unclear Lactate [138]
Lauric acid omega-hydroxylase (CYP4A11) DME0029 Unclear - Unclear Y-100032 [66]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Enasidenib [30]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - Oxidationn Voxelotor [41]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Gliquidone [50]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Clotiazepam [43]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear PT2977 [70]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear E-7070 [55]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Iclaprim [51]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Fedratinib hydrochloride [79] , [80]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Teniposide [119]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Unclear - Unclear Bufuralol [139]
Microsomal glutathione S-transferase 1 (MGST1) DME0621 Unclear - Unclear Glyceryl trinitrate [140]
Monoamine oxidase type A (MAO-A) DME0044 Unclear - Unclear Phenylethylamine [141]
NADP-dependent malic enzyme (ME1) DME0504 Unclear - Unclear Malate [136] , [137]
NADPH-dependent carbonyl reductase 3 (CBR3) DME0068 Reduction - Reduction Isatin [142]
Neprilysin (MME) DME0168 Oxidation - Degradation Liraglutide [123]
Neprilysin (MME) DME0168 Hydrolysis - Hydrolysis Semaglutide [143]
Nonenzymatical (Non-ME) DMEN081 Unclear - Unclear Lenvatinib mesylate [5]
Nonenzymatical (Non-ME) DMEN081 Hydrolysis - Hydrolysis Tegaserod [144]
Nonribosomal peptide synthase sidC (SidC) DMEN370 Unclear - Unclear Insulin [133]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME1098 Reduction - Reduction CL-205086 [145]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME1048 Reduction - Reduction CL-205086 [145]
Oxysterol 7-alpha-hydroxylase (CYP39A1) DME0619 Unclear - Unclear CS-6969 [146]
Phosphomannomutase 2 (PMM2) DME0452 Unclear - Unclear Mannose [147]
Phosphomannose isomerase (MPI) DMEN278 Unclear - Unclear Mannose [147]
Prostaglandin dehydrogenase 1 (HPGD) DME0566 Unclear - Unclear Dinoprostone [148]
Retinal dehydrogenase 2 (ALDH1A2) DME0287 Unclear - Unclear Decanal [4]
selenium-dependent xanthine dehydrogenase (XDH) DMEN318 Unclear - Unclear Dichloroindophenol [149]
Semicarbazide-sensitive amine oxidase (AOC2) DME0477 Unclear - Unclear Phenylethylamine [23]
Serum paraoxonase/arylesterase 1 (PON1) DME0169 Unclear - Unclear Coumaranone [150]
Serum paraoxonase/arylesterase 1 (PON1) DME0169 Unclear - Unclear Gamma-butyrolactone [150]
Serum paraoxonase/arylesterase 1 (PON1) DME0169 Unclear - Unclear Gamma-thiobutyrolactone [150] , [151]
Serum paraoxonase/arylesterase 1 (PON1) DME0169 Hydrolysis - Hydrolysis Homogentisic acid [150]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME0206 Unclear - Unclear HSDB-3165 [152]
Sulfotransferase (SULT) DMEN061 Unclear - Unclear Ephedrin [153]
Sulfotransferase 1A1 (SULT1A1) DME0008 Conjugation - Sulfation Daidzein [154]
Sulfotransferase 1A1 (SULT1A1) DME0008 Unclear - Unclear L-thyroxine [155]
Sulfotransferase 1E1 (SULT1E1) DME0061 Conjugation - Sulfation Daidzein [154]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Unclear - Unclear Enasidenib [30]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Conjugation - Glucuronidation Phloretin [156]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Conjugation - N1-Glucuronidation FYX-051 [157]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Conjugation - N2-Glucuronidation FYX-051 [157]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Unclear - Unclear Simvastatin [158]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Hydrolysis - Hydrolysis Tecovirimat [159]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Conjugation - Glucuronidation Voxelotor [41]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Unclear - Unclear Lenacapavir [73]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Unclear - Unclear Anthraflavic acid [156]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 Unclear - Unclear Enasidenib [30]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 Unclear - Unclear Simvastatin [158]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME0048 Hydrolysis - Hydrolysis Tecovirimat [159]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME0072 Unclear - Unclear BCP-13498 [160]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065 Conjugation - Glucuronidation Phloretin [156]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065 Conjugation - N1-Glucuronidation FYX-051 [157]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065 Conjugation - N2-Glucuronidation FYX-051 [157]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME0064 Conjugation - Glucuronidation Phloretin [156]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Unclear - Unclear Enasidenib [30]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Conjugation - Glucuronidation Phloretin [156]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Conjugation - N1-Glucuronidation FYX-051 [157]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Conjugation - N2-Glucuronidation FYX-051 [157]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Conjugation - Glucuronidation Voxelotor [41]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Unclear - Unclear BCP-13498 [161]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Unclear BCP-13498 [161]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066 Unclear - Unclear PT2977 [70]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Unclear - Unclear Simvastatin [158]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Unclear - Unclear BRN-3548355 [40]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Unclear BRN-3548355 [40]
UDP-glucuronyltransferase (UGT) DMEN064 Unclear - Unclear Digitoxin [162]
UDP-glucuronyltransferase (UGT) DMEN064 Conjugation - Glucuronidation Isavuconazonium [163]
UDP-glucuronyltransferase (UGT) DMEN064 Conjugation - Glucuronidation Isavuconazole [164]
Unclear metabolic mechanism (DME-unclear) DMEN352 Unclear - Unclear Glucosamine [165]
Unclear metabolic mechanism (DME-unclear) DMEN336 Oxidation - Hydrolyzationn Kestose [166]
⏷ Show the Full List of DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Catechol O-methyltransferase (COMT) DME0043 Conjugation - O-methylation Ethinylestradiol propanesulfonate [38] , [39]
Catechol O-methyltransferase (COMT) DME0043 Conjugation - O-methylation Ethinylestradiol propanesulfonate [38] , [39]
Catechol O-methyltransferase (COMT) DME0043 Conjugation - O-methylation Ethinylestradiol propanesulfonate [38] , [39]
Catechol O-methyltransferase (COMT) DME0043 Conjugation - O-methylation Ethinylestradiol propanesulfonate [38] , [39]
Catechol O-methyltransferase (COMT) DME0043 Conjugation - O-methylation Ethinylestradiol propanesulfonate [38] , [39]
dispepetidase (DPT) DMEN363 Unclear - Unclear BP-12941 [1]
N-acetyltransferase 2 (NAT2) DME0051 Conjugation - Acetylation BP-12941 [1]
Quinone reductase 1 (NQO1) DME0097 Multi-steps Reaction - Reduction; glucuronidation ARQ-501 [167]
Quinone reductase 1 (NQO1) DME0097 Multi-steps Reaction - Reduction; glucuronidation ARQ-501 [167]
UDP-glucuronyltransferase (UGT) DMEN064 Conjugation - Glucuronidation Isavuconazonium [163]
Full List of Drug(s) That Produce This DM By Metabolism
Lidocaine DR0953 Approved Anaesthesia
Temsirolimus DR1548 Approved Renal cell carcinoma
Lenvatinib mesylate DR0923 Approved Thyroid cancer
Thiazolidinedione DR5352 Approved Alzheimer disease
Disulfiram DR0519 Approved Alcohol dependence
Albendazole DR0055 Approved Giardiasis
Teniposide DR1550 Approved Acute lymphoblastic leukemia
Digitoxin DR0497 Approved Congestive heart failure
Dihydroergotamine DR0504 Approved Migraine
Diphenylpyraline DR2281 Approved Allergy
Finasteride DR0695 Approved Prostatic hyperplasia
Levonorgestrel DR0946 Approved Menorrhagia
Rifabutin DR1418 Approved Pulmonary tuberculosis
Infigratinib DR5886 Approved Discovery agent
Leflunomide DR0921 Approved Rheumatoid arthritis
Letermovir DR0928 Approved Cytomegalovirus infection
Revefenacin DR1412 Approved Chronic obstructive pulmonary disease
Simvastatin DR1485 Approved Dyslipidaemia
Tapentadol DR1531 Approved Neuropathic pain
Tegaserod DR1541 Approved Irritable bowel syndrome
Diphenhydramine DR0514 Approved Meniere disease
Exemestane DR0675 Approved Breast cancer
Fentanyl citrate DR0690 Approved Anaesthesia
Fingolimod DR0696 Approved Multiple sclerosis
Fingolimod hydrochloride DR0697 Approved Multiple sclerosis
Levobupivacaine DR0934 Approved Anaesthesia
Liraglutide DR0962 Approved Diabetes mellitus
Tecovirimat DR1537 Approved Smallpox
Telaprevir DR1543 Approved Viral hepatitis
Alfuzosin hydrochloride DR0063 Approved Prostatic hyperplasia
Avapritinib DR5452 Approved Gastrointestinal stromal tumour
Brexanolone DR0226 Approved Depression
Dicumarol DR1746 Approved Menorrhagia
Docetaxel DR0520 Approved Breast cancer
Fedratinib hydrochloride DR0683 Approved Myelofibrosis
Levomethadyl acetate hydrochloride DR0944 Approved Opiate dependence
Rasagiline mesylate DR1397 Approved Parkinsonism
Selinexor DR1472 Approved Multiple myeloma
Semaglutide DR1473 Approved Diabetes mellitus
Flecainide acetate DR0700 Approved Ventricular tachyarrhythmia
Iclaprim DR1897 Approved Methicillin-resistant staphylococcus infection
Isavuconazole DR0883 Approved Allergic bronchopulmonary aspergillosis
Oxazepam DR1214 Approved Anxiety disorder
Plecanatide DR5378 Approved Chronic idiopathic constipation
Pretomanid DR1338 Approved Pulmonary tuberculosis
Voxelotor DR1713 Approved Sickle-cell anaemia
Clotrimazole DR0362 Approved Candidiasis
Conivaptan hydrochloride DR0376 Approved Hyponatraemia
Dinoprostone DR0511 Approved Abortion
Elbasvir DR0561 Approved Viral hepatitis
Enasidenib DR0574 Approved Acute myeloid leukaemia
Fluprednisolone DR0725 Approved Asthma
Halcinonide DR0798 Approved Atopic dermatitis
Imiquimod DR0864 Approved Basal cell carcinoma
Isavuconazonium DR0884 Approved Allergic bronchopulmonary aspergillosis
Lefamulin DR0919 Approved Pneumocystis pneumonia
Lenacapavir DR5909 Approved Discovery agent
Methylergometrine DR1052 Approved Migraine
Mitapivat DR5898 Approved Discovery agent
Relugolix DR5569 Approved Prostate cancer
Rifaximin DR1422 Approved Hepatic encephalopathy
Selpercatinib DR5674 Approved Lung cancer
Sisomicin DR2408 Approved Infectious cystitis
Spectinomycin DR2379 Approved Gonococcal infection
Voxilaprevir DR1714 Approved Viral hepatitis
Cetirizine DR2269 Approved Allergy
Choline salicylate DR0316 Approved Rheumatoid arthritis
Eribulin DR0601 Approved Breast cancer
Trifarotene DR1640 Approved Acne vulgaris
Upadacitinib DR1660 Approved Rheumatoid arthritis
Ethinylestradiol propanesulfonate DR0658 Phase 4 Prostate cancer
Glyceryl trinitrate DR2513 Phase 4 Acute coronary syndrome
Pirprofen DR1304 Phase 4 Rheumatoid arthritis
Propiverine DR1363 Phase 4 Overactive bladder
Remoxipride DR1403 Phase 4 Schizophrenia
Daidzein DR1986 Phase 4 Dyslipidaemia
Ephedrin DR0586 Phase 4 Contraception
Tianeptine DR1589 Phase 4 Depression
Clotiazepam DR0361 Phase 4 Anxiety disorder
Dextropropoxyphene DR0478 Phase 4 Lung cancer
Dihydralazine DR0499 Phase 4 Essential hypertension
Gestodene DR0770 Phase 4 Contraception
Hyaluronan DR2724 Phase 4 Osteoarthritis
Etizolam DR0665 Phase 4 Insomnia
Grazoprevir DR0789 Phase 4 Viral hepatitis
Prasterone sulfate DR1324 Phase 4 Adrenocortical deficiency
Ramosetron DR1392 Phase 4 Irritable bowel syndrome
Dienogest DR0490 Phase 4 Endometriosis
Ergometrine DR0597 Phase 4 Postpartum haemorrhage
Ergonovine maleate DR0598 Phase 4 Abnormal vaginal bleeding
Esmirtazapine DR0625 Phase 4 Depression
Ferrum metallicum DR0882 Phase 4 Vitamin deficiency
Gliquidone DR0779 Phase 4 Diabetes mellitus
Glucosamine DR0781 Phase 4 Osteoarthritis
Guanoxan DR0797 Phase 4 Essential hypertension
Pyrantel DR1371 Phase 4 Hookworm disease
Sitaxentan DR1491 Phase 4 Pulmonary hypertension
CKD-501 DR0966 Phase 3 Diabetes mellitus
Y-100032 DR1309 Phase 3 Multiple myeloma
BRN-0077922 DR0786 Phase 3 Influenza virus infection
NSC-9705 DR0382 Phase 3 Osteoarthritis
BNP-1350 DR1901 Phase 3 Ovarian cancer
MRTX849 DR5978 Phase 3 Lung cancer
PT2977 DR5001 Phase 3 Renal cell carcinoma
TXA-127 DR1903 Phase 3 Histiocytic sarcoma
ARQ-501 DR1869 Phase 2 Leiomyosarcoma
GS-9620 DR1834 Phase 2 Viral hepatitis
GSK-1278863 DR1824 Phase 2 Asperger syndrome
AZD-2014 DR1837 Phase 2 Brain cancer
Ethanol DR0655 Phase 2 Diabetic nephropathy
ANW-43980 DR2036 Phase 2 Parkinsonism
BCP-13498 DR1359 Phase 2 Anaesthesia
BMS-275183 DR3224 Phase 2 Solid tumour/cancer
CBL-0102 DR1377 Phase 2 Creutzfeldt-Jakob disease
CERC-801 DR0759 Phase 2 Glycosylation disorder
BIIB-014 DR1842 Phase 2 Parkinsonism
FYX-051 DR1619 Phase 2 Diabetic nephropathy
AV-650 DR1614 Phase 2 Cerebral vasospasm
Glutathiol DR2049 Phase 2 Ovarian cancer
MK-3118 DR1833 Phase 2 Candidiasis
BC-3781 DR1830 Phase 2 Pneumocystis pneumonia
BP-12941 DR1867 Phase 2 Prostate cancer
E-7070 DR0873 Phase 2 Breast cancer
Estol-1581 DR1925 Phase 2 Phenylketonuria
XL-147 DR1854 Phase 2 Uterine cancer
TMC-120 DR1822 Phase 1/2 Human immunodeficiency virus infection
HSDB-3165 DR1317 Phase 1/2 Essential hypertension
LY-2940680 DR1816 Phase 1/2 Breast cancer
ZK-299 DR1820 Phase 1/2 Contraception
MLN-8054 DR1810 Phase 1 Colon cancer
R-58735 DR1798 Discontinued Cerebral ischaemia
RO-408757 DR1776 Discontinued Breast cancer
GBR-12909 DR1670 Discontinued Cocaine addiction
GW-873140 DR1794 Discontinued Human immunodeficiency virus infection
FT-0654944 DR2115 Preclinical Vitamin deficiency
GTPL-989 DR1936 Preclinical Pulmonary hypertension
Kestose DR2670 Preclinical Atopic dermatitis
Q-44287045 DR2664 Preclinical Colon cancer
W-201259 DR2222 Preclinical Salmonella infection
Bufuralol DR0241 Investigative Cardiac arrhythmia
BRN-3548355 DR0011 Investigative Discovery agent
Bromazepam DR0231 Investigative Anxiety disorder
L-thyroxine DR1950 Investigative Hypogonadism
Phenylethylamine DR1960 Investigative Discovery agent
Chloroxylenol DR0302 Investigative Pseudomonas infection
Inosine DR2101 Investigative Haemorrhagic stroke
Malate DR2056 Investigative Discovery agent
Phloretin DR1943 Investigative Discovery agent
Sudan I DR2858 Investigative Discovery agent
Bupranolol DR0244 Investigative Ventricular tachyarrhythmia
Gamma-butyrolactone DR2013 Investigative Discovery agent
Insulin DR2102 Investigative Diabetes mellitus
Manidipine 2HCl DR1002 Investigative Discovery agent
Mannose DR2146 Investigative Discovery agent
Provitamin D3 DR2481 Investigative Discovery agent
Anthraflavic acid DR1938 Investigative Discovery agent
Azetirelin DR2422 Investigative Discovery agent
CL-205086 DR2214 Investigative Amebiasis
Coumaranone DR2011 Investigative Discovery agent
CS-6969 DR2505 Investigative Alzheimer disease
CTK1G9578 DR0018 Investigative Discovery agent
DACTHF DR0019 Investigative Discovery agent
Decanal DR2033 Investigative Discovery agent
Dehydrocorticosterone DR2022 Investigative Discovery agent
Dichloroindophenol DR2045 Investigative Discovery agent
DMI-bisphosphate DR2092 Investigative Discovery agent
Gamma-thiobutyrolactone DR2014 Investigative Discovery agent
Glucose-bisphosphate DR2753 Investigative Discovery agent
Homogentisic acid DR2015 Investigative Discovery agent
Hydroxybutyryl-CoA DR2075 Investigative Discovery agent
Indan-1-ol DR2001 Investigative Discovery agent
Isatin DR1972 Investigative Discovery agent
K-6015 DR2441 Investigative Campylobacter gastroenteritis
Lactate DR2055 Investigative Discovery agent
Lorpiprazole DR0982 Investigative Anxiety disorder
Man-b-4MU DR2466 Investigative Discovery agent
Mannotetraose DR2694 Investigative Alzheimer disease
Medrogestone DR1010 Investigative Corpus luteum cyst
Melibiose DR2489 Investigative Discovery agent
Miocamycin DR1096 Investigative Pulmonary tuberculosis
Pyrocatechol DR2201 Investigative Discovery agent
Repinotan DR1405 Investigative Discovery agent
Hydroxy-cholesten-one DR0023 Investigative Discovery agent
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113 CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183)
114 Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections
115 FDA Label of Vosevi. The 2020 official website of the U.S. Food and Drug Administration
116 U. S. FDA Label -Rifaximin
117 U. S. FDA Label -Conivaptan hydrochloride
118 U. S. FDA Label -Fluprednisolone
119 Drug Interactions Flockhart Table:Docetaxel
120 CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. Calcif Tissue Int. 2007 Mar;80(3):154-9.
121 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
122 Inosine in Biology and Disease
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124 Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug. J Biol Chem. 1994 Apr 1;269(13):9714-20.
125 Iron dysregulation in Friedreich ataxia. Semin Pediatr Neurol. 2006 Sep;13(3):166-75.
126 ChaC2, an enzyme for slow turnover of cytosolic glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651.
127 Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14.
128 Bisphosphorylated metabolites of glycerate, glucose, and fructose: functions, metabolism and molecular pathology
129 FDA label of Selinexor. The 2020 official website of the U.S. Food and Drug Administration.
130 Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.
131 Hyaluronan: Metabolism and Function
132 The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem. 1997 Sep 19;272(38):23859-64.
133 Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
134 Biochemical properties of L-arabinose isomerase from Clostridium hylemonae to produce D-tagatose as a functional sweetener. PLoS One. 2018 Apr 23;13(4):e0196099.
135 The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer. Bioresour Technol. 2010 Dec;101(23):9171-7.
136 Thermostable, ammonium-activated malic enzyme of Clostridium thermocellum. Biochim Biophys Acta. 1981 Aug 13;660(2):251-5.
137 The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):377-83.
138 Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues. Cancer Cell Int. 2015 Feb 15;15:19.
139 The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6
140 Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab Rev. 2011 May;43(2):300-6.
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142 Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis. Chem Biol Interact. 2009 Mar 16;178(1-3):234-41.
143 Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41.
144 Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity Clin Pharmacokinet. 2002;41(13):1021-42. doi: 10.2165/00003088-200241130-00002.
145 Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8.
146 Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression. Asian Pac J Cancer Prev. 2014;15(23):10187-92.
147 Mannose metabolism: more than meets the eye. Biochem Biophys Res Commun. 2014 Oct 17;453(2):220-8.
148 LABEL:ERVIDIL- dinoprostone insert
149 Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized
150 Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
151 Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease
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153 Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11.
154 Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8.
155 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
156 Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
157 DrugBank(Pharmacology-Metabolism):FYX-051
158 Simvastatin Tablet, Film-Coated
159 LABEL:POXX- tecovirimat monohydrate injection, solution, concentrate TPOXX- tecovirimat monohydrate capsule
160 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
161 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
162 Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):226-33.
163 DrugBank(Pharmacology-Metabolism)Isavuconazonium
164 EMA Label: Cresemba, Isavuconazole - European Medicines Agency - Europa EU
165 Uptake and metabolism of N-acetylglucosamine and glucosamine by Streptococcus mutans
166 Extracellular fructooligosaccharide degradation in Anaerostipes hadrus for co-metabolism with non-fructooligosaccharide utilizers
167 Metabolic profile, enzyme kinetics, and reaction phenotyping of -lapachone metabolism in human liver and intestine in vitro

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